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5 results on '"duration of bleeding"'

1. The Duration of Menstrual Blood Loss: Historical to Current Understanding

Author

Marwan Habiba and Giuseppe Benagiano

Subjects
menstruation, menstrual bleeding, duration of bleeding, menstrual phase, endometrium, Reproduction, QH471-489
Abstract

Most published research focuses on the amount of menstrual blood loss and, to a lesser extent, on cyclicity. Little attention has been paid to the duration of bleeding, the factors that enable its cessation within a ‘normal’ timeframe, or to patterns that entail interruption and resumption of blood loss. The definition of what constitutes normal remains arbitrary and there is no therapy specifically designed to shorten the duration of bleeding. Here, we critically review the literature that addresses the duration of bleeding and the factors that trigger endometrial breakdown and repair. Available reports used population averages which mask inter- and intra-individual variations. The duration of bleeding is not necessarily linked to the amount of loss but may be influenced by age, ethnicity, habitus, region and altitude of residence, dieting and stress. The onset of bleeding has been linked to declining steroid production by the corpus luteum. There remains considerable controversy around the extent of endometrial shedding at menstruation. This is likely to vary within and between women. The significance of a change from previous patterns, very short or prolonged bleeding, days of light loss or spotting before or after days of bleeding, or of bleed-free days that punctuate flow, remain poorly understood.

Published
2023
Full Text
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2. The Duration of Menstrual Blood Loss: Historical to Current Understanding.

Author

Habiba, Marwan and Benagiano, Giuseppe

Subjects
AGE distribution, RACE, POPULATION geography, DIET, MENORRHAGIA, DISEASE duration, BLOOD loss estimation, RESIDENTIAL patterns, WOMEN'S health, ENDOMETRIUM, PSYCHOLOGICAL stress
Abstract

Most published research focuses on the amount of menstrual blood loss and, to a lesser extent, on cyclicity. Little attention has been paid to the duration of bleeding, the factors that enable its cessation within a 'normal' timeframe, or to patterns that entail interruption and resumption of blood loss. The definition of what constitutes normal remains arbitrary and there is no therapy specifically designed to shorten the duration of bleeding. Here, we critically review the literature that addresses the duration of bleeding and the factors that trigger endometrial breakdown and repair. Available reports used population averages which mask inter- and intra-individual variations. The duration of bleeding is not necessarily linked to the amount of loss but may be influenced by age, ethnicity, habitus, region and altitude of residence, dieting and stress. The onset of bleeding has been linked to declining steroid production by the corpus luteum. There remains considerable controversy around the extent of endometrial shedding at menstruation. This is likely to vary within and between women. The significance of a change from previous patterns, very short or prolonged bleeding, days of light loss or spotting before or after days of bleeding, or of bleed-free days that punctuate flow, remain poorly understood. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
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3. Use of tranexamic acid for controlling bleeding in thoracolumbar scoliosis surgery with posterior instrumentation

Author

Nayara Lopes Gomes, Luis Eduardo Carelli Teixeira da Silva, Vinícius Magno da Rocha, Luis Cláudio Schettino, Julie Calixto Lobo, Alderico Girão Campos de Barros, and Cleiton Dias Naves

Subjects
Gynecology, medicine.medical_specialty, Tranexamic acid, Escoliose, Transfusão de sangue, business.industry, Ácido tranexâmico, Blood transfusion, Scoliosis surgery, Escoliose/cirurgia, Tempo de sangramento, medicine, Orthopedics and Sports Medicine, Surgery, Scoliosis/surgery, Duration of bleeding, business
Abstract

OBJECTIVE: Scoliosis surgery involves major blood loss and frequently requires blood transfusion. The cost and risks involved in using allogeneic blood have motivated investigation of methods capable of reducing patients' bleeding during operations. One of these methods is to use antifibrinolytic drugs, and tranexamic acid is among these. The aim of this study was to assess the use of this drug for controlling bleeding in surgery to treat idiopathic scoliosis.METHODS: This was a retrospective study in which the medical files of 40 patients who underwent thoracolumbar arthrodesis by means of a posterior route were analyzed. Of these cases, 21 used tranexamic acid and were placed in the test group. The others were placed in the control group. The mean volumes of bleeding during and after the operation and the need for blood transfusion were compared between the two groups.RESULTS: The group that used tranexamic acid had significantly less bleeding during the operation than the control group. There was no significant difference between the groups regarding postoperative bleeding and the need for blood transfusion.CONCLUSIONS: Tranexamic acid was effective in reducing bleeding during the operation, as demonstrated in other studies. The correlation between its use and the reduction in the need for blood transfusion is multifactorial and could not be established in this study. We believe that tranexamic acid may be a useful resource and that it deserves greater attention in randomized double-blind prospective series, with proper control over variables that directly influence blood loss. OBJETIVO: A cirurgia de escoliose envolve elevada perda sanguínea e necessita frequentemente de hemotransfusão. O custo e os riscos envolvidos no uso do sangue alogênico têm motivado pesquisas de métodos capazes de reduzir o sangramento operatório nos pacientes. Um desses métodos é o uso de drogas antifibrinolíticas, entre as quais está o ácido tranexâmico (ATX). O objetivo deste estudo foi verificar o uso dessa droga no controle do sangramento em cirurgias de escoliose idiopática.MÉTODOS: Estudo retrospectivo no qual foram analisados os prontuários de 40 pacientes submetidos à artrodese toracolombar por via posterior. Desses, apenas 21 usaram o ATX e foram relacionados no grupo teste. Os demais foram relacionados no grupo controle. Foram comparadas as médias de sangramento per e pós-operatório e a necessidade de hemotransfusão entre os dois grupos.RESULTADOS: O grupo que usou o ATX teve sangramento peroperatório significativamente menor do que o grupo controle. Não houve diferença significativa entre os grupos para o sangramento pós-operatório e a necessidade de hemotransfusão.CONCLUSÕES: O ATX foi eficaz na redução do sangramento peroperatório, conforme demostrado em outros estudos. A correlação entre o seu uso e a redução da necessidade de hemotransfusão é multifatorial e não pôde ser estabelecida neste trabalho. Acreditamos que o ácido tranexâmico possa ser um recurso útil e merece maior atenção em séries prospectivas, duplo-cegas, randomizadas, com o devido controle das variáveis que interferem diretamente na perda sanguínea.

Published
2015

4. Use of tranexamic acid for controlling bleeding in thoracolumbar scoliosis surgery with posterior instrumentation

Author

Cleiton Dias Naves, Nayara Lopes Gomes, Alderico Girão Campos de Barros, Vinícius Magno da Rocha, Julie Calixto Lobo, Luis Eduardo Carelli Teixeira da Silva, and Luis Cláudio Schettino

Subjects
medicine.medical_specialty, Tranexamic acid, Blood transfusion, Antifibrinolytic, medicine.drug_class, medicine.medical_treatment, Arthrodesis, lcsh:Medicine, lcsh:Orthopedic surgery, Tempo de sangramento, medicine, Scoliosis/surgery, Duration of bleeding, Escoliose, Transfusão de sangue, business.industry, Ácido tranexâmico, Thoracolumbar scoliosis, lcsh:R, Retrospective cohort study, General Medicine, Scoliosis surgery, Surgery, Escoliose/cirurgia, lcsh:RD701-811, Anesthesia, Posterior instrumentation, Original Article, business, medicine.drug
Abstract

Scoliosis surgery involves major blood loss and frequently requires blood transfusion. The cost and risks involved in using allogeneic blood have motivated investigation of methods capable of reducing patients' bleeding during operations. One of these methods is to use antifibrinolytic drugs, and tranexamic acid is among these. The aim of this study was to assess the use of this drug for controlling bleeding in surgery to treat idiopathic scoliosis.This was a retrospective study in which the medical files of 40 patients who underwent thoracolumbar arthrodesis by means of a posterior route were analyzed. Of these cases, 21 used tranexamic acid and were placed in the test group. The others were placed in the control group. The mean volumes of bleeding during and after the operation and the need for blood transfusion were compared between the two groups.The group that used tranexamic acid had significantly less bleeding during the operation than the control group. There was no significant difference between the groups regarding postoperative bleeding and the need for blood transfusion.Tranexamic acid was effective in reducing bleeding during the operation, as demonstrated in other studies. The correlation between its use and the reduction in the need for blood transfusion is multifactorial and could not be established in this study. We believe that tranexamic acid may be a useful resource and that it deserves greater attention in randomized double-blind prospective series, with proper control over variables that directly influence blood loss.A cirurgia de escoliose envolve elevada perda sanguínea e necessita frequentemente de hemotransfusão. O custo e os riscos envolvidos no uso do sangue alogênico têm motivado pesquisas de métodos capazes de reduzir o sangramento operatório nos pacientes. Um desses métodos é o uso de drogas antifibrinolíticas, entre as quais está o ácido tranexâmico (ATX). O objetivo deste estudo foi verificar o uso dessa droga no controle do sangramento em cirurgias de escoliose idiopática.Estudo retrospectivo no qual foram analisados os prontuários de 40 pacientes submetidos à artrodese toracolombar por via posterior. Desses, apenas 21 usaram o ATX e foram relacionados no grupo teste. Os demais foram relacionados no grupo controle. Foram comparadas as médias de sangramento per e pós-operatório e a necessidade de hemotransfusão entre os dois grupos.O grupo que usou o ATX teve sangramento peroperatório significativamente menor do que o grupo controle. Não houve diferença significativa entre os grupos para o sangramento pós-operatório e a necessidade de hemotransfusão.O ATX foi eficaz na redução do sangramento peroperatório, conforme demostrado em outros estudos. A correlação entre o seu uso e a redução da necessidade de hemotransfusão é multifatorial e não pôde ser estabelecida neste trabalho. Acreditamos que o ácido tranexâmico possa ser um recurso útil e merece maior atenção em séries prospectivas, duplo-cegas, randomizadas, com o devido controle das variáveis que interferem diretamente na perda sanguínea.

Published
2015

5. Use of tranexamic acid for controlling bleeding in thoracolumbar scoliosis surgery with posterior instrumentation.

Author

da Rocha VM, de Barros AG, Naves CD, Gomes NL, Lobo JC, Villela Schettino LC, and da Silva LE

Abstract

Objective: Scoliosis surgery involves major blood loss and frequently requires blood transfusion. The cost and risks involved in using allogeneic blood have motivated investigation of methods capable of reducing patients' bleeding during operations. One of these methods is to use antifibrinolytic drugs, and tranexamic acid is among these. The aim of this study was to assess the use of this drug for controlling bleeding in surgery to treat idiopathic scoliosis., Methods: This was a retrospective study in which the medical files of 40 patients who underwent thoracolumbar arthrodesis by means of a posterior route were analyzed. Of these cases, 21 used tranexamic acid and were placed in the test group. The others were placed in the control group. The mean volumes of bleeding during and after the operation and the need for blood transfusion were compared between the two groups., Results: The group that used tranexamic acid had significantly less bleeding during the operation than the control group. There was no significant difference between the groups regarding postoperative bleeding and the need for blood transfusion., Conclusions: Tranexamic acid was effective in reducing bleeding during the operation, as demonstrated in other studies. The correlation between its use and the reduction in the need for blood transfusion is multifactorial and could not be established in this study. We believe that tranexamic acid may be a useful resource and that it deserves greater attention in randomized double-blind prospective series, with proper control over variables that directly influence blood loss.

Published
2015
Full Text
View/download PDF

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