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In dogs, myocardial injury (MI) is a poorly characterized clinical entity; therefore, this study aimed to provide a detailed description of dogs affected by this condition. Dogs diagnosed with MI according to the concentration of cardiac troponin I (cTnI) were retrospectively searched. Signalment, diagnostic, therapeutic, and outcome data were retrieved. Dogs were divided into six echocardiographic (dilated cardiomyopathy phenotype; hypertrophic cardiomyopathy phenotype; hypertrophic cardiomyopathy phenotype with systolic dysfunction; abnormal echogenicity only; endocarditis; and no echocardiographic abnormalities suggestive of MI), four electrocardiographic (abnormalities of impulse formation; abnormalities of impulse conduction; abnormalities of ventricular repolarization; and no electrocardiographic abnormalities suggestive of MI), and nine etiological (infective; inflammatory; neoplastic; metabolic; toxic; nutritional; immune-mediated; traumatic/mechanical; and unknown) categories. Statistical analysis was performed to compare cTnI values among different categories and analyze survival. One hundred two dogs were included. The median cTnI value was 3.71 ng/mL (0.2–180 ng/mL). Echocardiographic and electrocardiographic abnormalities were documented in 86 of 102 and 89 of 102 dogs, respectively. Among echocardiographic and electrocardiographic categories, the dilated cardiomyopathy phenotype (n = 52) and abnormalities of impulse formation (n = 67) were overrepresented, respectively. Among dogs in which a suspected etiological trigger was identified (68/102), the infective category was overrepresented (n = 20). Among dogs belonging to different echocardiographic, electrocardiographic, and etiological categories, cTnI did not differ significantly. The median survival time was 603 days; only eight of 102 dogs died due to MI. Dogs with MI often have an identifiable suspected trigger, show various echocardiographic and electrocardiographic abnormalities, and frequently survive to MI-related complications. [ABSTRACT FROM AUTHOR]

The existence of morphological defects in the heart or large vessels present at birth is characterized as congenital heart disease and is considered rare when compared to acquired heart diseases. These changes can cause clinical, anatomical and hemodynamic changes in the patient, making an assertive diagnosis necessary to guarantee a better prognosis for the patient. Among congenital heart diseases, we can mention ventricular septal defect and patent ductus arteriosus, in which the first condition is quite common in felines and the second is considered rare in these animals. The objective of this work is to describe the case of a feline, of mixed breed, of approximately one month of age with a history of apathy, prostration and acute breathing difficulty. Physical examination revealed inspiratory and expiratory dyspnea, pale oral and ocular mucous membranes, increased heart and respiratory rate, cachexia and dehydration. On cardiac and pulmonary field auscultation, there was marked muffling and significant radiographic pleural effusion was observed. After drainage, grade IV / VI systolic murmur was noted on auscultation and generalized cardiomegaly on radiographic examination. Doppler echocardiography revealed ventricular septal defect in the perimembranous region and persistence of the arterial duct was suspected, as well as signs of dilated cardiomyopathy phenotype. The animal was euthanized and the aforementioned changes were confirmed in a post-mortem examination. [ABSTRACT FROM AUTHOR]

A six-year-old Cavalier King Charles spaniel was referred with a two-month history of severe exercise intolerance and syncope. Clinical signs had developed during a local wave of coronavirus disease (COVID-19) two weeks after its family members had manifested symptoms of this viral disease and their positivity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed. Cardiologic assessment documented myocardial injury complicated by systolic dysfunction. An extensive diagnostic work-up allowed us to rule out common causes of myocardial compromise, both infective and not. Accordingly, serological and molecular tests aimed at diagnosing SARS-CoV-2 infection were subsequently performed, especially in light of the dog’s peculiar history. Results of such tests, interpreted in the light of previous findings and current knowledge from human medicine, supported a presumptive diagnosis of COVID-19-associated myocardial injury, a clinical entity hitherto poorly described in this species.

Simple Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, is continuing to spread worldwide. As with many emerging infectious diseases, COVID-19 is of zoonotic origin, meaning that animals are susceptible to infection, including domestic pets such as dogs. Despite epidemiological surveys conducted in dogs living either in SARS-CoV-2-positive households or in geographic areas affected by COVID-19 steadily increasing, clinical reports aimed at characterising disease manifestation are currently scant in this species. This case report accurately describes the development of myocardial injury complicated by left ventricular systolic dysfunction in a SARS-CoV-2-positive dog. Interestingly, the clinical picture described herein closely resembles the cardiological compromise documented in SARS-CoV-2-positive humans and can therefore contribute to filling the current knowledge gap that exists between human and veterinary medicine concerning COVID-19. A six-year-old Cavalier King Charles spaniel was referred with a two-month history of severe exercise intolerance and syncope. Clinical signs had developed during a local wave of coronavirus disease (COVID-19) two weeks after its family members had manifested symptoms of this viral disease and their positivity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed. Cardiologic assessment documented myocardial injury complicated by systolic dysfunction. An extensive diagnostic work-up allowed us to rule out common causes of myocardial compromise, both infective and not. Accordingly, serological and molecular tests aimed at diagnosing SARS-CoV-2 infection were subsequently performed, especially in light of the dog's peculiar history. Results of such tests, interpreted in the light of previous findings and current knowledge from human medicine, supported a presumptive diagnosis of COVID-19-associated myocardial injury, a clinical entity hitherto poorly described in this species. [ABSTRACT FROM AUTHOR]