Search

Your search keyword '"for the FINGER study group"' showing total 8 results
Start Over Author "for the FINGER study group"
8 results on '"for the FINGER study group"'

1. Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Author

Ruth Stephen, Yawu Liu, Tiia Ngandu, Riitta Antikainen, Juha Hulkkonen, Juha Koikkalainen, Nina Kemppainen, Jyrki Lötjönen, Esko Levälahti, Riitta Parkkola, Pauliina Pippola, Juha Rinne, Timo Strandberg, Jaakko Tuomilehto, Ritva Vanninen, Miia Kivipelto, Hilkka Soininen, Alina Solomon, and for the FINGER study group

Subjects
Prevention, Cognitive impairment, Dementia, Randomized controlled trial, Lifestyle, Neuroimaging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported beneficial effects on cognition for a 2-year multimodal intervention (diet, exercise, cognitive training, vascular risk monitoring) versus control (general health advice). This study reports exploratory analyses of brain MRI measures. Methods FINGER targeted 1260 older individuals from the general Finnish population. Participants were 60–77 years old, at increased risk for dementia but without dementia/substantial cognitive impairment. Brain MRI scans were available for 132 participants (68 intervention, 64 control) at baseline and 112 participants (59 intervention, 53 control) at 2 years. MRI measures included regional brain volumes, cortical thickness, and white matter lesion (WML) volume. Cognition was assessed at baseline and 1- and 2-year visits using a comprehensive neuropsychological test battery. We investigated the (1) differences between the intervention and control groups in change in MRI outcomes (FreeSurfer 5.3) and (2) post hoc sub-group analyses of intervention effects on cognition in participants with more versus less pronounced structural brain changes at baseline (mixed-effects regression models, Stata 12). Results No significant differences between the intervention and control groups were found on the changes in MRI measures. Beneficial intervention effects on processing speed were more pronounced in individuals with higher baseline cortical thickness in Alzheimer’s disease signature areas (composite measure of entorhinal, inferior and middle temporal, and fusiform regions). The randomization group × time × cortical thickness interaction coefficient was 0.198 (p = 0.021). A similar trend was observed for higher hippocampal volume (group × time × hippocampus volume interaction coefficient 0.1149, p = 0.085). Conclusions The FINGER MRI exploratory sub-study did not show significant differences between the intervention and control groups on changes in regional brain volumes, regional cortical thicknesses, or WML volume after 2 years in at-risk elderly without substantial impairment. The cognitive benefits on processing speed of the FINGER intervention may be more pronounced in individuals with fewer structural brain changes on MRI at baseline. This suggests that preventive strategies may be more effective if started early, before the occurrence of more pronounced structural brain changes. Trial registration ClinicalTrials.gov, NCT01041989. Registered January 5, 2010.

Published
2019
Full Text
View/download PDF

2. Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Author

Stephen, Ruth, Liu, Yawu, Ngandu, Tiia, Antikainen, Riitta, Hulkkonen, Juha, Koikkalainen, Juha, Kemppainen, Nina, Lötjönen, Jyrki, Levälahti, Esko, Parkkola, Riitta, Pippola, Pauliina, Rinne, Juha, Strandberg, Timo, Tuomilehto, Jaakko, Vanninen, Ritva, Kivipelto, Miia, Soininen, Hilkka, Solomon, Alina, and for the FINGER study group

Published
2019
Full Text
View/download PDF

3. Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial : Results of a Post-Hoc Subgroup Analysis

Author

Stephen, Ruth, Ngandu, Tiia, Liu, Yawu, Peltonen, Markku, Antikainen, Riitta, Kemppainen, Nina, Laatikainen, Tiina, Lötjönen, Jyrki, Rinne, Juha, Strandberg, Timo, Tuomilehto, Jaakko, Vanninen, Ritva, Soininen, Hilkka, Kivipelto, Miia, Solomon, Alina, for the FINGER Study Group, HUS Internal Medicine and Rehabilitation, Timo Strandberg / Principal Investigator, Department of Medicine, Clinicum, University of Helsinki, Tampere University, and Seinäjoen keskussairaala VA

Subjects
Male, Aging, THE JOURNAL OF GERONTOLOGY: Biological Sciences, PREDICTION, HIPPOCAMPAL VOLUME, Health Behavior, Neuroimaging, BLOOD-PRESSURE, PROGRESSION, Gerona/1, Risk Assessment, Hippocampus, Factors Associated With Cognitive Decline and Aging, AcademicSubjects/MED00280, Cognition, Humans, BRAIN ATROPHY, Correlation of Data, Geriatric Assessment, Aged, Prevention, NEURODEGENERATION, Organ Size, PREVENT COGNITIVE IMPAIRMENT, Brain Cortical Thickness, Magnetic Resonance Imaging, FINNISH GERIATRIC INTERVENTION, Heart Disease Risk Factors, Positron-Emission Tomography, 3121 General medicine, internal medicine and other clinical medicine, LINK, Risk reduction, AcademicSubjects/SCI00960, SERUM-LIPIDS, Female, Dementia, 3111 Biomedicine, Risk Reduction Behavior
Abstract

The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with imaging biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied in the context of an intervention. This study investigated associations between change in CAIDE score and change in neuroimaging biomarkers (brain magnetic resonance imaging [MRI] and Pittsburgh Compound B-positron emission tomography [PiB-PET] measures) during the 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (post-hoc analyses). FINGER targeted at-risk older adults, aged 60-77 years, from the general population. Participants were randomized to either multidomain intervention (diet, exercise, cognitive training, and vascular risk management) or control group (general health advice). Neuroimaging (MRI and PiB-PET) data from baseline and 2-year visits were used. A toal of 112 participants had repeated brain MRI measures (hippocampal, total gray matter, and white matter lesion volumes, and Alzheimer's disease signature cortical thickness). Repeated PiB-PET scans were available for 39 participants. Reduction in CAIDE score (indicating lower dementia risk) during the intervention was associated with less decline in hippocampus volume in the intervention group, but not the control group (Randomization group × CAIDE change interaction β coefficient =-0.40, p =. 02). Associations for other neuroimaging measures were not significant. The intervention may have benefits on hippocampal volume in individuals who succeed in improving their overall risk level as indicated by a reduction in CAIDE score. This exploratory finding requires further testing and validation in larger studies. publishedVersion

Published
2021

4. Telomere length change in a multidomain lifestyle intervention to prevent cognitive decline:a randomized clinical trial

Author

Sindi, S. (Shireen), Solomon, A. (Alina), Kåreholt, I. (Ingemar), Hovatta, I. (Iiris), Antikainen, R. (Riitta), Hänninen, T. (Tuomo), Levälahti, E. (Esko), Laatikainen, T. (Tiina), Lehtisalo, J. (Jenni), Lindström, J. (Jaana), Paajanen, T. (Teemu), Peltonen, M. (Markku), Singh Khalsa, D. (Dharma), Wolozin, B. (Benjamin), Strandberg, T. (Timo), Tuomilehto, J. (Jaakko), Soininen, H. (Hilkka), Ngandu, T. (Tiia), Kivipelto, M. (Miia), and F. S. (FINGER Study Group)

Subjects
behavioural intervention, dementia prevention, telomeres, older adults
Abstract

Background: Shorter leukocyte telomere length (LTL) is associated with aging and dementia. Impact of lifestyle changes on LTL, and relation to cognition and genetic susceptibility for dementia, has not been investigated in randomized controlled trials (RCTs). Methods: Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability is a 2-year RCT enrolling 1260 participants at risk for dementia from the general population, aged 60–77 years, randomly assigned (1:1) to multidomain lifestyle intervention or control group. The primary outcome was cognitive change (Neuropsychological Test Battery z-score). Relative LTL was measured using quantitative real-time polymerase chain reaction (trial registration: NCT01041989). Results: This exploratory LTL substudy included 756 participants (377 intervention, 379 control) with baseline and 24-month LTL measurements. The mean annual LTL change (SD) was −0.016 (0.19) in the intervention group and −0.023 (0.17) in the control group. Between-group difference was nonsignificant (unstandardized β-coefficient 0.007, 95% CI −0.015 to 0.030). Interaction analyses indicated better LTL maintenance among apolipoprotein E (APOE)-ε4 carriers versus noncarriers: 0.054 (95% CI 0.007 to 0.102); younger versus older participants: −0.005 (95% CI −0.010 to −0.001); and those with more versus less healthy lifestyle changes: 0.047 (95% CI 0.005 to 0.089). Cognitive intervention benefits were more pronounced among participants with better LTL maintenance for executive functioning (0.227, 95% CI 0.057 to 0.396) and long-term memory (0.257, 95% CI 0.024 to 0.489), with a similar trend for Neuropsychological Test Battery total score (0.127, 95% CI −0.011 to 0.264). Conclusions: This is the first large RCT showing that a multidomain lifestyle intervention facilitated LTL maintenance among subgroups of older people at risk for dementia, including APOE-ε4 carriers. LTL maintenance was associated with more pronounced cognitive intervention benefits. Clinical Trials Registration Number: NCT01041989

Published
2021

5. Change in CAIDE dementia risk score and neuroimaging biomarkers during a 2-year multidomain lifestyle randomized controlled trial:results of a post-hoc subgroup analysis

Author

Stephen, R. (Ruth), Ngandu, T. (Tiia), Liu, Y. (Yawu), Peltonen, M. (Markku), Antikainen, R. (Riitta), Kemppainen, N. (Nina), Laatikainen, T. (Tiina), Lötjönen, J. (Jyrki), Rinne, J. (Juha), Strandberg, T. (Timo), Tuomilehto, J. (Jaakko), Vanninen, R. (Ritva), Soininen, H. (Hilkka), Kivipelto, M. (Miia), Solomon, A. (Alina), and h. F. (he FINGER Study Group)

Subjects
Prevention, Risk reduction, Dementia, Hippocampus
Abstract

The CAIDE (Cardiovascular Risk Factors, Aging and Dementia) Risk Score is a validated tool estimating dementia risk. It was previously associated with imaging biomarkers. However, associations between dementia risk scores (including CAIDE) and dementia-related biomarkers have not been studied in the context of an intervention. This study investigated associations between change in CAIDE score and change in neuroimaging biomarkers (brain magnetic resonance imaging [MRI] and Pittsburgh Compound B-positron emission tomography [PiB-PET] measures) during the 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) (post-hoc analyses). FINGER targeted at-risk older adults, aged 60–77 years, from the general population. Participants were randomized to either multidomain intervention (diet, exercise, cognitive training, and vascular risk management) or control group (general health advice). Neuroimaging (MRI and PiB-PET) data from baseline and 2-year visits were used. A toal of 112 participants had repeated brain MRI measures (hippocampal, total gray matter, and white matter lesion volumes, and Alzheimer’s disease signature cortical thickness). Repeated PiB-PET scans were available for 39 participants. Reduction in CAIDE score (indicating lower dementia risk) during the intervention was associated with less decline in hippocampus volume in the intervention group, but not the control group (Randomization group × CAIDE change interaction β coefficient = −0.40, p = .02). Associations for other neuroimaging measures were not significant. The intervention may have benefits on hippocampal volume in individuals who succeed in improving their overall risk level as indicated by a reduction in CAIDE score. This exploratory finding requires further testing and validation in larger studies.

Published
2021

6. Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

Author

Stephen, R. (Ruth), Liu, Y. (Yawu), Ngandu, T. (Tiia), Antikainen, R. (Riitta), Hulkkonen, J. (Juha), Koikkalainen, J. (Juha), Kemppainen, N. (Nina), Lötjönen, J. (Jyrki), Levälahti, E. (Esko), Parkkola, R. (Riitta), Pippola, P. (Pauliina), Rinne, J. (Juha), Strandberg, T. (Timo), Tuomilehto, J. (Jaakko), Vanninen, R. (Ritva), Kivipelto, M. (Miia), Soininen, H. (Hilkka), Solomon, A. (Alina), f. t. (for the FINGER study group), Stephen, R. (Ruth), Liu, Y. (Yawu), Ngandu, T. (Tiia), Antikainen, R. (Riitta), Hulkkonen, J. (Juha), Koikkalainen, J. (Juha), Kemppainen, N. (Nina), Lötjönen, J. (Jyrki), Levälahti, E. (Esko), Parkkola, R. (Riitta), Pippola, P. (Pauliina), Rinne, J. (Juha), Strandberg, T. (Timo), Tuomilehto, J. (Jaakko), Vanninen, R. (Ritva), Kivipelto, M. (Miia), Soininen, H. (Hilkka), Solomon, A. (Alina), and f. t. (for the FINGER study group)

Abstract

Background: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a multicenter randomized controlled trial that reported beneficial effects on cognition for a 2-year multimodal intervention (diet, exercise, cognitive training, vascular risk monitoring) versus control (general health advice). This study reports exploratory analyses of brain MRI measures. Methods: FINGER targeted 1260 older individuals from the general Finnish population. Participants were 60–77 years old, at increased risk for dementia but without dementia/substantial cognitive impairment. Brain MRI scans were available for 132 participants (68 intervention, 64 control) at baseline and 112 participants (59 intervention, 53 control) at 2 years. MRI measures included regional brain volumes, cortical thickness, and white matter lesion (WML) volume. Cognition was assessed at baseline and 1- and 2-year visits using a comprehensive neuropsychological test battery. We investigated the (1) differences between the intervention and control groups in change in MRI outcomes (FreeSurfer 5.3) and (2) post hoc sub-group analyses of intervention effects on cognition in participants with more versus less pronounced structural brain changes at baseline (mixed-effects regression models, Stata 12). Results: No significant differences between the intervention and control groups were found on the changes in MRI measures. Beneficial intervention effects on processing speed were more pronounced in individuals with higher baseline cortical thickness in Alzheimer’s disease signature areas (composite measure of entorhinal, inferior and middle temporal, and fusiform regions). The randomization group × time × cortical thickness interaction coefficient was 0.198 (p = 0.021). A similar trend was observed for higher hippocampal volume (group × time × hippocampus volume interaction coefficient 0.1149, p = 0.085). Conclusions: The FINGER MRI exploratory sub-study did not show s

Published
2019

7. White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial.

Author

Stephen, Ruth, Solomon, Alina, Ngandu, Tiia, Levälahti, Esko, Rinne, Juha O., Kemppainen, Nina, Parkkola, Riitta, Antikainen, Riitta, Strandberg, Timo, Kivipelto, Miia, Soininen, Hilkka, Yawu Liu, Liu, Yawu, and FINGER study group

Subjects
DIFFUSION tensor imaging, WHITE matter (Nerve tissue), FINGERS, PATHOLOGICAL physiology, COGNITIVE training
Abstract

Background: Early pathological changes in white matter microstructure can be studied using the diffusion tensor imaging (DTI). It is not only important to study these subtle pathological changes leading to cognitive decline, but also to ascertain how an intervention would impact the white matter microstructure and cognition in persons at-risk of dementia.Objectives: To study the impact of a multidomain lifestyle intervention on white matter and cognitive changes during the 2-year Finnish Geriatric Intervention Study to prevent Cognitive Impairment and Disability (FINGER), a randomized controlled trial in at-risk older individuals (age 60-77 years) from the general population.Methods: This exploratory study consisted of a subsample of 60 FINGER participants. Participants were randomized to either a multidomain intervention (diet, exercise, cognitive training, and vascular risk management, n = 34) or control group (general health advice, n = 26). All underwent baseline and 2-year brain DTI. Changes in fractional anisotropy (FA), diffusivity along domain (F1) and non-domain (F2) diffusion orientations, mean diffusivity (MD), axial diffusivity (AxD), radial diffusivity (RD), and their correlations with cognitive changes during the 2-year multidomain intervention were analyzed.Results: FA decreased, and cognition improved more in the intervention group compared to the control group (p < 0.05), with no significant intergroup differences for changes in F1, F2, MD, AxD, or RD. The cognitive changes were significantly positively related to FA change, and negatively related to RD change in the control group, but not in the intervention group.Conclusion: The 2-year multidomain FINGER intervention may modulate white matter microstructural alterations. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

8. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial.

Author

Sindi, Shireen, Ngandu, Tiia, Hovatta, Iiris, Kåreholt, Ingemar, Antikainen, Riitta, Hänninen, Tuomo, Levälahti, Esko, Laatikainen, Tiina, Lindström, Jaana, Paajanen, Teemu, Peltonen, Markku, Khalsa, Dharma Singh, Wolozin, Benjamin, Strandberg, Timo, Tuomilehto, Jaakko, Soininen, Hilkka, Kivipelto, Miia, Solomon, Alina, and FINGER study group

Subjects
TELOMERES, LEUCOCYTES, RANDOMIZED controlled trials, MILD cognitive impairment, MAXIMUM likelihood statistics, ALZHEIMER'S disease, COGNITION disorders, COGNITIVE therapy, COMPARATIVE studies, NEUROPSYCHOLOGICAL tests, RESEARCH methodology, MEDICAL cooperation, PEOPLE with disabilities, RESEARCH, RESEARCH funding, EVALUATION research, LIFESTYLES, DISEASE complications, PHYSIOLOGY, PSYCHOLOGY
Abstract

Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60-77 years identified from the general population. Participants were randomly assigned to the lifestyle intervention (diet, exercise, cognitive training, and vascular risk management) and control (general health advice) groups. Primary outcome was change in cognition (comprehensive neuropsychological test battery). Secondary outcomes were changes in cognitive domains: memory, executive functioning, and processing speed. 775 participants (392 control, 383 intervention) had baseline LTL (peripheral blood DNA). Mixed effects regression models with maximum likelihood estimation were used to analyze change in cognition as a function of randomization group, time, baseline LTL, and their interaction. Intervention and control groups did not significantly differ at baseline. Shorter LTL was related to less healthy baseline lifestyle. Intervention benefits on executive functioning were more pronounced among those with shorter baseline LTL (p-value for interaction was 0.010 adjusted for age and sex, and 0.007 additionally adjusted for baseline lifestyle factors). The FINGER intervention cognitive benefits were more pronounced with shorter baseline LTL, particularly for executive functioning, indicating that the multidomain lifestyle intervention was especially beneficial among higher-risk individuals. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results