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3. Preclinical evaluation of methotrexate-loaded polyelectrolyte complexes and thermosensitive hydrogels as treatment for rheumatoid arthritis

Author

Agostini, Sandra Barbosa Neder, primary, Malta, Iago Henrique Silva, additional, Rodrigues, Rafaela Figueiredo, additional, Freitas, Jennifer Tavares Jacon, additional, Lino, Mônica Esselin de Sousa, additional, dos Santos, Rafaela Silva, additional, Elisei, Lívia Silvestre, additional, Moraes, Thamyris Reis, additional, Giusto, Luana Aparecida dos Reis, additional, de Oliveira, Merelym Ketterym, additional, Bassi da Silva, Jéssica, additional, Bruschi, Marcos Luciano, additional, Santos, Aline Martins dos, additional, Nogueira, Denismar Alves, additional, Novaes, Rômulo Dias, additional, Pereira, Gislaine Ribeiro, additional, Galdino, Giovane, additional, and Carvalho, Flávia Chiva, additional

Published
2021
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4. Investigation of the Involvement of the Endocannabinoid System in TENS-Induced Antinociception

Author

de Oliveira, Herick Ulisses, primary, dos Santos, Rafaela Silva, additional, Malta, Iago Henrique Silva, additional, Pinho, José Phellipe, additional, Almeida, Ana Flávia Santos, additional, Sorgi, Carlos Arterio, additional, Peti, Ana Paula Ferranti, additional, Xavier, Gabriela Santos, additional, Reis, Luciana Maria dos, additional, Faccioli, Lúcia Helena, additional, Cruz, Jader dos Santos, additional, Ferreira, Enio, additional, and Galdino, Giovane, additional

Published
2020
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8. Involvement of Spinal Cannabinoid CB 2 Receptors in Exercise-Induced Antinociception.

Author

Dos Santos RS, Sorgi CA, Peti APF, Veras FP, Faccioli LH, and Galdino G

Subjects
Animals, Female, Hyperalgesia metabolism, Indoles pharmacology, Mice, Inbred C57BL, Pain chemically induced, Pain Management, Pain Measurement drug effects, Piperidines pharmacology, Receptor, Cannabinoid, CB1, Arachidonic Acids pharmacology, Endocannabinoids pharmacology, Pain physiopathology, Physical Conditioning, Animal methods, Polyunsaturated Alkamides pharmacology, Receptor, Cannabinoid, CB2 drug effects
Abstract

Muscle pain affects approximately 11-24% of the global population. Several studies have shown that exercise is a non-pharmacological therapy to pain control. It has been suggested that the endocannabinoid system is involved in this antinociceptive effect. However, the participation of this pathway is unclear. The present study aimed to investigate whether spinal cannabinoid CB 2 receptors participate in the exercise-induced antinociception. The inflammatory muscle pain model was induced by the intramuscular injection of carrageenan. Tactile allodynia and thermal hyperalgesia were determined with the von Frey filaments and hot-plate tests. C57BL/6J female mice underwent a swimming training protocol that lasted 3 weeks. This protocol of exercise reduced carrageenan-induced tactile allodynia and thermal hyperalgesia and this effect was prevented by the cannabinoid CB 2 receptors inverse agonist AM630 and potentiated by MAFP (inhibitor of the enzyme that metabolizes endocannabinoids) and minocycline (microglia inhibitor). In addition, exercise increased the endocannabinoid anandamide levels and cannabinoid CB 2 receptors expression whereas it reduced Iba1 (microglial marker) protein expression as well as pro-inflammatory cytokines (TNF-α and IL-1β) in the spinal cord of mice with inflammatory muscle pain. Swimming training also reduced muscle temperature of carrageen-treated animals. The present study suggests that activation of spinal cannabinoid CB 2 receptors and reduction of activated microglia are involved in exercise-induced antinociception., (Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.)

Published
2019
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