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4 results on '"farber cancer institute"'

1. Effect of chemotherapy (with and without radiotherapy) on the intelligence of children and adolescents treated for acute lymphoblastic leukemia

Author

Cao, Shu-Chun, Legerstee, Jeroen S, van Bellinghen, Marc, Lemiere, Jurgen, Sleurs, Charlotte, Segers, Heidi, Danckaerts, Marina, and Dierckx, Bram

Subjects
NEUROPSYCHOLOGICAL OUTCOMES, Social Sciences, Experimental and Cognitive Psychology, acute lymphoblastic leukemia, NEUROCOGNITIVE OUTCOMES, CRANIAL RADIATION, SDG 3 - Good Health and Well-being, Psychology, Multidisciplinary, antineoplastic agents, Psychology, cancer, WHITE-MATTER ANISOTROPY, child, neuropsychological tests, Science & Technology, LONG-TERM SURVIVORS, survivors, FARBER CANCER INSTITUTE, intelligence, COGNITIVE IMPAIRMENT, Biomedical Social Sciences, RANDOMIZED-TRIAL, Social Sciences, Biomedical, Psychiatry and Mental health, Oncology, adolescent, adverse effects, CHILDHOOD LEUKEMIA, PEDIATRIC BRAIN-TUMORS, Life Sciences & Biomedicine
Abstract

OBJECTIVE: This meta-analysis assesses cognitive functioning in children with acute lymphoblastic leukemia post-treatment who were treated with either chemotherapy-only (CT-only) or in combination with radiation therapy (CTRT). METHODS: The databases Pubmed and PsychInfo were searched between 1-1-2000 and 31-12-2021. Data were analyzed using Comprehensive Meta-Analysis (version 2). RESULTS: Mean weighted intelligence after treatment was 100.2 (number of studies n = 51, 95% CI: 98.8-101.5). For CT-only, it was 100.8 (95% CI: 99.5-102.2) and for CTRT 97.8 (95% CI: 95.9-100.2). Compared to recruited healthy controls, treated children had on average lower IQ scores (n = 23, mean difference -7.8, 95% CI: -10.7 to -5.0, p

Published
2023

2. Influence of Cranial Radiotherapy on Outcome in Children With Acute Lymphoblastic Leukemia Treated With Contemporary Therapy

Author

Andrea Biondi, Lewis B. Silverman, Ajay Vora, Stephen P. Hunger, Rob Pieters, Meenakshi Devidas, Maria Grazia Valsecchi, Nicholas Goulden, Ching-Hon Pui, Mervi Taskinen, Gabriele Escherich, Martin Schrappe, Franco Locatelli, Anita Andreano, Anja Moericke, Keizo Horibe, Vora, A, Andreano, A, Pui, C, Hunger, S, Schrappe, M, Moericke, A, Biondi, A, Escherich, G, Silverman, L, Goulden, N, Taskinen, M, Pieters, R, Horibe, K, Devidas, M, Locatelli, F, and Valsecchi, M

Subjects
medicine.medical_specialty, Study groups, Antimetabolites, Antineoplastic, Cancer Research, Adolescent, Lymphoblastic Leukemia, 03 medical and health sciences, 0302 clinical medicine, Retrospective Studie, Internal medicine, medicine, Secondary Prevention, Humans, Cumulative incidence, Child, Retrospective Studies, Randomized Controlled Trials as Topic, Cranial radiotherapy, business.industry, Infant, Retrospective cohort study, ORIGINAL REPORTS, Precursor Cell Lymphoblastic Leukemia-Lymphoma, 3. Good health, Surgery, Transplantation, minimal residual disease, farber cancer institute, childhood t-cell, prognostic-factors, aieop-bfm, risk, trial, metaanalyses, chemotherapy, methotrexate, medicine.anatomical_structure, Methotrexate, Treatment Outcome, Oncology, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, 030220 oncology & carcinogenesis, Child, Preschool, Linear Models, Linear Model, Bone marrow, Cranial Irradiation, business, ALL, 030215 immunology, medicine.drug, Human
Abstract

Purpose We sought to determine whether cranial radiotherapy (CRT) is necessary to prevent relapse in any subgroup of children with acute lymphoblastic leukemia (ALL). Patients and Methods We obtained aggregate data on relapse and survival outcomes for 16,623 patients age 1 to 18 years old with newly diagnosed ALL treated between 1996 and 2007 by 10 cooperative study groups from around the world. The proportion of patients eligible for prophylactic CRT varied from 0% to 33% by trial and was not related to the proportion eligible for allogeneic stem-cell transplantation in first complete remission. Using a random effects model, with CRT as a dichotomous covariate, we performed a single-arm meta-analysis to compare event-free survival and cumulative incidence of isolated or any CNS relapse and isolated bone marrow relapse in high-risk subgroups of patients who either did or did not receive CRT. Results Although there was significant heterogeneity in all outcome end points according to trial, CRT was associated with a reduced risk of relapse only in the small subgroup of patients with overt CNS disease at diagnosis, who had a significantly lower risk of isolated CNS relapse (4% with CRT v 17% without CRT; P = .02) and a trend toward lower risk of any CNS relapse (7% with CRT v 17% without CRT; P = .09). However, this group had a relatively high rate of events regardless of whether or not they received CRT (32% [95% CI, 26% to 39%] v 34% [95% CI, 19% to 54%]; P = .8). Conclusion CRT does not have an impact on the risk of relapse in children with ALL treated on contemporary protocols.

Published
2016

3. Endogenous BRCA1-IRIS may influence DNA replication initiation machinery.

Abstract

The article cites a study by researcher W.M. ElShamy and D.M. Livingston, published in a 2004 issue of "Nature Cell Biology," which reports endogenous BRCA1-IRIS may positively influence the DNA replication initiation machinery. Breast cancer is the most common malignancy among women, and mutations in the BRCA genes produce increased susceptibility to these malignancies in certain families. BRCA1-IRIS also co-immunoprecipitated with DNAreplication- licensing proteins and with known replication initiation sites. Suppression of BRCA1-IRIS expression hindered the normal departure of geminin from prereplication complexes, and depressed the rate of cellular DNA replication and possibly initiation-related synthesis.

Published
2004

4. Endogenous BRCA1-IRIS may influence DNA replication initiation machinery.

Abstract

The article cites a study which states that endogenous BRCA1-IRIS may positively influence the DNA replication initiation machinery. Suppression of BRCA1-IRIS expression hindered the normal departure of geminin from prereplication complexes, and depressed the rate of cellular DNA replication and possibly initiation-related synthesis. In contrast, BRCA1-IRIS overexpression stimulated DNA replication, wrote researchers W.M. ElShamy and D.M. Livingston. ElShamy and colleagues published their findings in the journal "Nature Cell Biology."

Published
2004

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