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Your search keyword '"eIF2α(PO)"' showing total 3 results
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3 results on '"eIF2α(PO)"'

1. Expression of a novel versican variant in dorsal root ganglia from spared nerve injury rats

Author

Bogen, Oliver, Bender, Olaf, Alvarez, Pedro, Kern, Marie, Tomiuk, Stefan, Hucho, Ferdinand, and Levine, Jon D

Subjects
Peripheral Neuropathy, Genetics, Neurodegenerative, Neurosciences, Animals, Codon, Terminator, Exons, Ganglia, Spinal, Male, Neuralgia, RNA Stability, RNA, Messenger, Rats, Rats, Sprague-Dawley, Versicans, Versican, nerve injury, neuropathic pain, nonsense mediated RNA decay, eIF2 alpha(PO4)(2-), Isolectin B4, eIF2α(PO), Biochemistry and Cell Biology, Neurology & Neurosurgery
Abstract

The size and modular structure of versican and its gene suggest the existence of multiple splice variants. We have identified, cloned, and sequenced a previously unknown exon located within the noncoding gene sequence downstream of exon 8. This exon, which we have named exon 8β, specifies two stop-codons. mRNAs of the versican gene with exon 8β are predicted to be constitutively degraded by nonsense-mediated RNA decay. Here, we tested the hypothesis that these transcripts become expressed in a model of neuropathic pain.

Published
2019

2. Expression of a novel versican variant in dorsal root ganglia from spared nerve injury rats

Author

Stefan Tomiuk, Oliver Bogen, Pedro Alvarez, Ferdinand Hucho, Jon D. Levine, Marie Kern, and Olaf Bender

Subjects
Male, 0301 basic medicine, RNA Stability, Messenger, eIF2α(PO4)2, Neurodegenerative, Rats, Sprague-Dawley, Exon, Versicans, 0302 clinical medicine, Ganglia, Spinal, Isolectin B4, Exons, Cell biology, Codon, Terminator, Molecular Medicine, Versican, medicine.symptom, Research Article, Dorsum, Spinal, Biology, 03 medical and health sciences, Cellular and Molecular Neuroscience, Genetics, medicine, Animals, splice, Terminator, RNA, Messenger, Codon, Peripheral Neuropathy, Gene, neuropathic pain, Neurology & Neurosurgery, Modular structure, Neurosciences, nonsense mediated RNA decay, eIF2 alpha(PO4)(2-), Nerve injury, Rats, carbohydrates (lipids), 030104 developmental biology, Anesthesiology and Pain Medicine, biology.protein, RNA, Neuralgia, Ganglia, Sprague-Dawley, Biochemistry and Cell Biology, nerve injury, Isolectin b4, eIF2α(PO), 030217 neurology & neurosurgery
Abstract

The size and modular structure of versican and its gene suggest the existence of multiple splice variants. We have identified, cloned, and sequenced a previously unknown exon located within the noncoding gene sequence downstream of exon 8. This exon, which we have named exon 8β, specifies two stop-codons. mRNAs of the versican gene with exon 8β are predicted to be constitutively degraded by nonsense-mediated RNA decay. Here, we tested the hypothesis that these transcripts become expressed in a model of neuropathic pain.

Published
2019
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3. Expression of a novel versican variant in dorsal root ganglia from spared nerve injury rats.

Author

Bogen O, Bender O, Alvarez P, Kern M, Tomiuk S, Hucho F, and Levine JD

Subjects
Animals, Codon, Terminator genetics, Exons genetics, Exons physiology, Male, Neuralgia genetics, RNA Stability genetics, RNA Stability physiology, RNA, Messenger genetics, RNA, Messenger metabolism, Rats, Rats, Sprague-Dawley, Versicans genetics, Codon, Terminator metabolism, Ganglia, Spinal metabolism, Neuralgia metabolism, Versicans metabolism
Published
2019
Full Text
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