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1. Synthesis of CF 3 -Containing Spiro-[Indene-Proline] Derivatives via Rh(III)-Catalyzed C-H Activation/Annulation.

Author

Bubnova, Alexandra S., Vorobyeva, Daria V., Godovikov, Ivan A., Smol'yakov, Alexander F., and Osipov, Sergey N.

Subjects
*ANNULATION, *ALKYNES, *MOIETIES (Chemistry), *RHODIUM, *RING formation (Chemistry), *PROLINE
Abstract

An efficient method of accessing new CF3-containing spiro-[indene-proline] derivatives has been developed based on a Cp*Rh(III)-catalyzed tandem C-H activation/[3+2]–annulation reaction of 5-aryl-2-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-2-carboxylates with alkynes. An important feature of this spiro annulation process is the feasibility of dehydroproline moiety to act as a directing group in the selective activation of the aromatic C-H bond. [ABSTRACT FROM AUTHOR]

Published
2023
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