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While the advantages of photonic quantum computing, including direct compatibility with communication, are apparent, several imperfections such as loss and distinguishability presently limit actual implementations. These imperfections are unlikely to be completely eliminated, and it is therefore beneficial to investigate which of these are the most dominant and what is achievable under their presence. In this work, we provide an in-depth investigation of the influence of photon loss, multi-photon terms and photon distinguishability on the generation of photonic 3-partite Greenberger–Horne–Zeilinger states via established fusion protocols. We simulate the generation process for spontaneous parametric down-conversion and solid-state-based single-photon sources using realistic parameters and show that different types of imperfections are dominant with respect to the fidelity and generation success probability. Our results indicate what are the dominant imperfections for the different photon sources and in which parameter regimes we can hope to implement photonic quantum computing in the near future.