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Hastalıkların mekanizmalarını daha iyi anlamak ve etkili tedavi yöntemleri geliştirebilmek amacıyla in vivo ve in vitro modellerin kullanımı, modern tıbbın ve biyomedikal araştırmaların temel taşlarından biri olarak kabul edilmektedir. Deney hayvanları, bilimsel araştırmalar için vazgeçilmez bir gereklilik olarak karşımıza çıkmakta ve hastalıkların patofizyolojisini anlamada kritik bir rol oynamaktadır. Nefrotoksisite, böbrek dokusunun çeşitli kimyasal maddeler veya ksenobiyotikler tarafından maruz kaldığı zararlı etkileri ifade eder. Bu durum, böbrek hasarına yol açabilecek birçok farklı madde tarafından tetiklenebilir. Örneğin, antibiyotikler (özellikle aminoglikozidler ve vankomisin), non-steroidal antiinflamatuar ilaçlar (NSAID'ler), antiviral ilaçlar, tıbbi görüntülemede kullanılan kontrast maddeler, ağır metaller (kurşun ve cıva) ve kemoterapi ilaçları, böbrek dokusu üzerinde toksik etkiye sahip maddeler arasında yer alır. Böbrekler, bu ilaçlar ve kimyasalların toksik etkilerine karşı oldukça savunmasızdır ve bu savunmasızlık, ciddi böbrek hasarlarına yol açabilir. Ksenobiyotikler, özellikle ilaçlar, akut böbrek hasarı (ABH), kronik böbrek hastalığı (KBH), akut böbrek yetmezliği (ABY) ve son dönem böbrek hastalığı (SDBH) gibi ciddi sağlık sorunlarının önde gelen nedenleri arasındadır. İlaç kaynaklı nefrotoksisite, genellikle üç ana mekanizma üzerinden incelenir: Proksimal tübüler hasar ve akut tübüler nekroz (ATN), kristal formdaki ksenobiyotik veya ilaç metabolitlerinin neden olduğu tübüler tıkanıklık ve ilaçlar ile metabolitlerinin indüklediği interstisyel nefrit. Böbrek fonksiyonlarını gösteren biyokimyasal parametrelerdeki değişiklikler, nefrotoksisitenin tanısında kritik bir rol oynar. Bu derlemede, deneysel nefrotoksisite modelleri, tanısında kullanılan biyobelirteçler ve bu biyobelirteçlerin klinik önemleri ayrıntılı olarak ele alınmıştır.

Copyright of Journal of Literature Pharmacy Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Academic Research in Nursing (JAREN) is the property of Hemsirelikte Egitim ve Arastirma Dergisi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The current study has been conducted to determine folic acid (FA) knowledge, prevalence of use and related factors in the preconception period.The cross-sectional study has been completed with the participation of 384 pregnant women. The data of the study has been collected with the "Personal Information Form" and "Questions on Prevalence and Knowledge of Folic Acid Supplement Use" surveys. In the study, the total FA knowledge score of pregnant women has been found below the average as 4.12±2.65 (Min-Max=0-10). It has been determined that there was a significant difference among FA knowledge total score and age (p=0.009), education level (p=0.001), employment status (p=0.001), whether the pregnancy was planned (p=0.001), receiving care during the preconception period (p=0.007) and time to start FA supplementation (p= 0.030) It has been determined that 17.2% of the pregnant women participating in the study knew the right time to start FA supplementation and 17.7% of the pregnant women started FA supplementation in the preconception period. It has been determined that informing all women of reproductive age about using FA supplements during the preconception period and directing them to use FA is an important predictor of preventing health problems such as Neural Tube Defect. [ABSTRACT FROM AUTHOR]

Aim: Although brucellosis is a contagious infectious disease, it shows symptoms similar to other types of infections. Since brucellosis is an infectious disease, acute phase reactants such as C-reactive protein (CRP) and ferritin increase their values. In our study, it was aimed to determine the clinical importance of Vitamin D, Ferritin, Folic Acid, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma Glutamyl Transferase (GGT) levels in patients diagnosed with Brucellosis. Methods: The study included 50 patients (case group) who applied to the Dicle University Hospitals Infection Diseases clinic and polyclinic and were diagnosed with Brucellosis, and 25 healthy individuals older than 18 years of age and similar in gender (control group). Titers of 1/320 and above in the Brucella Coombs Test (BCT) method were considered Brucellosis positive. Roche Cobas E 601 device (Roche Diagnostics, USA); CRP, ALT, AST and GGT levels were studied by spectrophotometric method with Beckman Coulter DxC 700 AU (Beckman Coulter, USA) device. Before the study, Dicle University Faculty of Medicine Non-Invasive Clinical Research Ethics Committee Permission was obtained. Results: Brucellosis of the patients, 26 (52%) were female and 24 (48%) were male; The control group consisted of 12 (48%) females and 13 (52%) males. Samples with agglutination were considered positive, and those without agglutination were considered negative. Vitamin D levels in the control group were found to be significantly lower than the patient group (p:0.007). Although HGB, PLT and Folic acid values were lower in the patient group than in the control group, although the ferritin level was higher, there was no significant difference between the two groups. Conclusion: As a result of this study, when the patient and control groups were compared, only the vitamin D level was found to be significantly higher in the patient group. CRP and ferritin, which are inflammation markers, were found to be high in the patient group. These results suggest that vitamin D may play a role in the diagnostic parameter in the pathogenesis of brucellosis. We think that this and similar studies that we have done will contribute to the acquisition of regional epidemiological data. [ABSTRACT FROM AUTHOR]

Depression is a psychological and physiological destruction process. In recent years, it has been one of the leading causes of public health problems in our country and in the world. Our aim in this study; To contribute to the literature in the light of the data we obtained by measuring the levels of vitamin D, folic acid and vitamin B12 in patients who applied to the emergency department after suicidal attempts. In the study, vitamin D, folic acid and vitamin B12 levels in blood tests taken from patients who applied to Sivas Cumhuriyet University Faculty of Medicine Department of Emergency Medicine between July 2019 and December 2020 with suicide attempts and healthy volunteers selected in line with the criteria were retrospectively analyzed. Consent forms received from Sivas Cumhuriyet University ethics committee with decision number 2020-06/14 were read and signed by healthy volunteers similar in gender and age and the patient group included in the study. Groups were formed by taking detailed anamnesis and physical examinations from volunteers who agreed to participate in the research. In our study, we compared the levels of vitamin D, folic acid and vitamin B12 in patients who applied to the emergency department after a suicide attempt with the normal population. Vitamin D and vitamin B12 levels were found to be significantly lower in the patient group compared to the control group. Our current clinical study supports many studies in the literature, with the detection of low levels of vitamin D and vitamin B12 after the examinations of the patient group who came to the emergency room with a depressive episode and the control group. [ABSTRACT FROM AUTHOR]

Hidradenitis supurativa (HS) is a chronic, follicular and occlusive cutaneous disease that mainly affects the folliculopilosebaceous unit, especially in areas of skin which is rich in apocrine glands such as axillary, inguinal, perianal, genital and inframammary regions. The pathogenesis of HS is not understood completely. Dysregulation of the immune system may contribute to HS etiology. Genetics, diet, smoking, obesity, mechanical trauma hormonal factors may be associated with HS (1,2). In our retrospective study, we aimed to review the data on diabetes and folic acid deficiency, which were mentioned in a few articles before, as factors accompanying HS in our patients. We found that 1/3 of 24 patients had high HbA1c levels, and folic acid levels were at the desired value in only four patients. This limited number of data seems to support the idea of further studies on this subject.

Objective: Breath holding spells are a benign, non-paroxysmal disorder observed in childhood. The pathogenesis of breath holding spells is still unclear. Dysfunction of the autonomic nervous system, iron deficiency, genetic predisposition, interleukin 1, nitric oxide and cerebral erythropoietin have been implicated in the pathogenesis. The purpose of this study was to compare vitamin B12 and folic acid levels between patients diagnosed with breath holding spells and a healthy group. Material and Methods: Fifty-one cases diagnosed with breath holding spells in the pediatric neurology clinic were included in the study group (Group 1), and 78 healthy patients presenting to the general clinic in the control group (Group 2). Hemoglobin, hematocrit, mean erythrocyte volume, vitamin B12, folic acid, ferritin, iron, and iron binding capacity levels were compared between the study and the control groups. Results: Mean folate levels were 18.92±12.83 (5.27-91) ng/mL in the study group and 9.95±8.92 (2-37) ng/mL in the control group. Mean B12 levels were 274.13±214.37 (75-1201) pg/mL in the study group and 408.82±194.18 (120-959) pg/mL in the control group. Statistically significant differences in both vitamin B12 and folic acid levels were observed between the groups (p=0.000 and p=0.002, respectively). No significant difference was determined between the attack groups' (<15/month, >15/month) vitamin B12 (p=0.570) or folic acid (p=0.643) levels. Conclusion: Based on this study, vitamin B12 and folic acid levels should be routinely evaluated in patients diagnosed with breath holding spells. [ABSTRACT FROM AUTHOR]

Aim: Viral wart is a common benign infectious dermatosis. It remains unclear why not everyone exposed to HPV develops warts. It is known that vitamin and mineral deficiencies can affect impair natural and acquired immunity and lead to a tendency to get more infections. This study aimed to determine the potential utility of evaluating vitamin B12, folic acid, and ferritin levels in patients with viral warts. Material and Methods: In this retrospective study, 70 patients who were diagnosed with viral warts in the dermatology outpatient clinic of Karabük University Training and Research Hospital between January 2018 and December 2019 were included. 70 healthy individuals matched with viral wart patients in terms of gender and age were included as the control group. Serum vitamin B12, folic acid, and ferritin levels of both groups were detected and compared from the hospital automation system. Results: Vitamin B12 level was detected statistically significantly lower in the viral wart group as compared to the control group (p=0.046). Although serum ferritin levels were found lower in the viral wart group, this difference was not statistically significant (p=0.677). No statistically significant difference was detected between the viral wart and control groups in terms of folate levels (p=0.879). Conclusion: In patients with viral warts with low serum vitamin B12 levels, replacement therapy could be considered. Also, the evaluation of serum ferritin level, an iron storage parameter in the body, is important in patients with viral warts infection.

Copyright of Ahi Evran Medical Journal is the property of Ahi Evran University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The aim of this study is to evaluate the effects of age, sex, and socio-economic status (SES) on concentrations of vitamin B12 (vit-B12), folate, iron, and ferritin through the pediatric age span, and to show the relationship of these nutrients with blood count parameters such as hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), and red cell distribution (RDW). Material and Method: The study comprised of 30,504 venous blood samples (54.5% of girls and 45.5% of boys). The study group was stratified; group I: 1-6 years (n=3,870), group II: 7-12 years (n=11,019), and group III: 13-18 years (n=15,615). Serum vit-B12, folate, ferritin, iron and total iron-binding capacity (TIBC) were measured using a Beckman Coulter DXI 800, and the blood count was analyzed using a Sysmex XE 2100 analyzer. Results: The Hb, Hct, MCV, and RDW levels were significantly different between the age groups of boys and girls (p<0.001, for all). Hb and Hct were the highest in boys aged 13-18 years, and higher than those of girls in the same age group (p<0.001). The MCV and RDW were also significantly different across the age groups (p<0.001). The iron deficiency prevalences were 12.3% and 4.2% for the girls and boys respectively. Serum folate and vit-B12 showed decrement with age across the age groups. The prevalences of vit-B12 deficiency were 27.1% and 28.3% and 6.0% and 6.8% for folate deficiency for girls and boys. Iron, TIBC,and ferritin levels were significantly different between the high and medium SES. Conclusion: The results of this study are important in that the monitorization of ferritin, vit-B12, and folate levels greatly contribute to clinical practice because of the roles of vit-B12, folate, and iron in mental, emotional, and metabolic development. However, there is a need for larger and multicenter studies that can represent the nutrients of Turkish children and adolescents nationwide. [ABSTRACT FROM AUTHOR]

Purpose: The aim of the study was to examine the mental health outcomes of folic acid (FA) supplement use in the antenatal and postnatal periods. Materials and Methods: This descriptive-prospective longitudinal study was conducted between 1 December 2019 and 30 January 2021 in a Family Health Center in eastern Turkey. The study was performed at one week in the postpartum period, at 6-8 weeks in the postpartum period, and at six months in the postpartum period. A total of 162 healthy pregnant women were included in the study. A Personal Information Form, the Beck Anxiety Inventory (BAI), and the Edinburgh Postpartum Depression Scale (EPDS) were used to collect data. Results: While 32.7% (n=53) of the participants used FA supplementation from the pre-pregnancy period and in the first trimester of pregnancy (6 months in total), and 34.6% (n=56) used FA supplementation only in the first trimester of pregnancy. It was determined that 32.7% (n=53) of the participants did not use any FA supplement. Of those who did not use FA, 37.0% were in the antenatal period, and 50.8% were on the postnatal 6-8 days. It was determined that the participants experienced mild/moderate/severe anxiety in different weeks. BAI and EPDS scores were the lowest in the prenatal period, at 6-8 weeks in the postpartum period, and at 6 months in the postpartum period in those who used FA supplementation for 6 months. BAI and EPDS scores decreased significantly from the antenatal, to the postnatal 6-8-week, and to the postnatal 6-month measurements. Conclusion: The use of FA supplements can be effective in preventing symptoms of anxiety and depression in the antenatal and postnatal period. [ABSTRACT FROM AUTHOR]

Copyright of Archives of Clinical & Experimental Medicine is the property of Archives of Clinical & Experimental Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Van Tip Dergisi is the property of Yuzuncu Yil University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Ahi Evran Medical Journal is the property of Ahi Evran University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Meandros Medical & Dental Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Physical Medicine & Rehabilitation Sciences is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Meandros Medical & Dental Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Amaç: Vitamin B12 ve folik asit DNA sentezi, tamiri ve ekspresyonunda önemli görevler alırlar. Bu çalışmada çocukluk çağı kanserleri ile vitamin B12 ve folik asit düzeyleri arasındaki ilişki araştırıldı.Gereç ve Yöntem: Kasım 2013 ve Aralık 2015 arasında yeni tanı alan solid tümörlü 125, lenfoproliferatif/miyeloproliferatif malign hastalığı olan 113 hasta ve 63 kontrol çalışmaya dahil edildi. Vitamin B12 ve folik asit düzeyleri tanısal çalışmaların bir parçası olarak tanı anında ölçüldü.Bulgular: Vitamin B12 ve folik asit düzeyleri malign hastalığı olan çocuklarda kontrol grubuna oranla anlamlı olarak düşük bulundu. Homosistein düzeyleri ise kontrol grubuna göre istatistiksel olarak daha yüksekti. Folik asit düzeyleri lenfoproliferatif/miyeloproliferatif malign hastalığı olanlarda solid tümör grubuna oranla daha düşüktü.Sonuç: Düşük vitamin B12 ve folik asit düzeyleri kanser tanısında destekleyici belirteçler olarak kullanılabilir. Bu ilişkinin gelecekte daha geniş serilerle ortaya konması gerekmektedir.

Amaç: Bu araştırmada Kadın Hastalıkları ve Doğum polikliniğine başvuran gebelerin folik asit hakkında bilgi durumu, folik asit farkındalığı, aktif folik asit kullanımı, gebe kalmadan önce kullanıp kullanmadığı ve gebelerde folik asit kullanımına etki eden faktörleri belirlemek amaçlanmıştır.Gereç ve Yöntemler: Düzce Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim dalı Obstetri polikliniğine 15-31 Ocak 2017 tarihleri arasında başvuran 355 kişi araştırmanın evrenini oluşturmuştur. Örneklem seçimine gidilmemiştir. Araştırmaya katılmayı kabul eden 142 gebeye 17 sorudan oluşan anket yüz yüze görüşme tekniği ile uygulanmıştır.Bulgular: Araştırmaya katılan 142 kişinin yaş ortalaması 28,2±6,1 (min=17, maks=42) idi. Araştırmaya katılanlar ortalama 2,4±1,4 (min=1, maks=6) kez gebe kalmıştır. Ortalama ilk gebe kalma yaşı 22,9±4,8 (min=14, maks=39) idi. Folik asidin bulunduğu besinleri doğru ifade etmiş olanlar 55 kişi (%38,7), folik asitçe yeterli beslendiğini düşünenler 82 kişi (%57,7), Nöral Tüp Defekti (NTD) tanımını doğru bilenler 11 kişidir (%7,7). Araştırma grubunda daha önceki gebeliğinde NTD’li çocuk doğuran 1 kadın (%0,7) vardır. Folik asit kullanımının NTD oluşma riskini azaltabildiğini veya ortadan kaldırabildiğini bilen 32 (%22,5) kadındır. Folik asit kullanma durumuna bakıldığında 66 kadın (%46,5) sadece gebeliğin erken döneminde, 17 kadın (%12,0) ise hem gebelik öncesi hem gebeliğin erken döneminde folik asit kullanmıştır. Anket uygulandıktan sonra katılımcılara folik asit kullanımı konusunda eğitim verilmiştir.Sonuç: Düzce Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim dalı Obstetri polikliniğinde yapılan bu çalışmada gebe kadınlarda folik asidin farkındalığı, bilgi düzeyi ve kullanımı düşük bulunmuştur. Gebelerde folik asit kullanımını yaygınlaştırmak ve folik asidin NTD’lerini önlediği hakkında farkındalığı artırmak için halka, sağlık eğitimi verilmelidir.

maç: Bu çalışmada Down sendromlu çocuk sahibi olan hastalarda MTHFR (Metilentetrahidrofolat redüktaz) geni C677T ve A1298C polimorfizmleri allel frekansları ve genotip dağılımlarını belirlemek ve bu genotipler ile folat ve homosistein düzeyleri arasındaki ilişkiyi araştırmak amaçlanmıştır.Gereç ve Yöntem: MTHFR geninin iki yaygın varyantı C677T ve A1298C, Türkiye Çukurova Bölgesi’ nde Down Sendromu tanısı almış çocukların annelerinde (hasta grubu, n=67) ve sağlıklı çocuk sahibi annelerde (kontrol grubu, n=66) araştırılmıştır. MTHFR genotipleri PZR amplifiye ürünlerinin RFLP analizi ile belirlenmiştir. Bulgular: C677T polimorfizmi için genotip ve allel frekansları bakımından hasta ve kontrol grupları arasındaki fark istatistiksel olarak anlamlı bulunmuştur. Hasta grubunda T alleli frekansına ait oran (%53.7) yüksek iken kontrol grubunda C alleli frekansına ait oran (%62.9) yüksektir. Ayrıca A1298C polimorfizmi için genotip ve allel frekansları bakımından hasta ve kontrol grupları arasındaki fark istatistiksel olarak anlamlı değildir. Hasta grubunda C alleli frekansına ait oran (%40.8) yüksek iken kontrol grubunda A alleli frekansına ait oran (%70.3) yüksektir. Sonuç: C677T polimorfizmi Down sendromlu çocuk sahibi olma durumu ile ilişkili iken A1298C polimorfizmi ilişkili değildir. 1298C alleli ile 677T alleli Down sendromu riski ile yakın ilişkili olabilir.

Copyright of Turkish Journal of Public Health is the property of Turkish Journal of Public Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Online Turkish Journal of Health Sciences (OTJHS) / Online Türk Sağlık Bilimleri Dergisi is the property of Oguz KARABAY and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

It is important to note that folic acid is an important molecule in terms of human health. Folic acid that is one of the important molecules in human body plays an important role in the prevention of birth defects of the baby's brain (anencephaly) and spine (spina bifida). This molecule that is a form of vitamin B-9 can be easily dissolved in water media. Besides the molecule have important roles in nucleic acid production. Folic acid that is a complex type of vitamin B takes charge in the creating more red blood cells, preventing hearing loss, and preserving the brain health of infants. Because of the importance of folic acids and its derivatives, in this study, we analyzed the chemical reactivity of folic acid and its derivatives using DFT and Molecular Docking Programmes and investigated the power of the interactions with some well- known target proteins of the aforementioned molecules. Folic acid and its cadmium, copper and mercury complexes are performed in molecular docking studies for the activity against creatine kinase target protein in human brain. [ABSTRACT FROM AUTHOR]

Objective: Homocysteine is a sulfur containing amino acid that is formed during methionine metabolism. Patients under long-term antiepileptic drug treatment often have hyperhomocysteinemia. These patients have low levels of serum folate, vitamin B12 and vitamin B6, all of which are associated with homocysteine metabolism. We have investigated the effects of valproic acid and new generation antiepileptic drugs (lamotrigine and levetiracetam) on plasma levels of homocysteine and aminothiols as well as serum vitamin B12 and folic acid. Materials and methods: Forty-seven idiopathic epileptic patients on antiepileptic drugs were compared with 38 age-matched healthy controls. Commercial immunoassay methods were used for vitamin B12 and folic acid analyses. Homocysteine, cysteine, cysteinylglycine and glutathione levels were determined by high performance liquid chromatography. Results: There was no significant difference in patient and control values in terms of vitamin B12, folic acid and homocysteine. Valproic acid and lamotrigine seemed to effect aminothiol redox status. Glutathione levels of epileptic patients receiving valproic acid and lamotrigine were higher than controls. Conclusion: Our results suggest that redox homeostasis may be impaired and glutathione synthesis increased in response to the oxidative stress caused by antiepileptic drug use. [ABSTRACT FROM AUTHOR]

In the days following the conception, neural tube forms in the embryo and closes at the end of the 4th week. It is not possible to complete the formation of the neural tube in some situations that exact cause is unknown, but many factors seem to play role together, and severe congenital anomalies called neural tube defects occur. Generally women are not aware of their pregnancy in the first few weeks that embryonic development is critical. For this reason, folic acid use is important before pregnancy. Folic acid, one of the water-soluble group B vitamins, has been found to facilitate the cell cycle, which is extremely critical in closing the neural tube. It has been proven by randomized controlled trials that folic acid use before pregnancy and during the first 3 months of gestation reduces neural tube defects up to 70%. Despite its role in preventing congenital anomalies, folic acid use rates in the preconceptional period are inadequate. In our study, it was aimed to examine women's knowledge levels about folic acid use, and preconceptional folic acid use among women. [ABSTRACT FROM AUTHOR]

Copyright of Online Turkish Journal of Health Sciences (OTJHS) / Online Türk Sağlık Bilimleri Dergisi is the property of Oguz KARABAY and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and Design: Pernio is an inflammatory disease that occurs in the acral regions of the body after exposure to cold. The study aimed to investigate the demographic findings of patients diagnosed with pernio and to determine the role of vitamin B12, folate and ferritin values in the pathogenesis of pernio. Materials and Methods: This study was conducted in pernio patients diagnosed at the Ağrı State Hospital, Dermatology Outpatient Clinic (Ağrı, Turkey) between September 2015 and April 2016. The healthy control group participants were of similar age and gender. Vitamin B12, folate and ferritin levels were compared between the groups. Results: The patient and control groups were similar in age and gender. Vitamin B12 and ferritin levels were significantly lower in the patient group (p<0.05). Folate levels did not differ significantly between the groups (p>0.05). Conclusion: According to the data obtained from our study, when the demographic findings of the pernio patients were compared with those in the literature, the results were found to be similar. In the patients with pernio, it is likely that low Vitamin B12 was involved in the pernio etiology via the mechanism of vasoconstriction/vasodilatation. [ABSTRACT FROM AUTHOR]

Objective: Diffuse hair loss is one of the most common hair diseases in women and multiple factors play role in ethiopathogenesis of this disease. The aim of this study was to investigate the role of serum vitamin levels in female patients with diffuse hair loss. Material and Methods:We retrospectively evaluated medical data of patients who were admitted to the dermatology outpatient clinic at hospital between October 2017-May 2018 with a diagnosis of diffuse hair loss. 60 patients with hair loss in the last six months and 60 controls were included in the study. The control group was created retrospectively from medical records of individuals who followed up with nevus and no complaints of hair loss. In the both groups, individuals with history of other systemic disease and drug intake, pregnancy, lactation period were excluded. Serum vitamin levels of both groups were statistically compared. Results: The mean age of the patient group was 34.3 year (17 to 53 year old) and the mean age of the control group was 30.5 year (16 to 56 year old). Although the mean serum zinc and folic acid levels were lower in the group with hair loss compared to the control group, there was no statistically significant difference (p>0.05). Mean serum iron and ferritin levels were higher in hair loss group than control group but no statistically significant difference was found. Conclusion: Iron deficiency anemia, folate, and zinc deficiency are thought to be factors that can cause disease in female patients with the complaint of hair loss. When we do not find a deficiency in laboratory tests, we think that the administration of zinc and folic acid and iron-containing preparations will be ineffective and unnecessary. [ABSTRACT FROM AUTHOR]

Aim: In the present study, we aimed to analyze comorbid conditions associated with operated myelomeningocele and their relationship with folic acid usage during pregnancy. Material and Method: Eighty-one newborns who were operated on due to myelomeningocele were included in this study. The patient's files were retrospectively reviewed, and the data of the patients were recorded. The patients were divided into two groups: folic acid users and non-folic acid users during pregnancy. The two groups were compared in terms of weight, height, hemogram, biochemistry, time of diagnosis, delivery method, maturity, localization, type (meningocel or myelomeningocel), neurological deficit, scoliosis, hydrocephalus, timing of surgery, ventriculomegaly, treatment method, additional pathology, tethered cord syndrome, dermal sinus, maternal disease, and number of malformations such as cerebrospinal fluid fistula. Results: The rate of folic acid usage during the antenatal period was 44.4%. Myelomeningocele was located in lumbar (40.7%) and sacral (46.9%) regions. The rate of operation with early diagnosis newborn (1

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim: The dramatic increase in childhood asthma and allergic diseases over the last 50 years has become a serious public health problem, especially in highincome countries. Exposure to epigenetic mechanisms such as altered DNA methylation in early life is thought to have permanent effects on health in adulthood. In this context, there is a growing interest in specific nutrients such as folate, which are known to have direct effects on epigenetic pathways that control gene expression during early development. In addition, gene polymorphisms of the methylenetetrahydrofolate reductase enzyme, which has an important role in folate metabolism, and the unmetabolized folic acid in the circulation dependent on high intake of folic acid have thought to be increased risk of development of asthma and allergic diseases in childhood. In this study, cohort studies and potential mechanisms about folate and its effects on childhood asthma and allergic diseases were aimed to be compiled. Method: 'Folate, Folic Acid, Childhood Asthma, Allergic Diseases, Methylenetetrahydrofolate reductase' keywords and the articles of the last 10 years have been included in this study by using Science Direct, PubMed and Google Academic databases and international journals published in the field of childhood asthma and allergic diseases and folate. Result/Conclusion: Relevant studies of folic acid and childhood asthma and allergic diseases are generally epidemiological studies and the results are contradictory. There is a need for randomized controlled trial to be done on people to make this relationship clearer. [ABSTRACT FROM AUTHOR]

Copyright of Cukurova Medical Journal / Çukurova Üniversitesi Tip Fakültesi Dergisi is the property of Cukurova University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and Design: Homocysteine, a sulfur-containing amino acid, is known to be related with autoimmunity-inflammation, cardiovascular disease and DNA methylation. In this case-control study, we aimed to determine plasma homocysteine, folic acid, vitamin B12 and vitamin B6 levels in patients with psoriasis. Materials and Methods: Smoking, alcohol and coffee consumption habits were recorded in adult patients with plaque-type psoriasis and age- and sex-matched controls. Height and weight measurements were performed and Psoriasis Area and Severity Index (PASI) scores were calculated. Fasting venous blood samples were collected to determine homocysteine, folic acid, vitamin B12, vitamin B6, glucose, total cholesterol, triglyceride, high density lipoprotein (HDL), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Results: There was no significant difference between psoriasis patients (n=43) and controls (n=47) in body mass index and alcohol and coffee consumption. Smoking rate was significantly high in psoriasis patients. The median PASI score was 10.0 (8.3-12.8). Plasma homocysteine, folic acid, vitamin B12, vitamin B6, total cholesterol, triglyseride, ESR and CRP values were not significantly different between patients and the controls. HDL level was low in psoriasis patients (p=0.001). Plasma homocysteine level was higher in males than in females. There was no relationship of homocysteine levels with patient's age, PASI scores, ESR, CRP values and lipids. Homocysteine levels were inversely related with folic acid and vitamin B12 (p=0.000, r=-0.436, p=0.047, r=-0.204, respectively). We did not find any relationship between homocysteine and vitamin B6 levels. Conclusion: There was no increase in plasma homocysteine levels in psoriasis patients we followed up. Homocysteine level increases in inflammatory disorders and this increase is accepted as a cardiovascular disease marker. Homocysteine homeostasis may be balanced in our patients because of the genetic background and/or nutritional habits in this population [ABSTRACT FROM AUTHOR]

Aim: In this study, it was aimed to determine the knowledge status of folic acid, the awareness of folic acid, the use of active folic acid, whether it was used before pregnancy and the factors affecting the use of folic acid in pregnants who applied to the Obstetrics and Gynecology clinic. Material and Methods: Between 15 and 31 January 2017, 355 women who applied to Duzce University Medical Faculty Obstetrics and Gynecology Clinic forms the universe. Sample was not selected. The questionnaire consisting of 17 questions was conducted by face to face interview technique on 142 pregnant women who accepted to participate the survey. Results: The mean age of 142 participants who participate the study was 28.2±6.1 (min=17, max=42). Women who participated the study were pregnant average 2.4±1.4 (min=1, max=6). The mean age at first pregnancy was 22.9±4.8 (min=14, max=39). The number of women who expressed folic acid correctly was 55 (38,7%), who think that they have fed enough food which include folic acid was 82 (57.7%), and who knew the correct definition of neural tube defect (NTD) was 11 (7.7%). In the study group, there were 1 female (0.7%) who gave birth to NTD in her previous pregnancy. 32 (22.5%) females knew that using folic acid could reduce or eliminate the risk of NTD formation. İn terms of time to use folic acid, 66 women (46.5%) used folic acid only in the early period of pregnancy and 17 women (12.0%) used folic acid both before pregnancy and early pregnancy. After the questionnaire was administered, participants were trained in the use of folic acid. Conclusion: This study was conducted in the Duzce University Faculty of Medicine, Department of Obstetrics and Gynecology and found that folic acid awareness, folic acid knowledge level and folic acid use of pregnant women were low. Health education should be given to the public to extend the use of folic acid in pregnancies and increase awareness about folic acid prevent NTD. [ABSTRACT FROM AUTHOR]

Aim: The adequacy of 50 mcg folic acid supplementation given to low-birth-weight babies was investigated. The folate levels of the mothers and infants, and breastmilk, and the optimum dose for folic acid supplementation were also investigated. Material and Methods: After obtaining blood from 141 low-birth- weight infants on the 1st day of life for serum and red cell folate levels, the infants were randomly allocated into three groups according to the folic acid supplement dose. Forty-six infants were given 25 µg/d folic acid, 39 were given 50 µg/d folic acid, and 44 were given 75 µg/d folic acid. Folic acid could not be given to 12 infants. Follow-up blood samples were obtained at the end of folic acid supplementation. Maternal samples for red cell and serum folate levels and breast milk folate levels were obtained within the first 48 hours and the samples for measuring breastmilk folate level were obtained on the 3rd day postnatally. The feeding modes of the infants, maternal folic acid intake, and details of neonate intensive care unit course were recorded. Results: The mean birth weight and gestational age of the infants were found as 1788.2±478.4 g and 33.5±2.9 weeks, respectively. The mean serum and red cell folate levels on admission were found as 21.2±12.2 ng/mL and 922.7±460.7 ng/mL, respectively. The mean maternal serum and red cell folate levels and the mean breast milk folate levels were found as 12.3±7.5 ng/mL, 845.5±301.4 ng/mL, and 30.6±33.0 ng/m, respectively. The breast milk folate levels of mothers who were supplemented with folic acid during pregnancy were significantly higher compared with mothers who were not supplemented with folic acid (p<0.001). Infants who were supplemented with folic acid had higher follow-up serum folate levels compared with the basal level in all groups, but there was no statistically significant difference between the groups. Conclusion: This study showed that the folic acid doses of 25, 50, and 75 µcg/d affected serum folate levels similarly. We can conclude that the dose of 25 µcg/d is adequate for low-birth-weight infants. [ABSTRACT FROM AUTHOR]

The article discusses a study which assessed the correlation between reductase (MTHFR) C677T (rs1801133) polymorphism and homocysteine, vitamin B12, and folate levels, and DNA fragmentation in patients with ovarian cancer. Topics covered include findings which showed that there is no association between MTHFR C677T polymorphism and ovarian cancer, and that patients with ovarian cancer had increased DNA fragmentation.

The 66 (age 101.1 + 58.9 months) leukemia cases admitted to our clinic were evaluated for the frequency of pre-treatment folic acid, vitamin B12 (VB12) and 25-hydroxy vitamin D (25-OH VD) deficiency/excess. In the patient group, folic acid (6.9 ± 6.2 vs. 9.5 ± 4.5, p = 0.0001 respectively) and 25-OH VD (19.5 ± 17.8 vs. 23.8 ± 16.7 µg/L, p= 0.042) were lower than the control while the ratio of patients who had low (18.5% vs. 0%, p = 0.001) and high (4.6% vs. 0%, p = 0.001) folic acid, low VB12 (12.1% vs. 0%, p = 0.012) and very low 25-OH VD (<10 mg/L) (34.4% vs. 0%; p = 0.021) were higher than the control. The ratios of patients who had high levels of VB12 were lower (19.7% vs. 34.7%, p = 0.012). No apparent relationship seemed between the risk of leukemia and the deficiency /excess of the parameters. Replacement therapy (VB12 and folic acid) was administered after achievement of remission. Both patients who did not achieve remission, had both folic acid and VB12 deficiency. Our data, accentuates the importance of such a pre-treatment screening in leukemia patients. [ABSTRACT FROM AUTHOR]

Introduction: Our aim in this study was to investigate effects of vitamin B12 and folic acid malabsorption to homocysteine levels in celiac patients. Materials and Methods: Between 2-17 years of ages 32 celiac patients before treatment, 14 celiac patient in remission and 30 healthy controls involved in this study. Homocystein levels were evaluated in all groups. In addition plasma levels of vitamin B12 and folic acid determined in celiac and remission groups. Results: Homocysteine levels as arithmetic mean±SD found 22.8±1.69 µmol/L in celiac group, 17.31±1.94 µmol/L in remission group and 15.21±1.69 µmol/L in control group. Folic acid levels as arithmetic mean±SD found 7.04±0.74 ng/ ml in celiac patients and 12.95±1.9 ng/ml in remission group. There is statistically significant difference between folic acid and homocysteine levels of two groups (p<0.05). Vitamin B12 levels as arithmetic mean±SD found 433.31±70.91 pg/ml in celiac patients and 400.33±78.36 pg/ml in remission group. Difference between two groups is not statistically significant (p>0.05). Conclusions: In our study homocysteine levels were found to be higher in celiac group than remission group. In this study, difference in folic acid levels between two groups may show that changes in folic acid levels related to changes in homocysteine levels. [ABSTRACT FROM AUTHOR]

The electrochemical properties of folic acid were investigated in pH range 1.0-9.0 by cyclic, linear sweep and adsorptive stripping voltammetry. The compound was irreversibly oxidized at an anodically pre-treated boron-doped diamond electrode in one or two oxidation steps, which are concentration- and/or pH-dependent. Using square-wave stripping mode, folic acid yielded well-defined voltammetric responses in both 0.1 M perchloric acid and 0.1 M Britton-Robinson buffer, pH 6.0 with limits of detection 0.035 μg/mL (7.93 10-8 M) and 0.14 μg/mL (3.2×10-8 M), respectively, after an accumulation of 120 s at open-circuit condition. Practical applicability of the newly developed approach was verified by the direct assays of tablet dosage forms. [ABSTRACT FROM AUTHOR]

Objective: There are studies which determine the connection between deficiency or surplus of serum vitamin D, folic acid and B12, asthma and wheezing attacks. This study aimed to determine whether or not there was any significant connection between serum vitamin D, folic acid and B12 levels and recurrent wheezing attacks. Materials and Methods: One hundred and seven children aged 0-3 years who presented with a history of at least 3 episodes of wheezing and no secondary causes, and 86 healthy children in similar age group were included in this study. A questionnaire was applied which examined the sociodemographic characteristics and risk factors of the children and their families. Serum 25 OH D3, folic acid and B12 levels of the patients and the control group were measured. Results: The two groups were similar in respect of age or gender. The mean serum 25 OH D3 level was 26.64 ± 11.01 ng/mL in the patient group and 33.98 ± 10 ng/mL in the control group (p< 0.001). Vitamin D deficiency was found to be 45 (42%) children in the patient group, and 15 (17.4%) children in the control group (p= 0.0002). No statistically significant difference was seen between the groups in B12 or folic acid levels (p= 0.78, p= 0.60, respectively). Conclusion: The vitamin D intake and the serum vitamin D level were lower in the children with recurrent wheezing compared to the control group which indicate that deficiency of vitamin D may have a role in the etiology of recurrent attacks of wheezing. This evidence proved that the vitamin D intake, and if needed, the serum level need to be controlled. No relationship was determined between the deficiency of B12 and folic acid and recurrent wheezing attacks. There is a need for further studies on the subject of B12 and folic acid. [ABSTRACT FROM AUTHOR]