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Purpose: To determine whether there are bilateral and interdigit differences in the maximal force production of experienced climbers and whether these differences are mediated by ability level or preferred style of climbing. Methods: Thirty-six male climbers (age 30 [9.4] y) took part in a single-session trial to test their maximal force production on both hands. The tests included a one-arm maximal isometric finger flexor strength test (MIFS) and a one-arm individual MIFS. Bilateral differences were analyzed by strongest hand (defined as the hand that produced the highest MIFS value) and dominance (defined as the writing hand). Results: A pairwise t test found that MIFS was significantly greater for the strongest hand (mean difference = 4.1%, 95% CI, −0.052 to 0.029, P <.001), with handedness explaining 89% of the variation. A 2-way mixed-model analysis of variance determined that there were no interactions between preferred style (bouldering or sport climbing) and MIFS or between ability level (advanced or elite) and MIFS. Conclusions: Climbers have significant finger flexor strength bilateral asymmetries between their strongest and weakest hand. Moreover, when dominance is controlled, this difference in strength is present, with the dominant hand producing more force. Neither preferred style of climbing nor the ability level of the climbers could explain these asymmetries. As such, practitioners should consider regularly monitoring unilateral strength, aiming to minimize the likelihood of large bilateral asymmetry occurring. [ABSTRACT FROM AUTHOR]

Based on the results of ornithological studies, conducted in the Karagai Biosphere Reserve in 2008–2022, a list of bird species has been compiled. It consists of 134 (including 118 breeding or, probably, breeding) species. In 2006, chaffinch and tree pipit dominated in number in forest biotopes. The group of subdominants included willow tit, common chiffchaff, great tit and pied flycatcher. In 2018, most numerous chaffinch and tree pipit slightly outnumbered great tit, common redstart, common chiffchaff, and great spotted woodpecker. In ecological groups, dendrophiles prevailed (63% of all species). The share of limnophiles made up 17%, campophiles and sclerophiles – 10% each. Characteristic of the taiga complex breeding (or expected to nest), species, i.e. hazel grouse, deaf cuckoo, long-tailed and great grey owls, bramble finch, common crossbill, and common bullfinch were encountered.

Wheat stands out as the most extensively cultivated cereal crop and serves as a primary food source across numerous regions worldwide. Therefore, to assess wheat breeding material for sustained food security, an experiment was carried out. The research material comprised 44 genotypes, encompassing 8 lines, 4 testers, and 32 F1 generations utilized for the assessment of various indices, including plant height (PH), flag leaf area (FLA), spikelet per spike (SPS), grain per spike (GPS), spike length (SL), 1000-grain weight (TGW), tillers per plant (TP), grain yield per plant (GYP), biological yield per plant (BYP), harvest index (HI), and relative water content (RWC). The data obtained from the studied attributes underwent an analysis of variance to discern significant differences among the lines and testers for each evaluated trait. The results revealed notable variations, indicating the significance of both genetic factors and environmental conditions on trait expression. Among the evaluated traits, Line (L3) and Tester (T2) consistently demonstrated the genotypes exhibiting good combining ability for both general combining ability (GCA) and specific combining ability (SCA). Such favorable combining ability suggests that the offspring resulting from crosses involving Line L3 and tester T2 are likely to inherit desirable traits for drought tolerance. Particularly, the cross between Line L3 and tester T2 mentioned exceptional performance in most of the studied traits and proved to be a promising combination for withstanding drought conditions. The observed variations in the performance of different lines and testers under different environments emphasize the importance of selecting genotypes with adaptive traits for specific conditions. By examining dominant and additive gene action, researchers can better understand the genetic basis of drought tolerance in wheat. Consequently, the recommendation is to enhance the production of the varieties that are superior performers with improved attributes by focusing on selection in later (F3-F5) segregating generations in the wheat breeding program. [ABSTRACT FROM AUTHOR]

Aggressive interactions can strongly influence an animal's performance in subsequent contests. Winners of aggressive contests are more likely to win successive contests and losers are more likely to lose successive contests. Such winner and loser effects can significantly influence an animal's dominance status, ability to acquire resources and reproductive success. Thus, quantifying the magnitudes of winner and loser effects across taxa is important for our understanding of hierarchy formation, life history trade-offs and reproductive tactics in different species. Furthermore, it is unclear whether the magnitude of winner effects differ from that of loser effects. Finally, experimenters often employ one of two distinct methods for quantifying the strength of winner and loser effects: self-selection and random assignment. Due to selection bias, it is possible that self-selection protocols overestimate the magnitude of winner and loser effects. We therefore systematically searched the literature to conduct a comprehensive meta-analysis of winner and loser effects. We analysed a total of 168 effect sizes from arachnids, crustaceans, fishes, insects, mammals and reptiles. We found that prior winners tend to win approximately two-thirds of their subsequent fights, while prior losers tend to lose approximately two-thirds of their subsequent fights. While we did not find that studies using self-selection generated effect size estimates that significantly differed from random assignment protocols, future studies should still avoid self-selection protocols. Overall, our study highlights the ubiquity of winner and loser effects across the animal kingdom and suggests several avenues for future research to unravel the evolutionary origins and mechanistic underpinnings of such experience effects. • Across taxa, winning increases the odds of winning subsequent fights. • Across taxa, losing increases the odds of losing subsequent fights. • We found no evidence that winner effects differed in magnitude from loser effects. • Self-selection generates similar effect sizes as random assignment protocols. [ABSTRACT FROM AUTHOR]

The forests are major resources for carbon sequestration and help to mitigate the adverse effect of atmospheric carbon and reduce global warming. The present study was conducted to estimate the carbon sequestration potential of the Quercus floribunda forests at two different aspects and three altitudes. Ten quadrates of 10 × 10 m size were laid out in each forest for the estimation of stand density, tree biomass, and soil samples were collected from each quadrate. Q. floribunda was the dominating tree at studied altitudes and aspects with the IVI values of 161.14 and 124.96 in the southern aspect and northern aspects, respectively. the highest values of above-ground biomass density (AGBD), below-ground biomass density (BGBD), total biomass density (TBD), and total carbon density (TCD) was recorded at the upper elevation (2500–2700 m) of southern and northern aspects. In the southern aspect values of AGBD (476.67 < 575.67 Mg/ha), BGBD (124.8 < 148.9 Mg/ha), TBD (601.53 < 724 Mg/ha), TCD (300.83 < 362.03 Mg/ha) were higher than northern aspect. The values of AGBD, BGBD, TBD, and TCD were reported maximum (638 Mg/ha, 163.1 Mg/ha, 800.5 Mg/ha, and 400.35 Mg/ha; respectively) in the upper elevation. Soil organic carbon (SOC), soil organic matter (SOM), and soil organic carbon stock (SOCS) decreased with increasing altitudes and depths which were found higher in the southern aspect. Bulk density (BD) and P increased with altitudes and depth however bulk density was equal (1.29 g cc-1) in both aspects whereas P was also found higher (31.43 kg/ha) in the southern aspect. Highest available nitrogen (398 kg/ha) was recorded in the northern aspect at middle altitude. The available potassium was highest in the northern aspect. At lower altitudes, available potassium ranges between 246–615 kg/ha. Soil pH was found slightly acidic in all the sites ranging from 4.91 to 5.74 in different soil depths. Dehydrogenase activity was ranged between 1.35 and 8.74 µg/g/h from lower to upper soil depth and decreased with an increase in soil depths and increased with altitudes, whereas found highest in the southern aspect. The present study suggested that tree density, tree biomass, carbon sequestration potential, and soil health in Q. floribunda forests were substantially influenced by the altitude as well as the aspect. These findings contribute valuable insights for climate change mitigation and forest management strategies in the study region.

The examination of decision-making styles (DMS) is crucial for understanding how individuals approach choices and form preferences. Two influential frameworks in the DMS discourse, proposed by Scott & Bruce, and Rowe, provide insightful lenses for correlating dominant styles with an array of personal characteristics.

The past decade has seen an explosion in the identification of genetic causes of neurodevelopmental disorders, including Mendelian, de novo, and somatic factors. These discoveries provide opportunities to understand cellular and molecular mechanisms as well as potential gene-gene and gene-environment interactions to support novel therapies. Stem cell-based models, particularly human brain organoids, can capture disease-associated alleles in the context of the human genome, engineered to mirror disease-relevant aspects of cellular complexity and developmental timing. These models have brought key insights into neurodevelopmental disorders as diverse as microcephaly, autism, and focal epilepsy. However, intrinsic organoid-to-organoid variability, low levels of certain brain-resident cell types, and long culture times required to reach maturity can impede progress. Several recent advances incorporate specific morphogen gradients, mixtures of diverse brain cell types, and organoid engraftment into animal models. Together with nonhuman primate organoid comparisons, mechanisms of human neurodevelopmental disorders are emerging.

Introduction: Symbiotic microbial have a significant impact on the growth and metabolism of medicinal plants. Schisandra chinensis is a very functionally rich medicinal herb; however, its microbial composition and diversity have been poorly studied. Methods: In the present study, the core microbiomes associated with the rhizospheric soil, roots, stems, leaves, and fruits of S. chinensis from six geographic locations were analyzed by a macro-genomics approach. Results: Alpha and beta diversity analyses showed that the diversity of microbial composition of S. chinensis fruits did not differ significantly among the geographic locations as compared to that in different plant compartments. Principal coordinate analysis showed that the microbial communities of S. chinensis fruits from the different ecological locations were both similar and independent. In all S. chinensis samples, Proteobacteria was the most dominant bacterial phylum, and Ascomycota and Basidiomycota were the most dominant fungal phyla. Nitrospira, Bradyrhizobium, Sphingomonas, and Pseudomonas were the marker bacterial populations in rhizospheric soils, roots, stems and leaves, and fruits, respectively, and Penicillium, Golubevia, and Cladosporium were the marker fungal populations in the rhizospheric soil and roots, stems and leaves, and fruits, respectively. Functional analyses showed a high abundance of the microbiota mainly in biosynthesis. Discussion: The present study determined the fungal structure of the symbiotic microbiome of S. chinensis, which is crucial for improving the yield and quality of S. chinensis. [ABSTRACT FROM AUTHOR]

Bilateral skill symmetry in sport refers to an individual's ability to successfully perform sporting actions with both sides of the body. Two scarcely researched areas in relation to bilateral skills are the effects of opposition proximity on skill execution and bilateral skill in high-performance female athletes. In this study, we used Nacsport to code all skill executions (hand pass, kick pass, hop, solo and shot) during 121 games by both male and female participants (76 male, 45 female), classified as Tier 1 (n = 181, 134) and Tier 2 (n = 238, 115) high performance, adult Gaelic Football players. Irrespective of the participants' tier group or gender, these players relied upon their dominant side for most skill executions (Kick Pass Dominant Foot Mdn : MT1 = 90%, MT2 = 98.6%, FT1 = 100%, FT2 = 100%; Solo Dominant Foot: Mdn MT1 = 95%, MT2 = 97.3%, FT1: 100%, FT2: 100%; Hand Pass Dominant Hand Mdn : MT1: 83.7%, MT2: 99%, FT1: 95.5%, FT2: 95.5%; Hop Dominant Hand Mdn : MT1: 91.9%, MT2: 94.7%, FT1: 98.1%, FT2: 98.1%; Play Dominant Foot Mdn : MT1: 74.5%, MT2: 94.5%, FT1: 94.7%, FT2: 88.2%). There were no consistent differences between tier groups or genders in relation to dominant side use, but top tier male players were generally less reliant on the dominant limb than were female players from both tiers. In general, top tier male players performed more successfully than either second tier male players or female players in both tiers. Most skills were executed under conditions of low opponent proximity, limiting the requirement for participants to use their non-dominant limbs. These findings illustrate the demands of Gaelic football in relation to bilateral skills, and we identified new research questions for future investigators. [ABSTRACT FROM AUTHOR]

Invasive plant species are often characterized by superior resource acquisition capabilities compared with native species, contributing to their success in new environments. However, the dominance of these species varies, and not all invasive species become dominant, nor are all native species uniformly vulnerable to competitive exclusion. In this study, we analyzed 19 functional traits across 144 herbaceous plant species in Guangzhou, China. The studied species included 31 invasive dominant species (IDS), 19 invasive non-dominant species (INS), 63 native dominant species (NDS), and 31 native non-dominant species (NNS). Our findings reveal no significant differences in functional traits between IDS and INS, indicating a broad trait similarity within invasive categories. Pronounced similarities between invasive species and NDS suggest an ecological equivalency that facilitates successful integration and competition in new habitats. Notable differences in several key traits—height, leaf thickness, leaf water content, stoichiometry, photosynthetic rate, water use efficiency, and nitrogen use efficiency—indicate a competitive superiority in resource acquisition and utilization for invasive species over NNS. These distinctions are vital for understanding the mechanisms driving the success of invasive species and are crucial for developing strategies to manage their impact on native ecosystems. [ABSTRACT FROM AUTHOR]

Copyright of Human Sciences Journal / Revue des Sciences Humaines is the property of Universite des Freres Mentouri Constantine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The research aimed to conduct a thematic analysis of the selected Balti folksongs, with the goal of identifying the dominant themes in these songs and examining how they reflect intricate nuances and values embedded within Balti society. Qualitative research methods were employed, using data meticulously selected from works of Syed Muhammad Abbas Kazmi and Muhammad Abbas Khargrong as primary sources. Moreover, various books and articles were used as supplementary sources. Analysis followed Johnny Saldana's code-to-theory model, involving three stages of coding: first, second, & third cycle coding. Findings revealed that culture, religion, politics, affection, & fidelity are all elements contributing to a balanced & harmonious life in Balti society, providing sense of identity, purpose and stability. Conversely, accusations were found to create conflicts, & disrupt harmony in individuals' lives. Research concludes by suggesting pathways for future researchers to explore interconnections & relations among these dominant features. Translated versions of songs were used to make research accessible to foreign scholars, fostering cross-cultural collaboration across linguistic barriers. [ABSTRACT FROM AUTHOR]

Background: Acute Respiratory Infection (ARI) is a contagious illness affecting diverse age groups, including toddlers, and is among the top ten reasons for Community Health Center visits. Purpose: This study aims to analyze the influence of dominant risk factors on the incidence of ARI in toddlers. Methods: This study used an observational, analytic-cross sectional approach, at Puskesmas Kampung Lalang, Medan, in 2023. The total population was 394 toddlers (aged 0-59 months). In the determination of the number of samples using the sample size estimation formula, 198 samples were obtained by purposive sampling. Data analysis used Chi-Square test and Multiple Logistic Regression Enter Methods, with a significance level of 95%. Results: The results showed that the variables of Vitamin A administration (OR = 0.27, 95% CI: 0.10-0.77) and immunization status (OR = 0.36, 95% CI: 0.14-0.93) were associated with a decreased risk of ARI in toddlers. In contrast, exclusive breastfeeding (OR = 2.35, 95% CI: 1.11-5.01) was associated with increased risk, while the physical environment of the house (OR = 2.92, 95% CI: 1.28-6.64) was associated with increased risk of ARI. Conclusion: Vitamin A administration and immunization reduce the risk of respiratory tract infection among under-fives at Puskesmas Kampung Lalang. Exclusive breastfeeding and home conditions increased the same risk. Improving these risk factors is essential to reduce the prevalence of childhood respiratory infections in the area.

The article proposes a typology of righteous heroes on the material of L. N. Tolstoy’s stories “Father Sergius,” “False Coupon,” “Alyosha the Pot,” and F. M. Dostoevsky’s novels “Teenager,” “The Brothers Karamazov.” The “great sinners” Dostoevsky and Tolstoy have gospel prototypes — the prodigal son and the “prudent thief.” At the same time, both writers have static characters — righteous people carrying Christian ideals. In the later stories of Tolstoy and the novels of Dostoevsky, there is a teleological plot, which includes the plot motifs of the test, the choice of the hero, and his movement toward salvation. Turning to the ethical teaching of A. A. Ukhtomsky, created based on the works of Tolstoy and Dostoevsky, allows us to highlight the dominant character of the hero, which involves the rejection of egocentrism and determines his salvation, as well as the hero’s “doubles” and “interlocutors” who are capable of awakening his selfawareness. A comparison of the reading range of Tolstoy and Dostoevsky shows their attention to the works of John Climacus, Isaac the Syrian, and Tikhon of Zadonsk.

Background: Acute Respiratory Infection (ARI) is a contagious illness affecting diverse age groups, including toddlers, and is among the top ten reasons for Community Health Center visits. Purpose: This study aims to analyze the influence of dominant risk factors on the incidence of ARI in toddlers. Methods: This study used an observational, analytic-cross sectional approach, at Puskesmas Kampung Lalang, Medan, in 2023. The total population was 394 toddlers (aged 0-59 months). In the determination of the number of samples using the sample size estimation formula, 198 samples were obtained by purposive sampling. Data analysis used Chi-Square test and Multiple Logistic Regression Enter Methods, with a significance level of 95%. Results: The results showed that the variables of Vitamin A administration (OR = 0.27, 95% CI: 0.10-0.77) and immunization status (OR = 0.36, 95% CI: 0.14-0.93) were associated with a decreased risk of ARI in toddlers. In contrast, exclusive breastfeeding (OR = 2.35, 95% CI: 1.11-5.01) was associated with increased risk, while the physical environment of the house (OR = 2.92, 95% CI: 1.28-6.64) was associated with increased risk of ARI. Conclusion: Vitamin A administration and immunization reduce the risk of respiratory tract infection among under-fives at Puskesmas Kampung Lalang. Exclusive breastfeeding and home conditions increased the same risk. Improving these risk factors is essential to reduce the prevalence of childhood respiratory infections in the area. [ABSTRACT FROM AUTHOR]

The Reuleng River is a mangrove area located in Aceh Besar district. Environmental changes that occur in the structure and composition of the mangrove ecosystem in the Reuleng River affect the macrozoobenthos conditions in the area. This study aims to determine the structure of the makrozoobenthos community as a biomomonitoring instrument in the mangrove ecosystem area. The study was conducted from February 2021 to May 2021. Determination of the sampling location was carried out using the purposive sampling technique and sampling was determined in three areas, namely upstream, middle stream, and downstream. The results showed that there were 19 species grouped into 4 genera and 12 families. The Macrozoobenthos Diversity Index in the Reuleng River area ranges from 2.62. The species that dominate the mangrove ecosystem area is the Faunus ater species with a dominant index value (0.16) and the lowest dominant species in the mangrove ecosystem is Thalassina anomala (0.01). No specific species were found that dominate the area. Based on descriptive observations, there is a group of Makrozoobenthos that has a relationship with the psychochemical quality of the air. The results show that the balance of the community in the area is still vulnerable and experiencing the impact of environmental pressures. [ABSTRACT FROM AUTHOR]

Copyright of German International Journal of Modern Science / Deutsche Internationale Zeitschrift für Zeitgenössische Wissenschaft is the property of Artmedia24 and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The increasing number of plastic particles in the environment gives rise to a unique ecological niche called the plastisphere, which is characterized by a dynamic assemblage of microorganisms comprising autotrophs, heterotrophs, predators, and pathogens. This paper reviews the formation, characteristics, and factors influencing the terrestrial and aquatic plastisphere. The terrestrial and aquatic plastisphere forms when hitchhiking microorganisms, often bacteria, in the environment adhere to the surfaces of plastic particles and alter the surface properties of the particles for subsequent colonization of increasingly tightly clinging microorganisms. The terrestrial plastisphere is not as mobile as the aquatic plastisphere and is defined by the characteristics of the soil anchoring it. The microorganisms on the plastisphere are often defined by the dominant microorganisms in the surroundings, particularly those of the phyla Proteobacteria, Actinobacteria, Bacteroidota, Firmicutes, Chloroflexi, Acidobacteria, Cyanobacteria, Ascomycota, Basidiomycota, Chytridiomycota, Ciliophora, Ochrophyta, and Chlorophyta. However, the compositions and dominant microbial species on different plastic surfaces vary widely as they change with time, plastic properties, and biotic and abiotic environmental factors. Temporal changes in the plastisphere are due to succession. Plastic properties, particularly the type, surface properties, size, color, degree of aging, and chemical leaching, also affect the composition of the plastisphere. Biotic environmental factors comprising the dominant ambient microorganisms and interspecies interactions, together with the abiotic ones, including pH, temperature, nutrient availability, soil properties, salinity, and light, significantly shape the plastisphere. This review provides insight into the biodiversity of the plastisphere, and its roles in spreading pathogens and degrading plastics. [ABSTRACT FROM AUTHOR]

Background: Biostimulation is a management practice that improves the reproductive parameters, potentiates the desire, and improves the reproductive efficiency during the short breeding season in camels. Aim: This study aims to investigate the concurrent changes in hormonal profiles in response to management and behavioral situations on camel farms in the Eastern region of Saudi Arabia. Methods: A total of 10 male and 50 female camels were used in this study. The hormonal profile of male camels was evaluated weekly starting from December to August. Results: The results show that both serum testosterone and cortisol levels increased (P < 0.01) from December to March compared to April to August. A strong negative correlation was observed between testosterone levels and temperature (r = -0.81, P [Open Vet J 2024; 14(1.000): 108 -115]

ABSTRACTTraditional fermentation using natural microorganisms often results in uncontrolled and inconsistent product quality. Identifying dominant LAB and yeast species through morphological, physiological, and biochemical characterization, this study aimed to optimize the traditional fermentation process of injera dough fermentation. Ersho and dough were prepared in the laboratory, and LAB and yeast were identified and enumerated by smearing on a petri dish at 24-hour intervals from 0 to 96 hours of fermentation. The growth kinetics of both LAB and yeast in fermented teff dough significantly increased (p < 0.05) from 8.91 to 9.97 log CFU/gm and 5.98 to 7.62 log CFU/gm as fermentation time increased. Five dominant LAB species (Lactobacillus fermentum, Lactobacillus Brevis, Lactobacillus Plantarum, Bacillus subtilis, and Enterococcus casseliflavus) and three dominant yeast strains (Saccharomyces cerevisiae, Candida krusei, and Pichia kudriavzevii) were identified. Based on the physicochemical analysis and sensory acceptability result, application of a single starter culture in teff dough fermentation improved fermentation time and acid production.

Background. The topic of synonymy in the Even language has been insufficiently studied so far. The relevance of the study lies primarily in the fact that semantic synonyms have not yet received sufficient coverage in the Even language, while they play an important role in the development of the lexical system of the language. The purpose of the study is to identify the characteristics of the functioning of synonyms in the Even language, which is of value in typological comparative studies of both related and unrelated languages. The novelty is that for the first time in the Even language, semantic synonyms by shades of values are considered on the basis of analysis. Materials and methods. As a source of research, artistic and folklore works, the Even-Russian Dictionary by V.A. Robbek, M.E. Robbek. When studying semantic synonyms of the Even language, the methods of continuous sampling and linguistic analysis was used. Results. Based on the analysis of semantic synonyms in the Even language, it was revealed that they differ in shades of meaning and introduce an additional concept into the disclosure of the expressed reality, being stylistically neutral. Shades of meaning are expressed in the degree of manifestation of the feature, in the scope of the covered phenomena, actions, in abstractness and specificity, in additional meaning. Semantic synonymy is characteristic of parts of speech such as the noun, adjective, verb, adverb. Practical implications. The results of the study can be applied in teaching the Even language, compiling a dictionary of synonyms of the Even language.

Hepatitis C virus (HCV) is a blood-borne pathogen that transmits infection via transfusion. Hepatocellular carcinoma is the fifth most common cancer and a major cause of death in patients with chronic HCV infection. Response to treatment is mainly based on the genotypic characterization of HCV. The gold standard for genotyping HCV is by sequencing highly conserved regions such as NS5, core, E1, and 5’UTR. Serum samples of patients who visited the tertiary care hospital with clinical features suggestive of HCV infection formed the study group. HCV genotyping was performed using multiplex Polymerase Chain Reaction in the samples tested positive by Chemiluminescence Immunoassay (CLIA). The viral loads were also performed on selected patient samples. In the present study, Genotype 4 (35.71%), followed by Genotype 3 (17.53%) and 1 & 1b (12.34%) were the common genotypes observed. Genotype 1,1b & 4 mixed type and genotype 4 and 5 mixed type was detected in one sample each (0.65%). The mean measured value of HCV antibody was 11.51 ± 4.57. The viral load was detected in 61 out of 81 samples tested. The mean viral load ranged from 550 to 552769250IU/ml (log 2.74-log 8.74). Genotype 4 was the most common genotype demonstrated in our study as opposed to the other studies were genotype 3 was the dominant one in south India.

Background: Hypertension is a non-communicable disease with a high morbidity and mortality rate. This disease frequently triggers the iceberg phenomenon as numerous individuals remain unaware of the affliction. Aim: This study determines the most dominant risk factors for the incidence of hypertension. Methods: The quantitative study method used was conducted in September 2022. The study population utilized secondary data sourced from the Visit data at the Johar Baru Health Center in South Jakarta during 2021. The initial dataset consisted of 102,647 patients, out of which 13,946 had hypertension. Furthermore, data analysis involved employing the Chi-square test and Multiple Logistic Regression, with a significance level of 95%. Results: The Chi-Square test yielded significant results, indicating a relationship between risk factors for hypertension and seven out of the nine free variables examined. These variables included Body Mass Index (BMI) (p-value=0.000), excess salt consumption (p-value=0.000), underfeeding fruits and vegetables (p-value=.000), lack of physical activity (p-value=0.000), excess fat consumption (p-value=0.000), gender (p-value=0.000), and age (p-value=0.000), with a p-value of 0.05 had no relationship. Conclusion: The result showed that BMI was the most dominant risk factors for hypertension, with an OR of 1,610. Therefore, people with an abnormal BMI have a 1,610 times risk of developing hypertension.

This paper examines the signifying mechanism of gift-giving in ancient China from the perspective of semiotic rhetoric, aiming to answer the question of what can be regarded as li (roughly meaning ceremony, rite, courtesy, or gift) or, in other words, how the social meaning of gifts is constructed in giving semiosis. It describes four dominant rhetorical devices that existed in ritual and non-ritual gift exchanges in ancient China. The ritual gift tended to adopt simile and conceit as its meaning-construction device, becoming a symbolic good beyond ‘thingness’ and thus fulfilling the sociocultural function of ritual. Non-ritual giving activity made use of semiotic metonymy and synecdoche as a strategy of ‘indirectness’ to maintain the relationship between the giver and receiver in daily communications.

In response to the supernatural occurrences in the Marquis's castle, several characters of Ann Radcliffe's A Sicilian Romance adhere to the tenets of Lockean empiricism to interpret their sensory perception. Conversely, a few characters adopt Cartesian scepticism to dismiss the validity of sensory experience. To date, no exhaustive study of Ann Radcliffe's fiction has inspected the incorporation of Lockean empiricism and the Cartesian method of René Descartes into her novels. By conducting a historical analysis of the philosophical scene of the Enlightenment era, this paper aims to substantiate that not only does A Sicilian Romance encompass seminal philosophical notions of the age of Enlightenment, but it also points to the shifting philosophical scene within this period, characterised by the dominance of empiricism and the residuality of Cartesianism. By examining the reflection of these philosophies in Radcliffe's novel, this article challenges the supposition that the Gothic novel necessarily contains anti-Enlightenment impulses. [ABSTRACT FROM AUTHOR]

Exploring some characteristics of differential subordination and superordination of analytic univalent functions in an open unit disc is the aim of this work and additionally, we have the form's normalized Taylor-Maclaurin series: f(z) = z+ ∑n=2 ∞ anzn. It also aims to clarify the results of the sandwich. By utilizing the integral operator's properties to examine forth-order differential subordination and superordination of analytic univalent functions, some fascinating results are found and explore forth-order subordinations and superordinations in respect to the convolution. Ultimately, we acquired multiple outcomes concerning fourth-order sandwich theorems inside the open unit disk. [ABSTRACT FROM AUTHOR]

The article contains a geobotanical analysis of the types of plant communities with the participation of the rare endemic species Rosa potentilliflora Chrshan. et M. Pop. in the Turgen Gorge of the Trans-Ili Alatau. Rosa potentilliflora Chrshan. et M. Pop. It is rare, has a limited range and is endemic to the forest belt of the Turgen Gorge of the Trans-Ili Alatau. Associations of three plant coenopopulations and the percentage of projective design of vegetation cover are described, divided into tiers of plant communities. Within each cenopopulation, a transect measuring 10×10 m2 was laid out and the age composition of Rosa potentilliflora was determined. The development of the population of this species in the forest zone of the Turgen Gorge of the Trans-Ili Alatau is under normal conditions. In all three coenopopulations, the state of fully mature generative individuals was established, starting with seedlings of the Rosa potentilliflora plant. There is every reason to believe that there is no immediate threat to the Rosa potentilliflora population in the forest belt of the Turgen Gorge of the Trans-Ili Alatau. We were convinced that the species is very rare and occupies a small territory. The main distribution zones have been identified, it has been established that the population grows in the southeastern exposure of the forest belt, the main one is formed for growth only in an environment with good sunlight. [ABSTRACT FROM AUTHOR]

Background: Biostimulation is a management practice that improves the reproductive parameters, potentiates the desire, and improves the reproductive efficiency during the short breeding season in camels. Aim: This study aims to investigate the concurrent changes in hormonal profiles in response to management and behavioral situations on camel farms in the Eastern region of Saudi Arabia. Methods: A total of 10 male and 50 female camels were used in this study. The hormonal profile of male camels was evaluated weekly starting from December to August. Results: The results show that both serum testosterone and cortisol levels increased (p < 0.01) from December to March compared to April to August. A strong negative correlation was observed between testosterone levels and temperature (r = −0.81, p < 0.05), and a similarly robust negative correlation was found between cortisol levels and temperature (r = −0.83, p < 0.05). The dominant rutting males showed higher levels of testosterone than the submissive males. Serum testosterone levels increased (p < 0.01) in males out of rutting after hearing the sounds of other couples before and during mating. Conclusion: Hearing sounds emitted during mating increases the testosterone output, and improves the libido of male camels during the nonrutting period. It is important to keep two individually housed males for mating purposes. One male joins the herd alone in winter (winter rutter), and the other joins in spring (spring rutter), this could keep the libido extended rutting and improve the reproductive performance in camel herds. [ABSTRACT FROM AUTHOR]

Modern genetics research increasingly reveals that what is commonly termed Mendelian genetics occurs rarely in nature, especially with regard to the effects that genetic variation exerts on human characteristics. It has been argued that an inappropriate emphasis on Mendel’s work could distort the public understanding of genetics and indeed in the UK Mendel has been completely dropped from the official school syllabus. There is a widespread misunderstanding that Mendel studied common phenotypes such as height and colour in individual pea plants. In fact, he studied a handful of specially selected phenotypes which he observed to be always dichotomous in 22 specially bred varieties of pea and studied crosses between individuals from these different varieties. This approach enabled him to study a small number of phenotypes which did in fact exhibit truly Mendelian transmission. Modern molecular genetic studies have now demonstrated that these phenotypes result from loss of function variants which result in markedly reduced activity of specific proteins and which hence have recessive effects. Understanding that Mendel studied the effects of loss of function mutations in crosses between artificially bred varieties, rather than naturally occurring variation in a population, could allow his work to continue to be taught as part of a modern genetics curriculum. [ABSTRACT FROM AUTHOR]

The inland waters of Northern Kazakhstan are important components of the ecosystems of this region and have unique characteristics. Endorheic steppe lakes are important ecosystems with significant ecological value. They play an important role in maintaining biodiversity, they provide water resources for living organisms, they serve as breeding and migration sites for various animal species, and their zooplankton communities have a key role in the trophic web of these waters. Therefore, the purpose of this work is to study the diversity of zooplankton communities in some small steppe lakes in the northern part of Kazakhstan (Pavlodar, Kostanay, North Kazakhstan, and Akmola regions), which have different environmental conditions. Sampling to study the species diversity of zooplankton in the steppe water bodies of Northern Kazakhstan was carried out from 13 areas, 12 of which are plain lakes, and 1 of which is a reservoir, and sampling was performed in 2021 and 2022 during in the spring, summer, and autumn periods. Within the research period of 2021–2022, between 6 and 36 species of zooplankton were found in small steppe lakes. A total of 92 taxa were found. Rotifers (46 taxa) were found to have the richest number of species representatives. Cladocera were represented by 21 taxa, and Copepods by 25 taxa. All studied steppe lakes in the northern part of Kazakhstan are characterized by high specificity in terms of taxonomic composition, since the similarity indices did not exceed 0.632. According to cluster analysis, the studied samples of water bodies are divided into five clusters, in which lakes with a relatively similar taxonomic composition are combined. The halophile species (e.g., Arctodiaptomus salinarus) indicate water salinization. Our results confirm the applicability of the use of zooplankton in assessing water quality and the current ecological state of aquatic ecosystems. [ABSTRACT FROM AUTHOR]

Cases of Leber congenital amaurosis caused by mutations in CRX (LCA7) exhibit an early form of the disease and show signs of significant photoreceptor dysfunction and eventual loss. To establish a translational in vitro model system to study gene-editing-based therapies, we generated LCA7 retinal organoids harboring a dominant disease-causing mutation in CRX. Our LCA7 retinal organoids develop signs of immature and dysfunctional photoreceptor cells, providing us with a reliable in vitro model to recapitulate LCA7. Furthermore, we performed a proof-of-concept study in which we utilize allele-specific CRISPR/Cas9-based gene editing to knock out mutant CRX and saw moderate rescue of photoreceptor phenotypes in our organoids. This work provides early evidence for an effective approach to treat LCA7, which can be applied more broadly to other dominant genetic diseases.

Most patients with autosomal dominant hyper-IgE syndrome (AD-HIES) carry rare heterozygous STAT3 variants. Only six of the 135 in-frame variants reported have been experimentally shown to be dominant negative (DN), and it has been recently suggested that eight out-of-frame variants operate by haploinsufficiency. We experimentally tested these 143 variants, 7 novel out-of-frame variants found in HIES patients, and other STAT3 variants from the general population. Strikingly, all 15 out-of-frame variants were DN via their encoded (1) truncated proteins, (2) neoproteins generated from a translation reinitiation codon, and (3) isoforms from alternative transcripts or a combination thereof. Moreover, 128 of the 135 in-frame variants (95%) were also DN. The patients carrying the seven non-DN STAT3 in-frame variants have not been studied for other genetic etiologies. Finally, none of the variants from the general population tested, including an out-of-frame variant, were DN. Overall, our findings show that heterozygous STAT3 variants, whether in or out of frame, underlie AD-HIES through negative dominance rather than haploinsufficiency.

The aim of this study was to determine the dominant and non-dominant foot data in young soccer players and to investigate their relationship with each other. For this purpose, 14 healthy young male soccer players participated in the study. The mean age of the participants was 16.50± 1.09 years, mean height was 175.64± 5.48 cm, and mean body weight was 65.64± 9.47 kg. The study protocol was approved by the ethics committee of Selçuk University, Faculty of Sport Sciences. Dynamic balance tests with eyes open (GA) and eyes closed (SC) were used to evaluate the balance performances of the athletes. In the data obtained as a result of the tests, the significance of the difference between the dominant and non-dominant foot static balance parameters of the soccer players was tested with Paired Sample T test. While there was no difference in dynamic balance parameters in all values of dominant and non-dominant leg, significant differences were found in all parameters except ML parameter in dynamic balance tests performed with eyes open and eyes closed.

The population assemblage of Drosophilidae in the four districts of North Western Ghats was analysed. A total of 13,604 individuals comprising 17 species collected from 8 localities during the period of 2021–22 across various seasons. The study highlights the dominance of three species (Drosophila bipectinata Duda, D. malerkotliana Parshad & Paika and D. eugracilis Bock & Wheeler) belonging to ananassae and eugracilis subgroups. Overall collection data revealed the highest species richness and diversity for Dharwad and UK interior forests, whereas the maximum abundance and the highest evenness were observed in UK coastal and Belagavi forests respectively. The species rank-abundance curve revealed Dharwad forest had higher species richness and comparatively stable species assemblage. Drosophila eugracilis was the dominant species in localities of Dharwad and Belagavi forests, whereas D. bipectinata was the dominant species in both coastal and interior localities of UK forests. Rare faction curves plotted across the different seasons for all the forest localities revealed population assemblage and species richness of all forests across different seasons. Morisita index of similarities showed similarities for populations across localities and seasons. Nonparametric independent sample Kruskal-Wallis test was done to test distribution of abundance of individual species across spatial and temporal groups. The study reveals variation of population assemblage across the forests of Dharwad, Belagavi, and Uttara Kannada (coastal and interior) and dominance of D. bipectinata, D. malerkotliana and D. eugracilis.

The proportion of variation in complex traits that can be attributed to non-additive genetic effects has been a topic of intense debate. The availability of biobank-scale datasets of genotype and trait data from unrelated individuals opens up the possibility of obtaining precise estimates of the contribution of non-additive genetic effects. We present an efficient method to estimate the variation in a complex trait that can be attributed to additive (additive heritability) and dominance deviation (dominance heritability) effects across all genotyped SNPs in a large collection of unrelated individuals. Over a wide range of genetic architectures, our method yields unbiased estimates of additive and dominance heritability. We applied our method, in turn, to array genotypes as well as imputed genotypes (at common SNPs with minor allele frequency [MAF] > 1%) and 50 quantitative traits measured in 291,273 unrelated white British individuals in the UK Biobank. Averaged across these 50 traits, we find that additive heritability on array SNPs is 21.86% while dominance heritability is 0.13% (about 0.48% of the additive heritability) with qualitatively similar results for imputed genotypes. We find no statistically significant evidence for dominance heritability (p

Many neuromuscular disorders are caused by dominant missense mutations that lead to dominant-negative or gain-of-function pathology. This category of disease is challenging to address via drug treatment or gene augmentation therapy because these strategies may not eliminate the effects of the mutant protein or RNA. Thus, effective treatments are severely lacking for these dominant diseases, which often cause severe disability or death. The targeted inactivation of dominant disease alleles by gene editing is a promising approach with the potential to completely remove the cause of pathology with a single treatment. Here, we demonstrate that allele-specific CRISPR gene editing in a human model of axonal Charcot-Marie-Tooth (CMT) disease rescues pathology caused by a dominant missense mutation in the neurofilament light chain gene (NEFL, CMT type 2E). We utilized a rapid and efficient method for generating spinal motor neurons from human induced pluripotent stem cells (iPSCs) derived from a patient with CMT2E. Diseased motor neurons recapitulated known pathologic phenotypes at early time points of differentiation, including aberrant accumulation of neurofilament light chain protein in neuronal cell bodies. We selectively inactivated the disease NEFL allele in patient iPSCs using Cas9 enzymes to introduce a frameshift at the pathogenic N98S mutation. Motor neurons carrying this allele-specific frameshift demonstrated an amelioration of the disease phenotype comparable to that seen in an isogenic control with precise correction of the mutation. Our results validate allele-specific gene editing as a therapeutic approach for CMT2E and as a promising strategy to silence dominant mutations in any gene for which heterozygous loss-of-function is well tolerated. This highlights the potential for gene editing as a therapy for currently untreatable dominant neurologic diseases.

Key messageA common bean shattering-resistance allele of PvPdh1 reduces pod twists during dehiscence, shows dominance that varies by phenotyping method, is part of a selective sweep, and can be introgressed using CAPS markers. Some varieties of common bean (Phaseolus vulgaris L.) suffer from pod shattering, which can severely reduce yields, especially in arid conditions. The PvPdh1 locus on chromosome Pv03 has recently been described as a major locus controlling pod shattering in common bean and could be used to mitigate pod shattering in the future. Despite this, the role of a possible second locus on chromosome Pv08 remains unclear and patterns of dominance and epistasis between alleles of these genes have not been resolved. This information will be vital for efficient selection to decrease pod shattering. Further, the genetic diversity around the PvPdh1 gene has not yet been thoroughly explored, and there are not yet genetic screens that can be used to evaluate pod shattering in segregating populations. Here, we have developed a recombinant inbred population to determine the roles of genes implicated in pod shattering and evaluate the patterns of dominance among the relevant alleles. Our results suggest that a PvPdh1 allele reduces pod valve twisting, and its dominance varies by phenotyping method. This allele is the only genetic variant that provides environmentally stable and widespread resistance to pod shattering in Middle American common beans grown for grain. Further analyses identified a selective sweep around PvPdh1 with greater nucleotide diversity in individuals with the ancestral, shattering-susceptible allele. Finally, we developed simple, effective CAPS markers to facilitate the introgression of PvPdh1 into new varieties of common bean. These genetic resources will be critical for improving the aridity resilience of a major global staple.

Background: Hypertension is a non-communicable disease with a high morbidity and mortality rate. This disease frequently triggers the iceberg phenomenon as numerous individuals remain unaware of the affliction. Aim: This study determines the most dominant risk factors for the incidence of hypertension. Methods: The quantitative study method used was conducted in September 2022. The study population utilized secondary data sourced from the Visit data at the Johar Baru Health Center in South Jakarta during 2021. The initial dataset consisted of 102,647 patients, out of which 13,946 had hypertension. Furthermore, data analysis involved employing the Chi-square test and Multiple Logistic Regression, with a significance level of 95%. Results: The Chi-Square test yielded significant results, indicating a relationship between risk factors for hypertension and seven out of the nine free variables examined. These variables included Body Mass Index (BMI) (p-value=0.000), excess salt consumption (p-value=0.000), underfeeding fruits and vegetables (p-value=.000), lack of physical activity (pvalue= 0.000), excess fat consumption (p-value=0.000), gender (pvalue= 0.000), and age (p-value=0.000), with a p-value of <0.05. Meanwhile, smoking (p-value=0.516) and drinking alcohol (p-value=0.859) variables, with a p-value of >0.05 had no relationship. Conclusion: The result showed that BMI was the most dominant risk factors for hypertension, with an OR of 1,610. Therefore, people with an abnormal BMI have a 1,610 times risk of developing hypertension. [ABSTRACT FROM AUTHOR]

Hepatitis C virus (HCV) is a blood-borne pathogen that transmits infection via transfusion. Hepatocellular carcinoma is the fifth most common cancer and a major cause of death in patients with chronic HCV infection. Response to treatment is mainly based on the genotypic characterization of HCV. The gold standard for genotyping HCV is by sequencing highly conserved regions such as NS5, core, E1, and 5’UTR. Serum samples of patients who visited the tertiary care hospital with clinical features suggestive of HCV infection formed the study group. HCV genotyping was performed using multiplex Polymerase Chain Reaction in the samples tested positive by Chemiluminescence Immunoassay (CLIA). The viral loads were also performed on selected patient samples. In the present study, Genotype 4 (35.71%), followed by Genotype 3 (17.53%) and 1 & 1b (12.34%) were the common genotypes observed. Genotype 1,1b & 4 mixed type and genotype 4 and 5 mixed type was detected in one sample each (0.65%). The mean measured value of HCV antibody was 11.51 ± 4.57. The viral load was detected in 61 out of 81 samples tested. The mean viral load ranged from 550 to 552769250IU/ml (log 2.74-log 8.74). Genotype 4 was the most common genotype demonstrated in our study as opposed to the other studies were genotype 3 was the dominant one in south India. [ABSTRACT FROM AUTHOR]

Genetic testing has increased the number of variants identified in disease genes, but the diagnostic utility is limited by lack of understanding variant function. CARD11 encodes an adaptor protein that expresses dominant-negative and gain-of-function variants associated with distinct immunodeficiencies. Here, we used a "cloning-free" saturation genome editing approach in a diploid cell line to simultaneously score 2,542 variants for decreased or increased function in the region of CARD11 associated with immunodeficiency. We also described an exon-skipping mechanism for CARD11 dominant-negative activity. The classification of reported clinical variants was sensitive (94.6%) and specific (88.9%), which rendered the data immediately useful for interpretation of seven coding and splicing variants implicated in immunodeficiency found in our clinic. This approach is generalizable for variant interpretation in many other clinically actionable genes, in any relevant cell type.

Mutations in the calcium-binding protein calsequestrin cause the highly lethal familial arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In vivo, calsequestrin multimerizes into filaments, but there is not yet an atomic-resolution structure of a calsequestrin filament. We report a crystal structure of a human cardiac calsequestrin filament with supporting mutational analysis and in vitro filamentation assays. We identify and characterize a new disease-associated calsequestrin mutation, S173I, that is located at the filament-forming interface, and further show that a previously reported dominant disease mutation, K180R, maps to the same surface. Both mutations disrupt filamentation, suggesting that disease pathology is due to defects in multimer formation. An ytterbium-derivatized structure pinpoints multiple credible calcium sites at filament-forming interfaces, explaining the atomic basis of calsequestrin filamentation in the presence of calcium. Our study thus provides a unifying molecular mechanism through which dominant-acting calsequestrin mutations provoke lethal arrhythmias.