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Around a half of the people around the world are infected with H. pylori. Diseases related to this infection are treated by general practice (GP) doctors, doctors of internal medicine, pediatricians and gastroenterologists . The aim of this study is to evaluate gastroenterology and GP doctors' view on the H. pylori role in the development of most common gastric and duodenal diseases, their diagnostics and treatment tactics. The objectives of the study: to evaluate doctors' view towards H. pylori infection role in the developement of most common gastric and duodenal diseases, their diagnostics and treatments tactics and to compare the results with a similar study which was conducted in 1998. Methods and participants: 94 doctors - 42 gastroenterologists and 52 GP doctors - from different medical institutions around Lithuania completed a questionnaire. Chi-square test was applied to identify the statistical strenght of the relationship, while data was considered statistically significant, when p < 0,05. Results: gastroenterologists and GP doctors' view towards the H. pylori infection and gastroduodenal pathology caused by the infection was statistically significantly different (p

The development of new and useful pharmaceutical drugs is essential in order to improve the quality of drug therapeutics. Clinical trials play a central role in drug development. Over time, the clinical trial infrastructure has improved and is now integrating the contribution of clinical research coordinators (CRC). Nevertheless, the attitude of doctors towards clinical trials still favors conventional/historical methodologies. In the present study, we explored the view of doctors towards clinical trials for drug development, in order to improve communication among participants, sponsors, and investigators. A questionnaire was designed for this pilot study. The questionnaire included general attitudes, difficult points, the benefit of doctors in participating as investigators, special attention requirements, and the expected role of CRC in clinical trials for drug approval. In addition, the appropriate use of the outpatient clinic was examined. The questionnaire was provided to doctors in each department of Tokushima University Hospital in 2000 and 2004. Because of the small number of subjects included in this pilot study, no statistical analysis is presented. A total of 89 (81%) and62 (56%) doctors among 110 responded to the survey in 2000 and 2004, respectively. Inquiries about the familiarity of the physicians with clinical trials for drug approval revealed that 84% in 2000 and 66% in 2004 were aware of such trials. The attitude towards participating as investigators in the clinical trials was favorable, with a response of 66% in 2000 and 58% in 2004. Patients’ refusal and the informed consent process were considered difficult areas by many doctors. Expected roles of CRC included activities based on the nurse’s specialty. Although many doctors agreed to take care of the study participants separately from the clinical practice, they lacked the time to do so. In spite of the doctors’ workload reduction by introduction of the CRC concept, their views regarding clinical trials for drug approval remain conventional. Further refinement in the support process by CRC should be considered in our hospital, and the views of the doctors should be investigated in a larger study, in order to promote clinical trials for drug approval in Japan.