1. Single-Case Neuropsychological Assessment of a Patient with a Posterior Parietal Lesion Using Behavioral Testing and Resting-State fMRI
- Author
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Gilles Rode, François Cotton, Karen T. Reilly, Fadila Hadj-Bouziane, Laure Pisella, Carole Guedj, Elisa Martín-Arévalo, Department of Experimental Psychology [Grenade, Espagne], Mind, Brain and Behavior Research Center [Grenade, Espagne] (CIMCYC), University of Granada [Granada]-University of Granada [Granada], Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Neuroradiologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Hôpital Henry Gabrielle [CHU - HCL], Hospices Civils de Lyon (HCL), Universidad de Granada = University of Granada (UGR)-Universidad de Granada = University of Granada (UGR), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Hadj-Bouziane, Fadila
- Subjects
medicine.medical_specialty ,genetic structures ,media_common.quotation_subject ,fronto-occipital networks ,Posterior parietal cortex ,Intraparietal sulcus ,Superior parietal lobule ,Audiology ,behavioral disciplines and activities ,Neglect ,Lesion ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,medicine ,endogenous attention ,Neuropsychological assessment ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,media_common ,frontoparietal networks ,Resting state fMRI ,medicine.diagnostic_test ,Optic ataxia ,business.industry ,Visual field ,exogenous attention ,Neurology ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Neurology (clinical) ,medicine.symptom ,business ,resting-state fMRI - Abstract
International audience; This study integrated functional connectivity measures using resting-state fMRI and behavioral data from a single-case observation of patient (PER) one year after right-hemispheric hemorrhage in the intraparietal sulcus and superior parietal lobule (IPS/SPL). PER showed no sign of clinical neglect. Her behavioral performance in the visuo-manual pointing task and in the letter discrimination task under conditions of endogenous and exogenous attentional cueing was compared between the left (affected) and right (unaffected/control) peripheral visual fields. The resting-state fMRI demonstrated an imbalance between the right and left hemispheric frontoparietal functional connectivity within the dorsal attentional and motor networks. Although the frontal and occipital cortices were not structurally damaged, specific fronto-occipital functional connectivity was imbalanced, which was strongly associated with the behavioral changes. First, the activity in the right frontal eye field showed weaker correlations with the activity in the right inferior occipital area compared to the correlation with the activity in the left inferior occipital area. This imbalanced fronto-occipital functional connectivity was accompanied by a specific impairment in endogenous covert attention in the left visual field. Second, the activity within M1 in both hemispheres showed weaker correlations with the activity of the right cuneus compared to the correlation with the activity in the left cuneus. The imbalanced fronto-occipital functional connectivity was associated with the impairment of the reaching movement of the left and right hands towards the left visual field (optic ataxia). Altogether, our results showed that a lesion to the posterior parietal cortex affects the relationship between distal regions underlying the sensorimotor and attentional abilities
- Published
- 2021
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