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1. Genomic epidemiology of early SARS-CoV-2 transmission dynamics in Bangladesh

Author

Carnegie, L., McCrone, J. T., du Plessis, L., Hasan, M., Ali, M.Z., Begum, R., Hassan, M.Z., Islam, S., Rahman, M.H., Uddin, A.S.M., Sarker, M.S., Das, T., Hossain, M., Khan, M., Razu, M.H., Akram, A., Arina, S., Hoque, E., Molla, M.M.A., Nafisaa, T., Angra, P., Rambaut, A., Pullan, S.T., Osman, K.L., Hoque, M.A., Biswas, P., Flora, M.S., Raghwani, J., Fournié, G., Samad, M.A., and Hill, S.C.

Published
2024
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3. Genomic and epidemiological monitoring of yellow fever virus transmission potential

Author

Faria, NR, Kraemer, MUG, Hill, SC, Goes de Jesus, J, Aguiar, RS, Iani, FCM, Xavier, J, Quick, J, du Plessis, L, Dellicour, S, Thézé, J, Carvalho, RDO, Baele, G, Wu, C-H, Silveira, PP, Arruda, MB, Pereira, MA, Pereira, GC, Lourenço, J, Obolski, U, Abade, L, Vasylyeva, TI, Giovanetti, M, Yi, D, Weiss, DJ, Wint, GRW, Shearer, FM, Funk, S, Nikolay, B, Fonseca, V, Adelino, TER, Oliveira, MAA, Silva, MVF, Sacchetto, L, Figueiredo, PO, Rezende, IM, Mello, EM, Said, RFC, Santos, DA, Ferraz, ML, Brito, MG, Santana, LF, Menezes, MT, Brindeiro, RM, Tanuri, A, Dos Santos, FCP, Cunha, MS, Nogueira, JS, Rocco, IM, da Costa, AC, Komninakis, SCV, Azevedo, V, Chieppe, AO, Araujo, ESM, Mendonça, MCL, Dos Santos, CC, Dos Santos, CD, Mares-Guia, AM, Nogueira, RMR, Sequeira, PC, Abreu, RG, Garcia, MHO, Abreu, AL, Okumoto, O, Kroon, EG, de Albuquerque, CFC, Lewandowski, K, Pullan, ST, Carroll, M, de Oliveira, T, Sabino, EC, Souza, RP, Suchard, MA, Lemey, P, Trindade, GS, Drumond, BP, Filippis, AMB, Loman, NJ, Cauchemez, S, Alcantara, LCJ, and Pybus, OG

Subjects
Prevention, Genetics, Emerging Infectious Diseases, Rare Diseases, Infectious Diseases, Vaccine Related, Biodefense, Aetiology, 2.2 Factors relating to the physical environment, Infection, Aedes, Age Factors, Animals, Brazil, Disease Outbreaks, Epidemiological Monitoring, Evolution, Molecular, Genomics, Humans, Phylogeny, Polymerase Chain Reaction, Risk, Sex Factors, Spatio-Temporal Analysis, Yellow Fever, Yellow fever virus, General Science & Technology
Abstract

The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian Aedes species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.

Published
2018

4. Heavy Vehicle Simulator (HVS) Testing of Innovative Pavement Structures in South Africa

Author

Akhalwaya, I., Smit, M. A., Rust, F. C., Du Plessis, L., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Chabot, Armelle, editor, Hornych, Pierre, editor, Harvey, John, editor, and Loria-Salazar, Luis Guillermo, editor

Published
2020
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5. Towards modelling AR Sco: generalized particle dynamics and strong radiation-reaction regimes.

Author

Du Plessis, L, Venter, C, Harding, A K, Wadiasingh, Z, Kalapotharakos, C, and Els, P

Subjects
*PARTICLE dynamics, *RELATIVISTIC plasmas, *AUTOREGRESSIVE models, *ELECTROMAGNETIC fields, *MAGNETIC particles
Abstract

Numerical simulations of relativistic plasmas have become more feasible, popular, and crucial for various astrophysical sources with the availability of computational resources. The necessity for high-accuracy particle dynamics is especially highlighted in pulsar modelling due to the extreme associated electromagnetic fields and particle Lorentz factors. Including the radiation-reaction force in the particle dynamics adds even more complexity to the problem, but is crucial for such extreme astrophysical sources. We have also realized the need for such modelling concerning magnetic mirroring and particle injection models proposed for AR Sco, the first white dwarf pulsar. This paper demonstrates the benefits of using higher-order explicit numerical integrators with adaptive time-step methods to solve the full particle dynamics with radiation-reaction forces included. We show that for standard test scenarios, namely various combinations of uniform E - and B -fields and a static dipole B -field, the schemes we use are equivalent to and in extreme field cases outperform standard symplectic integrators in accuracy. We show that the higher-order schemes have massive computational time improvements due to the adaptive time-steps we implement, especially in non-uniform field scenarios and included radiation reaction where the particle gyro-radius rapidly changes. When balancing accuracy and computational time, we identified the adaptive Dormand–Prince eighth-order scheme to be ideal for our use cases. The schemes we use maintain accuracy and stability in describing the particle dynamics and we indicate how a charged particle enters radiation-reaction equilibrium and conforms to the analytical Aristotelian Electrodynamics expectations. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Infant and young child feeding practices and behaviours of positive deviants among caregivers of children (6 - 18 months) at risk of stunting in informal settlements in Harrismith, Free State Province, South Africa.

Author

Pilditch, K., du Plessis, L., and Drimie, S.

Subjects
*INFANTS, *FOOD of animal origin, *STUNTED growth, *BREASTFEEDING techniques, *CAREGIVERS, *BREASTFEEDING promotion, *NUTRITIONISTS
Abstract

Background. The positive deviance approach has been used to identify infant and young child feeding (IYCF) practices associated with a reduction in stunting, but this research is limited in South Africa (SA). Objective. To identify strategies among positive deviant (PD) caregivers of non-stunted children aged 6 - 18 months that influence infant and young child feeding (IYCF) practices and raise well-nourished children in two informal settlements in Harrismith. Methods. This study employed a mixed-method design using a PD approach. Demographic questionnaires were administered to 28 purposefully sampled caregiver-child pairs to determine caregiver, child and household characteristics. Socioeconomic scores were obtained from these interviews and used to select six PD and six non-positive deviant (NPD) caregivers for semi-structured qualitative interviews between March and June 2019. Results. Nutritional PD behaviours included consuming 'flesh foods' (meat) more often and practising responsive feeding and family eating. Non-nutritional PD behaviours included coping strategies involving health-seeking behaviour, financial strategy and social capital of caregivers. All caregivers displayed poor breastfeeding practices and an early introduction of solid foods. Primary healthcare nurses were reported to frequently provide breastfeeding advice from outdated prevention of mother-to-child transmission policy. Conclusions. Poor IYCF practices highlight the need for continued advocacy and promotion of IYCF in SA. Nutritional PD behaviours are key to health promotional messages relayed within the local community where the research was conducted. The presence of nutritional and non-nutritional PD behaviours highlights the need for a multi-sectoral response to addressing stunting and improving IYCF practices. [ABSTRACT FROM AUTHOR]

Published
2024
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12. The Importance of Strategic Management Resources for Successful Technical and Vocational Education and Training Governance in Lesotho.

Author

Khoabane, M. P. and du Plessis, L. M.

Subjects
VOCATIONAL education, STRATEGIC planning, HUMAN capital, PRAGMATISM, CORPORATE governance
Abstract

This article discusses strategic management resources for implementing a successful Technical and Vocational Education and Training (TVET) strategy in Lesotho. The Ministry of Education and Training (MOET) and TVET institutions use strategic management to achieve their strategic goals, but strategic resources are scarce. This hinders the expected development of human capital. Due to skills mismatches, TVET graduates leave institutions with irrelevant skills, causing unemployment, poverty and social inequality. TVET institutions lack strategic resources to implement TVET strategies. Pragmatism and a mixed-methods approach guided data collection, data analysis, and interpretation of the results of this study. MOET staff were interviewed to determine strategic management resources. TVET staff completed a questionnaire to assess access to the strategic resources needed to implement the strategy successfully. This study found that Lesotho's government and MOET do not comprehend TVET's strategic resources and do not support TVET institutions adequately. The study recommends revising public sector policies, stakeholders' collaboration, improvement of the robustness of TVET funding, enhanced leadership, and TVET corporate governance to support the successful implementation of the public sector TVET strategy. [ABSTRACT FROM AUTHOR]

Published
2023

13. Establishment and cryptic transmission of Zika virus in Brazil and the Americas

Author

Faria, N. R., Quick, J., Claro, I.M., Thézé, J., de Jesus, J. G., Giovanetti, M., Kraemer, M. U. G., Hill, S. C., Black, A., da Costa, A. C., Franco, L. C., Silva, S. P., Wu, C.-H., Raghwani, J., Cauchemez, S., du Plessis, L., Verotti, M. P., de Oliveira, W. K., Carmo, E. H., Coelho, G. E., Santelli, A. C. F. S., Vinhal, L. C., Henriques, C. M., Simpson, J. T., Loose, M., Andersen, K. G., Grubaugh, N. D., Somasekar, S., Chiu, C. Y., Muñoz-Medina, J. E., Gonzalez-Bonilla, C. R., Arias, C. F., Lewis-Ximenez, L. L., Baylis, S. A., Chieppe, A. O., Aguiar, S. F., Fernandes, C. A., Lemos, P. S., Nascimento, B. L. S., Monteiro, H. A. O., Siqueira, I. C., de Queiroz, M. G., de Souza, T. R., Bezerra, J. F., Lemos, M. R., Pereira, G. F., Loudal, D., Moura, L. C., Dhalia, R., França, R. F., Magalhães, T., Marques, Jr, E. T., Jaenisch, T., Wallau, G. L., de Lima, M. C., Nascimento, V., de Cerqueira, E. M., de Lima, M. M., Mascarenhas, D. L., Neto, J. P. Moura, Levin, A. S., Tozetto-Mendoza, T. R., Fonseca, S. N., Mendes-Correa, M. C., Milagres, F. P., Segurado, A., Holmes, E. C., Rambaut, A., Bedford, T., Nunes, M. R. T., Sabino, E. C., Alcantara, L. C. J., Loman, N. J., and Pybus, O. G.

Published
2017
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16. SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2

Author

Eales, O, Page, AJ, de Oliveira Martins, L, Wang, H, Bodinier, B, Haw, D, Jonnerby, J, Atchison, C, Robson, SC, Connor, TR, Loman, NJ, Golubchik, T, Nunez, RTM, Bonsall, D, Rambaut, A, Snell, LB, Livett, R, Ludden, C, Corden, S, Nastouli, E, Nebbia, G, Johnston, I, Lythgoe, K, Torok, ME, Goodfellow, IG, Prieto, JA, Saeed, K, Jackson, DK, Houlihan, C, Frampton, D, Hamilton, WL, Witney, AA, Bucca, G, Pope, CF, Moore, C, Thomson, EC, Harrison, EM, Smith, CP, Rogan, F, Beckwith, SM, Murray, A, Singleton, D, Eastick, K, Sheridan, LA, Randell, P, Jackson, LM, Ariani, CV, Gonçalves, S, Fairley, DJ, Loose, MW, Watkins, J, Moses, S, Nicholls, S, Bull, M, Amato, R, Smith, DL, Aanensen, DM, Barrett, JC, Aggarwal, D, Shepherd, JG, Curran, MD, Parmar, S, Parker, MD, Williams, C, Glaysher, S, Underwood, AP, Bashton, M, Pacchiarini, N, Loveson, KF, Byott, M, Carabelli, AM, Templeton, KE, de Silva, TI, Wang, D, Langford, CF, Sillitoe, J, Gunson, RN, Cottrell, S, O’Grady, J, Kwiatkowski, D, Lillie, PJ, Cortes, N, Moore, N, Thomas, C, Burns, PJ, Mahungu, TW, Liggett, S, Beckett, AH, Holden, MTG, Levett, LJ, Osman, H, Hassan-Ibrahim, MO, Simpson, DA, Chand, M, Gupta, RK, Darby, AC, Paterson, S, Pybus, OG, Volz, EM, de Angelis, D, Robertson, DL, Martincorena, I, Aigrain, L, Bassett, AR, Wong, N, Taha, Y, Erkiert, MJ, Chapman, MHS, Dewar, R, McHugh, MP, Mookerjee, S, Aplin, S, Harvey, M, Sass, T, Umpleby, H, Wheeler, H, McKenna, JP, Warne, B, Taylor, JF, Chaudhry, Y, Izuagbe, R, Jahun, AS, Young, GR, McMurray, C, McCann, CM, Nelson, A, Elliott, S, Lowe, H, Price, A, Crown, MR, Rey, S, Roy, S, Temperton, B, Shaaban, S, Hesketh, AR, Laing, KG, Monahan, IM, Heaney, J, Pelosi, E, Silviera, S, Wilson-Davies, E, Fryer, H, Adams, H, du Plessis, L, Johnson, R, Harvey, WT, Hughes, J, Orton, RJ, Spurgin, LG, Bourgeois, Y, Ruis, C, O’Toole, Á, Gourtovaia, M, Sanderson, T, Fraser, C, Edgeworth, J, Breuer, J, Michell, SL, Todd, JA, John, M, Buck, D, Gajee, K, Kay, GL, Peacock, SJ, Heyburn, D, Kitchman, K, McNally, A, Pritchard, DT, Dervisevic, S, Muir, P, Robinson, E, Vipond, BB, Ramadan, NA, Jeanes, C, Weldon, D, Catalan, J, Jones, N, da Silva Filipe, A, Fuchs, M, Miskelly, J, Jeffries, AR, Oliver, K, Park, NR, Ash, A, Koshy, C, Barrow, M, Buchan, SL, Mantzouratou, A, Clark, G, Holmes, CW, Campbell, S, Davis, T, Tan, NK, Brown, JR, Harris, KA, Kidd, SP, Grant, PR, Xu-McCrae, L, Cox, A, Madona, P, Pond, M, Randell, PA, Withell, KT, Graham, C, Denton-Smith, R, Swindells, E, Turnbull, R, Sloan, TJ, Bosworth, A, Hutchings, S, Pymont, HM, Casey, A, Ratcliffe, L, Jones, CR, Knight, BA, Haque, T, Hart, J, Irish-Tavares, D, Witele, E, Mower, C, Watson, LK, Collins, J, Eltringham, G, Crudgington, D, Macklin, B, Iturriza-Gomara, M, Lucaci, AO, McClure, PC, Carlile, M, Holmes, N, Storey, N, Rooke, S, Yebra, G, Craine, N, Perry, M, Alikhan, N - F, Bridgett, S, Cook, KF, Fearn, C, Goudarzi, S, Lyons, RA, Williams, T, Haldenby, ST, Durham, J, Leonard, S, Davies, RM, Batra, R, Blane, B, Spyer, MJ, Smith, P, Yavus, M, Williams, RJ, Mahanama, AIK, Samaraweera, B, Girgis, ST, Hansford, SE, Green, A, Beaver, C, Bellis, KL, Dorman, MJ, Kay, S, Prestwood, L, Rajatileka, S, Quick, J, Poplawski, R, Reynolds, N, Mack, A, Morriss, A, Whalley, T, Patel, B, Georgana, I, Hosmillo, M, Pinckert, ML, Stockton, J, Henderson, JH, Hollis, A, Stanley, W, Yew, WC, Myers, R, Thornton, A, Adams, A, Annett, T, Asad, H, Birchley, A, Coombes, J, Evans, JM, Fina, L, Gatica-Wilcox, B, Gilbert, L, Graham, L, Hey, J, Hilvers, E, Jones, S, Jones, H, Kumziene-Summerhayes, S, McKerr, C, Powell, J, Pugh, G, Taylor, S, Trotter, AJ, Williams, CA, Kermack, LM, Foulkes, BH, Gallis, M, Hornsby, HR, Louka, SF, Pohare, M, Wolverson, P, Zhang, P, MacIntyre-Cockett, G, Trebes, A, Moll, RJ, Ferguson, L, Goldstein, EJ, Maclean, A, Tomb, R, Starinskij, I, Thomson, L, Southgate, J, Kraemer, MUG, Raghwani, J, Zarebski, AE, Boyd, O, Geidelberg, L, Illingworth, CJ, Jackson, C, Pascall, D, Vattipally, S, Freeman, TM, Hsu, SN, Lindsey, BB, James, K, Lewis, K, Tonkin-Hill, G, Tovar-Corona, JM, Cox, MG, Abudahab, K, Menegazzo, M, MEng, BEWT, Yeats, CA, Mukaddas, A, Wright, DW, Colquhoun, R, Hill, V, Jackson, B, McCrone, JT, Medd, N, Scher, E, Keatley, J - P, Curran, T, Morgan, S, Maxwell, P, Smith, K, Eldirdiri, S, Kenyon, A, Holmes, AH, Price, JR, Wyatt, T, Mather, AE, Skvortsov, T, Hartley, JA, Guest, M, Kitchen, C, Merrick, I, Munn, R, Bertolusso, B, Lynch, J, Vernet, G, Kirk, S, Wastnedge, E, Stanley, R, Idle, G, Bradley, DT, Poyner, J, Mori, M, Jones, O, Wright, V, Brooks, E, Churcher, CM, Fragakis, M, Galai, K, Jermy, A, Judges, S, McManus, GM, Smith, KS, Westwick, E, Attwood, SW, Bolt, F, Davies, A, De Lacy, E, Downing, F, Edwards, S, Meadows, L, Jeremiah, S, Smith, N, Foulser, L, Charalampous, T, Patel, A, Berry, L, Boswell, T, Fleming, VM, Howson-Wells, HC, Joseph, A, Khakh, M, Lister, MM, Bird, PW, Fallon, K, Helmer, T, McMurray, CL, Odedra, M, Shaw, J, Tang, JW, Willford, NJ, Blakey, V, Raviprakash, V, Sheriff, N, Williams, L - A, Feltwell, T, Bedford, L, Cargill, JS, Hughes, W, Moore, J, Stonehouse, S, Atkinson, L, Lee, JCD, Shah, D, Alcolea-Medina, A, Ohemeng-Kumi, N, Ramble, J, Sehmi, J, Williams, R, Chatterton, W, Pusok, M, Everson, W, Castigador, A, Macnaughton, E, Bouzidi, KE, Lampejo, T, Sudhanva, M, Breen, C, Sluga, G, Ahmad, SSY, George, RP, Machin, NW, Binns, D, James, V, Blacow, R, Coupland, L, Smith, L, Barton, E, Padgett, D, Scott, G, Cross, A, Mirfenderesky, M, Greenaway, J, Cole, K, Clarke, P, Duckworth, N, Walsh, S, Bicknell, K, Impey, R, Wyllie, S, Hopes, R, Bishop, C, Chalker, V, Harrison, I, Gifford, L, Molnar, Z, Auckland, C, Evans, C, Johnson, K, Partridge, DG, Raza, M, Baker, P, Bonner, S, Essex, S, Murray, LJ, Lawton, AI, Burton-Fanning, S, Payne, BAI, Waugh, S, Gomes, AN, Kimuli, M, Murray, DR, Ashfield, P, Dobie, D, Ashford, F, Best, A, Crawford, L, Cumley, N, Mayhew, M, Megram, O, Mirza, J, Moles-Garcia, E, Percival, B, Driscoll, M, Ensell, L, Lowe, HL, Maftei, L, Mondani, M, Chaloner, NJ, Cogger, BJ, Easton, LJ, Huckson, H, Lewis, J, Lowdon, S, Malone, CS, Munemo, F, Mutingwende, M, Nicodemi, R, Podplomyk, O, Somassa, T, Beggs, A, Richter, A, Cormie, C, Dias, J, Forrest, S, Higginson, EE, Maes, M, Young, J, Davidson, RK, Jackson, KA, Turtle, L, Keeley, AJ, Ball, J, Byaruhanga, T, Chappell, JG, Dey, J, Hill, JD, Park, EJ, Fanaie, A, Hilson, RA, Yaze, G, Lo, S, Afifi, S, Beer, R, Maksimovic, J, McCluggage, K, Spellman, K, Bresner, C, Fuller, W, Marchbank, A, Workman, T, Shelest, E, Debebe, J, Sang, F, Zamudio, ME, Francois, S, Gutierrez, B, Vasylyeva, TI, Flaviani, F, Ragonnet-Cronin, M, Smollett, KL, Broos, A, Mair, D, Nichols, J, Nomikou, K, Tong, L, Tsatsani, I, O’Brien, PS, Rushton, S, Sanderson, R, Perkins, J, Cotton, S, Gallagher, A, Allara, E, Pearson, C, Bibby, D, Dabrera, G, Ellaby, N, Gallagher, E, Hubb, J, Lackenby, A, Lee, D, Manesis, N, Mbisa, T, Platt, S, Twohig, KA, Morgan, M, Aydin, A, Baker, DJ, Foster-Nyarko, E, Prosolek, SJ, Rudder, S, Baxter, C, Carvalho, SF, Lavin, D, Mariappan, A, Radulescu, C, Singh, A, Tang, M, Morcrette, H, Bayzid, N, Cotic, M, Balcazar, CE, Gallagher, MD, Maloney, D, Stanton, TD, Williamson, KA, Manley, R, Michelsen, ML, Sambles, CM, Studholme, DJ, Warwick-Dugdale, J, Eccles, R, Gemmell, M, Gregory, R, Hughes, M, Nelson, C, Rainbow, L, Vamos, EE, Webster, HJ, Whitehead, M, Wierzbicki, C, Angyal, A, Green, LR, Whiteley, M, Betteridge, E, Bronner, IF, Farr, BW, Goodwin, S, Lensing, SV, McCarthy, SA, Quail, MA, Rajan, D, Redshaw, NM, Scott, C, Shirley, L, Thurston, SAJ, Rowe, W, Gaskin, A, Le-Viet, T, Bonfield, J, Liddle, J, Whitwham, A, Ashby, D, Barclay, W, Taylor, G, Cooke, G, Ward, H, Darzi, A, Riley, S, Chadeau-Hyam, M, Donnelly, CA, Elliott, P, The COVID-19 Genomics UK (COG-UK) Consortium, Department of Health, Imperial College Healthcare NHS Trust- BRC Funding, Medical Research Council (MRC), Cancer Research UK, Commission of the European Communities, Wellcome Trust, National Institute for Health Research, and Imperial College Healthcare NHS Trust: Research Capability Funding (RCF)

Subjects
Delta variant, Science & Technology, SARS-CoV-2, COVID-19, 1103 Clinical Sciences, C500, Microbiology, Genetic diversity, B900, Infectious Diseases, England, COVID-19 Genomics UK (COG-UK) Consortium, 1108 Medical Microbiology, Mutation, Humans, Transmission advantage, Life Sciences & Biomedicine, Phylogeny, 0605 Microbiology
Abstract

Background Since the emergence of SARS-CoV-2, evolutionary pressure has driven large increases in the transmissibility of the virus. However, with increasing levels of immunity through vaccination and natural infection the evolutionary pressure will switch towards immune escape. Genomic surveillance in regions of high immunity is crucial in detecting emerging variants that can more successfully navigate the immune landscape. Methods We present phylogenetic relationships and lineage dynamics within England (a country with high levels of immunity), as inferred from a random community sample of individuals who provided a self-administered throat and nose swab for rt-PCR testing as part of the REal-time Assessment of Community Transmission-1 (REACT-1) study. During round 14 (9 September–27 September 2021) and 15 (19 October–5 November 2021) lineages were determined for 1322 positive individuals, with 27.1% of those which reported their symptom status reporting no symptoms in the previous month. Results We identified 44 unique lineages, all of which were Delta or Delta sub-lineages, and found a reduction in their mutation rate over the study period. The proportion of the Delta sub-lineage AY.4.2 was increasing, with a reproduction number 15% (95% CI 8–23%) greater than the most prevalent lineage, AY.4. Further, AY.4.2 was less associated with the most predictive COVID-19 symptoms (p = 0.029) and had a reduced mutation rate (p = 0.050). Both AY.4.2 and AY.4 were found to be geographically clustered in September but this was no longer the case by late October/early November, with only the lineage AY.6 exhibiting clustering towards the South of England. Conclusions As SARS-CoV-2 moves towards endemicity and new variants emerge, genomic data obtained from random community samples can augment routine surveillance data without the potential biases introduced due to higher sampling rates of symptomatic individuals.

Published
2022

19. SARS-CoV-2 evolution during treatment of chronic infection

Author

Kemp, S. A., Collier, D. A., Datir, R. P., Ferreira, I. A. T. M., Gayed, S., Jahun, A., Hosmillo, M., Rees-Spear, C., Mlcochova, P., Lumb, I. U., Roberts, D. J., Chandra, A., Temperton, N., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Gleadall, N., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., De Bie, E. M. D. D., Bunclark, K., Josipovic, M., Mackay, M., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Michael, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Robson, S. C., Loman, N. J., Connor, T. R., Golubchik, T., Martinez Nunez, R. T., Ludden, C., Corden, S., Johnston, I., Bonsall, D., Smith, C. P., Awan, A. R., Bucca, G., Estee Torok, M., Saeed, K., Prieto, J. A., Jackson, D. K., Hamilton, W. L., Snell, L. B., Moore, C., Harrison, E. M., Goncalves, S., Fairley, D. J., Loose, M. W., Watkins, J., Livett, R., Moses, S., Amato, R., Nicholls, S., Bull, M., Smith, D. L., Barrett, J., Aanensen, D. M., Curran, M. D., Parmar, S., Aggarwal, D., Shepherd, J. G., Parker, M. D., Glaysher, S., Bashton, M., Underwood, A. P., Pacchiarini, N., Loveson, K. F., Carabelli, A. M., Templeton, K. E., Langford, C. F., Sillitoe, J., de Silva, T. I., Wang, D., Kwiatkowski, D., Rambaut, A., O'Grady, J., Cottrell, S., Holden, M. T. G., Thomson, E. C., Osman, H., Andersson, M., Chauhan, A. J., Hassan-Ibrahim, M. O., Lawniczak, M., Alderton, A., Chand, M., Constantinidou, C., Unnikrishnan, M., Darby, A. C., Hiscox, J. A., Paterson, S., Martincorena, I., Robertson, D. L., Volz, E. M., Page, A. J., Pybus, O. G., Bassett, A. R., Ariani, C. V., Spencer Chapman, M. H., K. K., Li, Shah, R. N., Jesudason, N. G., Taha, Y., Mchugh, M. P., Dewar, R., Jahun, A. S., Mcmurray, C., Pandey, S., Mckenna, J. P., Nelson, A., Young, G. R., Mccann, C. M., Elliott, S., Lowe, H., Temperton, B., Roy, S., Price, A., Rey, S., Wyles, M., Rooke, S., Shaaban, S., de Cesare, M., Letchford, L., Silveira, S., Pelosi, E., Wilson-Davies, E., O'Toole, A., Hesketh, A. R., Stark, R., du Plessis, L., Ruis, C., Adams, H., Bourgeois, Y., Michell, S. L., Gramatopoulos, D., Edgeworth, J., Breuer, J., Todd, J. A., Fraser, C., Buck, D., John, M., Kay, G. 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P., Jeremiah, S., Smith, N., Leek, D., Sridhar, S., Forrest, S., Cormie, C., Gill, H. K., Dias, J., Higginson, E. E., Maes, M., Young, J., Wantoch, M., Jamrozy, D., Lo, S., Patel, M., Hill, V., Bewshea, C. M., Ellard, S., Auckland, C., Harrison, I., Bishop, C., Chalker, V., Richter, A., Beggs, A., Best, A., Percival, B., Mirza, J., Megram, O., Mayhew, M., Crawford, L., Ashcroft, F., Moles-Garcia, E., Cumley, N., Hopes, R., Asamaphan, P., Niebel, M. O., Gunson, R. N., Bradley, A., Maclean, A., Mollett, G., Blacow, R., Bird, P., Helmer, T., Fallon, K., Tang, J., Hale, A. D., Macfarlane-Smith, L. R., Harper, K. L., Carden, H., Machin, N. W., Jackson, K. A., Ahmad, S. S. Y., George, R. P., Turtle, L., O'Toole, E., Watts, J., Breen, C., Cowell, A., Alcolea-Medina, A., Charalampous, T., Patel, A., Levett, L. J., Heaney, J., Rowan, A., Taylor, G. P., Shah, D., Atkinson, L., Lee, J. C. D., Westhorpe, A. P., Jannoo, R., Lowe, H. L., Karamani, A., Ensell, L., Chatterton, W., Pusok, M., Dadrah, A., Symmonds, A., Sluga, G., Molnar, Z., Baker, P., Bonner, S., Essex, S., Barton, E., Padgett, D., Scott, G., Greenaway, J., Payne, B. A. I., Burton-Fanning, S., Waugh, S., Raviprakash, V., Sheriff, N., Blakey, V., Williams, L. -A., Moore, J., Stonehouse, S., Smith, L., Davidson, R. K., Bedford, L., Coupland, L., Wright, V., Chappell, J. G., Tsoleridis, T., Ball, J., Khakh, M., Fleming, V. M., Lister, M. M., Howson-Wells, H. C., Boswell, T., Joseph, A., Willingham, I., Duckworth, N., Walsh, S., Wise, E., Moore, N., Mori, M., Cortes, N., Kidd, S., Williams, R., Gifford, L., Bicknell, K., Wyllie, S., Lloyd, A., Impey, R., Malone, C. S., Cogger, B. J., Levene, N., Monaghan, L., Keeley, A. J., Partridge, D. G., Raza, M., Evans, C., Johnson, K., Abnizova, I., Aigrain, L., Ali, M., Allen, L., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Bassett, A., Battleday, K., Beal, J., Beale, M., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Betteridge, E., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Bonfield, J., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S. K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T. 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J., Jones, M., Kallepally, K., Kay, K., Keatley, J., Keith, A., King, A., Kitchin, L., Kleanthous, M., Klimekova, M., Korlevic, P., Krasheninnkova, K., Lane, G., Langford, C., Laverack, A., Law, K., Lensing, S., Lewis-Wade, A., Liddle, J., Lin, Q., Lindsay, S., Linsdell, S., Long, R., Lovell, J., Mack, J., Maddison, M., Makunin, A., Mamun, I., Mansfield, J., Marriott, N., Martin, M., Mayho, M., Mccarthy, S., Mcclintock, J., Mchugh, S., Mcminn, L., Meadows, C., Mobley, E., Moll, R., Morra, M., Morrow, L., Murie, K., Nash, S., Nathwani, C., Naydenova, P., Neaverson, A., Nerou, E., Nicholson, J., Nimz, T., Noell, G. G., O'Meara, S., Ohan, V., Olney, C., Ormond, D., Oszlanczi, A., Pang, Y. F., Pardubska, B., Park, N., Parmar, A., Patel, G., Payne, M., Peacock, S., Petersen, A., Plowman, D., Preston, T., Puethe, C., Quail, M., Rajan, D., Rance, R., Rawlings, S., Redshaw, N., Reynolds, J., Reynolds, M., Rice, S., Richardson, M., Roberts, C., Robinson, K., Robinson, M., Robinson, D., Rogers, H., Rojo, E. M., Roopra, D., Rose, M., Rudd, L., Sadri, R., Salmon, N., Saul, D., Schwach, F., Scott, C., Seekings, P., Shirley, L., Simms, A., Sinnott, M., Sivadasan, S., Siwek, B., Sizer, D., Skeldon, K., Skelton, J., Slater-Tunstill, J., Sloper, L., Smerdon, N., Smith, C., Smith, J., Smith, K., Smith, M., Smith, S., Smith, T., Sneade, L., Soria, C. D., Sousa, C., Souster, E., Sparkes, A., Spencer-Chapman, M., Squares, J., Steed, C., Stickland, T., Still, I., Stratton, M., Strickland, M., Swann, A., Swiatkowska, A., Sycamore, N., Swift, E., Symons, E., Szluha, S., Taluy, E., Tao, N., Taylor, K., Thompson, S., Thompson, M., Thomson, M., Thomson, N., Thurston, S., Toombs, D., Topping, B., Tovar-Corona, J., Ungureanu, D., Uphill, J., Urbanova, J., Jansen Van, P., Vancollie, V., Voak, P., Walker, D., Walker, M., Waller, M., Ward, G., Weatherhogg, C., Webb, N., Wells, A., Wells, E., Westwood, L., Whipp, T., Whiteley, T., Whitton, G., Whitwham, A., Widaa, S., Williams, M., Wilson, M., Wright, S., Farr, B. W., Quail, M. A., Thurston, S. A. J., Bronner, I. F., Redshaw, N. M., Lensing, S. V., Balcazar, C. E., Gallagher, M. D., Williamson, K. A., Stanton, T. D., Michelsen, M. L., Warwick-Dugdale, J., Manley, R., Farbos, A., Harrison, J. W., Sambles, C. M., Studholme, D. 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K., Medical Microbiology and Infection Prevention, AII - Infectious diseases, Collier, Dami A [0000-0001-5446-4423], Jahun, Aminu [0000-0002-4585-1701], Temperton, Nigel [0000-0002-7978-3815], Modis, Yorgo [0000-0002-6084-0429], Briggs, John AG [0000-0003-3990-6910], Goldstein, Richard A [0000-0001-5148-4672], Skittrall, Jordan P [0000-0002-8228-3758], Gkrania-Klotsas, Effrossyni [0000-0002-0930-8330], McCoy, Laura E [0000-0001-9503-7946], Gupta, Ravindra K [0000-0001-9751-1808], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Male, Time Factors, viruses, Passive, Antibodies, Viral, CITIID-NIHR BioResource COVID-19 Collaboration, 2.1 Biological and endogenous factors, Viral, Aetiology, Neutralizing, Lung, Phylogeny, neutralising antibodies, Infectivity, education.field_of_study, Genome, Multidisciplinary, Alanine, biology, High-Throughput Nucleotide Sequencing, Viral Load, Spike Glycoprotein, Virus Shedding, Adenosine Monophosphate, Aged, Antibodies, Neutralizing, COVID-19, Chronic Disease, Genome, Viral, Humans, Immune Evasion, Immune Tolerance, Immunization, Passive, Immunosuppression Therapy, Mutagenesis, Mutant Proteins, Mutation, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Evolution, Molecular, Infectious Diseases, Pneumonia & Influenza, Antibody, Infection, Viral load, Biotechnology, Evolution, General Science & Technology, antibody escape, Convalescent plasma, 030106 microbiology, Population, evasion, Antibodies, Virus, Article, Vaccine Related, resistance, 03 medical and health sciences, Immune system, COVID-19 Genomics UK (COG-UK) Consortium, Biodefense, Genetics, Viral shedding, education, COVID-19 Serotherapy, QR355, Prevention, Wild type, Molecular, Pneumonia, Virology, COVID-19 Drug Treatment, Coronavirus, Emerging Infectious Diseases, Good Health and Well Being, 030104 developmental biology, biology.protein, Immunization, immune suppression, mutation
Abstract

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. Here we show that chronic infection with SARS-CoV-2 leads to viral evolution and reduced sensitivity to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma, by generating whole-genome ultra-deep sequences for 23 time points that span 101 days and using in vitro techniques to characterize the mutations revealed by sequencing. There was little change in the overall structure of the viral population after two courses of remdesivir during the first 57 days. However, after convalescent plasma therapy, we observed large, dynamic shifts in the viral population, with the emergence of a dominant viral strain that contained a substitution (D796H) in the S2 subunit and a deletion (ΔH69/ΔV70) in the S1 N-terminal domain of the spike protein. As passively transferred serum antibodies diminished, viruses with the escape genotype were reduced in frequency, before returning during a final, unsuccessful course of convalescent plasma treatment. In vitro, the spike double mutant bearing both ΔH69/ΔV70 and D796H conferred modestly decreased sensitivity to convalescent plasma, while maintaining infectivity levels that were similar to the wild-type virus.The spike substitution mutant D796H appeared to be the main contributor to the decreased susceptibility to neutralizing antibodies, but this mutation resulted in an infectivity defect. The spike deletion mutant ΔH69/ΔV70 had a twofold higher level of infectivity than wild-type SARS-CoV-2, possibly compensating for the reduced infectivity of the D796H mutation. These data reveal strong selection on SARS-CoV-2 during convalescent plasma therapy, which is associated with the emergence of viral variants that show evidence of reduced susceptibility to neutralizing antibodies in immunosuppressed individuals.

Published
2021

20. Crossing the Rubicon in Higher Education

Author

du Plessis, L. and Lodewyckx, E.

Abstract

An invitational teaching ecosystem comprises an environment of 5 Ps: people, places, policies, programmes and processes. Invitational education is promoted amongst students and educators. This article reports on an empirical study conducted at a higher education institution that is offering programmes at multiple sites of delivery to determine the impact of mergers on an invitational ecosystem. Results indicate that access to learning resources that support teaching, as well as other social and personal factors in the learning environment, also inluence the quality of a student's learning. Enthusiasm, motivation and sensitivity of educators are noted by students as necessary to create an invitational ecosystem. Key priority areas on which higher education institutions should focus are highlighted in the indings. A qualitative approach was followed to understand and represent the opinions of the students at the different sites of delivery. This article attempts to represent the views of students on the balance between people, places, policies, programmes and processes within the educational transaction movements. (Contains 4 tables, 3 figures, and 1 note.)

Published
2007

21. Conflicts of interest are harming maternal and child health: time for scientific journals to end relationships with manufacturers of breast-milk substitutes

Author

Pereira-Kotze, C, Jeffery, B, Badham, J, Swart, EC, du Plessis, L, Goga, A, Lake, L, Kroon, M, Saloojee, H, Scott, C, Mercer, R, Waterston, T, Goldhagen, J, Clark, D, Baker, Phillip, Doherty, T, Pereira-Kotze, C, Jeffery, B, Badham, J, Swart, EC, du Plessis, L, Goga, A, Lake, L, Kroon, M, Saloojee, H, Scott, C, Mercer, R, Waterston, T, Goldhagen, J, Clark, D, Baker, Phillip, and Doherty, T

Published
2022

22. A computationally tractable birth-death model that combines phylogenetic and epidemiological data

Author

Hill, AL, Zarebski, AE, du Plessis, L, Parag, KV, Pybus, OG, Hill, AL, Zarebski, AE, du Plessis, L, Parag, KV, and Pybus, OG

Abstract

Inferring the dynamics of pathogen transmission during an outbreak is an important problem in infectious disease epidemiology. In mathematical epidemiology, estimates are often informed by time series of confirmed cases, while in phylodynamics genetic sequences of the pathogen, sampled through time, are the primary data source. Each type of data provides different, and potentially complementary, insight. Recent studies have recognised that combining data sources can improve estimates of the transmission rate and the number of infected individuals. However, inference methods are typically highly specialised and field-specific and are either computationally prohibitive or require intensive simulation, limiting their real-time utility. We present a novel birth-death phylogenetic model and derive a tractable analytic approximation of its likelihood, the computational complexity of which is linear in the size of the dataset. This approach combines epidemiological and phylodynamic data to produce estimates of key parameters of transmission dynamics and the unobserved prevalence. Using simulated data, we show (a) that the approximation agrees well with existing methods, (b) validate the claim of linear complexity and (c) explore robustness to model misspecification. This approximation facilitates inference on large datasets, which is increasingly important as large genomic sequence datasets become commonplace.

Published
2022

24. Nemaline myopathy in a six-month-old Pomeranian dog

Author

Bester, EG, Kitshoff, AM, Botha, WJ, van Wilpe, E, du Plessis, L, and Williams, J

Subjects
Masson trichrome, congenital, Gomori trichrome, histopathology, canine, nemaline myopathy, ultrastructure
Abstract

Nemaline myopathy - a clinically and genetically complex heterogenous group of disorders - is described uncommonly in humans and rarely in animals, and is characterised by progressive muscle weakness. The diagnosis is confirmed by histological and/or ultrastructural identification of subsarcolemmal, thread-like, rod-shaped structures called nemaline rod bodies within more than 40% of skeletal muscle fibres. These rods contain the Z-line protein, α-actinin, that can be effectively stained in skeletal muscles using Gomori or Masson trichrome and negatively stained with periodic acid-Schiff. Similar rod-like bodies have been found in smaller numbers in dogs with endocrine disorders and occasionally in other conditions in humans. This report is of a six-month-old Pomeranian dog which had progressive exercise intolerance over a two-month period associated with severe disuse muscle atrophy of the thoracic limbs, as well as gradual pelvic limb weakness and regurgitation of food. Baseline diagnostics ruled out endocrinopathies and after histological and ultrastructural evaluation of thoracic limb muscles and nerve biopsies confirmed nemaline myopathy. The clinical course, diagnostic test results, ultrastructure of skeletal muscle and peripheral nerve, gross necropsy findings and histopathology using various stains are described and illustrated.

Published
2022

25. Search for TeV emission from the Fermi Bubbles at low Galactic latitudes with H.E.S.S. inner Galaxy survey observations

Author

Moulin, E., Montanari, A., Malyshev, D., Abdalla, H., Aharonian, F., Ait Benkhali, F., Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., Bony Lavergne, M., Breuhaus, M., Brose, R., Brun, F., Bulik, T., Bylund, T., Cangemi, F., Caroff, S., Casanova, S., Catalano, J., Chambery, P., Chand, T., Chen, A., Cotter, G., Curyło, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Devin, J., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dreyer, L., Du Plessis, L., Duffy, C., Egberts, K., Einecke, S., Ernenwein, J. -P, Fegan, S., Feijen, K., Fiasson, A., Fichet Clairfontaine, G., Fontaine, G., Lott, F., Füßling, M., Funk, S., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M. H., Hattingh, S., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horns, D., Huang, Z., Huber, D., Hörbe, M., Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu, Konno, R., Kosack, K., Kostunin, D., Kreter, M., Kukec Mezek, G., Kundu, A., Lamanna, G., Le Stum, S., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P, Leuschner, F., Levy, C., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Majumdar, J., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Martí-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Moore, C., Morris, P., Muller, J., Murach, T., Nakashima, K., Naurois, M., Nayerhoda, A., Ndiyavala, H., Niemiec, J., Priyana Noel, A., O Brien, P., Oberholzer, L., Ohm, S., Olivera-Nieto, L., Ona Wilhelmi, E., Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Pita, S., Poireau, V., Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Reville, B., Rieger, F., Romoli, C., Rowell, G., Rudak, B., Rueda Ricarte, H., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Johannes Schäfer, Schutte, H. M., Schwanke, U., Schüssler, F., Senniappan, M., Seyffert, A. S., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Spackman, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, Ł., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Sun, L., Takahashi, T., Tanaka, T., Tavernier, T., Taylor, A. M., Terrier, R., Thiersen, J. H. E., Thorpe-Morgan, C., Tluczykont, M., Tomankova, L., Tsirou, M., Tsuji, N., Tuffs, R., Uchiyama, Y., Walt, D. J., Eldik, C., Rensburg, C., Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Y. W., Yassin, H., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zmija, A., Zouari, S., and Żywucka, N.

Abstract

The Fermi Bubbles were discovered about a decade ago in the Fermi-LAT data as a double-lobe structure extending up to 55° in Galactic latitudes above and below the Galactic Center. At the moment their origin is still unknown. The H.E.S.S. collaboration is currently performing the first ever survey in TeV gamma rays of the Milky Way inner region: the Inner Galaxy Survey. This survey is intended to achieve the best sensitivity to faint and diffuse emissions in a region of several degrees around the Galactic Centre. It provides an unprecedented sensitivity to dark matter signals, new diffuse emissions, and TeV outflows from the Galactic Centre. Understanding the properties of the Fermi Bubbles at low Galactic latitudes will provide key insights into their origin. We search for TeV emission at the base of the Fermi Bubbles using low-latitude spatial templates. The first results obtained with the 2014-2020 H.E.S.S. observations will be reported.

Published
2022

26. Genomic reconstruction of the SARS-CoV-2 epidemic in England

Author

Vöhringer, HS, Sanderson, T, Sinnott, M, De Maio, N, Nguyen, T, Goater, R, Schwach, F, Harrison, I, Hellewell, J, Ariani, CV, Gonçalves, S, Jackson, DK, Johnston, I, Jung, AW, Saint, C, Sillitoe, J, Suciu, M, Goldman, N, Panovska-Griffiths, J, Abnizova, I, Aigrain, L, Alderton, A, Ali, M, Allen, L, Amato, R, Anderson, R, Ariani, C, Austin-Guest, S, Bala, S, Barrett, J, Bassett, A, Battleday, K, Beal, J, Beale, M, Beaver, C, Bellany, S, Bellerby, T, Bellis, K, Berger, D, Berriman, M, Betteridge, E, Bevan, P, Binley, S, Bishop, J, Blackburn, K, Bonfield, J, Boughton, N, Bowker, S, Brendler-Spaeth, T, Bronner, I, Brooklyn, T, Buddenborg, SK, Bush, R, Caetano, C, Cagan, A, Carter, N, Cartwright, J, Monteiro, TC, Chapman, L, Chillingworth, T-J, Clapham, P, Clark, R, Clarke, A, Clarke, C, Cole, D, Cook, E, Coppola, M, Cornell, L, Cornwell, C, Corton, C, Crackett, A, Cranage, A, Craven, H, Craw, S, Crawford, M, Cutts, T, Dabrowska, M, Davies, M, Davies, R, Dawson, J, Day, C, Densem, A, Dibling, T, Dockree, C, Dodd, D, Dogga, S, Dorman, M, Dougan, G, Dougherty, M, Dove, A, Drummond, L, Drury, E, Dudek, M, Durham, J, Durrant, L, Easthope, E, Eckert, S, Ellis, P, Farr, B, Fenton, M, Ferrero, M, Flack, N, Fordham, H, Forsythe, G, Foulser, L, Francis, M, Fraser, A, Freeman, A, Galvin, A, Garcia-Casado, M, Gedny, A, Girgis, S, Glover, J, Goncalves, S, Goodwin, S, Gould, O, Gourtovaia, M, Gray, A, Gray, E, Griffiths, C, Gu, Y, Guerin, F, Hamilton, W, Hanks, H, Harrison, E, Harrott, A, Harry, E, Harvison, J, Heath, P, Hernandez-Koutoucheva, A, Hobbs, R, Holland, D, Holmes, S, Hornett, G, Hough, N, Huckle, L, Hughes-Hallet, L, Hunter, A, Inglis, S, Iqbal, S, Jackson, A, Jackson, D, James, K, Jamrozy, D, Verdejo, CJ, Jones, M, Kallepally, K, Kane, L, Kay, K, Kay, S, Keatley, J, Keith, A, King, A, Kitchin, L, Kleanthous, M, Klimekova, M, Korlevic, P, Krasheninnkova, K, Lane, G, Langford, C, Laverack, A, Law, K, Lawniczak, M, Lensing, S, Leonard, S, Letchford, L, Lewis, K, Lewis-Wade, A, Liddle, J, Lin, Q, Lindsay, S, Linsdell, S, Livett, R, Lo, S, Long, R, Lovell, J, Ludden, C, Mack, J, Maddison, M, Makunin, A, Mamun, I, Mansfield, J, Marriott, N, Martin, M, Mayho, M, McCarthy, S, McClintock, J, McGuigan, S, McHugh, S, McMinn, L, Meadows, C, Mobley, E, Moll, R, Morra, M, Morrow, L, Murie, K, Nash, S, Nathwani, C, Naydenova, P, Neaverson, A, Nelson, R, Nerou, E, Nicholson, J, Nimz, T, Noell, GG, O’Meara, S, Ohan, V, Oliver, K, Olney, C, Ormond, D, Oszlanczi, A, Palmer, S, Pang, YF, Pardubska, B, Park, N, Parmar, A, Patel, G, Patel, M, Payne, M, Peacock, S, Petersen, A, Plowman, D, Preston, T, Prestwood, L, Puethe, C, Quail, M, Rajan, D, Rajatileka, S, Rance, R, Rawlings, S, Redshaw, N, Reynolds, J, Reynolds, M, Rice, S, Richardson, M, Roberts, C, Robinson, K, Robinson, M, Robinson, D, Rogers, H, Rojo, EM, Roopra, D, Rose, M, Rudd, L, Sadri, R, Salmon, N, Saul, D, Scott, C, Seekings, P, Shirley, L, Simms, A, Sivadasan, S, Siwek, B, Sizer, D, Skeldon, K, Skelton, J, Slater-Tunstill, J, Sloper, L, Smerdon, N, Smith, C, Smith, J, Smith, K, Smith, M, Smith, S, Smith, T, Sneade, L, Soria, CD, Sousa, C, Souster, E, Sparkes, A, Spencer-Chapman, M, Squares, J, Stanley, R, Steed, C, Stickland, T, Still, I, Stratton, MR, Strickland, M, Swann, A, Swiatkowska, A, Sycamore, N, Swift, E, Symons, E, Szluha, S, Taluy, E, Tao, N, Taylor, K, Taylor, S, Thompson, S, Thompson, M, Thomson, M, Thomson, N, Thurston, S, Tonkin-Hill, G, Toombs, D, Topping, B, Tovar-Corona, J, Ungureanu, D, Uphill, J, Urbanova, J, Van Vuuren, PJ, Vancollie, V, Voak, P, Walker, D, Walker, M, Waller, M, Ward, G, Weatherhogg, C, Webb, N, Weldon, D, Wells, A, Wells, E, Westwood, L, Whipp, T, Whiteley, T, Whitton, G, Whitwham, A, Widaa, S, Williams, M, Wilson, M, Wright, S, Robson, SC, Connor, TR, Loman, NJ, Golubchik, T, Martinez Nunez, RT, Bonsall, D, Rambaut, A, Snell, LB, Corden, S, Nastouli, E, Nebbia, G, Lythgoe, K, Torok, ME, Goodfellow, IG, Prieto, JA, Saeed, K, Houlihan, C, Frampton, D, Hamilton, WL, Witney, AA, Bucca, G, Pope, CF, Moore, C, Thomson, EC, Harrison, EM, Smith, CP, Rogan, F, Beckwith, SM, Murray, A, Singleton, D, Eastick, K, Sheridan, LA, Randell, P, Jackson, LM, Fairley, DJ, Loose, MW, Watkins, J, Moses, S, Nicholls, S, Bull, M, Smith, DL, Aanensen, DM, Aggarwal, D, Shepherd, JG, Curran, MD, Parmar, S, Parker, MD, Williams, C, Glaysher, S, Underwood, AP, Bashton, M, Pacchiarini, N, Loveson, KF, Byott, M, Carabelli, AM, Templeton, KE, de Silva, TI, Wang, D, Langford, CF, Gunson, RN, Cottrell, S, O’Grady, J, Kwiatkowski, D, Lillie, PJ, Cortes, N, Moore, N, Thomas, C, Burns, PJ, Mahungu, TW, Liggett, S, Beckett, AH, Holden, MTG, Levett, LJ, Osman, H, Hassan-Ibrahim, MO, Simpson, DA, Chand, M, Gupta, RK, Darby, AC, Paterson, S, Pybus, OG, Volz, EM, de Angelis, D, Robertson, DL, Page, AJ, Bassett, AR, Wong, N, Taha, Y, Erkiert, MJ, Spencer Chapman, MH, Dewar, R, McHugh, MP, Mookerjee, S, Aplin, S, Harvey, M, Sass, T, Umpleby, H, Wheeler, H, McKenna, JP, Warne, B, Taylor, JF, Chaudhry, Y, Izuagbe, R, Jahun, AS, Young, GR, McMurray, C, McCann, CM, Nelson, A, Elliott, S, Lowe, H, Price, A, Crown, MR, Rey, S, Roy, S, Temperton, B, Shaaban, S, Hesketh, AR, Laing, KG, Monahan, IM, Heaney, J, Pelosi, E, Silviera, S, Wilson-Davies, E, Fryer, H, Adams, H, du Plessis, L, Johnson, R, Harvey, WT, Hughes, J, Orton, RJ, Spurgin, LG, Bourgeois, Y, Ruis, C, O’Toole, Á, Fraser, C, Edgeworth, J, Breuer, J, Michell, SL, Todd, JA, John, M, Buck, D, Gajee, K, Kay, GL, Peacock, SJ, Heyburn, D, Kitchman, K, McNally, A, Pritchard, DT, Dervisevic, S, Muir, P, Robinson, E, Vipond, BB, Ramadan, NA, Jeanes, C, Catalan, J, Jones, N, da Silva Filipe, A, Fuchs, M, Miskelly, J, Jeffries, AR, Park, NR, Ash, A, Koshy, C, Barrow, M, Buchan, SL, Mantzouratou, A, Clark, G, Holmes, CW, Campbell, S, Davis, T, Tan, NK, Brown, JR, Harris, KA, Kidd, SP, Grant, PR, Xu-McCrae, L, Cox, A, Madona, P, Pond, M, Randell, PA, Withell, KT, Graham, C, Denton-Smith, R, Swindells, E, Turnbull, R, Sloan, TJ, Bosworth, A, Hutchings, S, Pymont, HM, Casey, A, Ratcliffe, L, Jones, CR, Knight, BA, Haque, T, Hart, J, Irish-Tavares, D, Witele, E, Mower, C, Watson, LK, Collins, J, Eltringham, G, Crudgington, D, Macklin, B, Iturriza-Gomara, M, Lucaci, AO, McClure, PC, Carlile, M, Holmes, N, Storey, N, Rooke, S, Yebra, G, Craine, N, Perry, M, Alikhan, N-F, Bridgett, S, Cook, KF, Fearn, C, Goudarzi, S, Lyons, RA, Williams, T, Haldenby, ST, Davies, RM, Batra, R, Blane, B, Spyer, MJ, Smith, P, Yavus, M, Williams, RJ, Mahanama, AIK, Samaraweera, B, Girgis, ST, Hansford, SE, Green, A, Bellis, KL, Dorman, MJ, Quick, J, Poplawski, R, Reynolds, N, Mack, A, Morriss, A, Whalley, T, Patel, B, Georgana, I, Hosmillo, M, Pinckert, ML, Stockton, J, Henderson, JH, Hollis, A, Stanley, W, Yew, WC, Myers, R, Thornton, A, Adams, A, Annett, T, Asad, H, Birchley, A, Coombes, J, Evans, JM, Fina, L, Gatica-Wilcox, B, Gilbert, L, Graham, L, Hey, J, Hilvers, E, Jones, S, Jones, H, Kumziene-Summerhayes, S, McKerr, C, Powell, J, Pugh, G, Trotter, AJ, Williams, CA, Kermack, LM, Foulkes, BH, Gallis, M, Hornsby, HR, Louka, SF, Pohare, M, Wolverson, P, Zhang, P, MacIntyre-Cockett, G, Trebes, A, Moll, RJ, Ferguson, L, Goldstein, EJ, Maclean, A, Tomb, R, Starinskij, I, Thomson, L, Southgate, J, Kraemer, MUG, Raghwani, J, Zarebski, AE, Boyd, O, Geidelberg, L, Illingworth, CJ, Jackson, C, Pascall, D, Vattipally, S, Freeman, TM, Hsu, SN, Lindsey, BB, Tovar-Corona, JM, Cox, M, Abudahab, K, Menegazzo, M, Taylor, BEW, Yeats, CA, Mukaddas, A, Wright, DW, de Oliveira Martins, L, Colquhoun, R, Hill, V, Jackson, B, McCrone, JT, Medd, N, Scher, E, Keatley, J-P, Curran, T, Morgan, S, Maxwell, P, Eldirdiri, S, Kenyon, A, Holmes, AH, Price, JR, Wyatt, T, Mather, AE, Skvortsov, T, Hartley, JA, Guest, M, Kitchen, C, Merrick, I, Munn, R, Bertolusso, B, Lynch, J, Vernet, G, Kirk, S, Wastnedge, E, Idle, G, Bradley, DT, Poyner, J, Mori, M, Jones, O, Wright, V, Brooks, E, Churcher, CM, Fragakis, M, Galai, K, Jermy, A, Judges, S, McManus, GM, Smith, KS, Westwick, E, Attwood, SW, Bolt, F, Davies, A, De Lacy, E, Downing, F, Edwards, S, Meadows, L, Jeremiah, S, Smith, N, Charalampous, T, Patel, A, Berry, L, Boswell, T, Fleming, VM, Howson-Wells, HC, Joseph, A, Khakh, M, Lister, MM, Bird, PW, Fallon, K, Helmer, T, McMurray, CL, Odedra, M, Shaw, J, Tang, JW, Willford, NJ, Blakey, V, Raviprakash, V, Sheriff, N, Williams, L-A, Feltwell, T, Bedford, L, Cargill, JS, Hughes, W, Moore, J, Stonehouse, S, Atkinson, L, Lee, JCD, Shah, D, Alcolea, A, Ohemeng-Kumi, N, Ramble, J, Sehmi, J, Williams, R, Chatterton, W, Pusok, M, Everson, W, Castigador, A, Macnaughton, E, El Bouzidi, K, Lampejo, T, Sudhanva, M, Breen, C, Sluga, G, Ahmad, SSY, George, RP, Machin, NW, Binns, D, James, V, Blacow, R, Coupland, L, Smith, L, Barton, E, Padgett, D, Scott, G, Cross, A, Mirfenderesky, M, Greenaway, J, Cole, K, Clarke, P, Duckworth, N, Walsh, S, Bicknell, K, Impey, R, Wyllie, S, Hopes, R, Bishop, C, Chalker, V, Gifford, L, Molnar, Z, Auckland, C, Evans, C, Johnson, K, Partridge, DG, Raza, M, Baker, P, Bonner, S, Essex, S, Murray, LJ, Lawton, AI, Burton-Fanning, S, Payne, BAI, Waugh, S, Gomes, AN, Kimuli, M, Murray, DR, Ashfield, P, Dobie, D, Ashford, F, Best, A, Crawford, L, Cumley, N, Mayhew, M, Megram, O, Mirza, J, Moles-Garcia, E, Percival, B, Ensell, L, Lowe, HL, Maftei, L, Mondani, M, Chaloner, NJ, Cogger, BJ, Easton, LJ, Huckson, H, Lewis, J, Lowdon, S, Malone, CS, Munemo, F, Mutingwende, M, Nicodemi, R, Podplomyk, O, Somassa, T, Beggs, A, Richter, A, Cormie, C, Dias, J, Forrest, S, Higginson, EE, Maes, M, Young, J, Davidson, RK, Jackson, KA, Turtle, L, Keeley, AJ, Ball, J, Byaruhanga, T, Chappell, JG, Dey, J, Hill, JD, Park, EJ, Fanaie, A, Hilson, RA, Yaze, G, Afifi, S, Beer, R, Maksimovic, J, Masters, KM, Spellman, K, Bresner, C, Fuller, W, Marchbank, A, Workman, T, Shelest, E, Debebe, J, Sang, F, Zamudio, ME, Francois, S, Gutierrez, B, Vasylyeva, TI, Flaviani, F, Ragonnet-Cronin, M, Smollett, KL, Broos, A, Mair, D, Nichols, J, Nomikou, K, Tong, L, Tsatsani, I, O’Brien, S, Rushton, S, Sanderson, R, Perkins, J, Cotton, S, Gallagher, A, Allara, E, Pearson, C, Bibby, D, Dabrera, G, Ellaby, N, Gallagher, E, Hubb, J, Lackenby, A, Lee, D, Manesis, N, Mbisa, T, Platt, S, Twohig, KA, Morgan, M, Aydin, A, Baker, DJ, Foster-Nyarko, E, Prosolek, SJ, Rudder, S, Baxter, C, Carvalho, SF, Lavin, D, Mariappan, A, Radulescu, C, Singh, A, Tang, M, Morcrette, H, Bayzid, N, Cotic, M, Balcazar, CE, Gallagher, MD, Maloney, D, Stanton, TD, Williamson, KA, Manley, R, Michelsen, ML, Sambles, CM, Studholme, DJ, Warwick-Dugdale, J, Eccles, R, Gemmell, M, Gregory, R, Hughes, M, Nelson, C, Rainbow, L, Vamos, EE, Webster, HJ, Whitehead, M, Wierzbicki, C, Angyal, A, Green, LR, Whiteley, M, Bronner, IF, Farr, BW, Lensing, SV, McCarthy, SA, Quail, MA, Redshaw, NM, Thurston, SAJ, Rowe, W, Gaskin, A, Le-Viet, T, Birney, E, Volz, E, Funk, S, Martincorena, I, Barrett, JC, and Gerstung, M

Abstract

The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021.

Published
2021

28. Searching for TeV Gamma-Ray Emission from SGR 1935+2154 during Its 2020 X-Ray and Radio Bursting Phase

Author

Abdalla, H., Aharonian, F., Ait Benkhali, F., Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., de Bony de Lavergne, M., Breuhaus, M., Brose, R., Brun, F., Brun, P., Bryan, M., Büchele, M., Bulik, T., Bylund, T., Cangemi, F., Caroff, S., Carosi, A., Casanova, S., Chambery, P., Chand, T., Chandra, S., Chen, A., Cotter, G., Curyło, M., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Deil, C., Devin, J., Dirson, L., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dreyer, L., Duffy, C., Du Plessis, L., Dyks, J., Egberts, K., Eichhorn, F., Einecke, S., Emery, G., Ernenwein, J.-P., Feijen, K., Fegan, S., Fiasson, A., Fichet de Clairfontaine, G., Fontaine, G., Funk, S., Füßling, M., Gabici, S., Gallant, Y. A., Ghafourizade, S., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M.-H., Hahn, J., Haupt, M., Hattingh, S., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hörbe, M., Horns, D., Huang, Z., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Jardin-Blicq, A., Joshi, V., Jung-Richardt, I., Kasai, E., Kastendieck, M. A., Katarzyński, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., and Kluźniak, W.

Subjects
ddc:520, ddc:530, 520 Astronomie und zugeordnete Wissenschaften, 530 Physik
Abstract

Magnetar hyperflares are the most plausible explanation for fast radio bursts (FRBs)—enigmatic powerful radio pulses with durations of several milliseconds and high brightness temperatures. The first observational evidence for this scenario was obtained in 2020 April when an FRB was detected from the direction of the Galactic magnetar and soft gamma-ray repeater SGR 1935+2154. The FRB was preceded by two gamma-ray outburst alerts by the BAT instrument aboard the Swift satellite, which triggered follow-up observations by the High Energy Stereoscopic System (H.E.S.S.). H.E.S.S. observed SGR 1935+2154 for 2 hr on 2020 April 28. The observations are coincident with X-ray bursts from the magnetar detected by INTEGRAL and Fermi-GBM, thus providing the first very high energy gamma-ray observations of a magnetar in a flaring state. High-quality data acquired during these follow-up observations allow us to perform a search for short-time transients. No significant signal at energies E > 0.6 TeV is found, and upper limits on the persistent and transient emission are derived. We here present the analysis of these observations and discuss the obtained results and prospects of the H.E.S.S. follow-up program for soft gamma-ray repeaters.

Published
2021

30. Search for enhanced TeV gamma ray emission from Giant Molecular Clouds using H.E.S.S

Author

Abdalla, H., Aharonian, F., Ait Benkhali, F., Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Batzofin, R., Becherini, Y., Berge, D., Bernlöhr, K., Bi, B., Böttcher, M., Boisson, C., Bolmont, J., Bony Lavergne, M., Breuhaus, M., Brose, R., Brun, F., Bulik, T., Bylund, T., Cangemi, F., Caroff, S., Casanova, S., Catalano, J., Chambery, P., Chand, T., Chen, A., Cotter, G., Curyło, M., Dalgleish, H., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Devin, J., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dreyer, L., Du Plessis, L., Duffy, C., Egberts, K., Einecke, S., Ernenwein, J. -P, Fegan, S., Feijen, K., Fiasson, A., Fichet Clairfontaine, G., Fontaine, G., Lott, F., Füßling, M., Funk, S., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M. -H, Hattingh, S., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horns, D., Huang, Z., Huber, D., Hörbe, M., Jamrozy, M., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzyński, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu, Konno, R., Kosack, K., Kostunin, D., Kreter, M., Kukec Mezek, G., Kundu, A., Lamanna, G., Le Stum, S., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P, Leuschner, F., Levy, C., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Martí-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Naurois, M., Nayerhoda, A., Ndiyavala, H., Niemiec, J., Priyana Noel, A., O Brien, P., Oberholzer, L., Ohm, S., Olivera-Nieto, L., Ona Wilhelmi, E., Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Pita, S., Poireau, V., Prokhorov, D. A., Prokoph, H., Pühlhofer, G., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Reville, B., Rieger, F., Romoli, C., Rowell, G., Rudak, B., Rueda Ricarte, H., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Johannes Schäfer, Schutte, H. M., Schwanke, U., Schüssler, F., Senniappan, M., Seyffert, A. S., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Spackman, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, Ł., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Sun, L., Takahashi, T., Tanaka, T., Tavernier, T., Taylor, A. M., Terrier, R., Thiersen, J. H. E., Thorpe-Morgan, C., Tluczykont, M., Tomankova, L., Tsirou, M., Tsuji, N., Tuffs, R., Uchiyama, Y., Walt, D. J., Eldik, C., Rensburg, C., Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Y. W., Yassin, H., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zmija, A., Zouari, S., Żywucka, N., Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), HESS, for the H.E.S.S. collaboration, and H.E.S.S.

Subjects
dimension: 3, accelerator, Astrophysics::High Energy Astrophysical Phenomena, Hadron, FOS: Physical sciences, Neutral pions, Cosmic ray, cosmic radiation: density, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Cherenkov counter: atmosphere, 7. Clean energy, Dense gas, Imaging atmospheric Cherenkov telescopes, Clouds, Cosmology, Gamma rays, Cosmic ray interactions, diffuse emission, Giant molecular clouds, Ray density, TeV gamma-ray emission, VHE, Pion, TRACER, gas, HESS, TeV, cloud, matter: density, Cherenkov radiation, Astrophysics::Galaxy Astrophysics, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Molecular cloud, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, imaging, model: hadronic, Galaxy, background: hadronic, Cherenkov counter, gamma ray: emission, 13. Climate action, cosmic radiation: galaxy, HESS - Abteilung Hinton, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

Cosmic Ray (CR) interactions with the dense gas inside Giant Molecular Clouds (GMCs) produce neutral pions, which in turn decay into gamma rays. Thus, the gamma ray emission from GMCs is a direct tracer of the cosmic ray density and the matter density inside the clouds. Detection of enhanced TeV emission from GMCs, i.e., an emission significantly larger than what is expected from the average Galactic cosmic rays illuminating the cloud, can imply a variation in the local cosmic ray density, due to, for example, the presence of a recent accelerator in proximity to the cloud. Such gamma-ray observations can be crucial in probing the cosmic ray distribution across our Galaxy, but are complicated to perform with present generation Imaging Atmospheric Cherenkov Telescopes (IACTs). These studies require differentiating between the strong cosmic-ray induced background, the large scale diffuse emission, and the emission from the clouds, which is difficult to the small field of view of present generation IACTs. In this contribution, we use H.E.S.S. data collected over 16 years to search for TeV emission from GMCs in the inner molecular galacto-centric ring of our Galaxy. We implement a 3D FoV likelihood technique, and simultaneously model the hadronic background, the galactic diffuse emission and the emission expected from known VHE sources to probe for excess TeV gamma ray emission from GMCs., PoS: Proceedings of Science, 395, ISSN:1824-8039, Proceedings of 37th International Cosmic Ray Conference

Published
2021

31. Searching for TeV Gamma-Ray Emission from SGR 1935+2154 during Its 2020 X-Ray and Radio Bursting Phase

Author

Abdalla, H., primary, Aharonian, F., additional, Ait Benkhali, F., additional, Angüner, E. O., additional, Arcaro, C., additional, Armand, C., additional, Armstrong, T., additional, Ashkar, H., additional, Backes, M., additional, Baghmanyan, V., additional, Barbosa Martins, V., additional, Barnacka, A., additional, Barnard, M., additional, Becherini, Y., additional, Berge, D., additional, Bernlöhr, K., additional, Bi, B., additional, Böttcher, M., additional, Boisson, C., additional, Bolmont, J., additional, de Bony de Lavergne, M., additional, Breuhaus, M., additional, Brose, R., additional, Brun, F., additional, Brun, P., additional, Bryan, M., additional, Büchele, M., additional, Bulik, T., additional, Bylund, T., additional, Cangemi, F., additional, Caroff, S., additional, Carosi, A., additional, Casanova, S., additional, Chambery, P., additional, Chand, T., additional, Chandra, S., additional, Chen, A., additional, Cotter, G., additional, Curyło, M., additional, Damascene Mbarubucyeye, J., additional, Davids, I. D., additional, Davies, J., additional, Deil, C., additional, Devin, J., additional, Dirson, L., additional, Djannati-Ataï, A., additional, Dmytriiev, A., additional, Donath, A., additional, Doroshenko, V., additional, Dreyer, L., additional, Duffy, C., additional, Du Plessis, L., additional, Dyks, J., additional, Egberts, K., additional, Eichhorn, F., additional, Einecke, S., additional, Emery, G., additional, Ernenwein, J.-P., additional, Feijen, K., additional, Fegan, S., additional, Fiasson, A., additional, Fichet de Clairfontaine, G., additional, Fontaine, G., additional, Funk, S., additional, Füßling, M., additional, Gabici, S., additional, Gallant, Y. A., additional, Ghafourizade, S., additional, Giavitto, G., additional, Giunti, L., additional, Glawion, D., additional, Glicenstein, J. F., additional, Grondin, M.-H., additional, Hahn, J., additional, Haupt, M., additional, Hattingh, S., additional, Hermann, G., additional, Hinton, J. A., additional, Hofmann, W., additional, Hoischen, C., additional, Holch, T. L., additional, Holler, M., additional, Hörbe, M., additional, Horns, D., additional, Huang, Z., additional, Huber, D., additional, Jamrozy, M., additional, Jankowsky, D., additional, Jankowsky, F., additional, Jardin-Blicq, A., additional, Joshi, V., additional, Jung-Richardt, I., additional, Kasai, E., additional, Kastendieck, M. A., additional, Katarzyński, K., additional, Katz, U., additional, Khangulyan, D., additional, Khélifi, B., additional, Klepser, S., additional, Kluźniak, W., additional, Komin, Nu., additional, Konno, R., additional, Kosack, K., additional, Kostunin, D., additional, Kreter, M., additional, Kukec Mezek, G., additional, Kundu, A., additional, Lamanna, G., additional, Lemière, A., additional, Lemoine-Goumard, M., additional, Lenain, J.-P., additional, Le Stum, S., additional, Leuschner, F., additional, Levy, C., additional, Lohse, T., additional, Luashvili, A., additional, Lypova, I., additional, Mackey, J., additional, Majumdar, J., additional, Malyshev, D., additional, Marandon, V., additional, Marchegiani, P., additional, Marcowith, A., additional, Mares, A., additional, Martí-Devesa, G., additional, Marx, R., additional, Maurin, G., additional, Meintjes, P. J., additional, Meyer, M., additional, Mitchell, A., additional, Moderski, R., additional, Mohrmann, L., additional, Montanari, A., additional, Moore, C., additional, Morris, P., additional, Moulin, E., additional, Muller, J., additional, Murach, T., additional, Nakashima, K., additional, Nayerhoda, A., additional, de Naurois, M., additional, Ndiyavala, H., additional, Niemiec, J., additional, Oakes, L., additional, O’Brien, P., additional, Odaka, H., additional, Ohm, S., additional, Olivera-Nieto, L., additional, de Ona Wilhelmi, E., additional, Ostrowski, M., additional, Panny, S., additional, Panter, M., additional, Parsons, R. D., additional, Peron, G., additional, Peyaud, B., additional, Piel, Q., additional, Pita, S., additional, Poireau, V., additional, Priyana Noel, A., additional, Prokhorov, D. A., additional, Prokoph, H., additional, Pühlhofer, G., additional, Punch, M., additional, Quirrenbach, A., additional, Raab, S., additional, Rauth, R., additional, Reichherzer, P., additional, Reimer, A., additional, Reimer, O., additional, Remy, Q., additional, Renaud, M., additional, Reville, B., additional, Rieger, F., additional, Rinchiuso, L., additional, Romoli, C., additional, Rowell, G., additional, Rudak, B., additional, Rueda Ricarte, H., additional, Ruiz-Velasco, E., additional, Sahakian, V., additional, Sailer, S., additional, Salzmann, H., additional, Sanchez, D. A., additional, Santangelo, A., additional, Sasaki, M., additional, Schäfer, J., additional, Schüssler, F., additional, Schutte, H. M., additional, Schwanke, U., additional, Seglar-Arroyo, M., additional, Senniappan, M., additional, Seyffert, A. S., additional, Shafi, N., additional, Shapopi, J. N. S., additional, Shiningayamwe, K., additional, Simoni, R., additional, Sinha, A., additional, Sol, H., additional, Spackman, H., additional, Specovius, A., additional, Spencer, S., additional, Spir-Jacob, M., additional, Stawarz, Ł., additional, Sun, L., additional, Steenkamp, R., additional, Stegmann, C., additional, Steinmassl, S., additional, Steppa, C., additional, Takahashi, T., additional, Tanaka, T., additional, Tavernier, T., additional, Taylor, A. M., additional, Terrier, R., additional, Thiersen, J. H. E., additional, Thorpe-Morgan, C., additional, Tiziani, D., additional, Tluczykont, M., additional, Tomankova, L., additional, Trichard, C., additional, Tsirou, M., additional, Tsuji, N., additional, Tuffs, R., additional, Uchiyama, Y., additional, van der Walt, D. J., additional, van Eldik, C., additional, van Rensburg, C., additional, van Soelen, B., additional, Vasileiadis, G., additional, Veh, J., additional, Venter, C., additional, Vincent, P., additional, Vink, J., additional, Völk, H. J., additional, Wadiasingh, Z., additional, Wagner, S. J., additional, Watson, J., additional, Werner, F., additional, White, R., additional, Wierzcholska, A., additional, deWilt, P., additional, Wong, Yu Wun, additional, Yassin, H., additional, Yusafzai, A., additional, Zacharias, M., additional, Zanin, R., additional, Zargaryan, D., additional, Zdziarski, A. A., additional, Zech, A., additional, Zhu, S. J., additional, Zorn, J., additional, Zouari, S., additional, and Żywucka, N., additional

Published
2021
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32. Genomic epidemiology of Mycobacterium bovis infection in sympatric badger and cattle populations in Northern Ireland

Author

Joseph Crispell, Roland Harwood, Fraser Menzies, Jimena Guerrero, Paul R. McAdam, Robin A. Skuce, John Lavery, S. Thompson, Pepler Pt, Roman Biek, Andrew W. Byrne, Jordon Graham, Liliana C. M. Salvador, Rowland R. Kao, Trimble N, Wright L, Katarina Oravcova, Eleanor Presho, Adrian R. Allen, Akhmetova A, and du Plessis L

Subjects
Badger, Population, Context (language use), bovine tuberculosis, genome sequencing, transmission dynamics, law.invention, Coalescent theory, law, biology.animal, Animals, education, Northern Ireland/epidemiology, education.field_of_study, Genetic diversity, Mycobacterium bovis, biology, General Medicine, Genomics, biology.organism_classification, Mycobacterium bovis/genetics, Transmission (mechanics), Evolutionary biology, Tuberculosis, Bovine/microbiology, Genetic structure, Mustelidae/microbiology, Cattle
Abstract

Bovine tuberculosis (bTB) is a costly, epidemiologically complex, multi-host, endemic disease. Lack of understanding of transmission dynamics may undermine eradication efforts. Pathogen whole-genome sequencing improves epidemiological inferences, providing a means to determine the relative importance of inter- and intra-species host transmission for disease persistence. We sequenced an exceptional data set of 619 Mycobacterium bovis isolates from badgers and cattle in a 100 km2 bTB 'hotspot' in Northern Ireland. Historical molecular subtyping data permitted the targeting of an endemic pathogen lineage, whose long-term persistence provided a unique opportunity to study disease transmission dynamics in unparalleled detail. Additionally, to assess whether badger population genetic structure was associated with the spatial distribution of pathogen genetic diversity, we microsatellite genotyped hair samples from 769 badgers trapped in this area. Birth death models and TransPhylo analyses indicated that cattle were likely driving the local epidemic, with transmission from cattle to badgers being more common than badger to cattle. Furthermore, the presence of significant badger population genetic structure in the landscape was not associated with the spatial distribution of M. bovis genetic diversity, suggesting that badger-to-badger transmission is not playing a major role in transmission dynamics. Our data were consistent with badgers playing a smaller role in transmission of M. bovis infection in this study site, compared to cattle. We hypothesize, however, that this minor role may still be important for persistence. Comparison to other areas suggests that M. bovis transmission dynamics are likely to be context dependent, with the role of wildlife being difficult to generalize., Microbial Genomics, 9 (5), ISSN:2057-5858

Published
2021

33. Search for Dark Matter Annihilation Signals from Unidentified Fermi-LAT Objects with H.E.S.S.

Author

Abdalla, H., primary, Aharonian, F., additional, Ait Benkhali, F., additional, Angüner, E. O., additional, Arcaro, C., additional, Armand, C., additional, Armstrong, T., additional, Ashkar, H., additional, Backes, M., additional, Baghmanyan, V., additional, Barbosa-Martins, V., additional, Barnacka, A., additional, Barnard, M., additional, Becherini, Y., additional, Berge, D., additional, Bernlöhr, K., additional, Bi, B., additional, Böttcher, M., additional, Boisson, C., additional, Bolmont, J., additional, de Bony de Lavergne, M., additional, Breuhaus, M., additional, Brose, R., additional, Brun, F., additional, Bulik, T., additional, Bylund, T., additional, Cangemi, F., additional, Caroff, S., additional, Casanova, S., additional, Chambery, P., additional, Catalano, J., additional, Chand, T., additional, Chen, A., additional, Cotter, G., additional, Curyło, M., additional, Dalgleish, H., additional, Mbarubucyeye, J. Damascene, additional, Davids, I. D., additional, Davies, J., additional, Devin, J., additional, Djannati-Ataï, A., additional, Dmytriiev, A., additional, Donath, A., additional, Doroshenko, V., additional, Dreyer, L., additional, du Plessis, L., additional, Duffy, C., additional, Egberts, K., additional, Einecke, S., additional, Emery, G., additional, Ernenwein, J.-P., additional, Feijen, K., additional, Fegan, S., additional, Fiasson, A., additional, de Clairfontaine, G. Fichet, additional, Fontaine, G., additional, Funk, S., additional, Füssling, M., additional, Gabici, S., additional, Gallant, Y. A., additional, Ghafourizade, S., additional, Giavitto, G., additional, Giunti, L., additional, Glawion, D., additional, Glicenstein, J. F., additional, Grondin, M.-H., additional, Hattingh, S., additional, Haupt, M., additional, Hermann, G., additional, Hinton, J. A., additional, Hofmann, W., additional, Hoischen, C., additional, Holch, T. L., additional, Holler, M., additional, Hörbe, M., additional, Horns, D., additional, Huang, Z., additional, Huber, D., additional, Jamrozy, M., additional, Jankowsky, D., additional, Jankowsky, F., additional, Joshi, V., additional, Jung-Richardt, I., additional, Kasai, E., additional, Katarzyński, K., additional, Katz, U., additional, Khangulyan, D., additional, Khélifi, B., additional, Klepser, S., additional, Kluźniak, W., additional, Komin, Nu., additional, Konno, R., additional, Kosack, K., additional, Kostunin, D., additional, Kreter, M., additional, Kukec Mezek, G., additional, Kundu, A., additional, Lamanna, G., additional, Le Stum, S., additional, Lemière, A., additional, Lemoine-Goumard, M., additional, Lenain, J.-P., additional, Leuschner, F., additional, Levy, C., additional, Luashvili, A., additional, Lohse, T., additional, Lypova, I., additional, Mackey, J., additional, Majumdar, J., additional, Malyshev, D., additional, Marandon, V., additional, Marchegiani, P., additional, Marcowith, A., additional, Mares, A., additional, Martí-Devesa, G., additional, Marx, R., additional, Maurin, G., additional, Meintjes, P. J., additional, Meyer, M., additional, Mitchell, A., additional, Moderski, R., additional, Mohrmann, L., additional, Montanari, A., additional, Moore, C., additional, Morris, P., additional, Moulin, E., additional, Muller, J., additional, Murach, T., additional, Nakashima, K., additional, Nayerhoda, A., additional, de Naurois, M., additional, Ndiyavala, H., additional, Niemiec, J., additional, Noel, A., additional, Oberholzer, L., additional, O’Brien, P., additional, Ohm, S., additional, Olivera-Nieto, L., additional, de Ona Wilhelmi, E., additional, Ostrowski, M., additional, Panter, M., additional, Panny, S., additional, Parsons, R. D., additional, Peron, G., additional, Pita, S., additional, Poireau, V., additional, Prokhorov, D. A., additional, Prokoph, H., additional, Pühlhofer, G., additional, Punch, M., additional, Quirrenbach, A., additional, Reichherzer, P., additional, Reimer, A., additional, Reimer, O., additional, Remy, Q., additional, Renaud, M., additional, Rieger, F., additional, Romoli, C., additional, Rowell, G., additional, Rudak, B., additional, Rueda Ricarte, H., additional, Ruiz-Velasco, E., additional, Sahakian, V., additional, Sailer, S., additional, Salzmann, H., additional, Sanchez, D. A., additional, Santangelo, A., additional, Sasaki, M., additional, Schäfer, J., additional, Schüssler, F., additional, Schutte, H. M., additional, Schwanke, U., additional, Senniappan, M., additional, Seyffert, A. S., additional, Shapopi, J. N. S., additional, Shiningayamwe, K., additional, Simoni, R., additional, Sinha, A., additional, Spackman, H., additional, Sol, H., additional, Specovius, A., additional, Spencer, S., additional, Spir-Jacob, M., additional, Stawarz, Ł., additional, Sun, L., additional, Steenkamp, R., additional, Stegmann, C., additional, Steinmassl, S., additional, Steppa, C., additional, Takahashi, T., additional, Tanaka, T., additional, Tavernier, T., additional, Taylor, A. M., additional, Terrier, R., additional, Thorpe-Morgan, C., additional, Thiersen, J. H. E., additional, Tluczykont, M., additional, Tomankova, L., additional, Tsirou, M., additional, Tsuji, M., additional, Tuffs, R., additional, Uchiyama, Y., additional, van der Walt, D. J., additional, van Eldik, C., additional, van Rensburg, C., additional, van Soelen, B., additional, Vasileiadis, G., additional, Veh, J., additional, Venter, C., additional, Vincent, P., additional, Viana, A., additional, Vink, J., additional, Völk, H. J., additional, Wagner, S. J., additional, Werner, F., additional, White, R., additional, Wierzcholska, A., additional, Wong, Yu Wun, additional, Yassin, H., additional, Yusafzai, A., additional, Zacharias, M., additional, Zanin, R., additional, Zargaryan, D., additional, Zdziarski, A. A., additional, Zech, A., additional, Zhu, S. J., additional, Zmija, A., additional, Zorn, J., additional, Zouari, S., additional, and Żywucka, N., additional

Published
2021
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35. Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author

Collier, D. A., De Marco, A., Ferreira, I. A. T. M., Meng, B., Datir, R. P., Walls, A. C., Kemp, S. A., Bassi, J., Pinto, D., Silacci-Fregni, C., Bianchi, S., Tortorici, M. A., Bowen, J., Culap, K., Jaconi, S., Cameroni, E., Snell, G., Pizzuto, M. S., Pellanda, A. F., Garzoni, C., Riva, A., Baker, S., Dougan, G., Hess, C., Kingston, N., Lehner, P. J., Lyons, P. A., Matheson, N. J., Owehand, W. H., Saunders, C., Summers, C., Thaventhiran, J. E. D., Toshner, M., Weekes, M. P., Bucke, A., Calder, J., Canna, L., Domingo, J., Elmer, A., Fuller, S., Harris, J., Hewitt, S., Kennet, J., Jose, S., Kourampa, J., Meadows, A., O'Brien, C., Price, J., Publico, C., Rastall, R., Ribeiro, C., Rowlands, J., Ruffolo, V., Tordesillas, H., Bullman, B., Dunmore, B. J., Fawke, S., Graf, S., Hodgson, J., Huang, C., Hunter, K., Jones, E., Legchenko, E., Matara, C., Martin, J., Mescia, F., O'Donnell, C., Pointon, L., Pond, N., Shih, J., Sutcliffe, R., Tilly, T., Treacy, C., Tong, Z., Wood, J., Wylot, M., Bergamaschi, L., Betancourt, A., Bower, G., Cossetti, C., De Sa, A., Epping, M., Grenfell, R., Hinch, A., Huhn, O., Jackson, S., Jarvis, I., Lewis, D., Marsden, J., Nice, F., Okecha, G., Omarjee, O., Perera, M., Richoz, N., Romashova, V., Yarkoni, N. S., Sharma, R., Stefanucci, L., Stephens, J., Strezlecki, M., Turner, L., De Bie, E. M. D. D., Bunclark, K., Josipovic, M., Mackay, M., Rossi, S., Selvan, M., Spencer, S., Yong, C., Ansaripour, A., Michael, A., Mwaura, L., Patterson, C., Polwarth, G., Polgarova, P., di Stefano, G., Fahey, C., Michel, R., Bong, S. -H., Coudert, J. D., Holmes, E., Allison, J., Butcher, H., Caputo, D., Clapham-Riley, D., Dewhurst, E., Furlong, A., Graves, B., Gray, J., Ivers, T., Kasanicki, M., Le Gresley, E., Linger, R., Meloy, S., Muldoon, F., Ovington, N., Papadia, S., Phelan, I., Stark, H., Stirrups, K. E., Townsend, P., Walker, N., Webster, J., Mccoy, L. E., Smith, K. G. C., Bradley, J. R., Temperton, N., Ceron-Gutierrez, L., Barcenas-Morales, G., Robson, S. C., Loman, N. J., Connor, T. R., Golubchik, T., Martinez Nunez, R. T., Ludden, C., Corden, S., Johnston, I., Bonsall, D., Smith, C. P., Awan, A. R., Bucca, G., Torok, M. E., Saeed, K., Prieto, J. A., Jackson, D. K., Hamilton, W. L., Snell, L. B., Moore, C., Harrison, E. M., Goncalves, S., Fairley, D. J., Loose, M. W., Watkins, J., Livett, R., Moses, S., Amato, R., Nicholls, S., Bull, M., Smith, D. L., Barrett, J., Aanensen, D. M., Curran, M. D., Parmar, S., Aggarwal, D., Shepherd, J. G., Parker, M. D., Glaysher, S., Bashton, M., Underwood, A. P., Pacchiarini, N., Loveson, K. F., Carabelli, A. M., Templeton, K. E., Langford, C. F., Sillitoe, J., de Silva, T. I., Wang, D., Kwiatkowski, D., Rambaut, A., O'Grady, J., Cottrell, S., Holden, M. T. G., Thomson, E. C., Osman, H., Andersson, M., Chauhan, A. J., Hassan-Ibrahim, M. O., Lawniczak, M., Alderton, A., Chand, M., Constantinidou, C., Unnikrishnan, M., Darby, A. C., Hiscox, J. A., Paterson, S., Martincorena, I., Robertson, D. L., Volz, E. M., Page, A. J., Pybus, O. G., Bassett, A. R., Ariani, C. V., Spencer Chapman, M. H., K. K., Li, Shah, R. N., Jesudason, N. G., Taha, Y., Mchugh, M. P., Dewar, R., Jahun, A. S., Mcmurray, C., Pandey, S., Mckenna, J. P., Nelson, A., Young, G. R., Mccann, C. M., Elliott, S., Lowe, H., Temperton, B., Roy, S., Price, A., Rey, S., Wyles, M., Rooke, S., Shaaban, S., de Cesare, M., Letchford, L., Silveira, S., Pelosi, E., Wilson-Davies, E., Hosmillo, M., O'Toole, A., Hesketh, A. R., Stark, R., du Plessis, L., Ruis, C., Adams, H., Bourgeois, Y., Michell, S. L., Gramatopoulos, D., Edgeworth, J., Breuer, J., Todd, J. A., Fraser, C., Buck, D., John, M., Kay, G. L., Palmer, S., Peacock, S. J., Heyburn, D., Weldon, D., Robinson, E., Mcnally, A., Muir, P., Vipond, I. B., Boyes, J., Sivaprakasam, V., Salluja, T., Dervisevic, S., Meader, E. J., Park, N. R., Oliver, K., Jeffries, A. R., Ott, S., da Silva Filipe, A., Simpson, D. A., Williams, C., Masoli, J. A. H., Knight, B. A., Jones, C. R., Koshy, C., Ash, A., Casey, A., Bosworth, A., Ratcliffe, L., Xu-McCrae, L., Pymont, H. M., Hutchings, S., Berry, L., Jones, K., Halstead, F., Davis, T., Holmes, C., Iturriza-Gomara, M., Lucaci, A. O., Randell, P. A., Cox, A., Madona, P., Harris, K. A., Brown, J. R., Mahungu, T. W., Irish-Tavares, D., Haque, T., Hart, J., Witele, E., Fenton, M. L., Liggett, S., Graham, C., Swindells, E., Collins, J., Eltringham, G., Campbell, S., Mcclure, P. C., Clark, G., Sloan, T. J., Jones, C., Lynch, J., Warne, B., Leonard, S., Durham, J., Williams, T., Haldenby, S. T., Storey, N., Alikhan, N. -F., Holmes, N., Carlile, M., Perry, M., Craine, N., Lyons, R. A., Beckett, A. H., Goudarzi, S., Fearn, C., Cook, K., Dent, H., Paul, H., Davies, R., Blane, B., Girgis, S. T., Beale, M. A., Bellis, K. L., Dorman, M. J., Drury, E., Kane, L., Kay, S., Mcguigan, S., Nelson, R., Prestwood, L., Rajatileka, S., Batra, R., Williams, R. J., Kristiansen, M., Green, A., Justice, A., Mahanama, A. I. K., Samaraweera, B., Hadjirin, N. F., Quick, J., Poplawski, R., Kermack, L. M., Reynolds, N., Hall, G., Chaudhry, Y., Pinckert, M. L., Georgana, I., Moll, R. J., Thornton, A., Myers, R., Stockton, J., Williams, C. A., Yew, W. C., Trotter, A. J., Trebes, A., MacIntyre-Cockett, G., Birchley, A., Adams, A., Plimmer, A., Gatica-Wilcox, B., Mckerr, C., Hilvers, E., Jones, H., Asad, H., Coombes, J., Evans, J. M., Fina, L., Gilbert, L., Graham, L., Cronin, M., Kumziene-Summerhayes, S., Taylor, S., Jones, S., Groves, D. C., Zhang, P., Gallis, M., Louka, S. F., Starinskij, I., Jackson, C., Gourtovaia, M., Tonkin-Hill, G., Lewis, K., Tovar-Corona, J. M., James, K., Baxter, L., Alam, M. T., Orton, R. J., Hughes, J., Vattipally, S., Ragonnet-Cronin, M., Nascimento, F. F., Jorgensen, D., Boyd, O., Geidelberg, L., Zarebski, A. E., Raghwani, J., Kraemer, M. U. G., Southgate, J., Lindsey, B. B., Freeman, T. M., Keatley, J. -P., Singer, J. B., de Oliveira Martins, L., Yeats, C. A., Abudahab, K., Taylor, B. E. W., Menegazzo, M., Danesh, J., Hogsden, W., Eldirdiri, S., Kenyon, A., Mason, J., Robinson, T. I., Holmes, A., Hartley, J. A., Curran, T., Mather, A. E., Shankar, G., Jones, R., Howe, R., Morgan, S., Wastenge, E., Chapman, M. R., Mookerjee, S., Stanley, R., Smith, W., Peto, T., Eyre, D., Crook, D., Vernet, G., Kitchen, C., Gulliver, H., Merrick, I., Guest, M., Munn, R., Bradley, D. T., Wyatt, T., Beaver, C., Foulser, L., Churcher, C. M., Brooks, E., Smith, K. S., Galai, K., Mcmanus, G. M., Bolt, F., Coll, F., Meadows, L., Attwood, S. W., Davies, A., De Lacy, E., Downing, F., Edwards, S., Scarlett, G. P., Jeremiah, S., Smith, N., Leek, D., Sridhar, S., Forrest, S., Cormie, C., Gill, H. K., Dias, J., Higginson, E. E., Maes, M., Young, J., Wantoch, M., Jamrozy, D., Lo, S., Patel, M., Hill, V., Bewshea, C. M., Ellard, S., Auckland, C., Harrison, I., Bishop, C., Chalker, V., Richter, A., Beggs, A., Best, A., Percival, B., Mirza, J., Megram, O., Mayhew, M., Crawford, L., Ashcroft, F., Moles-Garcia, E., Cumley, N., Hopes, R., Asamaphan, P., Niebel, M. O., Gunson, R. N., Bradley, A., Maclean, A., Mollett, G., Blacow, R., Bird, P., Helmer, T., Fallon, K., Tang, J., Hale, A. D., Macfarlane-Smith, L. R., Harper, K. L., Carden, H., Machin, N. W., Jackson, K. A., Ahmad, S. S. Y., George, R. P., Turtle, L., O'Toole, E., Watts, J., Breen, C., Cowell, A., Alcolea-Medina, A., Charalampous, T., Patel, A., Levett, L. J., Heaney, J., Rowan, A., Taylor, G. P., Shah, D., Atkinson, L., Lee, J. C. D., Westhorpe, A. P., Jannoo, R., Lowe, H. L., Karamani, A., Ensell, L., Chatterton, W., Pusok, M., Dadrah, A., Symmonds, A., Sluga, G., Molnar, Z., Baker, P., Bonner, S., Essex, S., Barton, E., Padgett, D., Scott, G., Greenaway, J., Payne, B. A. I., Burton-Fanning, S., Waugh, S., Raviprakash, V., Sheriff, N., Blakey, V., Williams, L. -A., Moore, J., Stonehouse, S., Smith, L., Davidson, R. K., Bedford, L., Coupland, L., Wright, V., Chappell, J. G., Tsoleridis, T., Ball, J., Khakh, M., Fleming, V. M., Lister, M. M., Howson-Wells, H. C., Boswell, T., Joseph, A., Willingham, I., Duckworth, N., Walsh, S., Wise, E., Moore, N., Mori, M., Cortes, N., Kidd, S., Williams, R., Gifford, L., Bicknell, K., Wyllie, S., Lloyd, A., Impey, R., Malone, C. S., Cogger, B. J., Levene, N., Monaghan, L., Keeley, A. J., Partridge, D. G., Raza, M., Evans, C., Johnson, K., Betteridge, E., Farr, B. W., Goodwin, S., Quail, M. A., Scott, C., Shirley, L., Thurston, S. A. J., Rajan, D., Bronner, I. F., Aigrain, L., Redshaw, N. M., Lensing, S. V., Mccarthy, S., Makunin, A., Balcazar, C. E., Gallagher, M. D., Williamson, K. A., Stanton, T. D., Michelsen, M. L., Warwick-Dugdale, J., Manley, R., Farbos, A., Harrison, J. W., Sambles, C. M., Studholme, D. J., Lackenby, A., Mbisa, T., Platt, S., Miah, S., Bibby, D., Manso, C., Hubb, J., Dabrera, G., Ramsay, M., Bradshaw, D., Schaefer, U., Groves, N., Gallagher, E., Lee, D., Williams, D., Ellaby, N., Hartman, H., Manesis, N., Patel, V., Ledesma, J., Twohig, K. A., Allara, E., Pearson, C., Cheng, J. K. J., Bridgewater, H. E., Frost, L. R., Taylor-Joyce, G., Brown, P. E., Tong, L., Broos, A., Mair, D., Nichols, J., Carmichael, S. N., Smollett, K. L., Nomikou, K., Aranday-Cortes, E., Johnson, N., Nickbakhsh, S., Vamos, E. E., Hughes, M., Rainbow, L., Eccles, R., Nelson, C., Whitehead, M., Gregory, R., Gemmell, M., Wierzbicki, C., Webster, H. J., Fisher, C. L., Signell, A. W., Betancor, G., Wilson, H. D., Nebbia, G., Flaviani, F., Cerda, A. C., Merrill, T. V., Wilson, R. E., Cotic, M., Bayzid, N., Thompson, T., Acheson, E., Rushton, S., O'Brien, S., Baker, D. J., Rudder, S., Aydin, A., Sang, F., Debebe, J., Francois, S., Vasylyeva, T. I., Zamudio, M. E., Gutierrez, B., Marchbank, A., Maksimovic, J., Spellman, K., Mccluggage, K., Morgan, M., Beer, R., Afifi, S., Workman, T., Fuller, W., Bresner, C., Angyal, A., Green, L. R., Parsons, P. J., Tucker, R. M., Brown, R., Whiteley, M., Bonfield, J., Puethe, C., Whitwham, A., Liddle, J., Rowe, W., Siveroni, I., Le-Viet, T., Gaskin, A., Johnson, R., Abnizova, I., Ali, M., Allen, L., Anderson, R., Ariani, C., Austin-Guest, S., Bala, S., Bassett, A., Battleday, K., Beal, J., Beale, M., Bellany, S., Bellerby, T., Bellis, K., Berger, D., Berriman, M., Bevan, P., Binley, S., Bishop, J., Blackburn, K., Boughton, N., Bowker, S., Brendler-Spaeth, T., Bronner, I., Brooklyn, T., Buddenborg, S. K., Bush, R., Caetano, C., Cagan, A., Carter, N., Cartwright, J., Monteiro, T. C., Chapman, L., Chillingworth, T. -J., Clapham, P., Clark, R., Clarke, A., Clarke, C., Cole, D., Cook, E., Coppola, M., Cornell, L., Cornwell, C., Corton, C., Crackett, A., Cranage, A., Craven, H., Craw, S., Crawford, M., Cutts, T., Dabrowska, M., Davies, M., Dawson, J., Day, C., Densem, A., Dibling, T., Dockree, C., Dodd, D., Dogga, S., Dougherty, M., Dove, A., Drummond, L., Dudek, M., Durrant, L., Easthope, E., Eckert, S., Ellis, P., Farr, B., Fenton, M., Ferrero, M., Flack, N., Fordham, H., Forsythe, G., Francis, M., Fraser, A., Freeman, A., Galvin, A., Garcia-Casado, M., Gedny, A., Girgis, S., Glover, J., Gould, O., Gray, A., Gray, E., Griffiths, C., Gu, Y., Guerin, F., Hamilton, W., Hanks, H., Harrison, E., Harrott, A., Harry, E., Harvison, J., Heath, P., Hernandez-Koutoucheva, A., Hobbs, R., Holland, D., Holmes, S., Hornett, G., Hough, N., Huckle, L., Hughes-Hallet, L., Hunter, A., Inglis, S., Iqbal, S., Jackson, A., Jackson, D., Verdejo, C. J., Jones, M., Kallepally, K., Kay, K., Keatley, J., Keith, A., King, A., Kitchin, L., Kleanthous, M., Klimekova, M., Korlevic, P., Krasheninnkova, K., Lane, G., Langford, C., Laverack, A., Law, K., Lensing, S., Lewis-Wade, A., Lin, Q., Lindsay, S., Linsdell, S., Long, R., Lovell, J., Mack, J., Maddison, M., Mamun, I., Mansfield, J., Marriott, N., Martin, M., Mayho, M., Mcclintock, J., Mchugh, S., Mcminn, L., Meadows, C., Mobley, E., Moll, R., Morra, M., Morrow, L., Murie, K., Nash, S., Nathwani, C., Naydenova, P., Neaverson, A., Nerou, E., Nicholson, J., Nimz, T., Noell, G. G., O'Meara, S., Ohan, V., Olney, C., Ormond, D., Oszlanczi, A., Pang, Y. F., Pardubska, B., Park, N., Parmar, A., Patel, G., Payne, M., Peacock, S., Petersen, A., Plowman, D., Preston, T., Quail, M., Rance, R., Rawlings, S., Redshaw, N., Reynolds, J., Reynolds, M., Rice, S., Richardson, M., Roberts, C., Robinson, K., Robinson, M., Robinson, D., Rogers, H., Rojo, E. M., Roopra, D., Rose, M., Rudd, L., Sadri, R., Salmon, N., Saul, D., Schwach, F., Seekings, P., Simms, A., Sinnott, M., Sivadasan, S., Siwek, B., Sizer, D., Skeldon, K., Skelton, J., Slater-Tunstill, J., Sloper, L., Smerdon, N., Smith, C., Smith, J., Smith, K., Smith, M., Smith, S., Smith, T., Sneade, L., Soria, C. D., Sousa, C., Souster, E., Sparkes, A., Spencer-Chapman, M., Squares, J., Steed, C., Stickland, T., Still, I., Stratton, M., Strickland, M., Swann, A., Swiatkowska, A., Sycamore, N., Swift, E., Symons, E., Szluha, S., Taluy, E., Tao, N., Taylor, K., Thompson, S., Thompson, M., Thomson, M., Thomson, N., Thurston, S., Toombs, D., Topping, B., Tovar-Corona, J., Ungureanu, D., Uphill, J., Urbanova, J., Van, P. J., Vancollie, V., Voak, P., Walker, D., Walker, M., Waller, M., Ward, G., Weatherhogg, C., Webb, N., Wells, A., Wells, E., Westwood, L., Whipp, T., Whiteley, T., Whitton, G., Widaa, S., Williams, M., Wilson, M., Wright, S., Harvey, W., Virgin, H. W., Lanzavecchia, A., Piccoli, L., Doffinger, R., Wills, M., Veesler, D., Corti, D., and Gupta, R. K.

Subjects
0301 basic medicine, Male, Models, Molecular, Passive, Antibodies, Viral, Neutralization, 0302 clinical medicine, Models, Monoclonal, 80 and over, Viral, Neutralizing antibody, Neutralizing, Aged, 80 and over, Vaccines, Vaccines, Synthetic, Multidisciplinary, biology, Antibodies, Monoclonal, C500, Middle Aged, C700, Spike Glycoprotein, Vaccination, Spike Glycoprotein, Coronavirus, Female, Angiotensin-Converting Enzyme 2, Antibody, Aged, Antibodies, Neutralizing, COVID-19, COVID-19 Vaccines, HEK293 Cells, Humans, Immune Evasion, Immunization, Passive, Mutation, Neutralization Tests, SARS-CoV-2, medicine.drug_class, B100, Monoclonal antibody, Antibodies, Virus, 03 medical and health sciences, Immune system, medicine, COVID-19 Serotherapy, QR355, Synthetic, Molecular, Virology, Coronavirus, 030104 developmental biology, Immunization, biology.protein, 030217 neurology & neurosurgery
Abstract

Transmission of SARS-CoV-2 is uncontrolled in many parts of the world; control is compounded in some areas by the higher transmission potential of the B.1.1.7 variant1, which has now been reported in 94 countries. It is unclear whether the response of the virus to vaccines against SARS-CoV-2 on the basis of the prototypic strain will be affected by the mutations found in B.1.1.7. Here we assess the immune responses of individuals after vaccination with the mRNA-based vaccine BNT162b22. We measured neutralizing antibody responses after the first and second immunizations using pseudoviruses that expressed the wild-type spike protein or a mutated spike protein that contained the eight amino acid changes found in the B.1.1.7 variant. The sera from individuals who received the vaccine exhibited a broad range of neutralizing titres against the wild-type pseudoviruses that were modestly reduced against the B.1.1.7 variant. This reduction was also evident in sera from some patients who had recovered from COVID-19. Decreased neutralization of the B.1.1.7 variant was also observed for monoclonal antibodies that target the N-terminal domain (9 out of 10) and the receptor-binding motif (5 out of 31), but not for monoclonal antibodies that recognize the receptor-binding domain that bind outside the receptor-binding motif. Introduction of the mutation that encodes the E484K substitution in the B.1.1.7 background to reflect a newly emerged variant of concern (VOC 202102/02) led to a more-substantial loss of neutralizing activity by vaccine-elicited antibodies and monoclonal antibodies (19 out of 31) compared with the loss of neutralizing activity conferred by the mutations in B.1.1.7 alone. The emergence of the E484K substitution in a B.1.1.7 background represents a threat to the efficacy of the BNT162b2 vaccine.

Published
2021

36. Science verification of the new FlashCam-based camera in the 28m telescope of H.E.S.S

Author

Pühlhofer, G., Bernlöhr, K., Bi, B., Hermann, G., Hinton, J., Jung-Richardt, I., Leuschner, F., Marandon, V., Mitchell, A., Mohrmann, L., Parsons, D., Sailer, S., Salzmann, H., Steinmassl, S., Werner, F., Abdalla, H., Aharonian, F., Ait Benkhali, F., Angüner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa Martins, V., Barnacka, A., Barnard, M., Batzofin, R., Becherini, Y., Berge, D., Böttcher, M., Boisson, C., Bolmont, J., Bony Lavergne, M., Breuhaus, M., Brose, R., Brun, F., Bulik, T., Bylund, T., Cangemi, F., Caroff, S., Casanova, S., Catalano, J., Chambery, P., Chand, T., Chen, A., Cotter, G., Curyło, M., Dalgleish, H., Damascene Mbarubucyeye, J., Davids, I. D., Davies, J., Devin, J., Djannati-Ataï, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dreyer, L., Du Plessis, L., Duffy, C., Egberts, K., Einecke, S., Ernenwein, J. -P, Fegan, S., Feijen, K., Fiasson, A., Fichet Clairfontaine, G., Fontaine, G., Lott, F., Füßling, M., Funk, S., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M. -H, Hattingh, S., Haupt, M., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horns, D., Huang, Z., Huber, D., Hörbe, M., Jamrozy, M., Jankowsky, F., Joshi, V., Kasai, E., Katarzyński, K., Katz, U., Khangulyan, D., Khélifi, B., Klepser, S., Kluźniak, W., Komin, Nu, Konno, R., Kosack, K., Kostunin, D., Kreter, M., Kukec Mezek, G., Kundu, A., Lamanna, G., Le Stum, S., Lemière, A., Lemoine-Goumard, M., Lenain, J. -P, Levy, C., Lohse, T., Luashvili, A., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marchegiani, P., Marcowith, A., Mares, A., Martí-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Moderski, R., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Naurois, M., Nayerhoda, A., Ndiyavala, H., Niemiec, J., Priyana Noel, A., O Brien, P., Oberholzer, L., Ohm, S., Olivera-Nieto, L., Ona Wilhelmi, E., Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Pita, S., Poireau, V., Prokhorov, D. A., Prokoph, H., Punch, M., Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Reville, B., Rieger, F., Romoli, C., Rowell, G., Rudak, B., Rueda Ricarte, H., Ruiz-Velasco, E., Sahakian, V., Sanchez, D. A., Santangelo, A., Sasaki, M., Johannes Schäfer, Schutte, H. M., Schwanke, U., Schüssler, F., Senniappan, M., Seyffert, A. S., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Spackman, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, Ł., Steenkamp, R., Stegmann, C., Steppa, C., Sun, L., Takahashi, T., Tanaka, T., Tavernier, T., Taylor, A. M., Terrier, R., Thiersen, J. H. E., Thorpe-Morgan, C., Tluczykont, M., Tomankova, L., Tsirou, M., Tsuji, N., Tuffs, R., Uchiyama, Y., Walt, D. J., Eldik, C., Rensburg, C., Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Völk, H. J., Wagner, S. J., Watson, J., White, R., Wierzcholska, A., Wong, Y. W., Yassin, H., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zmija, A., Zouari, S., and Żywucka, N.

Subjects
Computer science, business.industry, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, FOS: Physical sciences, Cherenkov Telescope Array, law.invention, Telescope, Software, law, Computer graphics (images), ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION, HESS - Abteilung Hinton, Astrophysics - Instrumentation and Methods for Astrophysics, business, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

In October 2019 the central 28m telescope of the H.E.S.S. experiment has been upgraded with a new camera. The camera is based on the FlashCam design which has been developed in view of a possible future implementation in the medium-sized telescopes of the Cherenkov Telescope Array (CTA). We report here on the results of the science verification program that has been performed after commissioning of the new camera, to show that the camera and software pipelines are working up to expectations., Comment: Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021)

Published
2021
Full Text
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37. The implementation of a bilingual-bicultural literacy intervention programme for deaf learners in Namibia

Author

Bruwer, Beausetha Juhetha, Van Staden, A., Du Plessis, L. T., Bruwer, Beausetha Juhetha, Van Staden, A., and Du Plessis, L. T.

Abstract

The Bilingual-Bicultural approach is considered the best approach to teach deaf learners. This approach also provides the best opportunity for deaf learners to become biliterate. Namibia too has adopted the Bilingual-Bicultural approach to teaching deaf learners and are a signatory to national and international policies and laws to ensure deaf learners are provided with the best opportunity for an education. Contrary to the adoption of the Bilingual-Bicultural approach, policies and laws, no impact has been seen on an improvement in the deaf learners’ academic performance. Deaf learners still leave school with low literacy levels and unsure of their future. The main purpose of this study was to find the best instructional practices to teach deaf learners through the Bilingual-Bicultural approach. This was done through the implementation of an intervention programme that can narrow the delay and gap in language learning and literacy. The study adopted a programme evaluation within a multi-method research design. The research objectives accommodated the implementation of a Bilingual-Bicultural literacy intervention programme for deaf learners. The data for the study consisted of quantitative data in the form of measurements based on diagnostic tests and qualitative data in the form of document analysis, participant and non-participant observations as well as unstructured interviews. The variety of data directed the study to a multi-data analysis. The themes that were established for feedback of the research findings originated from the research objectives and the programme evaluation questions that were drawn up to guide the evaluation of the Bilingual-Bicultural literacy programme. The emphasis of the intervention programme was to draw up new and adopted Integrated Planning Manuals that are based on the NSL and Written English syllabuses and prescribed language skills of both language subjects. From the new IPMs, lessons were designed for both language subjects. Teac

Published
2021

38. Search for Dark Matter Annihilation Signals from Unidentified Fermi-LAT Objects with HESS

Author

Abdalla, H., Aharonian, F., Ait Benkhali, F., Anguner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa-Martins, V., Barnacka, A., Barnard, M., Becherini, Yvonne, Berge, D., Bernloehr, K., Bi, B., Bottcher, M., Boisson, C., Bolmont, J., de Bony de Lavergne, M., Breuhaus, M., Brose, R., Brun, F., Bulik, T., Bylund, Tomas, Cangemi, F., Caroff, S., Casanova, S., Chambery, P., Catalano, J., Chand, T., Chen, A., Cotter, G., Curylo, M., Dalgleish, H., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Devin, J., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dreyer, L., du Plessis, L., Duffy, C., Egberts, K., Einecke, S., Emery, G., Ernenwein, J. -P, Feijen, K., Fegan, S., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Funk, S., Fuessling, M., Gabici, S., Gallant, Y. A., Ghafourizade, S., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M. -H, Hattingh, S., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horbe, M., Horns, D., Huang, Z., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzynski, K., Katz, U., Khangulyan, D., Khelifi, B., Klepser, S., Kluzniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Kukec Mezek, Gasper, Kundu, A., Lamanna, G., Le Stum, S., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P, Leuschner, F., Levy, C., Luashvili, A., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niemiec, J., Noel, A., Oberholzer, L., O'Brien, P., Ohm, S., Olivera-Nieto, L., de Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Pita, S., Poireau, V., Prokhorov, D. A., Prokoph, H., Puhlhoefer, G., Punch, Michael, Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Romoli, C., Rowell, G., Rudak, B., Rueda Ricarte, H., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schaefer, J., Schussler, F., Schutte, H. M., Schwanke, U., Senniappan, Mohanraj, Seyffert, A. S., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Spackman, H., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tanaka, T., Tavernier, T., Taylor, A. M., Terrier, R., Thorpe-Morgan, C., Thiersen, J. H. E., Tluczykont, M., Tomankova, L., Tsirou, M., Tsuji, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Viana, A., Vink, J., Voelk, H. J., Wagner, S. J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yassin, H., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zmija, A., Zorn, J., Zouari, S., Zywucka, N., Abdalla, H., Aharonian, F., Ait Benkhali, F., Anguner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V., Barbosa-Martins, V., Barnacka, A., Barnard, M., Becherini, Yvonne, Berge, D., Bernloehr, K., Bi, B., Bottcher, M., Boisson, C., Bolmont, J., de Bony de Lavergne, M., Breuhaus, M., Brose, R., Brun, F., Bulik, T., Bylund, Tomas, Cangemi, F., Caroff, S., Casanova, S., Chambery, P., Catalano, J., Chand, T., Chen, A., Cotter, G., Curylo, M., Dalgleish, H., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Devin, J., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V., Dreyer, L., du Plessis, L., Duffy, C., Egberts, K., Einecke, S., Emery, G., Ernenwein, J. -P, Feijen, K., Fegan, S., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Funk, S., Fuessling, M., Gabici, S., Gallant, Y. A., Ghafourizade, S., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M. -H, Hattingh, S., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Horbe, M., Horns, D., Huang, Z., Huber, D., Jamrozy, M., Jankowsky, D., Jankowsky, F., Joshi, V., Jung-Richardt, I., Kasai, E., Katarzynski, K., Katz, U., Khangulyan, D., Khelifi, B., Klepser, S., Kluzniak, W., Komin, Nu., Konno, R., Kosack, K., Kostunin, D., Kreter, M., Kukec Mezek, Gasper, Kundu, A., Lamanna, G., Le Stum, S., Lemiere, A., Lemoine-Goumard, M., Lenain, J. -P, Leuschner, F., Levy, C., Luashvili, A., Lohse, T., Lypova, I., Mackey, J., Majumdar, J., Malyshev, D., Marandon, V., Marchegiani, P., Marcowith, A., Mares, A., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moore, C., Morris, P., Moulin, E., Muller, J., Murach, T., Nakashima, K., Nayerhoda, A., de Naurois, M., Ndiyavala, H., Niemiec, J., Noel, A., Oberholzer, L., O'Brien, P., Ohm, S., Olivera-Nieto, L., de Ona Wilhelmi, E., Ostrowski, M., Panter, M., Panny, S., Parsons, R. D., Peron, G., Pita, S., Poireau, V., Prokhorov, D. A., Prokoph, H., Puhlhoefer, G., Punch, Michael, Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Rieger, F., Romoli, C., Rowell, G., Rudak, B., Rueda Ricarte, H., Ruiz-Velasco, E., Sahakian, V., Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schaefer, J., Schussler, F., Schutte, H. M., Schwanke, U., Senniappan, Mohanraj, Seyffert, A. S., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Spackman, H., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Sun, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Takahashi, T., Tanaka, T., Tavernier, T., Taylor, A. M., Terrier, R., Thorpe-Morgan, C., Thiersen, J. H. E., Tluczykont, M., Tomankova, L., Tsirou, M., Tsuji, M., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Viana, A., Vink, J., Voelk, H. J., Wagner, S. J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yassin, H., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zmija, A., Zorn, J., Zouari, S., and Zywucka, N.

Abstract

Cosmological N-body simulations show that Milky Way-sized galaxies harbor a population of unmerged dark matter (DM) subhalos. These subhalos could shine in gamma-rays and eventually be detected in gamma-ray surveys as unidentified sources. We performed a thorough selection among unidentified Fermi-Large Area Telescope Objects (UFOs) to identify them as possible tera-electron-volt-scale DM subhalo candidates. We search for very-high-energy (E greater than or similar to 100 GeV) gamma-ray emissions using H.E.S.S. observations toward four selected UFOs. Since no significant very-high-energy gamma-ray emission is detected in any data set of the four observed UFOs or in the combined UFO data set, strong constraints are derived on the product of the velocity-weighted annihilation cross section sigma v by the J factor for the DM models. The 95% confidence level observed upper limits derived from combined H.E.S.S. observations reach sigma vJ values of 3.7 x 10(-5) and 8.1 x 10(-6) GeV(2 )cm(-2 )s(-1) in the W (+) W (-) and tau (+) tau (-) channels, respectively, for a 1 TeV DM mass. Focusing on thermal weakly interacting massive particles, the H.E.S.S. constraints restrict the J factors to lie in the range 6.1 x 10(19)-2.0 x 10(21) GeV(2 )cm(-5) and the masses to lie between 0.2 and 6 TeV in the W (+) W (-) channel. For the tau (+) tau (-) channel, the J factors lie in the range 7.0 x 10(19)-7.1 x 10(20) GeV(2 )cm(-5) and the masses lie between 0.2 and 0.5 TeV. Assuming model-dependent predictions from cosmological N-body simulations on the J-factor distribution for Milky Way-sized galaxies, the DM models with masses >0.3 TeV for the UFO emissions can be ruled out at high confidence level.

Published
2021
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39. LMC N132D : A mature supernova remnant with a power-law gamma-ray spectrum extending beyond 8 TeV

Author

Abdalla, H., Aharonian, F., Benkhali, F. Ait, Anguner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V, Martins, V. Barbosa, Barnacka, A., Barnard, M., Batzofin, R., Becherini, Yvonne, Berge, D., Bernloehr, K., Bi, B., Boettcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Breuhaus, M., Brose, R., Brun, F., Bulik, T., Bylund, Tomas, Cangemi, F., Caroff, S., Casanova, S., Catalano, J., Chambery, P., Chand, T., Chen, A., Cotter, G., Curylo, M., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Devin, J., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V, Dreyer, L., Du Plessis, L., Duffy, C., Egberts, K., Einecke, S., Ernenwein, J-P, Fegan, S., Feijen, K., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Lott, F., Fussling, M., Funk, S., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M-H, Hattingh, S., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hoerbe, M., Horns, D., Huang, Zhiqiu, Huber, D., Jamrozy, M., Jankowsky, F., Joshi, V, Jung-Richardt, I, Kasai, E., Katarzynski, K., Katz, U., Khangulyan, D., Khelifi, B., Klepser, S., Kluzniak, W., Komin, Nu, Konno, R., Kosack, K., Kostunin, D., Kreter, M., Kukec Mezek, Gasper, Kundu, A., Lamanna, G., Le Stum, S., Lemiere, A., Lemoine-Goumard, M., Lenain, J-P, Leuschner, F., Levy, C., Lohse, T., Luashvili, A., Lypova, I, Mackey, J., Majumdar, J., Malyshev, D., Marandon, V, Marchegiani, P., Marcowith, A., Mares, A., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moore, C., Moulin, E., Muller, J., Murach, T., Nakashima, K., de Naurois, M., Nayerhoda, A., Ndiyavala, H., Niemiec, J., Noel, A. Priyana, O'Brien, P., Oberholzer, L., Odaka, H., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Pita, S., Poireau, V, Prokhorov, D. A., Prokoph, H., Puehlhofer, G., Punch, Michael, Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Reville, B., Rieger, F., Romoli, C., Rowell, G., Rudak, B., Ricarte, H. Rueda, Ruiz-Velasco, E., Sahakian, V, Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schaefer, J., Schuessler, F., Schutte, H. M., Schwanke, U., Senniappan, Mohanraj, Seyffert, A. S., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Sun, L., Takahashi, T., Tanaka, T., Tavernier, T., Taylor, A. M., Terrier, R., Thiersen, J. H. E., Thorpe-Morgan, C., Tluczykont, M., Tomankova, L., Tsirou, M., Tsuji, N., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Voelk, H. J., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yassin, H., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zmija, A., Zouari, S., Zywucka, N., Abdalla, H., Aharonian, F., Benkhali, F. Ait, Anguner, E. O., Arcaro, C., Armand, C., Armstrong, T., Ashkar, H., Backes, M., Baghmanyan, V, Martins, V. Barbosa, Barnacka, A., Barnard, M., Batzofin, R., Becherini, Yvonne, Berge, D., Bernloehr, K., Bi, B., Boettcher, M., Boisson, C., Bolmont, J., de Lavergne, M. de Bony, Breuhaus, M., Brose, R., Brun, F., Bulik, T., Bylund, Tomas, Cangemi, F., Caroff, S., Casanova, S., Catalano, J., Chambery, P., Chand, T., Chen, A., Cotter, G., Curylo, M., Mbarubucyeye, J. Damascene, Davids, I. D., Davies, J., Devin, J., Djannati-Atai, A., Dmytriiev, A., Donath, A., Doroshenko, V, Dreyer, L., Du Plessis, L., Duffy, C., Egberts, K., Einecke, S., Ernenwein, J-P, Fegan, S., Feijen, K., Fiasson, A., de Clairfontaine, G. Fichet, Fontaine, G., Lott, F., Fussling, M., Funk, S., Gabici, S., Gallant, Y. A., Giavitto, G., Giunti, L., Glawion, D., Glicenstein, J. F., Grondin, M-H, Hattingh, S., Haupt, M., Hermann, G., Hinton, J. A., Hofmann, W., Hoischen, C., Holch, T. L., Holler, M., Hoerbe, M., Horns, D., Huang, Zhiqiu, Huber, D., Jamrozy, M., Jankowsky, F., Joshi, V, Jung-Richardt, I, Kasai, E., Katarzynski, K., Katz, U., Khangulyan, D., Khelifi, B., Klepser, S., Kluzniak, W., Komin, Nu, Konno, R., Kosack, K., Kostunin, D., Kreter, M., Kukec Mezek, Gasper, Kundu, A., Lamanna, G., Le Stum, S., Lemiere, A., Lemoine-Goumard, M., Lenain, J-P, Leuschner, F., Levy, C., Lohse, T., Luashvili, A., Lypova, I, Mackey, J., Majumdar, J., Malyshev, D., Marandon, V, Marchegiani, P., Marcowith, A., Mares, A., Marti-Devesa, G., Marx, R., Maurin, G., Meintjes, P. J., Meyer, M., Mitchell, A., Moderski, R., Mohrmann, L., Montanari, A., Moore, C., Moulin, E., Muller, J., Murach, T., Nakashima, K., de Naurois, M., Nayerhoda, A., Ndiyavala, H., Niemiec, J., Noel, A. Priyana, O'Brien, P., Oberholzer, L., Odaka, H., Ohm, S., Olivera-Nieto, L., Wilhelmi, E. de Ona, Ostrowski, M., Panny, S., Panter, M., Parsons, R. D., Peron, G., Pita, S., Poireau, V, Prokhorov, D. A., Prokoph, H., Puehlhofer, G., Punch, Michael, Quirrenbach, A., Reichherzer, P., Reimer, A., Reimer, O., Remy, Q., Renaud, M., Reville, B., Rieger, F., Romoli, C., Rowell, G., Rudak, B., Ricarte, H. Rueda, Ruiz-Velasco, E., Sahakian, V, Sailer, S., Salzmann, H., Sanchez, D. A., Santangelo, A., Sasaki, M., Schaefer, J., Schuessler, F., Schutte, H. M., Schwanke, U., Senniappan, Mohanraj, Seyffert, A. S., Shapopi, J. N. S., Shiningayamwe, K., Simoni, R., Sinha, A., Sol, H., Specovius, A., Spencer, S., Spir-Jacob, M., Stawarz, L., Steenkamp, R., Stegmann, C., Steinmassl, S., Steppa, C., Sun, L., Takahashi, T., Tanaka, T., Tavernier, T., Taylor, A. M., Terrier, R., Thiersen, J. H. E., Thorpe-Morgan, C., Tluczykont, M., Tomankova, L., Tsirou, M., Tsuji, N., Tuffs, R., Uchiyama, Y., van der Walt, D. J., van Eldik, C., van Rensburg, C., van Soelen, B., Vasileiadis, G., Veh, J., Venter, C., Vincent, P., Vink, J., Voelk, H. J., Wagner, S. J., Watson, J., Werner, F., White, R., Wierzcholska, A., Wong, Yu Wun, Yassin, H., Yusafzai, A., Zacharias, M., Zanin, R., Zargaryan, D., Zdziarski, A. A., Zech, A., Zhu, S. J., Zmija, A., Zouari, S., and Zywucka, N.

Abstract

Context. Supernova remnants (SNRs) are commonly thought to be the dominant sources of Galactic cosmic rays up to the knee of the cosmic-ray spectrum at a few PeV. Imaging Atmospheric Cherenkov Telescopes have revealed young SNRs as very-high-energy (VHE, >100 GeV) gamma-ray sources, but for only a few SNRs the hadronic cosmic-ray origin of their gamma-ray emission is indisputably established. In all these cases, the gamma-ray spectra exhibit a spectral cutoff at energies much below 100 TeV and thus do not reach the PeVatron regime. Aims. The aim of this work was to achieve a firm detection for the oxygen-rich SNR LMC N132D in the VHE gamma-ray domain with an extended set of data, and to clarify the spectral characteristics and the localization of the gamma-ray emission from this exceptionally powerful gamma-ray-emitting SNR. Methods. We analyzed 252 h of High Energy Stereoscopic System (H.E.S.S.) observations towards SNR N132D that were accumulated between December 2004 and March 2016 during a deep survey of the Large Magellanic Cloud, adding 104 h of observations to the previously published data set to ensure a > 5 sigma detection. To broaden the gamma-ray spectral coverage required for modeling the spectral energy distribution, an analysis of Fermi-LAT Pass 8 data was also included. Results. We unambiguously detect N132D at VHE with a significance of 5.7 sigma. We report the results of a detailed analysis of its spectrum and localization based on the extended H.E.S.S. data set. The joint analysis of the extended H.E.S.S and Fermi-LAT data results in a spectral energy distribution in the energy range from 1.7 GeV to 14.8 TeV, which suggests a high luminosity of N132D at GeV and TeV energies. We set a lower limit on a gamma-ray cutoff energy of 8 TeV with a confidence level of 95%. The new gamma-ray spectrum as well as multiwavelength observations of N132D when compared to physical models suggests a hadronic origin of the VHE gamma-ray emission. Conclusions. S

Published
2021
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40. Assessing nutrition intervention programmes that addressed malnutrition among young children in South Africa between 1994-2010

Author

Iversen, P.O., Marais, D., du Plessis, L., and Herselman, M.

Subjects
Child health services -- Management, Company business management, Agricultural industry, Food/cooking/nutrition, Health
Abstract

Several nutrition intervention programmes have been implemented to alleviate malnutrition among young children in South Africa. However, both nationwide studies and smaller, region-based reports show that many of these programmes have failed to improve nutritional health among the target groups. This is an overview of the most important nutrition intervention programmes implemented in post-apartheid South Africa. It is based on data sampled between 1994 and 2010, and collected from HighWire Press and MEDLINE data bases, local journals, official reports as well as experience gathered over the past two decades. Abstracts and nutrition issues related to chronic and communicable and non-communicable diseases were not included. The main aim of the implemented supplementation programmes after the Second World War was to correct states of undernutrition. However, these efforts did not benefit the disadvantaged groups, particularly the coloureds and the blacks. Following the downfall of the apartheid regime, various nutrition intervention programmes have been implemented with varying degrees of success. These include health facility-based programmes, community-based programmes as well as nutrition promotion strategies. The more holistic approach of the Integrated Nutrition Programme since 1994 is commendable, but programmes have failed to restore adequate growth rates among the impoverished children. Most likely, the failures are not as a result of inappropriate policies and strategies or lack of knowledge about relevant solutions, but rather inadequate implementation and scale of the programmes. In order to ensure a satisfactory improvement in nutritional health in South Africa, the various programmes should undergo regular evaluations to identify pitfalls and shortcomings. The fight against undernutrition and hunger, which are rooted in poverty and social inequalities, remains a major challenge for the South African health authorities. Urgent scale-up of the current nutrition intervention programmes as well as evaluation of their implementation are needed, coupled with strategies for education, skills development, job creation and poverty alleviation. Key words: Children, nutrition, South Africa, supplementation, INTRODUCTION Despite it being more than 15 years after the downfall of the apartheid regime, the nutrition situation of young South African children has not shown significant improvement. It is [...]

Published
2012

41. The effect of human mobility and control measures on the COVID-19 epidemic in China

Author

Kraemer, M U G, Yang, C-H, Gutierrez, B, Wu, C-H, Klein, B, Pigott, D M, du Plessis, L, Faria, N R, Li, R, Hanage, W P, Brownstein, J S, Layan, M, Vespignani, A, Tian, H, Dye, C, Pybus, O G, and Scarpino, S V

Abstract

The ongoing COVID-19 outbreak expanded rapidly throughout China. Major behavioral, clinical, and state interventions have been undertaken to mitigate the epidemic and prevent the persistence of the virus in human populations in China and worldwide. It remains unclear how these unprecedented interventions, including travel restrictions, affected COVID-19 spread in China. We use real-time mobility data from Wuhan and detailed case data including travel history to elucidate the role of case importation on transmission in cities across China and ascertain the impact of control measures. Early on, the spatial distribution of COVID-19 cases in China was explained well by human mobility data. Following the implementation of control measures, this correlation dropped and growth rates became negative in most locations, although shifts in the demographics of reported cases were still indicative of local chains of transmission outside Wuhan. This study shows that the drastic control measures implemented in China substantially mitigated the spread of COVID-19.

Published
2020

42. Constraining the emission geometry and mass of the white Dwarf Pulsar AR Sco

Author

Du Plessis, L., Venter, C., Harding, A.K., Wadiasingh, Z., and 26594080 - Wadiasingh, Zorawar (Supervisor)

Subjects
Astrophysics::Solar and Stellar Astrophysics
Abstract

MSc (Astrophysical Sciences), North-West University, Potchefstroom Campus Marsh et al. (2016) detected radio and optical pulsations from the binary system AR Scorpii (AR Sco). This system, with an orbital period of 3.55 h, is composed of a cool, low-mass M-dwarf and a white dwarf with a spin period of 1.95 min. Buckley et al. (2017) found that the emission from the white dwarf is strongly linearly polarised (up to 40%) with periodically changing intensities. This periodic non-thermal emission is thought to be synchrotron emission (Buckley et al., 2017; Takata et al., 2017) that is powered by the highly magnetised \begin{equation} <> alpha=\left(86.6_{-2.8}^{+3.0}\right)^{\circ} \end{equation} Using these observations, I was able to do rst-order spectral calculations to constrain some of the parameters for the system. Lastly, using phase-resolved optical observations, I was able to obtain and at the di erent orbital phases. Masters

Published
2020

43. Investigate the relationship between production bonuses and productivity of employees in different wage categories

Author

Du Plessis, L., Botha, C.J., and 10201262 - Botha, Christoffel Jacobus (Supervisor)

Subjects
productivity, wage categories, employee motivation, Employee productivity, incentives to motivate, wage level
Abstract

MBA, North-West University, Potchefstroom Campus Platinum mines in South Africa are still very labour-intensive due to conventional mining methods being used. Having employees working in tough environments might cause them to lose motivation, leading to a decrease in productivity. Financial incentives are most commonly used to motivate employees to increase their productivity. The literature study focused on employee productivity, incentives and employee motivation. The factors that influence productivity, the types of incentives used and how employees are motivated were the main focus points. Previous studies with similar objectives were compared to determine whether the results of this study are supported by previous research. A questionnaire was developed based on the literature study to determine which rewards motivate the most and whether production bonuses can be used to motivate employees. The questionnaire also measured the respondents’ opinions regarding rewards and their influence on their productivity. The target population was a platinum mine in the North West province of South Africa. A total of 275 questionnaires were retrieved and used for statistical analysis. Descriptive statistical analysis was done to determine whether the sample was representative of the target population and to describe the sample. Exploratory factor analysis was done to determine the number of constructs identified in this study. These factors were then used together with the frequency data to determine the differences between wage categories. Effect sizes were used to determine the size of the differences between the wage categories. The factors that were identified were productivity, motivation, willingness to do work, section productivity, demotivation and clear targets. The results indicated that rewards had a large positive effect on productivity and motivation and a large negative effect on demotivation. It was also concluded that production bonuses can be used to motivate employees to increase their productivity. Rewards were also a large contributor to employee happiness. The study further concluded that there is a difference in how employees in different wage categories are influenced by production bonuses. Based on the conclusions, recommendations are made to management on how they can use these results to assist in the planning and revising of production bonuses and reward systems. The study was evaluated based on the achievement of the primary and secondary objectives and whether the research question was answered. The study had some limitations, which are discussed before recommendations are made for future studies. Masters

Published
2020

49. Evaluation of two nano-silane-modified emulsion stabilised pavements using accelerated pavement testing.

Author

Rust, F.C., Smit, M.A., Akhalwaya, I., Jordaan, G.J., and du Plessis, L.

Subjects
PAVEMENT testing, ACCELERATED life testing, EMULSIONS, PAVEMENTS, CONSTRUCTION materials, SILANE
Abstract

Upgrading, maintenance and rehabilitation of road infrastructure is expensive, especially in view of the growing scarcity and cost of suitable road building materials. In areas with high mica content and secondary minerals such as smectite in the natural materials, stabilisation with cement is not viable. The Council for Scientific and Industrial Research of South Africa has embarked on a research programme to evaluate the performance of substandard materials improved with anionic nano-silane modified bitumen emulsions for use in base and subbase layers. This work comprises laboratory testing as well as Accelerated Pavement Testing using the Heavy Vehicle Simulator (HVS). The results of a full-scale HVS test on a light pavement as well as initial analysis on a medium traffic road are discussed. It has been shown that stabilisation of available substandard materials using an anionic nano-silane modified bitumen emulsion compared with the standard approach of importing high quality crushed aggregate can lead to savings as high as 40%–50% for equivalent performance. In addition, there was also a significant reduction in construction effort and time. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Uncovering the Nexus between the Informal Waste Economy and Municipal Solid Waste Management in the Mangaung Metropolitan Municipality.

Author

Mofokeng, M., du Plessis, A., and du Plessis, L.

Subjects
SOLID waste, MUNICIPAL solid waste incinerator residues, RECYCLING & the environment, GOVERNMENT policy, GOVERNMENT standards
Abstract

The aim of this article is to explore the untapped potential of the local informal waste economic sector in relation to solid waste management practices in local government. More specifically, it analyses the extent to which the informal waste economy is synchronised with municipal solid waste management policies and strategies. Waste pickers or recyclers play an important role in promoting local economic development. Consequently, waste pickers are not only responsible for recycling useful waste, but they also contribute significantly to the waste economy. The methodological approach of the article entails unobtrusive research methods (conceptual analysis and documentary analysis). It assessed authoritative documents such as official government policy documents, reports, the worldwide web, accredited academic journal articles and other relevant documents applicable to the informal waste economy and solid waste management in local government. The study found that the Mangaung Metropolitan Municipality has focused predominately on solid waste management, with the exclusion of the informal waste economy. This research offers recommendations on how the Mangaung Metropolitan Municipality can formalise the informal waste economy. This article provides a fresh perspective and highlights research gaps on the need to integrate the informal waste economy and municipal solid waste management policies, plans, projects and programmes in the Mangaung Metropolitan Municipality. [ABSTRACT FROM AUTHOR]

Published
2022

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