17 results on '"for the Mobilise-D consortium"'
Search Results
2. Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium
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M. Encarna Micó-Amigo, Tecla Bonci, Anisoara Paraschiv-Ionescu, Martin Ullrich, Cameron Kirk, Abolfazl Soltani, Arne Küderle, Eran Gazit, Francesca Salis, Lisa Alcock, Kamiar Aminian, Clemens Becker, Stefano Bertuletti, Philip Brown, Ellen Buckley, Alma Cantu, Anne-Elie Carsin, Marco Caruso, Brian Caulfield, Andrea Cereatti, Lorenzo Chiari, Ilaria D’Ascanio, Bjoern Eskofier, Sara Fernstad, Marcel Froehlich, Judith Garcia-Aymerich, Clint Hansen, Jeffrey M. Hausdorff, Hugo Hiden, Emily Hume, Alison Keogh, Felix Kluge, Sarah Koch, Walter Maetzler, Dimitrios Megaritis, Arne Mueller, Martijn Niessen, Luca Palmerini, Lars Schwickert, Kirsty Scott, Basil Sharrack, Henrik Sillén, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Alison J. Yarnall, Lynn Rochester, Claudia Mazzà, Silvia Del Din, and for the Mobilise-D consortium
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Real-world gait ,Algorithms ,DMOs ,Validation ,Wearable sensor ,Walking ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Background Although digital mobility outcomes (DMOs) can be readily calculated from real-world data collected with wearable devices and ad-hoc algorithms, technical validation is still required. The aim of this paper is to comparatively assess and validate DMOs estimated using real-world gait data from six different cohorts, focusing on gait sequence detection, foot initial contact detection (ICD), cadence (CAD) and stride length (SL) estimates. Methods Twenty healthy older adults, 20 people with Parkinson’s disease, 20 with multiple sclerosis, 19 with proximal femoral fracture, 17 with chronic obstructive pulmonary disease and 12 with congestive heart failure were monitored for 2.5 h in the real-world, using a single wearable device worn on the lower back. A reference system combining inertial modules with distance sensors and pressure insoles was used for comparison of DMOs from the single wearable device. We assessed and validated three algorithms for gait sequence detection, four for ICD, three for CAD and four for SL by concurrently comparing their performances (e.g., accuracy, specificity, sensitivity, absolute and relative errors). Additionally, the effects of walking bout (WB) speed and duration on algorithm performance were investigated. Results We identified two cohort-specific top performing algorithms for gait sequence detection and CAD, and a single best for ICD and SL. Best gait sequence detection algorithms showed good performances (sensitivity > 0.73, positive predictive values > 0.75, specificity > 0.95, accuracy > 0.94). ICD and CAD algorithms presented excellent results, with sensitivity > 0.79, positive predictive values > 0.89 and relative errors
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- 2023
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- View/download PDF
3. Design and validation of a multi-task, multi-context protocol for real-world gait simulation
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Kirsty Scott, Tecla Bonci, Francesca Salis, Lisa Alcock, Ellen Buckley, Eran Gazit, Clint Hansen, Lars Schwickert, Kamiar Aminian, Stefano Bertuletti, Marco Caruso, Lorenzo Chiari, Basil Sharrack, Walter Maetzler, Clemens Becker, Jeffrey M. Hausdorff, Ioannis Vogiatzis, Philip Brown, Silvia Del Din, Björn Eskofier, Anisoara Paraschiv-Ionescu, Alison Keogh, Cameron Kirk, Felix Kluge, Encarna M. Micó-Amigo, Arne Mueller, Isabel Neatrour, Martijn Niessen, Luca Palmerini, Henrik Sillen, David Singleton, Martin Ullrich, Beatrix Vereijken, Marcel Froehlich, Gavin Brittain, Brian Caulfield, Sarah Koch, Anne-Elie Carsin, Judith Garcia-Aymerich, Arne Kuederle, Alison Yarnall, Lynn Rochester, Andrea Cereatti, Claudia Mazzà, and for the Mobilise-D consortium
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Digital mobility outcomes ,Technical validation ,Wearable sensors ,Neurological diseases ,Mobility monitoring ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Background Measuring mobility in daily life entails dealing with confounding factors arising from multiple sources, including pathological characteristics, patient specific walking strategies, environment/context, and purpose of the task. The primary aim of this study is to propose and validate a protocol for simulating real-world gait accounting for all these factors within a single set of observations, while ensuring minimisation of participant burden and safety. Methods The protocol included eight motor tasks at varying speed, incline/steps, surface, path shape, cognitive demand, and included postures that may abruptly alter the participants’ strategy of walking. It was deployed in a convenience sample of 108 participants recruited from six cohorts that included older healthy adults (HA) and participants with potentially altered mobility due to Parkinson’s disease (PD), multiple sclerosis (MS), proximal femoral fracture (PFF), chronic obstructive pulmonary disease (COPD) or congestive heart failure (CHF). A novelty introduced in the protocol was the tiered approach to increase difficulty both within the same task (e.g., by allowing use of aids or armrests) and across tasks. Results The protocol proved to be safe and feasible (all participants could complete it and no adverse events were recorded) and the addition of the more complex tasks allowed a much greater spread in walking speeds to be achieved compared to standard straight walking trials. Furthermore, it allowed a representation of a variety of daily life relevant mobility aspects and can therefore be used for the validation of monitoring devices used in real life. Conclusions The protocol allowed for measuring gait in a variety of pathological conditions suggests that it can also be used to detect changes in gait due to, for example, the onset or progression of a disease, or due to therapy. Trial registration: ISRCTN—12246987.
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- 2022
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4. A multi-sensor wearable system for the assessment of diseased gait in real-world conditions
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Francesca Salis, Stefano Bertuletti, Tecla Bonci, Marco Caruso, Kirsty Scott, Lisa Alcock, Ellen Buckley, Eran Gazit, Clint Hansen, Lars Schwickert, Kamiar Aminian, Clemens Becker, Philip Brown, Anne-Elie Carsin, Brian Caulfield, Lorenzo Chiari, Ilaria D’Ascanio, Silvia Del Din, Bjoern M. Eskofier, Judith Garcia-Aymerich, Jeffrey M. Hausdorff, Emily C. Hume, Cameron Kirk, Felix Kluge, Sarah Koch, Arne Kuederle, Walter Maetzler, Encarna M. Micó-Amigo, Arne Mueller, Isabel Neatrour, Anisoara Paraschiv-Ionescu, Luca Palmerini, Alison J. Yarnall, Lynn Rochester, Basil Sharrack, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Ugo Della Croce, Claudia Mazzà, Andrea Cereatti, and for the Mobilise-D consortium
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gait analysis ,IMU ,wearable sensors ,ecological conditions ,pressure insoles ,distance sensors ,Biotechnology ,TP248.13-248.65 - Abstract
Introduction: Accurately assessing people’s gait, especially in real-world conditions and in case of impaired mobility, is still a challenge due to intrinsic and extrinsic factors resulting in gait complexity. To improve the estimation of gait-related digital mobility outcomes (DMOs) in real-world scenarios, this study presents a wearable multi-sensor system (INDIP), integrating complementary sensing approaches (two plantar pressure insoles, three inertial units and two distance sensors).Methods: The INDIP technical validity was assessed against stereophotogrammetry during a laboratory experimental protocol comprising structured tests (including continuous curvilinear and rectilinear walking and steps) and a simulation of daily-life activities (including intermittent gait and short walking bouts). To evaluate its performance on various gait patterns, data were collected on 128 participants from seven cohorts: healthy young and older adults, patients with Parkinson’s disease, multiple sclerosis, chronic obstructive pulmonary disease, congestive heart failure, and proximal femur fracture. Moreover, INDIP usability was evaluated by recording 2.5-h of real-world unsupervised activity.Results and discussion: Excellent absolute agreement (ICC >0.95) and very limited mean absolute errors were observed for all cohorts and digital mobility outcomes (cadence ≤0.61 steps/min, stride length ≤0.02 m, walking speed ≤0.02 m/s) in the structured tests. Larger, but limited, errors were observed during the daily-life simulation (cadence 2.72–4.87 steps/min, stride length 0.04–0.06 m, walking speed 0.03–0.05 m/s). Neither major technical nor usability issues were declared during the 2.5-h acquisitions. Therefore, the INDIP system can be considered a valid and feasible solution to collect reference data for analyzing gait in real-world conditions.
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- 2023
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5. On the use of wearable sensors as mobility biomarkers in the marketing authorization of new drugs: A regulatory perspective
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Marco Viceconti, Maria Tome, Wilhelmus Dartee, Igor Knezevic, Sabina Hernandez Penna, Claudia Mazzà, Brian Caulfield, Judith Garcia-Aymerich, Clemens Becker, Walter Maetzler, Thierry Troosters, Basil Sharrack, Giorgio Davico, Solange Corriol-Rohou, Lynn Rochester, and the Mobilise-D Consortium
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digital mobility outcomes ,regulatory qualification ,mobility biomarkers ,wearable sensors ,mobility disability ,Medicine (General) ,R5-920 - Abstract
The loss of mobility is a common trait in multiple health conditions (e.g., Parkinson's disease) and is associated with reduced quality of life. In this context, being able to monitor mobility in the real world, is important. Until recently, the technology was not mature enough for this; but today, miniaturized sensors and novel algorithms promise to monitor mobility accurately and continuously in the real world, also in pathological populations. However, before any such methodology can be employed to support the development and testing of new drugs in clinical trials, they need to be qualified by the competent regulatory agencies (e.g., European Medicines Agency). Nonetheless, to date, only very narrow scoped requests for regulatory qualification were successful. In this work, the Mobilise-D Consortium shares its positive experience with the European regulator, summarizing the two requests for Qualification Advice for the Mobilise-D methodologies submitted in October 2019 and June 2020, as well as the feedback received, which resulted in two Letters of Support publicly available for consultation on the website of the European Medicines Agency. Leveraging on this experience, we hereby propose a refined qualification strategy for the use of digital mobility outcome (DMO) measures as monitoring biomarkers for mobility in drug trials.
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- 2022
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6. Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement-the Mobilise-D study protocol.
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A Stefanie Mikolaizak, Lynn Rochester, Walter Maetzler, Basil Sharrack, Heleen Demeyer, Claudia Mazzà, Brian Caulfield, Judith Garcia-Aymerich, Beatrix Vereijken, Valdo Arnera, Ram Miller, Paolo Piraino, Nadir Ammour, Mark Forrest Gordon, Thierry Troosters, Alison J Yarnall, Lisa Alcock, Heiko Gaßner, Jürgen Winkler, Jochen Klucken, Christian Schlenstedt, Henrik Watz, Anne-Marie Kirsten, Ioannis Vogiatzis, Nikolaos Chynkiamis, Emily Hume, Dimitrios Megaritis, Alice Nieuwboer, Pieter Ginis, Ellen Buckley, Gavin Brittain, Giancarlo Comi, Letizia Leocani, Jorunn L Helbostad, Lars Gunnar Johnsen, Kristin Taraldsen, Hubert Blain, Valérie Driss, Anja Frei, Milo A Puhan, Ashley Polhemus, Magda Bosch de Basea, Elena Gimeno, Nicholas S Hopkinson, Sara C Buttery, Jeffrey M Hausdorff, Anat Mirelman, Jordi Evers, Isabel Neatrour, David Singleton, Lars Schwickert, Clemens Becker, Carl-Philipp Jansen, and clinical validation study (WP4) on behalf of Mobilise-D consortium
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Medicine ,Science - Abstract
BackgroundThe development of optimal strategies to treat impaired mobility related to ageing and chronic disease requires better ways to detect and measure it. Digital health technology, including body worn sensors, has the potential to directly and accurately capture real-world mobility. Mobilise-D consists of 34 partners from 13 countries who are working together to jointly develop and implement a digital mobility assessment solution to demonstrate that real-world digital mobility outcomes have the potential to provide a better, safer, and quicker way to assess, monitor, and predict the efficacy of new interventions on impaired mobility. The overarching objective of the study is to establish the clinical validity of digital outcomes in patient populations impacted by mobility challenges, and to support engagement with regulatory and health technology agencies towards acceptance of digital mobility assessment in regulatory and health technology assessment decisions.Methods/designThe Mobilise-D clinical validation study is a longitudinal observational cohort study that will recruit 2400 participants from four clinical cohorts. The populations of the Innovative Medicine Initiative-Joint Undertaking represent neurodegenerative conditions (Parkinson's Disease), respiratory disease (Chronic Obstructive Pulmonary Disease), neuro-inflammatory disorder (Multiple Sclerosis), fall-related injuries, osteoporosis, sarcopenia, and frailty (Proximal Femoral Fracture). In total, 17 clinical sites in ten countries will recruit participants who will be evaluated every six months over a period of two years. A wide range of core and cohort specific outcome measures will be collected, spanning patient-reported, observer-reported, and clinician-reported outcomes as well as performance-based outcomes (physical measures and cognitive/mental measures). Daily-living mobility and physical capacity will be assessed directly using a wearable device. These four clinical cohorts were chosen to obtain generalizable clinical findings, including diverse clinical, cultural, geographical, and age representation. The disease cohorts include a broad and heterogeneous range of subject characteristics with varying chronic care needs, and represent different trajectories of mobility disability.DiscussionThe results of Mobilise-D will provide longitudinal data on the use of digital mobility outcomes to identify, stratify, and monitor disability. This will support the development of widespread, cost-effective access to optimal clinical mobility management through personalised healthcare. Further, Mobilise-D will provide evidence-based, direct measures which can be endorsed by regulatory agencies and health technology assessment bodies to quantify the impact of disease-modifying interventions on mobility.Trial registrationISRCTN12051706.
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- 2022
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7. Consensus based framework for digital mobility monitoring.
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Felix Kluge, Silvia Del Din, Andrea Cereatti, Heiko Gaßner, Clint Hansen, Jorunn L Helbostad, Jochen Klucken, Arne Küderle, Arne Müller, Lynn Rochester, Martin Ullrich, Bjoern M Eskofier, Claudia Mazzà, and Mobilise-D consortium
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Medicine ,Science - Abstract
Digital mobility assessment using wearable sensor systems has the potential to capture walking performance in a patient's natural environment. It enables monitoring of health status and disease progression and evaluation of interventions in real-world situations. In contrast to laboratory settings, real-world walking occurs in non-conventional environments and under unconstrained and uncontrolled conditions. Despite the general understanding, there is a lack of agreed definitions about what constitutes real-world walking, impeding the comparison and interpretation of the acquired data across systems and studies. The goal of this study was to obtain expert-based consensus on specific aspects of real-world walking and to provide respective definitions in a common terminological framework. An adapted Delphi method was used to obtain agreed definitions related to real-world walking. In an online survey, 162 participants from a panel of academic, clinical and industrial experts with experience in the field of gait analysis were asked for agreement on previously specified definitions. Descriptive statistics was used to evaluate whether consent (> 75% agreement as defined a priori) was reached. Of 162 experts invited to participate, 51 completed all rounds (31.5% response rate). We obtained consensus on all definitions ("Walking" > 90%, "Purposeful" > 75%, "Real-world" > 90%, "Walking bout" > 80%, "Walking speed" > 75%, "Turning" > 90% agreement) after two rounds. The identification of a consented set of real-world walking definitions has important implications for the development of assessment and analysis protocols, as well as for the reporting and comparison of digital mobility outcomes across studies and systems. The definitions will serve as a common framework for implementing digital and mobile technologies for gait assessment and are an important link for the transition from supervised to unsupervised gait assessment.
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- 2021
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8. A multi-sensor wearable system for the assessment of diseased gait in real-world conditions
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Salis, Francesca, Bertuletti, Stefano, Tecla, Bonci, Caruso, Marco, Kirsty, Scott, Lisa, Alcock, Ellen, Buckley, Eran, Gazit, Clint, Hansen, Lars, Schwickert, Kamiar, Aminian, Clemens, Becker, Philip, Brown, Anne-Elie, Carsin, Brian, Caulfield, Chiari, Lorenzo, Ilaria, D'Ascanio, Silvia Del Din, Eskofier, Bjoern M., Judith, Garcia-Aymerich, Hausdorff, Jeffrey M., Hume, Emily C., Cameron, Kirk, Felix, Kluge, Sarah, Koch, Arne, Kuederle, Walter, Maetzler, Mico'-Amigo, Encarna M., Arne, Mueller, Isabel, Neatrour, Anisoara, Paraschiv-Ionescu, Luca, Palmerini, Yarnall, Alison J., Lynn, Rochester, Basil, Sharrack, David, Singleton, Beatrix, Vereijken, Ioannis, Vogiatzis, Ugo Della Croce, Claudia, Mazza', Cereatti, Andrea, for the Mobilise-D consortium, Salis, Francesca, Carsin, Anne-Elie, García Aymerich, Judith, Koch, Sarah, and Mobilise-D consortium
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Histology ,wearable sensors ,gait analysis ,pressure insoles ,Biomedical Engineering ,Bioengineering ,ecological conditions ,spatial-temporal gait parameters ,ddc:600 ,IMU ,distance sensors ,imu ,Biotechnology - Abstract
Introduction:Accurately assessing people’s gait, especially in real-world conditions and in case of impaired mobility, is still a challenge due to intrinsic and extrinsic factors resulting in gait complexity. To improve the estimation of gait-related digital mobility outcomes (DMOs) in real-world scenarios, this study presents a wearable multi-sensor system (INDIP), integrating complementary sensing approaches (two plantar pressure insoles, three inertial units and two distance sensors). Methods:The INDIP technical validity was assessed against stereophotogrammetry during a laboratory experimental protocol comprising structured tests (including continuous curvilinear and rectilinear walking and steps) and a simulation of daily-life activities (including intermittent gait and short walking bouts). To evaluate its performance on various gait patterns, data were collected on 128 participants from seven cohorts: healthy young and older adults, patients with Parkinson’s disease, multiple sclerosis, chronic obstructive pulmonary disease, congestive heart failure, and proximal femur fracture. Moreover, INDIP usability was evaluated by recording 2.5-h of real-world unsupervised activity. Results and discussion:Excellent absolute agreement (ICC >0.95) and very limited mean absolute errors were observed for all cohorts and digital mobility outcomes (cadence ≤0.61 steps/min, stride length ≤0.02m, walking speed ≤0.02m/s) in the structured tests. Larger, but limited, errors were observed during the daily-life simulation (cadence 2.72–4.87 steps/min, stride length 0.04–0.06m, walking speed 0.03–0.05m/s). Neither major technical nor usability issues were declared during the 2.5-h acquisitions. Therefore, the INDIP system can be considered a valid and feasible solution to collect reference data for analyzing gait in real-world conditions.
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- 2023
9. A Quality Control Check to Ensure Comparability of Stereophotogrammetric Data between Sessions and Systems
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Kirsty Scott, Tecla Bonci, Lisa Alcock, Ellen Buckley, Clint Hansen, Eran Gazit, Lars Schwickert, Andrea Cereatti, Claudia Mazzà, and on behalf of the Mobilise-D Consortium
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optoelectronic stereophotogrammetry ,3D motion capture ,quality control ,spot check ,accuracy ,systematic errors ,Chemical technology ,TP1-1185 - Abstract
Optoelectronic stereophotogrammetric (SP) systems are widely used in human movement research for clinical diagnostics, interventional applications, and as a reference system for validating alternative technologies. Regardless of the application, SP systems exhibit different random and systematic errors depending on camera specifications, system setup and laboratory environment, which hinders comparing SP data between sessions and across different systems. While many methods have been proposed to quantify and report the errors of SP systems, they are rarely utilized due to their complexity and need for additional equipment. In response, an easy-to-use quality control (QC) check has been designed that can be completed immediately prior to a data collection. This QC check requires minimal training for the operator and no additional equipment. In addition, a custom graphical user interface ensures automatic processing of the errors in an easy-to-read format for immediate interpretation. On initial deployment in a multicentric study, the check (i) proved to be feasible to perform in a short timeframe with minimal burden to the operator, and (ii) quantified the level of random and systematic errors between sessions and systems, ensuring comparability of data in a variety of protocol setups, including repeated measures, longitudinal studies and multicentric studies.
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- 2021
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10. Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium
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Micó-Amigo, M. Encarna, Bonci, Tecla, Paraschiv-Ionescu, Anisoara, Ullrich, Martin, Kirk, Cameron, Soltani, Abolfazl, Küderle, Arne, Gazit, Eran, Salis, Francesca, Alcock, Lisa, Aminian, Kamiar, Becker, Clemens, Bertuletti, Stefano, Brown, Philip, Buckley, Ellen, Cantu, Alma, Carsin, Anne-Elie, Caruso, Marco, Caulfield, Brian, Cereatti, Andrea, Chiari, Lorenzo, D'Ascanio, Ilaria, Eskofier, Bjoern, Fernstad, Sara, Froehlich, Marcel, Garcia-Aymerich, Judith, Hansen, Clint, Hausdorff, Jeffrey M., Hiden, Hugo, Hume, Emily, Keogh, Alison, Kluge, Felix, Koch, Sarah, Maetzler, Walter, Megaritis, Dimitrios, Mueller, Arne, Niessen, Martijn, Palmerini, Luca, Schwickert, Lars, Scott, Kirsty, Sharrack, Basil, Sillén, Henrik, Singleton, David, Vereijken, Beatrix, Vogiatzis, Ioannis, Yarnall, Alison J., Rochester, Lynn, Mazzà, Claudia, Del Din, Silvia, and the Mobilise-D Consortium
- Abstract
Background Although digital mobility outcomes (DMOs) can be readily calculated from real-world data collected with wearable devices and ad-hoc algorithms, technical validation is still required. The aim of this paper is to comparatively assess and validate DMOs estimated using real-world gait data from six different cohorts, focusing on gait sequence detection, foot initial contact detection (ICD), cadence (CAD) and stride length (SL) estimates. Methods Twenty healthy older adults, 20 people with Parkinson’s disease, 20 with multiple sclerosis, 19 with proximal femoral fracture, 17 with chronic obstructive pulmonary disease and 12 with congestive heart failure were monitored for 2.5h in the real-world, using a single wearable device worn on the lower back. A reference system combining inertial modules with distance sensors and pressure insoles was used for comparison of DMOs from the single wearable device. We assessed and validated three algorithms for gait sequence detection, four for ICD, three for CAD and four for SL by concurrently comparing their performances (e.g., accuracy, specificity, sensitivity, absolute and relative errors). Additionally, the effects of walking bout (WB) speed and duration on algorithm performance were investigated. Results We identified two cohort-specific top performing algorithms for gait sequence detection and CAD, and a single best for ICD and SL. Best gait sequence detection algorithms showed good performances (sensitivity > 0.73, positive predictive values > 0.75, specificity > 0.95, accuracy > 0.94). ICD and CAD algorithms presented excellent results, with sensitivity > 0.79, positive predictive values > 0.89 and relative errors Algorithms’ performances were lower for short walking bouts; slower gait speeds ( Conclusions Overall, the identified algorithms enabled a robust estimation of key DMOs. Our findings showed that the choice of algorithm for estimation of gait sequence detection and CAD should be cohort-specific (e.g., slow walkers and with gait impairments). Short walking bout length and slow walking speed worsened algorithms’ performances.
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- 2023
11. An Objective Methodology for the Selection of a Device for Continuous Mobility Assessment
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Tecla Bonci, Alison Keogh, Silvia Del Din, Kirsty Scott, Claudia Mazzà, and on behalf of the Mobilise-D consortium
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wearable technology ,real-world assessment ,continuous monitoring ,healthcare challenges ,inertial measurement units ,digital mobility outcomes ,Chemical technology ,TP1-1185 - Abstract
Continuous monitoring by wearable technology is ideal for quantifying mobility outcomes in “real-world” conditions. Concurrent factors such as validity, usability, and acceptability of such technology need to be accounted for when choosing a monitoring device. This study proposes a bespoke methodology focused on defining a decision matrix to allow for effective decision making. A weighting system based on responses (n = 69) from a purpose-built questionnaire circulated within the IMI Mobilise-D consortium and its external collaborators was established, accounting for respondents’ background and level of expertise in using wearables in clinical practice. Four domains (concurrent validity, CV; human factors, HF; wearability and usability, WU; and data capture process, CP), associated evaluation criteria, and scores were established through literature research and group discussions. While the CV was perceived as the most relevant domain (37%), the others were also considered highly relevant (WU: 30%, HF: 17%, CP: 16%). Respondents (~90%) preferred a hidden fixation and identified the lower back as an ideal sensor location for mobility outcomes. Overall, this study provides a novel, holistic, objective, as well as a standardized approach accounting for complementary aspects that should be considered by professionals and researchers when selecting a solution for continuous mobility monitoring.
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- 2020
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12. Connecting real-world digital mobility assessment to clinical outcomes for regulatory and clinical endorsement–the Mobilise-D study protocol
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Mikolaizak, A. Stefanie, Rochester, Lynn, Maetzler, Walter, Sharrack, Basil, Demeyer, Heleen, Mazzà, Claudia, Caulfield, Brian, Garcia-Aymerich, Judith, Vereijken, Beatrix, Arnera, Valdo, Miller, Ram, Piraino, Paolo, Ammour, Nadir, Gordon, Mark Forrest, Troosters, Thierry, Yarnall, Alison J., Alcock, Lisa, Gaßner, Heiko, Winkler, Jürgen, Klucken, Jochen, Schlenstedt, Christian, Watz, Henrik, Kirsten, Anne-Marie, Vogiatzis, Ioannis, Chynkiamis, Nikolaos, Hume, Emily, Megaritis, Dimitrios, Nieuwboer, Alice, Ginis, Pieter, Buckley, Ellen, Brittain, Gavin, Comi, Giancarlo, Leocani, Letizia, Helbostad, Jorunn L., Johnsen, Lars Gunnar, Taraldsen, Kristin, Blain, Hubert, Driss, Valérie, Frei, Anja, Puhan, Milo A., Polhemus, Ashley, Bosch de Basea, Magda, Gimeno, Elena, Hopkinson, Nicholas S., Buttery, Sara C., Hausdorff, Jeffrey M., Mirelman, Anat, Evers, Jordi, Neatrour, Isabel, Singleton, David, Schwickert, Lars, Becker, Clemens, Jansen, Carl-Philipp, members of the clinical validation study on behalf of Mobilise, D. consortium, Phillips, Thomas, Mikolaizak, A. Stefanie, García Aymerich, Judith, Bosch de Basea i Gómez, Magda, 1982, Gimeno, Elena, and Mobilise-D consortium
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Multidisciplinary ,Frailty ,General Science & Technology ,Chronic obstructive pulmonary disease ,Walking ,Data management ,Parkinson disease ,Multiple sclerosis ,Observational Studies as Topic ,Pulmonary Disease, Chronic Obstructive ,clinical validation study (WP4) on behalf of Mobilise-D consortium ,Cancer treatment ,Medicine and Health Sciences ,Humans ,Gait analysis ,ddc:610 ,and members of the clinical validation study (WP4) on behalf of Mobilise-D consortium ,Physical Therapy Modalities ,Monitoring, Physiologic ,Lung volume reduction surgery - Abstract
Background: The development of optimal strategies to treat impaired mobility related to ageing and chronic disease requires better ways to detect and measure it. Digital health technology, including body worn sensors, has the potential to directly and accurately capture real-world mobility. Mobilise-D consists of 34 partners from 13 countries who are working together to jointly develop and implement a digital mobility assessment solution to demonstrate that real-world digital mobility outcomes have the potential to provide a better, safer, and quicker way to assess, monitor, and predict the efficacy of new interventions on impaired mobility. The overarching objective of the study is to establish the clinical validity of digital outcomes in patient populations impacted by mobility challenges, and to support engagement with regulatory and health technology agencies towards acceptance of digital mobility assessment in regulatory and health technology assessment decisions. Methods/design: The Mobilise-D clinical validation study is a longitudinal observational cohort study that will recruit 2400 participants from four clinical cohorts. The populations of the Innovative Medicine Initiative-Joint Undertaking represent neurodegenerative conditions (Parkinson's Disease), respiratory disease (Chronic Obstructive Pulmonary Disease), neuro-inflammatory disorder (Multiple Sclerosis), fall-related injuries, osteoporosis, sarcopenia, and frailty (Proximal Femoral Fracture). In total, 17 clinical sites in ten countries will recruit participants who will be evaluated every six months over a period of two years. A wide range of core and cohort specific outcome measures will be collected, spanning patient-reported, observer-reported, and clinician-reported outcomes as well as performance-based outcomes (physical measures and cognitive/mental measures). Daily-living mobility and physical capacity will be assessed directly using a wearable device. These four clinical cohorts were chosen to obtain generalizable clinical findings, including diverse clinical, cultural, geographical, and age representation. The disease cohorts include a broad and heterogeneous range of subject characteristics with varying chronic care needs, and represent different trajectories of mobility disability. Discussion: The results of Mobilise-D will provide longitudinal data on the use of digital mobility outcomes to identify, stratify, and monitor disability. This will support the development of widespread, cost-effective access to optimal clinical mobility management through personalised healthcare. Further, Mobilise-D will provide evidence-based, direct measures which can be endorsed by regulatory agencies and health technology assessment bodies to quantify the impact of disease-modifying interventions on mobility. Trial registration: ISRCTN12051706. This work was supported by the Mobilise-D project that has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No. 820820. This JU receives support from the European Union's Horizon 2020 research and innovation program and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The funding bodies do not have ultimate authority over any activities (study design, collection, management, analysis, interpretation of data, writing of reports and decision to submit for publication. A draft protocol for the clinical validation was provided as part of the grant/funding application. Content in this publication reflects the authors’ view and neither IMI nor the European Union, EFPIA, or any Associated Partners are responsible for any use that may be made of the information contained herein. ISGlobal acknowledges support from the Spanish Ministry of Science, Innovation and Universities through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. Heleen Demeyer is a post-doctoral fellow of the FWO Flanders. Heiko Gaßner is supported by the Fraunhofer Internal Programs under Grant No. Attract 044-602140 and 044-602150
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- 2022
13. On the use of wearable sensors as mobility biomarkers in the marketing authorization of new drugs: A regulatory perspective
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Viceconti, Marco, Tome, Maria, Dartee, Wilhelmus, Knezevic, Igor, Penna, Sabina Hernandez, Mazzà, Claudia, Caulfield, Brian, Garcia-Aymerich, Judith, Becker, Clemens, Maetzler, Walter, Troosters, Thierry, Sharrack, Basil, Davico, Giorgio, Corriol-Rohou, Solange, Rochester, Lynn, and Mobilise-D Consortium
- Abstract
The loss of mobility is a common trait in multiple health conditions (e.g., Parkinson's disease) and is associated with reduced quality of life. In this context, being able to monitor mobility in the real world, is important. Until recently, the technology was not mature enough for this; but today, miniaturized sensors and novel algorithms promise to monitor mobility accurately and continuously in the real world, also in pathological populations. However, before any such methodology can be employed to support the development and testing of new drugs in clinical trials, they need to be qualified by the competent regulatory agencies (e.g., European Medicines Agency). Nonetheless, to date, only very narrow scoped requests for regulatory qualification were successful. In this work, the Mobilise-D Consortium shares its positive experience with the European regulator, summarizing the two requests for Qualification Advice for the Mobilise-D methodologies submitted in October 2019 and June 2020, as well as the feedback received, which resulted in two Letters of Support publicly available for consultation on the website of the European Medicines Agency. Leveraging on this experience, we hereby propose a refined qualification strategy for the use of digital mobility outcome (DMO) measures as monitoring biomarkers for mobility in drug trials.
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- 2022
14. An Algorithm for Accurate Marker-Based Gait Event Detection in Healthy and Pathological Populations During Complex Motor Tasks
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Bonci, Tecla, Salis, Francesca, Scott, Kirsty, Alcock, Lisa, Becker, Clemens, Bertuletti, Stefano, Buckley, Ellen, Caruso, Marco, Cereatti, Andrea, Del Din, Silvia, Gazit, Eran, Hansen, Clint, Hausdorff, Jeffrey M., Maetzler, Walter, Palmerini, Luca, Rochester, Lynn, Schwickert, Lars, Sharrack, Basil, Vogiatzis, Ioannis, Mazzà, Claudia, and on behalf of the Mobilise-D consortium
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human activities - Abstract
There is growing interest in the quantification of gait as part of complex motor tasks. This requires gait events (GEs) to be detected under conditions different from straight walking. This study aimed to propose and validate a new marker-based GE detection method, which is also suitable for curvilinear walking and step negotiation. The method was first tested against existing algorithms using data from healthy young adults (YA,n= 20) and then assessed in data from 10 individuals from the following five cohorts: older adults, chronic obstructive pulmonary disease, multiple sclerosis, Parkinson’s disease, and proximal femur fracture. The propagation of the errors associated with GE detection on the calculation of stride length, duration, speed, and stance/swing durations was investigated. All participants performed a variety of motor tasks including curvilinear walking and step negotiation, while reference GEs were identified using a validated methodology exploiting pressure insole signals. Sensitivity, positive predictive values (PPV), F1-score, bias, precision, and accuracy were calculated. Absolute agreement [intraclass correlation coefficient (ICC2,1ICC2,1)] between marker-based and pressure insole stride parameters was also tested. In the YA cohort, the proposed method outperformed the existing ones, with sensitivity, PPV, and F1 scores ≥ 99% for both GEs and conditions, with a virtually null bias (
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- 2022
15. A Quality Control Check to Ensure Comparability of Stereophotogrammetric Data between Sessions and Systems
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Scott, Kirsty, Bonci, Tecla, Alcock, Lisa, Buckley, Ellen, Hansen, Clint, Gazit, Eran, Schwickert, Lars, Cereatti, Andrea, Mazzà, Claudia, and Mobilise-D Consortium
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Movement ,TP1-1185 ,gait ,human movement ,Biochemistry ,Article ,Analytical Chemistry ,3D motion capture ,03 medical and health sciences ,0302 clinical medicine ,optoelectronic stereophotogrammetry ,quality control ,spot check ,accuracy ,systematic errors ,Humans ,Electrical and Electronic Engineering ,Instrumentation ,Chemical technology ,030229 sport sciences ,Atomic and Molecular Physics, and Optics ,Accuracy ,Gait ,Human movement ,Optoelectronic stereophotogrammetry ,Quality control ,Spot check ,Systematic errors ,Quality Control ,Photogrammetry ,3. Good health ,030217 neurology & neurosurgery - Abstract
Optoelectronic stereophotogrammetric (SP) systems are widely used in human movement research for clinical diagnostics, interventional applications, and as a reference system for validating alternative technologies. Regardless of the application, SP systems exhibit different random and systematic errors depending on camera specifications, system setup and laboratory environment, which hinders comparing SP data between sessions and across different systems. While many methods have been proposed to quantify and report the errors of SP systems, they are rarely utilized due to their complexity and need for additional equipment. In response, an easy-to-use quality control (QC) check has been designed that can be completed immediately prior to a data collection. This QC check requires minimal training for the operator and no additional equipment. In addition, a custom graphical user interface ensures automatic processing of the errors in an easy-to-read format for immediate interpretation. On initial deployment in a multicentric study, the check (i) proved to be feasible to perform in a short timeframe with minimal burden to the operator, and (ii) quantified the level of random and systematic errors between sessions and systems, ensuring comparability of data in a variety of protocol setups, including repeated measures, longitudinal studies and multicentric studies. This work was supported by the Mobilise-D project that has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No. 820820. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation program and the European Federation of Pharmaceutical Industries and Associations (EFPIA). Content in this publication reflects the authors’ view and neither IMI nor the European Union, EFPIA, or any Associated Partners are responsible for any use that may be made of the information contained herein.
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- 2021
16. Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device
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Cameron Kirk, Arne Küderle, M. Encarna Micó-Amigo, Tecla Bonci, Anisoara Paraschiv-Ionescu, Martin Ullrich, Abolfazl Soltani, Eran Gazit, Francesca Salis, Lisa Alcock, Kamiar Aminian, Clemens Becker, Stefano Bertuletti, Philip Brown, Ellen Buckley, Alma Cantu, Anne-Elie Carsin, Marco Caruso, Brian Caulfield, Andrea Cereatti, Lorenzo Chiari, Ilaria D’Ascanio, Judith Garcia-Aymerich, Clint Hansen, Jeffrey M. Hausdorff, Hugo Hiden, Emily Hume, Alison Keogh, Felix Kluge, Sarah Koch, Walter Maetzler, Dimitrios Megaritis, Arne Mueller, Martijn Niessen, Luca Palmerini, Lars Schwickert, Kirsty Scott, Basil Sharrack, Henrik Sillén, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Alison J. Yarnall, Lynn Rochester, Claudia Mazzà, Bjoern M. Eskofier, Silvia Del Din, and Mobilise-D consortium
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Medicine ,Science - Abstract
Abstract This study aimed to validate a wearable device’s walking speed estimation pipeline, considering complexity, speed, and walking bout duration. The goal was to provide recommendations on the use of wearable devices for real-world mobility analysis. Participants with Parkinson’s Disease, Multiple Sclerosis, Proximal Femoral Fracture, Chronic Obstructive Pulmonary Disease, Congestive Heart Failure, and healthy older adults (n = 97) were monitored in the laboratory and the real-world (2.5 h), using a lower back wearable device. Two walking speed estimation pipelines were validated across 4408/1298 (2.5 h/laboratory) detected walking bouts, compared to 4620/1365 bouts detected by a multi-sensor reference system. In the laboratory, the mean absolute error (MAE) and mean relative error (MRE) for walking speed estimation ranged from 0.06 to 0.12 m/s and − 2.1 to 14.4%, with ICCs (Intraclass correlation coefficients) between good (0.79) and excellent (0.91). Real-world MAE ranged from 0.09 to 0.13, MARE from 1.3 to 22.7%, with ICCs indicating moderate (0.57) to good (0.88) agreement. Lower errors were observed for cohorts without major gait impairments, less complex tasks, and longer walking bouts. The analytical pipelines demonstrated moderate to good accuracy in estimating walking speed. Accuracy depended on confounding factors, emphasizing the need for robust technical validation before clinical application. Trial registration: ISRCTN – 12246987.
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- 2024
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17. A multi-sensor wearable system for the assessment of diseased gait in real-world conditions.
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Salis F, Bertuletti S, Bonci T, Caruso M, Scott K, Alcock L, Buckley E, Gazit E, Hansen C, Schwickert L, Aminian K, Becker C, Brown P, Carsin AE, Caulfield B, Chiari L, D'Ascanio I, Del Din S, Eskofier BM, Garcia-Aymerich J, Hausdorff JM, Hume EC, Kirk C, Kluge F, Koch S, Kuederle A, Maetzler W, Micó-Amigo EM, Mueller A, Neatrour I, Paraschiv-Ionescu A, Palmerini L, Yarnall AJ, Rochester L, Sharrack B, Singleton D, Vereijken B, Vogiatzis I, Della Croce U, Mazzà C, Cereatti A, and For The Mobilise-D Consortium
- Abstract
Introduction: Accurately assessing people's gait, especially in real-world conditions and in case of impaired mobility, is still a challenge due to intrinsic and extrinsic factors resulting in gait complexity. To improve the estimation of gait-related digital mobility outcomes (DMOs) in real-world scenarios, this study presents a wearable multi-sensor system (INDIP), integrating complementary sensing approaches (two plantar pressure insoles, three inertial units and two distance sensors). Methods: The INDIP technical validity was assessed against stereophotogrammetry during a laboratory experimental protocol comprising structured tests (including continuous curvilinear and rectilinear walking and steps) and a simulation of daily-life activities (including intermittent gait and short walking bouts). To evaluate its performance on various gait patterns, data were collected on 128 participants from seven cohorts: healthy young and older adults, patients with Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease, congestive heart failure, and proximal femur fracture. Moreover, INDIP usability was evaluated by recording 2.5-h of real-world unsupervised activity. Results and discussion: Excellent absolute agreement (ICC >0.95) and very limited mean absolute errors were observed for all cohorts and digital mobility outcomes (cadence ≤0.61 steps/min, stride length ≤0.02 m, walking speed ≤0.02 m/s) in the structured tests. Larger, but limited, errors were observed during the daily-life simulation (cadence 2.72-4.87 steps/min, stride length 0.04-0.06 m, walking speed 0.03-0.05 m/s). Neither major technical nor usability issues were declared during the 2.5-h acquisitions. Therefore, the INDIP system can be considered a valid and feasible solution to collect reference data for analyzing gait in real-world conditions., Competing Interests: AM and FK are employees of, and may hold stock in, Novartis. BME reports consulting activities with adidas AG, Siemens AG, SiemensHealthineers AG, WSAudiology GmbH outside of the study. He is a shareholder in Portabiles HealthCare Technologies GmbH. In addition, BME holds a patent related to gait assessment. LP and LC are co-founders and own shares of mHealth Technologies (https://mhealthtechnologies.it/). LS and CB are consultants of Philipps Healthcare, Bosch Healthcare, Eli Lilly, Gait-up. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Salis, Bertuletti, Bonci, Caruso, Scott, Alcock, Buckley, Gazit, Hansen, Schwickert, Aminian, Becker, Brown, Carsin, Caulfield, Chiari, D’Ascanio, Del Din, Eskofier, Garcia-Aymerich, Hausdorff, Hume, Kirk, Kluge, Koch, Kuederle, Maetzler, Micó-Amigo, Mueller, Neatrour, Paraschiv-Ionescu, Palmerini, Yarnall, Rochester, Sharrack, Singleton, Vereijken, Vogiatzis, Della Croce, Mazzà and Cereatti and for the Mobilise-D consortium.)
- Published
- 2023
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