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5 results on '"endothelialdysfunction"'

1. THE PLACE OF THE ENDOTHELIAL VASOREGULATION FACTORS IN THE FORMATION OF THE HYPERTENSION IN CONDITION OF THE CHRONIC STRESS

Author

I. S. Lutskyy, S. V. Ziablices, M. S. Kishenia, L. V. Liutykova, and P. A. Chernobrivec

Subjects
arterial hypertension, chronic stress, nitrogen oxide, endothelin, endothelialdysfunction, Medicine (General), R5-920
Abstract

Purpose: the assessment of place of the endothelial vasoregulation factors (nitrogen oxide (no) and endothelin 1 (et-1)) in the formation of the arterial hypertension (AH) in condition of chronic stress (CS) was held.Materials and methods: 160 railroad engineers (RRE) were examined. They had work experience from 1 to 35 years. As controls, 100 healthy volunteers wereexamined. The level of adrenocorticotropic hormone, cortisol and corticosterone in the blood as a condition of the stress system (SS) were measured.Results: it was found out that the effect of stress reaction is accompanied by the serial reaction of the SS: activation period, adaptation and disadaptation. In the activation and the adaptation periods was marked increase synthesis of NO against the background moderate increase of ET-1 concentration. The disadaptation period was accompanied by decrease in NO production and doubling the level of ET-1, an increase of the thickness of the carotid intima-media complex (as evidence of vascular remodeling processes). Insufficient synthesis of the vasodilators, excessive production of the vasoconstrictors, remodeling of the vascular wall contributed to the formation, process and progression of the hypertension.Conclusion: these results specify the pathogenic mechanisms of AH in condition of CS.

Published
2015
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2. Pancreas fat content, insulin homeostasis and circulating endothelial microparticles in male essential hypertensive patients

Author

Universidad de Sevilla. Departamento de Fisiología, Instituto de Salud Carlos III, Alfaro Lara, Verónica Inmaculada, Muñoz Hernández, Rocío, Giménez Miranda, Luis, Beltrán Romero, Luis Matías, Castell Montsalve, Francisco Javier, Stiefel García-Junco, Pablo Enrique, Universidad de Sevilla. Departamento de Fisiología, Instituto de Salud Carlos III, Alfaro Lara, Verónica Inmaculada, Muñoz Hernández, Rocío, Giménez Miranda, Luis, Beltrán Romero, Luis Matías, Castell Montsalve, Francisco Javier, and Stiefel García-Junco, Pablo Enrique

Abstract

Thepancreasfatcontenthasbeenpoorlyinvestigatedinessentialhypertension.Theauthorsaimtorelatepancreasandliverfatcontentwithparametersmeasuringinsulinresistance, beta-cell function and also with markers of endothelial dysfunction andplateletorendothelialcelldestruction.Theauthorsstudiedagroupof40malehyper-tensivepatientswithwell-controlledbloodpressure,maintainingastableweight,andhavingnotchangedtheirmedicationduringthelastyear.Pancreasfatcontentwascor-relatedwithHOMA-IR(r=.616,p<.001),HOMA-S(r=−.439,p<.005),betacellfunctionparameter(r=.457,p<.005),andQUICKI(r=.412,p<.01),whereasliverfatwasnotpatientsinthehighestquartileofpancreasfatcontenthadmorecirculatingendothelialmicroparticlesthanpatientsintheotherquartiles(median129[94.3–200]vs.60.9[49.4–88.8],p=.002).However,patientsinthehighestquartileofthepancreasfat content distribution did not differ from the lowest in hyperemic response afterischemianorcirculatingplateletmicroparticlescount.Liverfatcontentwasnotrelatedto any of the parameters studied. In a multivariate stepwise binary logistic regres-sionanalysis(WaldMethod)circulatingendothelialmicroparticlesremainsignificantlyassociatedwithpancreasfatcontentafteradjustingforconfoundingfactors,suchastobacco,diabetesmellitus,hypercholesterolemia,ormetabolicsyndrome.Ourresultsreflectthatinessentialhypertension,pancreasfatcontentissuperiortoliverfattostudybeta-cellfunctionalityandinsulinresistance.Moreover,theauthorsdescribedforthefirsttimethatpancreasfatcontentisrelatedtoendothelialcelldestruction.Furtherstudiesareneededtoconfirmthispoint.

Published
2022

3. PROTEIN SVCAM - 1 AND ITS SIGNIFICANCE IN PERINATOLOGY

Author

Gorelik, S.K. and Blinov, A.E.

Subjects
preeclampsia, sVCAM – 1, embryonic structures, endothelialdysfunction, female genital diseases and pregnancy complications, reproductive and urinary physiology, perinatalpathology
Abstract

Preeclampsia is a risk factor for perinatal pathology, as it is characterized by a mismatch between the capacity of the mother’s adaptation systems to adequately meet the needs of the developing fetus.In pregnant women with preeclampsia, the endothelium of the vessels is the target of various pathological effects. Numerous studies confirm that when preeclampsia is added to chronic hypertension, there will be an increase in the sVCAM - 1 protein in the maternal serum. Protein sVCAM - 1 is an early marker of endothelial ysfunction, as well as a predictor of perinatal pathology

Published
2019
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4. Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension

Author

Jens Minnerup, Anna Maria Fernàndez Planas, Guadalupe Soria, Anja Meissner, Ministerio de Economía y Competitividad (España), European Commission, German Academic Exchange Service, and Else Kröner-Fresenius Foundation

Subjects
Male, medicine.medical_specialty, Disease, 030204 cardiovascular system & hematology, Bioinformatics, Biochemistry, Vascular dementia, Nitric oxide, Mouse model, Mice, Random Allocation, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Microvasculature, Internal medicine, medicine, Animals, Endothelial dysfunction, Cognitive decline, business.industry, Angiotensin II, Brain, medicine.disease, 3. Good health, Endothelialdysfunction, Mice, Inbred C57BL, Disease Models, Animal, Blood pressure, chemistry, Pathophysiology of hypertension, Hypertension, Cardiology, Female, Cerebral small-vessel diseases, business, 030217 neurology & neurosurgery
Abstract

Hypertension is a main risk factor for the development of cerebral small vessel disease (cSVD) – a major contributor to stroke and the most common cause of vascular dementia. Despite the increasing socioeconomic importance arising from cSVD, currently only a few specific treatment strategies with proven efficacy are known. Fundamental to the lack of specific treatments is poor understanding of the disease pathogenesis and a lack of appropriate animal models resembling all symptoms of the human disease. However, chronic hypertensive rat models have been shown to bear similarities to most key features of cSVD. Despite a significantly larger toolbox available for genotypic and phenotypic modifications compared to rats, mouse models of hypertension are unusual when modeling cSVD and associated cognitive impairment experimentally. In the present study, we therefore characterized hypertension‐mediated cerebrovascular alterations and accompanying structural and functional consequences by simultaneously treating adult wild‐type mice (C57BL/6N) with Angiotensin II (AngII) and the nitric oxide synthases inhibitor L‐NAME for 4 weeks. Hypertension associated to cerebral alterations reminiscent of early‐onset cSVD and vascular cognitive impairment when combined with additional AngII bolus injections. Most importantly, preventing the elevation of blood pressure (BP) protected from the development of cSVD symptoms and associated cognitive decline. Our data strongly support the suitability of this particular mouse model of AngII‐induced hypertension as an appropriate animal model for early‐onset cSVD and hence, vascular cognitive impairment, pathologies commonly preceding vascular dementia., We gratefullyacknowledge the following funding support research grant from theSpanish Ministry of Economy (MICINN SAF2014-56279), a MarieCurie Action of the 7th Framework Program of the EuropeanCommission (AM; 2013_229673), a stipend for returning scientistsgranted from the German Academic Exchange Service (AM;PKZ2015_91606607), and the Else Kr€oner Fresenius Stiftung (JM;2014_EKES.16).

Published
2017

5. Structural and functional brain alterations in a murine model of Angiotensin II-induced hypertension

Author

Ministerio de Economía y Competitividad (España), European Commission, German Academic Exchange Service, Else Kröner-Fresenius Foundation, Meissner, Anja, Jens Minnerup, Soria, Guadalupe, Planas, Anna M., Ministerio de Economía y Competitividad (España), European Commission, German Academic Exchange Service, Else Kröner-Fresenius Foundation, Meissner, Anja, Jens Minnerup, Soria, Guadalupe, and Planas, Anna M.

Abstract

Hypertension is a main risk factor for the development of cerebral small vessel disease (cSVD) – a major contributor to stroke and the most common cause of vascular dementia. Despite the increasing socioeconomic importance arising from cSVD, currently only a few specific treatment strategies with proven efficacy are known. Fundamental to the lack of specific treatments is poor understanding of the disease pathogenesis and a lack of appropriate animal models resembling all symptoms of the human disease. However, chronic hypertensive rat models have been shown to bear similarities to most key features of cSVD. Despite a significantly larger toolbox available for genotypic and phenotypic modifications compared to rats, mouse models of hypertension are unusual when modeling cSVD and associated cognitive impairment experimentally. In the present study, we therefore characterized hypertension‐mediated cerebrovascular alterations and accompanying structural and functional consequences by simultaneously treating adult wild‐type mice (C57BL/6N) with Angiotensin II (AngII) and the nitric oxide synthases inhibitor L‐NAME for 4 weeks. Hypertension associated to cerebral alterations reminiscent of early‐onset cSVD and vascular cognitive impairment when combined with additional AngII bolus injections. Most importantly, preventing the elevation of blood pressure (BP) protected from the development of cSVD symptoms and associated cognitive decline. Our data strongly support the suitability of this particular mouse model of AngII‐induced hypertension as an appropriate animal model for early‐onset cSVD and hence, vascular cognitive impairment, pathologies commonly preceding vascular dementia.

Published
2017

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