1. The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals.
- Author
-
Gong, Tong, Karlsson, Robert, Yao, Shuyang, Magnusson, Patrik K E, Ajnakina, Olesya, Steptoe, Andrew, Bhatta, Laxmi, Brumpton, Ben, Kumar, Ashish, Mélen, Erik, team, 23andMe research, Lin, Keng-Han, Tian, Chao, Fall, Tove, and Almqvist, Catarina
- Subjects
- *
GENOME-wide association studies , *TYPE 2 diabetes , *GENETIC variation , *SINGLE nucleotide polymorphisms , *LINKAGE disequilibrium , *FIXED effects model - Abstract
Dog ownership has been associated with several complex traits, and there is evidence of genetic influence. We performed a genome-wide association study of dog ownership through a meta-analysis of 31,566 Swedish twins in 5 discovery cohorts and an additional 65,986 European-ancestry individuals in 3 replication cohorts from Sweden, Norway, and the United Kingdom. Association tests with >7.4 million single-nucleotide polymorphisms were meta-analyzed using a fixed effect model after controlling for population structure and relatedness. We identified 2 suggestive loci using discovery cohorts, which did not reach genome-wide significance after meta-analysis with replication cohorts. Single-nucleotide polymorphism-based heritability of dog ownership using linkage disequilibrium score regression was estimated at 0.123 (CI 0.038–0.207) using the discovery cohorts and 0.018 (CI −0.002 to 0.039) when adding in replication cohorts. Negative genetic correlation with complex traits including type 2 diabetes, depression, neuroticism, and asthma was only found using discovery summary data. Furthermore, we did not identify any genes/gene-sets reaching even a suggestive level of significance. This genome-wide association study does not, by itself, provide clear evidence on common genetic variants that influence dog ownership among European-ancestry individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF