1. Trimester-Specific Reference Intervals of Thyroid Function in Healthy Pregnant Women in Macau
- Author
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Ka Wai CHOI and Hoi Kei LEONG
- Subjects
engineering journal ,pregnancy ,reference-intervals ,thyroid hormone - Abstract
— Background: To establish the trimester-specific reference intervals of thyrotropin (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) in healthy pregnant women in Macau. Methods: Serum samples were collected from 166 healthy pregnant Macau women since early pregnancy until the third trimester. The study was performed in Macau Kiang Wu Hospital from July 2020 to October 2021.Basic clinical and obstetrics data were gathered using questionnaires. Blood samples were sequentially collected from the pregnant women at the first (≤12weeks), the second (12-28 weeks) and the third (>28 weeks) trimesters, respectively. Result: Reference intervals of TSH were 0.02~3.30mIU/L, 0.45~3.80mIU/L and 0.18~3.43mIU/L in three trimesters. For FT4, Reference intervals were 12.82~22.0pmol/L, 9.86~15.58pmol/L and 10.10~15.30pmol/L in three trimesters. For FT3, Reference intervals were 3.53~6.0pmol/L, 2.74~4.65pmol/L and 2.62~4.45pmol/L in three trimesters. The concentration of TSH was significant lower in the first trimester compared to the second and third trimesters of pregnancy (median o.89, 1.66, 1.41mIU/L); TSH concentration differences between trimesters are significantly different (p0.05). Conclusion: This study is the first to establish trimester-specific reference intervals of TSH, FT4 and FT3 in healthy pregnant Macau women. Trimester-specific reference intervals may help in diagnosis and management of thyroid dysfunction during pregnancy which will prevent both maternal and fetal outcomes.
- Published
- 2022
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