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The objective of the work was to study the prevalence of undifferentiated oligophrenia in the offspring of antenatally exposed parents. The analysis included 2,908 offspring of the Techa River antenatally exposed residents within Chelyabinsk Oblast born in the period 1974-1992. 1,705 of them were born to an antenatally exposed mother, 1,668 – to an antenatally exposed father, and 368 – to both antenatally exposed parents. Mean in-utero dose for the cohort of in-utero exposed population was 5.8 mGy, while the mean dose of mothers of oligophrenic persons was 12.6 mGy, and that of antenatally exposed fathers – 5.3 mGy. It was found that the prevalence of oligophrenia of different degrees of severity compared to the control group, which included the offspring of unexposed persons of the same age, ethnicity and living in adjacent territories, tends to increase More than 20% of cases of moderate oligophrenia in both main and control groups were of familial nature. All cases of severe oligophrenia in the compared groups were sporadic. There was an increase (p0.05. No dependence of the prevalence of oligophrenia on the maternal and paternal in-utero dose has been detected.

Uncertainties of radiation risk of late radiation exposure effects in humans are to a great extent determined by completeness and quality of epidemiological data. The registry of the studied cohort is of fundamental importance for the cohort studies. Particular difficulties appear in the course of development of the exposed population offspring registry as these people in contrast to their parents were not affected by radiation exposure. The formation of the cohort of the exposed population offspring has its peculiarities and requires evaluation of its completeness and quality. The objective of this research is to study the value of the sex ratio as a possible criterion to assess the completeness and quality of the registry of the Techa River Cohort offspring. The register of descendants of the irradiated population at the end of 2019 included information on 25930 persons. The formation of the register of descendants of the population irradiated on the Techa River was started in the mid-1950s. At the same time, various documents were used to confirm the fact of birth of a child in irradiated persons. In the Techa River population the proportion of offspring with exposed mother and unexposed father is 22.2%, those with exposed father and unexposed mother made up 13.9%; the proportion of in utero exposed offspring is 44.6%. In accordance to the widely accepted published data it was to be expected that the number of male 1st-generation offspring in the cohort would be lower. However, the results of the conducted research show no changes in the sex ratio among offspring relative to the population-based control. Moreover, it was stated that the sex ratio in the population of the 1st-generation offspring of the exposed residents of the Techa River settlements should not be viewed as secondary. The assumption about the influence of the pre-conceptional exposure of the parents as well as that of the in utero exposure on changes in the sex ratio was not confirmed. It is shown that the decrease in the value of the sex ratio is associated with misreporting of the male 1st -generation offspring who died in childhood and at young age. The value of the sex ratio in groups formed based on the character and dose of exposure, depended mainly on the source of information used in the course of the offspring registry development.

The objective of this study was to assess main regularities of resettlement of the first generation offspring of the exposed Techa River population. In the given paper the information on places and periods of residence of the population exposed on the Techa River and their offspring, obtained from the medical-dosimetric database of the URCRM was used. Groups of the first generation offspring of exposed people living at various distances from the Techa River were identified. Main regularities of resettlement of a large group of offspring of the exposed Techa River population (26 300 persons) over the period 1950-2010 were revealed. Chelyabinsk Oblast is the main resettlement area of the first generation offspring of the exposed Techa River population. The proportion of offspring living outside of their primary resettlement area is gradually increasing. Offspring outflow from the Kurgan Oblast is greater than that from the Chelyabinsk Oblast. The main part (45.9%) of the first generation offspring of the exposed Techa River population alive as of 2010 was gathered in cities. Migration of the exposed population promoted increase in the number of marriages between exposed and unexposed persons, to the birth of offspring whose one parent (either mother or father) was exposed and led to decrease in the number of offspring whose both parents were exposed. In the current study for the first time peculiarities of resettlement of two generation of people residing on radioactively-contaminated territories, exposed people and their offspring, were compared. Marked differences in the nature of resettlement of the Techa River exposed population offspring relative to their parents were registered. Offspring migrated more frequently, which is expressed in the increase in their proportion in cities up to 45.9% as compared to that of exposed persons – 30.8% (p