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Your search keyword '"ergosterol peroxide, stigmasterol, aglaia simplicifolia, hela cervical cancer, ic50"' showing total 2 results
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2 results on '"ergosterol peroxide, stigmasterol, aglaia simplicifolia, hela cervical cancer, ic50"'

1. Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Author

Nunung Kurniasih, Asep Supriadin, Desi Harneti, Rizky Abdulah, Mohamad Nurul Azmi bin Mohamad Taib, and Unang Supratman

Subjects
ergosterol peroxide, stigmasterol, aglaia simplicifolia, hela cervical cancer, ic50, Chemistry, QD1-999
Abstract

Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.

Published
2021
Full Text
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2. Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Author

Asep Supriadin, Desi Harneti, Unang Supratman, Mohamad Nurul Azmi Mohamad Taib, Nunung Kurniasih, and Rizky Abdulah

Subjects
Aglaia simplicifolia, Meliaceae, Stigmasterol, biology, Ergosterol peroxide, medicine.medical_treatment, biology.organism_classification, In vitro, Steroid, ergosterol peroxide, stigmasterol, aglaia simplicifolia, hela cervical cancer, ic50, HeLa, Chemistry, chemistry.chemical_compound, chemistry, Biochemistry, medicine, Cytotoxicity, QD1-999
Abstract

Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.

Published
2021
Full Text
View/download PDF

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