1. Novel 4-aminopyrimido[4,5-b]quinoline derivatives as potential antimicrobial agents.
- Author
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el-Sayed OA, el-Bieh FM, el-Aqeel SI, al-Bassam BA, and Hussein ME
- Subjects
- Anti-Bacterial Agents, Bacteria drug effects, Chemical Phenomena, Chemistry, Physical, Fungi drug effects, Indicators and Reagents, Magnetic Resonance Spectroscopy, Mass Spectrometry, Microbial Sensitivity Tests, Pyrimidines pharmacology, Anti-Infective Agents chemical synthesis, Anti-Infective Agents pharmacology, Pyrimidines chemical synthesis, Quinolines chemical synthesis, Quinolines pharmacology
- Abstract
Two series of 4-aminopyrimido[4,5-b]quinoline derivatives substituted in the 2-position 6a-c and/or in 1-position 9a-e have been prepared by facile routes starting from 2-amino-3-cyanoquinoline 2,2-chloro-3-cyanoquinoline 4 and 2-arylamino-3-cyanoquinolines 8a-d. The reactions involved simple fusion with thiourea or urea and, in some cases, with guanidine. The prepared compounds were in vitro tested for antimicrobial activities against some selected Gram-positive, Gram-negative bacteria and fungi. The products containing the thio-function were the most active followed by those containing the imino-function while the carbonyl containing derivatives were without significant antimicrobial effect.
- Published
- 2002