1. Late Bedtime and Altered Diurnal Axial Length Rhythms of the Eye.
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Liu, Xiao Nicole, Yap, Stephanie Ee Leen, Chen, Xiao-Yu Eric, Philip, Krupa, Naduvilath, Thomas John, and Sankaridurg, Padmaja R.
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SLEEP quality , *CIRCADIAN rhythms , *YOUNG adults , *REFRACTIVE errors , *CHRONOTYPE - Abstract
AbstractPurposeMethodsResultsConclusionsAffecting one-third of the population worldwide and increasing, the sight-threatening condition myopia is causing a significant socio-economic burden. To better understand its etiology, recent studies investigated the role of ocular and systemic rhythms, yet results are conflicting. Here we profiled 24-h variations of axial length of the eye and salivary melatonin concentration in young adults with and without myopia and explored the potential impacts of bedtime on these rhythms.A total of 25 healthy young adults (age 25.0 ± 4.8 years, 13 females) completed this study, including 13 myopes (mean spherical equivalent refractive error −2.93 ± 1.46 diopters) and 12 non-myopes (0.14 ± 0.42 diopters). Saliva sample collection and axial length measurements were repeated for seven times over 24 h starting from 8 am. Information on sleep and chronotype was collected at first visit with the Pittsburgh Sleep Quality Index and the Morningness-Eveningness Questionnaire.Significant diurnal rhythms of axial length and salivary melatonin concentration were identified in both refractive groups (both
p < 0.001), with no myopia-related rhythm difference (interaction of measurement time-point × myopia,p = 0.9). Late bedtime was associated with altered rhythms (p = 0.009) and smaller diurnal change (p = 0.01) in axial length. Elevated melatonin levels were observed in myopes (p = 0.006) and in late sleepers (p = 0.017).These findings suggest that sleep/wake cycles may be involved in the regulation of axial length rhythms. Further research is needed to determine if there exists a causal relationship between the two. [ABSTRACT FROM AUTHOR]- Published
- 2024
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