1. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity
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Volta U, Bardella MT, Calabrò A, Troncone R, Corazza GR, Study Group for Non Celiac Gluten S.e.n.s.i.t.i.v.i.t.y. Authors’ contributions UV: Study design, clinical evaluation, enrollment of patients, data analysis, writing of the manuscript, final s.u.p.e.r.v.i.s.i.o.n. MTB: Study design, final supervision of the m.a.n.u.s.c.r.i.p.t. AC, RT: Study design, final supervision of the m.a.n.u.s.c.r.i.p.t. GRC: Study design, final supervision of the m.a.n.u.s.c.r.i.p.t. All authors read, approved the final m.a.n.u.s.c.r.i.p.t. The Study Group for Non Celiac Gluten Sensitivity, included Carmela Bagnato, Claudio Belcari, Antonella Bellantoni, Giacomo Caio, Francesca Calella, Maria Cappello, Carolina Ciacci, Cinzia D’Agate, Italo De Vitis, Antonio Di Sabatino, Gianmarco Fava, Maria Rita Frau, Alessandro Fugazza, Stefano Andrea Grassi, Giuseppina Larcinese, Giovanni Latella, Adriano Lauri, Angelo Lauria, Nicoletta Lenoci, Norma Beatriz Lopez Rios, Donatella Macchia, Mauro Minelli, Beba Molinari, Olivia Morelli, Maria Gloria Mumolo, Giovanni Niccoli, Caterina Pacenza, Francesco Pallone, Fabrizio Parente, Raffaella Pulitanò, Rossella Pumpo, Antonio Rispo, Flavio Romolo Rispoli, Francesco Tedone, Flavio Valiante, Giovanni Viviani, Paolo Usai S.a.t.t.a. All these authors performed clinical evaluation, as well as final supervision of the manuscript, RIEGLER, Gabriele, DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE, Da definire, Volta U, Bardella MT, Calabrò A, Troncone R, Corazza GR, Study Group for Non-Celiac Gluten Sensitivity, Volta, U, Bardella, Mt, Calabrò, A, Troncone, R, Corazza, Gr, Authors’ contributions UV: Study design, Study Group for Non Celiac Gluten S. e. n. s. i. t. i. v. i. t. y., Clinical, Evaluation, enrollment of, Patient, Data, Analysi, writing of the, Manuscript, MTB: Study design, final s. u. p. e. r. v. i. s. i. o. n., final supervision of the m. a. n. u. s. c. r. i. p. t., Ac, RT: Study, Design, GRC: Study design, final supervision of the m. a. n. u. s. c. r. i. p. t., All authors read, final supervision of the m. a. n. u. s. c. r. i. p. t., The Study Group for Non Celiac Gluten Sensitivity, approved the final m. a. n. u. s. c. r. i. p. t., included Carmela, Bagnato, Claudio, Belcari, Antonella, Bellantoni, Giacomo, Caio, Francesca, Calella, Maria, Cappello, Carolina, Ciacci, Cinzia, D’Agate, Italo De, Viti, Antonio Di, Sabatino, Gianmarco, Fava, Maria Rita, Frau, Alessandro, Fugazza, Stefano Andrea, Grassi, Giuseppina, Larcinese, Giovanni, Latella, Adriano, Lauri, Angelo, Lauria, Nicoletta, Lenoci, Norma Beatriz Lopez, Rio, Donatella, Macchia, Mauro, Minelli, Beba, Molinari, Olivia, Morelli, Maria Gloria, Mumolo, Giovanni, Niccoli, Caterina, Pacenza, Francesco, Pallone, Fabrizio, Parente, Raffaella, Pulitanò, Rossella, Pumpo, Riegler, Gabriele, Antonio, Rispo, Flavio Romolo, Rispoli, Francesco, Tedone, Flavio, Valiante, Giovanni, Viviani, All these authors performed clinical evaluation, Paolo Usai S. a. t. t. a., as well as final supervision of the, Manuscript, and The Study Group for Non-Celiac Gluten, Sensitivity
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Male ,Abdominal pain ,Constipation ,Gastrointestinal Diseases ,Non-celiac gluten sensitivity ,FODMAP ,prospective survey ,Intestinal mucosa ,Anti-gliadin antibodies ,Celiac disease ,Clinical picture ,Duodenal biopsy ,Prospective survey ,Adolescent ,Adult ,Age Factors ,Aged ,Aged, 80 and over ,Celiac Disease ,Child ,Child, Preschool ,Diet, Gluten-Free ,Female ,Food Hypersensitivity ,Glutens ,HLA-DQ Antigens ,Humans ,Intestinal Mucosa ,Italy ,Middle Aged ,Prevalence ,Prospective Studies ,Sex Factors ,Surveys and Questionnaires ,Young Adult ,Medicine (all) ,Diagnosis ,80 and over ,Irritable bowel syndrome ,Medicine(all) ,biology ,General Medicine ,Multicenter study ,Gluten-free diet ,medicine.symptom ,medicine.medical_specialty ,CELIAC DISEASE ,celiac disease ,gluten ,non celiac gluten sensitivity ,digestive system ,NO ,Bloating ,Internal medicine ,medicine ,Preschool ,business.industry ,nutritional and metabolic diseases ,medicine.disease ,digestive system diseases ,Diet ,Food intolerance ,Immunology ,biology.protein ,Commentary ,Gluten-Free ,Gluten free ,business ,Gluten - Abstract
none 6 no Background: Non-celiac gluten sensitivity (NCGS) is still an undefined syndrome with several unsettled issues despite the increasing awareness of its existence. We carried out a prospective survey on NCGS in Italian centers for the diagnosis of gluten-related disorders, with the aim of defining the clinical picture of this new syndrome and to establish roughly its prevalence compared with celiac disease. Methods: From November 2012 to October 2013, 38 Italian centers (27 adult gastroenterology, 5 internal medicine, 4 pediatrics, and 2 allergy) participated in this prospective survey. A questionnaire was used in order to allow uniform and accurate collection of clinical, biochemical, and instrumental data. Results: In total, 486 patients with suspected NCGS were identified in this 1-year period. The female/male ratio was 5.4 to 1, and the mean age was 38 years (range 3–81). The clinical picture was characterized by combined gastrointestinal (abdominal pain, bloating, diarrhea and/or constipation, nausea, epigastric pain, gastroesophageal reflux, aphthous stomatitis) and systemic manifestations (tiredness, headache, fibromyalgia-like joint/muscle pain, leg or arm numbness, 'foggy mind,' dermatitis or skin rash, depression, anxiety, and anemia). In the large majority of patients, the time lapse between gluten ingestion and the appearance of symptoms varied from a few hours to 1 day. The most frequent associated disorders were irritable bowel syndrome (47%), food intolerance (35%) and IgE-mediated allergy (22%). An associated autoimmune disease was detected in 14% of cases. Regarding family history, 18% of our patients had a relative with celiac disease, but no correlation was found between NCGS and positivity for HLA-DQ2/-DQ8. IgG anti-gliadin antibodies were detected in 25% of the patients tested. Only a proportion of patients underwent duodenal biopsy; for those that did, the biopsies showed normal intestinal mucosa (69%) or mild increase in intraepithelial lymphocytes (31%). The ratio between suspected NCGS and new CD diagnoses, assessed in 28 of the participating centers, was 1.15 to 1. Conclusions: This prospective survey shows that NCGS has a strong correlation with female gender and adult age. Based on our results, the prevalence of NCGS seems to be only slightly higher than that of celiac disease. none Volta U;Bardella MT;Calabrò A;Troncone R;Corazza GR;Study Group for Non-Celiac Gluten Sensitivity Volta U;Bardella MT;Calabrò A;Troncone R;Corazza GR;Study Group for Non-Celiac Gluten Sensitivity
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- 2014