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ObjectiveThis study aims to describe the characteristics of the brain network attributes in children diagnosed with Infantile Epileptic Spasms Syndrome (IESS) and to determine the influence exerted by adrenocorticotrophic hormone (ACTH) or methylprednisolone (MP) on network attributes.MethodsIn this retrospective cohort study, we recruited 19 infants diagnosed with IESS and 10 healthy subjects as the control from the Pediatric Neurology Department at the Third Affiliated Hospital of Zhengzhou University between October 2019 and December 2020. The first thirty-minute processed electroencephalograms (EEGs) were clipped and filtered into EEG frequency bands (2 s each). A comparative assessment was conducted between the IESS group and the controls as well as the pre- and post-treatment in the IESS group. Mutual information values for each EEG channel were collected and compared including characteristic path length (CPL), node degree (ND), clustering coefficient (CC), and betweenness centrality (BC), based on graph theory.ResultsComparing the control group, in the IESS group, there was an increase in CPL of the Delta band, and a decrease in ND and CC of the Delta band during the waking period, contrary to those during the sleeping period (P

An asymptotic analysis is conducted of the effect surface vibrations may play in mitigating the resistance present in the system consisting of a fluid contained between a pair of parallel flat plates in relative motion. Previous numerical computations of this situation, which has applications in both biological and technological contexts, have suggested that small vibrations that move at a fast phase speed can lead to substantial reductions in the resistance. The effect seems to be a somewhat intricate function of the wavelength of the vibration modes. Our analysis uncovers the properties of the various phenomena that are at work and describes the interplay between them. The techniques employed here lend themselves to the extension to other situations including problems in which propulsion effects in fluid systems can be induced by vibrations. [ABSTRACT FROM AUTHOR]

More than 0.6 MW of rf power at 476 MHz has been coupled to DIII-D plasmas by launching helicon (whistler) waves with a traveling-wave antenna (comb-line) in the fast-wave polarization (Van Compernolle et al 2021 Nucl. Fusion 61 116034) which resulted in the observation of electron heating of the core plasma with single-pass absorption based on ray-tracing in L-mode discharges. The coupling performance of the 1.5 m wide 30-element comb-line traveling-wave antenna has been consistent with expectations based on the 2015–2016 experiments on DIII-D with a low-power 12-element prototype (Pinsker et al 2018 Nucl. Fusion 58 106007). The conditioning process that was necessary to carry out high-power experiments is discussed; rf-specific impurities have not been observed. Parametric decay instabilities have been observed and are being investigated as a potential edge absorption mechanism (Porkolab et al 2023 AIP Conf. Proc. 2984 070004).

Objective: This study aims to describe the characteristics of the brain network attributes in children diagnosed with Infantile Epileptic Spasms Syndrome (IESS) and to determine the influence exerted by adrenocorticotrophic hormone (ACTH) or methylprednisolone (MP) on network attributes., Methods: In this retrospective cohort study, we recruited 19 infants diagnosed with IESS and 10 healthy subjects as the control from the Pediatric Neurology Department at the Third Affiliated Hospital of Zhengzhou University between October 2019 and December 2020. The first thirty-minute processed electroencephalograms (EEGs) were clipped and filtered into EEG frequency bands (2 s each). A comparative assessment was conducted between the IESS group and the controls as well as the pre- and post-treatment in the IESS group. Mutual information values for each EEG channel were collected and compared including characteristic path length (CPL), node degree (ND), clustering coefficient (CC), and betweenness centrality (BC), based on graph theory., Results: Comparing the control group, in the IESS group, there was an increase in CPL of the Delta band, and a decrease in ND and CC of the Delta band during the waking period, contrary to those during the sleeping period ( P  < 0.05), a decreased in CPL of the fast waves and an increase in ND and CC ( P  < 0.05) in the sleep-wake cycle, and a decrease in ND and CC of the Theta band in the waking phase. Post-treatment compared with the pre-treatment, during the waking ictal phase, there was a noted decrease in CPL in the Delta band and fast waves, while an increase was observed in ND and CC ( P  < 0.05)., Conclusions: The Delta band and fast waves are crucial components of the network attributes in IESS., Significance: This investigation provides a precise characterization of the brain network in children afflicted with IESS, and lays the groundwork for predicting the prognosis using graph theory., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Dong, Jin, Li, Lian, Wu, Xu, Zhang, Du, Jia, Wang and Zhao.)

Early-onset epileptic encephalopathies, including West syndrome (WS), are a group of neurological disorders characterized by developmental impairments and intractable seizures from early infancy. We have now identified biallelic CNPY3 variants in three individuals with WS; these include compound-heterozygous missense and frameshift variants in a family with two affected siblings (individuals 1 and 2) and a homozygous splicing variant in a consanguineous family (individual 3). All three individuals showed hippocampal malrotation. In individuals 1 and 2, electroencephalography (EEG) revealed characteristic fast waves and diffuse sharp- and slow-wave complexes. The fast waves were clinically associated with seizures. CNPY3 encodes a co-chaperone in the endoplasmic reticulum and regulates the subcellular distribution and responses of multiple Toll-like receptors. The amount of CNPY3 in lymphoblastoid cells derived from individuals 1 and 2 was severely lower than that in control cells. Cnpy3 -knockout mice exhibited spastic or dystonic features under resting conditions and hyperactivity and anxiolytic behavior during the open field test. Also, their resting EEG showed enhanced activity in the fast beta frequency band (20–35 Hz), which could mimic the fast waves in individuals 1 and 2. These data suggest that CNPY3 and Cnpy3 perform essential roles in brain function in addition to known Toll-like receptor-dependent immune responses. [ABSTRACT FROM AUTHOR]

In the solar atmosphere, there exist two frequently-observed phenomena, Moreton waves and EIT (extreme-ultraviolet imaging telescope) waves, whose physical nature is still under debate. In this work, we perform a three-dimensional ray-tracing simulation for the propagation of fast magnetoacoustic waves. We build a stratified solar atmosphere model and take partial ionization into consideration to give an exact description of chromosphere and transition region. The calculated result is compared with a flare event observation in which both Moreton waves and EIT waves were present. In agreement with observations, the calculated wavefront show different kinematical characteristics in different propagation directions during different times. Moreton waves and EIT waves have higher propagation speeds near the active region where the magnetic field strength is strong. The result suggests that both Moreton waves and EIT waves of this event can be interpreted as the fast magnetoacoustic waves propagating at different heights in the solar atmosphere. [ABSTRACT FROM AUTHOR]

Objective We analyzed the spatial distribution and concordance of fast (>10 Hz) and slow (<5 Hz) electroencephalogram (EEG) components of ictal activities and interictal epileptiform discharges (IIED) recorded by intracranial video EEG (IVEEG) in children with epileptic spasms (ES). Methods We studied eight children with ES, who underwent IVEEG before resective surgery for epilepsy. We quantified the root-mean-square (RMS) amplitude of the fast and slow components of ictal activities during ES and IIED. We compared the concordance between the spatial distributions of the fast and slow components of ES and IIED. Results There was a larger concordance between the spatial distributions of the fast and slow components in IIED than in ES ( p = 0.0206 and 0.0401). Conclusions The spatial concordance between the fast and slow EEG components was significantly different between ES and IIED. Significance The mechanisms underlying the generation of slow EEG components may differ between ES and IIED. The slow EEG components of ES might indicate an extensive epileptic network involving remote symptomatic zones for ES in either the cortical or subcortical areas. The high spatial concordance between the fast and slow components of IIED suggests the involvement of a local inhibitory process within the epileptic cortex. [ABSTRACT FROM AUTHOR]

In this paper, the solution of the system of homogeneous Biot equations, which was derived by Biot for the displacement vectors of plane monochrome elastic waves propagating in a homogeneous infinite two-phase medium, is expanded to the case where the propagation area of the elastic waves is limited and the wavefront is a piecewise smooth curved surface. It is shown that the arbitrary system of homogeneous Biot equations for the displacement vectors of the solid and liquid phases can be reduced to three different equations pertaining to the class of Helmholtz equations. From this, irrespective of the geometry of the seismic wavefront and the boundaries of the studied two-phase medium, there is the following. (1) Each displacement vector (of the solid and liquid phase) splits into three independent vectors satisfying three different Helmholtz equations. Two of these vectors correspond to the two types of compressional waves, namely, fast waves (waves of the first kind) and slow waves (waves of the second kind). The third vector describes shear waves. (2) The similar (related to the same wave type) components of the displacement vector in the solid and liquid phases satisfy the same Helmholtz equation and are linked with each other through a corresponding scalar factor that is expressed in terms of the coefficients of the Biot equations. Taking into account the established properties of the displacement vectors in the solid and liquid phases seems to be helpful in the problems dealing with calculation of elastic fields of arbitrary sources in piecewise-homogeneous two-phase media. [ABSTRACT FROM AUTHOR]

Recent in vitro studies have provided evidence of the propagation of two different longitudinal wave modes at ultrasonic frequencies in cancellous bone. The genesis of these two plane waves in fluid-saturated porous media is predicted by the poroelastic approach to wave propagation originally developed by Biot. However, wave velocity is usually analyzed as a function of bone mass density only; therefore, the influence of the cancellous bone microstructure over the wave velocity is not taken into account. In the present study, a descriptor of the microstructure is considered in Biot's theory. This model is used to evaluate the large experimental variability of both fast and slow wave velocities measured on randomly oriented human and bovine cancellous bone samples. The role of the anisotropic solid structure and fluid in the behavior of fast and slow wave velocities is examined. Experimental and theoretically predicted velocities are found in close agreement when analyzed as a function of both porosity and structural index. This model has the potential to be used to determine an acoustically derived structural index in cancellous bone. [ABSTRACT FROM AUTHOR]

Abstract: Objective: To evaluate the suppressive effect of electric cortical stimulation upon the seizure onset zone and the non-epileptic cortex covered by subdural electrodes in patients with neocortical epilepsy and mesial temporal lobe epilepsy (MTLE). Methods: Four patients with medically intractable focal epilepsy had implanted subdural electrodes for preoperative evaluation. Cortical functional mapping was performed by intermittently repeating bursts of electric stimulation, which consisted of 50Hz alternating square pulse of 0.3ms duration, 1–15mA, within 5s. The effect of this stimulation on the seizure onset zones and on the non-epileptic areas was evaluated by comparing spike frequency and electrocorticogram (ECoG) power spectra before and after stimulation. A similar comparison was performed in stimulation of 0.9Hz of the seizure onset zones for 15min. Results: When the seizure onset zone was stimulated with high frequency, spike frequency decreased by 24.7%. Logarithmic ECoG power spectra recorded at stimulated electrode significantly decreased in 10–32Hz band by high frequency stimulation of the seizure onset zone, and in 14–32Hz band by high frequency stimulation of the non-epileptic area. Low frequency stimulation of the seizure onset zone produced 18.5% spike reduction and slight power decrease in 12–14Hz. Conclusions: Both high and low frequency electric cortical stimulation of the seizure onset zone have a suppressive effect on epileptogenicity. Reduction of ECoG fast activities after electric cortical stimulation suggests the augmentation of inhibitory mechanisms in human cortex. [Copyright &y& Elsevier]

Abstract: The influence of an idealized moving wavy surface on the overlying airflow is investigated using direct numerical simulations (DNS). In the present simulations, the bulk Reynolds number is Re =8000 (; where U 0 is the forcing velocity of the flow, h the height of the domain and the kinematic viscosity) and the phase speed of the imposed waves relative to the friction velocity, i.e., the wave age varies from very slow to fast waves. The wave signal is clearly present in the airflow up to at least 0.15λ (where λ is the wave length) and is present up to higher levels for faster waves. In the kinetic energy budgets, pressure transport is mainly of importance for slow waves. For fast waves, viscous transport and turbulent transport dominate near the surface. Kinetic energy budgets for the wave and turbulent perturbations show a non-negligible transport of turbulent kinetic energy directed from turbulence to the wave perturbation in the airflow. The wave-turbulent energy transport depends on the size, tilt, and phase of the wave-induced part of the turbulent Reynolds stresses. According to the DNS data, slow waves are more efficient in generating isotropic turbulence than fast waves. Despite the differences in wave-shape as well as in Reynolds number between the idealized direct numerical simulations and the atmosphere, there are intriguing similarities in the turbulence structure. Important information about the turbulence above waves in the atmosphere can be obtained from DNS—the data must, however, be interpreted with care. [Copyright &y& Elsevier]

Abstract: A new code for lower hybrid antenna design and cold plasma wave coupling, named ALOHA, is presented. ALOHA takes into account the poloidal dimension of the antennas and the coupling to slow and fast waves. Comparisons with experimental data for the LH antennas installed on Tore Supra and the TOPLHA code show that ALOHA is a fast and efficient predictive tool. [Copyright &y& Elsevier]