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4 results on '"diagnostic imaging [Attention Deficit Disorder with Hyperactivity]"'

1. Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder

Author

Mara Parellada, Kerstin Konrad, Mark A. Bellgrove, Stefan Ehrlich, Thomas Frodl, Ruth O'Gorman Tuura, Evdokia Anagnostou, J. Antoni Ramos-Quiroga, David Coghill, Clyde Francks, Georgii Karkashadze, Damien A. Fair, Francisco X. Castellanos, Oscar Vilarroya, Eugenio H. Grevet, Yash Patel, Eileen Daly, Clodagh M. Murphy, Klaus-Peter Lesch, Kirsten O'Hearn, Claiton H.D. Bau, Jeffery N. Epstein, Daan van Rooij, Liesbeth Reneman, Eileen Oberwelland-Weiss, Timothy J. Silk, Yanli Zhang-James, Christine M. Freitag, Jane McGrath, Tomáš Paus, Jan Haavik, Louise Gallagher, Ting Li, Merel Postema, Celso Arango, Barbara Franke, Sara Calderoni, Jaap Oosterlaan, Andreas Reif, Paulo Mattos, Iva Ilioska, Leanne Tamm, Paul M. Thompson, Joost Janssen, Pieter J. Hoekstra, Neda Jahanshad, Jacqueline Fitzgerald, Odile A. van den Heuvel, Pedro G.P. Rosa, Tobias Banaschewski, Joseph A. King, Katya Rubia, Christine Deruelle, Marieke Klein, Stephen V. Faraone, Philip Shaw, Premika S.W. Boedhoe, Kerstin Jessica Plessen, Luisa Lázaro, Alessandra Retico, Jan K. Buitelaar, Paul Pauli, Guillaume Auzias, Joel T. Nigg, Christine Ecker, Annette Conzelmann, Jonna Kuntsi, Sarah Durston, Beatriz Luna, Silvia Brem, Marlene Behrmann, Jason P. Lerch, Susanne Walitza, Martine Hoogman, Filippo Muratori, Ilan Dinstein, Rosa Calvo, Mario Rodrigues Louzã, Geraldo F. Busatto, Daniel Brandeis, Institut de Neurosciences de la Timone (INT), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Neurology, Autism Spectrum Disorder, [SDV]Life Sciences [q-bio], CHILDREN, Review Article, 0302 clinical medicine, Transtorno do espectro autista, pathology [Brain], 130 000 Cognitive Neurology & Memory, GENETIC INFLUENCES, Neurociències, Multicenter Studies as Topic, Review Articles, Mapeamento encefálico, ComputingMilieux_MISCELLANEOUS, LIFE-SPAN, neuroimaging, Radiological and Ultrasound Technology, Consórcios de saúde, 05 social sciences, ENIGMA, Brain, 220 Statistical Imaging Neuroscience, Transtorno do déficit de atenção com hiperatividade, Autism spectrum disorders, Cerebral cortex, Trastorns de l'espectre autista, 3. Good health, IMAGING FINDINGS, Escorça cerebral, cortex, Autism spectrum disorder, Cortex, Trastorns per dèficit d'atenció amb hiperactivitat en els adults, Anatomy, Psychology, diagnostic imaging [Autism Spectrum Disorder], Clinical psychology, medicine.medical_specialty, DEFICIT HYPERACTIVITY DISORDER, BRAIN ABNORMALITIES, ADHD, ASD, subcortical volumes, Brain Structure and Function, Neuroimaging, pathology [Autism Spectrum Disorder], behavioral disciplines and activities, 050105 experimental psychology, 03 medical and health sciences, mental disorders, medicine, Attention deficit hyperactivity disorder, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, ddc:610, diagnostic imaging [Brain], METAANALYSIS, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Neurosciences, pathology [Attention Deficit Disorder with Hyperactivity], medicine.disease, Mental health, Subcortical volumes, Attention Deficit Disorder with Hyperactivity, Attention deficit disorder with hyperactivity in adults, Autism, diagnostic imaging [Attention Deficit Disorder with Hyperactivity], Neurology (clinical), Working group, 170 000 Motivational & Cognitive Control, CORTICAL THICKNESS, 030217 neurology & neurosurgery
Abstract

Human brain mapping 43(1), 37-55 (2022). doi:10.1002/hbm.25029 special issue: "Special Issue: The ENIGMA Consortium: the first 10 years / Issue Edited by: P.M. Thompson, N. Jahanshad, L. Schmaal, J.A. Turner, A. Winkler, S.I. Thomopoulos, G.F. Egan, P. Kochunov", Published by Wiley-Liss, New York, NY

Published
2022

2. Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders

Author

Committee, Writing, Disorder, Autism Spectrum, French, Leon, Grevet, Eugenio H, Groenewold, Nynke A, Grotegerd, Dominik, Gruber, Oliver, Gruner, Patricia, Guerrero-Pedraza, Amalia, Gur, Raquel E, Gur, Ruben C, Haar, Shlomi, Haarman, Bartholomeus C M, Thomopoulos, Sophia I, Haavik, Jan, Hahn, Tim, Hajek, Tomas, Harrison, Benjamin J, Harrison, Neil A, Hartman, Catharina A, Whalley, Heather C, Heslenfeld, Dirk J, Hibar, Derrek P, Hilland, Eva, Pozzi, Elena, Hirano, Yoshiyuki, Ho, Tiffany C, Hoekstra, Pieter J, Hoekstra, Liesbeth, Hohmann, Sarah, Hong, L. E., Höschl, Cyril, Høvik, Marie F, Howells, Fleur M, Nenadic, Igor, Abe, Yoshinari, Jalbrzikowski, Maria, James, Anthony C, Janssen, Joost, Jaspers-Fayer, Fern, Xu, Jian, Jonassen, Rune, Karkashadze, Georgii, King, Joseph A, Kircher, Tilo, Kirschner, Matthias, Abé, Christoph, Koch, Kathrin, Kochunov, Peter, Kohls, Gregor, Konrad, Kerstin, Krämer, Bernd, Krug, Axel, Kuntsi, Jonna, Kwon, Jun Soo, Landén, Mikael, Landrø, Nils I, Anticevic, Alan, Lazaro, Luisa, Lebedeva, Irina S, Leehr, Elisabeth J, Lera-Miguel, Sara, Lesch, Klaus-Peter, Lochner, Christine, Louza, Mario R, Luna, Beatriz, Lundervold, Astri J, MacMaster, Frank P, Alda, Martin, Maglanoc, Luigi A, Malpas, Charles B, Portella, Maria J, Marsh, Rachel, Martyn, Fiona M, Mataix-Cols, David, Mathalon, Daniel H, McCarthy, Hazel, McDonald, Colm, McPhilemy, Genevieve, Aleman, Andre, Meinert, Susanne, Menchón, José M, Minuzzi, Luciano, Mitchell, Philip B, Moreno, Carmen, Morgado, Pedro, Muratori, Filippo, Murphy, Clodagh M, Murphy, Declan, Mwangi, Benson, Alloza, Clara, Nabulsi, Leila, Nakagawa, Akiko, Nakamae, Takashi, Namazova, Leyla, Narayanaswamy, Janardhanan, Jahanshad, Neda, Nguyen, Danai D, Nicolau, Rosa, O'Gorman Tuura, Ruth L, O'Hearn, Kirsten, Alonso-Lana, Silvia, Oosterlaan, Jaap, Opel, Nils, Ophoff, Roel A, Oranje, Bob, García de la Foz, Victor Ortiz, Overs, Bronwyn J, Paloyelis, Yannis, Pantelis, Christos, Parellada, Mara, Pauli, Paul, Disorder, Bipolar, Ameis, Stephanie H, Picó-Pérez, Maria, Picon, Felipe A, Piras, Fabrizio, Piras, Federica, Plessen, Kerstin J, Pomarol-Clotet, Edith, Preda, Adrian, Puig, Olga, Quidé, Yann, Radua, Joaquim, Anagnostou, Evdokia, Ramos-Quiroga, J Antoni, Rasser, Paul E, Rauer, Lisa, Reddy, Janardhan, Redlich, Ronny, Reif, Andreas, Reneman, Liesbeth, Repple, Jonathan, Retico, Alessandra, Richarte, Vanesa, McIntosh, Andrew A, Richter, Anja, Rosa, Pedro G P, Rubia, Katya K, Hashimoto, Ryota, Sacchet, Matthew D, Salvador, Raymond, Santonja, Javier, Sarink, Kelvin, Sarró, Salvador, Satterthwaite, Theodore D, Arango, Celso, Sawa, Akira, Schall, Ulrich, Schofield, Peter R, Schrantee, Anouk, Seitz, Jochen, Serpa, Mauricio H, Setién-Suero, Esther, Shaw, Philip, Shook, Devon, Silk, Tim J, Arnold, Paul D, Sim, Kang, Simon, Schmitt, Simpson, Helen Blair, Singh, Aditya, Skoch, Antonin, Skokauskas, Norbert, Soares, Jair C, Soreni, Noam, Soriano-Mas, Carles, Spalletta, Gianfranco, Asherson, Philip, Spaniel, Filip, Lawrie, Stephen M, Stern, Emily R, Stewart, S Evelyn, Takayanagi, Yoichiro, Temmingh, Henk S, Tolin, David F, Tomecek, David, Tordesillas-Gutiérrez, Diana, Tosetti, Michela, Assogna, Francesca, Uhlmann, Anne, van Amelsvoort, Therese, van der Wee, Nic J A, van der Werff, Steven J A, van Haren, Neeltje E M, van Wingen, Guido A, Vance, Alasdair, Vázquez-Bourgon, Javier, Vecchio, Daniela, Venkatasubramanian, Ganesan, Auzias, Guillaume, Vieta, Eduard, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Voineskos, Aristotle N, Völzke, Henry, von Polier, Georg G, Walton, Esther, Weickert, Thomas W, Weickert, Cynthia Shannon, Weideman, Andrea S, Ayesa-Arriola, Rosa, Wittfeld, Katharina, Wolf, Daniel H, Wu, Mon-Ju, Yang, T. T., Yang, Sikun, Yoncheva, Yuliya, Yun, Je-Yeon, Cheng, Yuqi, Zanetti, Marcus V, Ziegler, Georg C, Bakker, Geor, Franke, Barbara, Hoogman, Martine, Buitelaar, Jan K, van Rooij, Daan, Andreassen, Ole A, Ching, Christopher R K, Veltman, Dick J, Schmaal, Lianne, Stein, Dan J, van den Heuvel, Odile A, Disorder, Major Depressive, Banaj, Nerisa, Turner, Jessica A, van Erp, Theo G M, Pausova, Zdenka, Thompson, Paul M, Paus, Tomáš, Attention-Deficit/Hyperactivity Disorder, Banaschewski, Tobias, Bandeira, Cibele E, Baranov, Alexandr, Bargalló, Núria, Bau, Claiton H D, Baumeister, Sarah, Baune, Bernhard T, Bellgrove, Mark A, Benedetti, Francesco, Disorder, Obsessive-Compulsive, Bertolino, Alessandro, Boedhoe, Premika S W, Boks, Marco, Bollettini, Irene, Del Mar Bonnin, Caterina, Borgers, Tiana, Borgwardt, Stefan, Brandeis, Daniel, Brennan, Brian P, Bruggemann, Jason M, Groups, Schizophrenia ENIGMA Working, Bülow, Robin, Busatto, Geraldo F, Calderoni, Sara, Calhoun, Vince D, Calvo, Rosa, Canales-Rodríguez, Erick J, Cannon, Dara M, Carr, Vaughan J, Cascella, Nicola, Cercignani, Mara, Patel, Yash, Chaim-Avancini, Tiffany M, Christakou, Anastasia, Coghill, David, Conzelmann, Annette, Crespo-Facorro, Benedicto, Cubillo, Ana I, Cullen, Kathryn R, Cupertino, Renata B, Daly, Eileen, Dannlowski, Udo, Parker, Nadine, Davey, Christopher G, Denys, Damiaan, Deruelle, Christine, Di Giorgio, Annabella, Dickie, Erin W, Dima, Danai, Dohm, Katharina, Ehrlich, Stefan, Ely, Benjamin A, Erwin-Grabner, Tracy, Shin, Jean, Ethofer, Thomas, Fair, Damien A, Fallgatter, Andreas, Faraone, Stephen V, Fatjó-Vilas, Mar, Fedor, Jennifer M, Fitzgerald, Kate D, Ford, Judith M, Frodl, Thomas, Fu, Cynthia H Y, Howard, Derek, Fullerton, Janice M, Gabel, Matt C, Glahn, David C, Roberts, Gloria, Gogberashvili, Tinatin, Goikolea, Jose M, Gotlib, Ian H, Goya-Maldonado, Roberto, Grabe, Hans, Green, Melissa J, Patel, Y., Parker, N., Shin, J., Howard, D., French, L., Thomopoulos, S. I., Pozzi, E., Abe, Y., Abe, C., Anticevic, A., Alda, M., Aleman, A., Alloza, C., Alonso-Lana, S., Ameis, S. H., Anagnostou, E., Mcintosh, A. A., Arango, C., Arnold, P. D., Asherson, P., Assogna, F., Auzias, G., Ayesa-Arriola, R., Bakker, G., Banaj, N., Banaschewski, T., Bandeira, C. E., Baranov, A., Bargallo, N., Bau, C. H. D., Baumeister, S., Baune, B. T., Bellgrove, M. A., Benedetti, F., Bertolino, A., Boedhoe, P. S. W., Boks, M., Bollettini, I., Del Mar Bonnin, C., Borgers, T., Borgwardt, S., Brandeis, D., Brennan, B. P., Bruggemann, J. M., Bulow, R., Busatto, G. F., Calderoni, S., Calhoun, V. D., Calvo, R., Canales-Rodriguez, E. J., Cannon, D. M., Carr, V. J., Cascella, N., Cercignani, M., Chaim-Avancini, T. M., Christakou, A., Coghill, D., Conzelmann, A., Crespo-Facorro, B., Cubillo, A. I., Cullen, K. R., Cupertino, R. B., Daly, E., Dannlowski, U., Davey, C. G., Denys, D., Deruelle, C., Di Giorgio, A., Dickie, E. W., Dima, D., Dohm, K., Ehrlich, S., Ely, B. A., Erwin-Grabner, T., Ethofer, T., Fair, D. A., Fallgatter, A. J., Faraone, S. V., Fatjo-Vilas, M., Fedor, J. M., Fitzgerald, K. D., Ford, J. M., Frodl, T., Fu, C. H. Y., Fullerton, J. M., Gabel, M. C., Glahn, D. C., Roberts, G., Gogberashvili, T., Goikolea, J. M., Gotlib, I. H., Goya-Maldonado, R., Grabe, H. J., Green, M. J., Grevet, E. H., Groenewold, N. A., Grotegerd, D., Gruber, O., Gruner, P., Guerrero-Pedraza, A., Gur, R. E., Gur, R. C., Haar, S., Haarman, B. C. M., Haavik, J., Hahn, T., Hajek, T., Harrison, B. J., Harrison, N. A., Hartman, C. A., Whalley, H. C., Heslenfeld, D. J., Hibar, D. P., Hilland, E., Hirano, Y., Ho, T. C., Hoekstra, P. J., Hoekstra, L., Hohmann, S., Hong, L. E., Hoschl, C., Hovik, M. F., Howells, F. M., Nenadic, I., Jalbrzikowski, M., James, A. C., Janssen, J., Jaspers-Fayer, F., Xu, J., Jonassen, R., Karkashadze, G., King, J. A., Kircher, T., Kirschner, M., Koch, K., Kochunov, P., Kohls, G., Konrad, K., Kramer, B., Krug, A., Kuntsi, J., Kwon, J. S., Landen, M., Landro, N. I., Lazaro, L., Lebedeva, I. S., Leehr, E. J., Lera-Miguel, S., Lesch, K. -P., Lochner, C., Louza, M. R., Luna, B., Lundervold, A. J., Macmaster, F. P., Maglanoc, L. A., Malpas, C. B., Portella, M. J., Marsh, R., Martyn, F. M., Mataix-Cols, D., Mathalon, D. H., Mccarthy, H., Mcdonald, C., Mcphilemy, G., Meinert, S., Menchon, J. M., Minuzzi, L., Mitchell, P. B., Moreno, C., Morgado, P., Muratori, F., Murphy, C. M., Murphy, D., Mwangi, B., Nabulsi, L., Nakagawa, A., Nakamae, T., Namazova, L., Narayanaswamy, J., Jahanshad, N., Nguyen, D. D., Nicolau, R., O'Gorman Tuura, R. L., O'Hearn, K., Oosterlaan, J., Opel, N., Ophoff, R. A., Oranje, B., Garcia De La Foz, V. O., Overs, B. J., Paloyelis, Y., Pantelis, C., Parellada, M., Pauli, P., Pico-Perez, M., Picon, F. A., Piras, F., Plessen, K. J., Pomarol-Clotet, E., Preda, A., Puig, O., Quide, Y., Radua, J., Ramos-Quiroga, J. A., Rasser, P. E., Rauer, L., Reddy, J., Redlich, R., Reif, A., Reneman, L., Repple, J., Retico, A., Richarte, V., Richter, A., Rosa, P. G. P., Rubia, K. K., Hashimoto, R., Sacchet, M. D., Salvador, R., Santonja, J., Sarink, K., Sarro, S., Satterthwaite, T. D., Sawa, A., Schall, U., Schofield, P. R., Schrantee, A., Seitz, J., Serpa, M. H., Setien-Suero, E., Shaw, P., Shook, D., Silk, T. J., Sim, K., Simon, S., Simpson, H. B., Singh, A., Skoch, A., Skokauskas, N., Soares, J. C., Soreni, N., Soriano-Mas, C., Spalletta, G., Spaniel, F., Lawrie, S. M., Stern, E. R., Stewart, S. E., Takayanagi, Y., Temmingh, H. S., Tolin, D. F., Tomecek, D., Tordesillas-Gutierrez, D., Tosetti, M., Uhlmann, A., Van Amelsvoort, T., Van Der Wee, N. J. A., Van Der Werff, S. J. A., Van Haren, N. E. M., Van Wingen, G. A., Vance, A., Vazquez-Bourgon, J., Vecchio, D., Venkatasubramanian, G., Vieta, E., Vilarroya, O., Vives-Gilabert, Y., Voineskos, A. N., Volzke, H., Von Polier, G. G., Walton, E., Weickert, T. W., Weickert, C. S., Weideman, A. S., Wittfeld, K., Wolf, D. H., Wu, M. -J., Yang, T. T., Yang, K., Yoncheva, Y., Yun, J. -Y., Cheng, Y., Zanetti, M. V., Ziegler, G. C., Franke, B., Hoogman, M., Buitelaar, J. K., Van Rooij, D., Andreassen, O. A., Ching, C. R. K., Veltman, D. J., Schmaal, L., Stein, D. J., Van Den Heuvel, O. A., Turner, J. A., Van Erp, T. G. M., Pausova, Z., Thompson, P. M., Paus, T., Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Pediatric surgery, Radiology and nuclear medicine, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Neuroscience - Neurodegeneration, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Med Staf Spec Psychiatrie (9), Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, General Paediatrics, ARD - Amsterdam Reproduction and Development, Radiology and Nuclear Medicine, APH - Personalized Medicine, ANS - Brain Imaging, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, University of Zurich, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Clinical Neuropsychology, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Child and Adolescent Psychiatry / Psychology, IBBA, and Cognitive Psychology

Subjects
Male, Obsessive-Compulsive Disorder, Bipolar Disorder, Autism Spectrum Disorder, Autism, [SDV]Life Sciences [q-bio], Gene Expression, cytology [Cerebral Cortex], Cohort Studies, Fetal Development, physiology [Gene Expression], 2738 Psychiatry and Mental Health, 0302 clinical medicine, diagnostic imaging [Cerebral Cortex], SCHIZOPHRENIA, BRAIN, Child, Obsessive-compulsive disorder (OCD), Original Investigation, Aged, 80 and over, Cerebral Cortex, 0303 health sciences, pathology [Depressive Disorder, Major], Principal Component Analysis, Adolescent psychiatry, 10058 Department of Child and Adolescent Psychiatry, Middle Aged, diagnostic imaging [Obsessive-Compulsive Disorder], REGIONS, Magnetic Resonance Imaging, 3. Good health, FALSE DISCOVERY RATE, Psychiatry and Mental health, Autism spectrum disorder, Schizophrenia, growth & development [Cerebral Cortex], Child, Preschool, Major depressive disorder, diagnostic imaging [Schizophrenia], Esquizofrènia, Female, Psiquiatria infantil, Psiquiatria de l'adolescència, diagnostic imaging [Autism Spectrum Disorder], Adult, medicine.medical_specialty, Adolescent, Human Development, 610 Medicine & health, diagnostic imaging [Bipolar Disorder], pathology [Autism Spectrum Disorder], diagnostic imaging [Depressive Disorder, Major], 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, Neuroimaging, SDG 3 - Good Health and Well-being, CEREBRAL-CORTEX, Child psychiatry, medicine, Attention deficit hyperactivity disorder, Humans, Bipolar disorder, ddc:610, Psychiatry, pathology [Schizophrenia], 030304 developmental biology, Aged, Depressive Disorder, Major, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, DENDRITE, Computational Biology, Correction, pathology [Attention Deficit Disorder with Hyperactivity], physiology [Fetal Development], medicine.disease, PATHOLOGY, pathology [Bipolar Disorder], pathology [Obsessive-Compulsive Disorder], 10036 Medical Clinic, Attention Deficit Disorder with Hyperactivity, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, Case-Control Studies, DENSITY, ORIGINS, HIPPOCAMPUS, diagnostic imaging [Attention Deficit Disorder with Hyperactivity], pathology [Cerebral Cortex], Autisme, business, Neuroscience, 030217 neurology & neurosurgery, physiology [Human Development]
Abstract

[Importance] Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood., [Objective] To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia., [Design, Setting, and Participants] Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244., [Main Outcomes and Measures] Interregional profiles of group difference in cortical thickness between cases and controls., [Results] A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders., [Conclusions and Relevance] In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders.

Published
2021

3. Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples

Author

Luisa Lázaro, Dmitry Kapilushniy, Elena Shumskaya, Katya Rubia, Ana Cubillo, Philip Shaw, Marcus V. Zanetti, Anders M. Dale, Thomas Ethofer, Andreas Reif, Pieter J. Hoekstra, Mariam Zentis, Sarah Baumeister, Sara Lera-Miguel, Kerstin J. Plessen, Anastasia Solovieva, Catharina A. Hartman, João P.O.F.T. Guimarães, Tonya White, Hazel McCarthy, Thomas Frodl, Stephanie E. Novotny, Martine Hoogman, Mara Cercignani, Gustavo Sudre, Patrick de Zeeuw, Tiffany M. Chaim-Avancini, Ivanei E. Bramati, Yolanda Vives-Gilabert, J. Antoni Ramos-Quiroga, Jonna Kuntsi, Clare Kelly, Joel T. Nigg, Dirk J. Heslenfeld, Tinatin Gogberashvili, Mark A. Bellgrove, Susanne Walitza, Sarah Hohmann, Jan Haavik, Kaylita Chantiluke, Joseph Biederman, Marcel P. Zwiers, Maarten Mennes, Neil A. Harrison, Hanan El Marroun, Norbert Skokauskas, Mitul A. Mehta, Annette Conzelmann, Fernanda Tovar-Moll, Rosa Nicolau, Juan Carlos Soliva Vila, Mario Rodrigues Louzã, Ruth O'Gorman Tuura, Anastasia Christakou, Barbara Franke, Charles B Malpas, Theo G.M. van Erp, Eileen Oberwelland Weiss, Terry L. Jernigan, Alysa E. Doyle, Daniel Brandeis, David Coghill, L. Reneman, Tobias Banaschewski, Geraldo F. Busatto, Sarah Durston, Anouk Schrantee, Philip Asherson, Lena Schwarz, Georgii Karkashadze, Kerstin Konrad, Anatoly Anikin, Neda Jahanshad, Paul M. Thompson, Georg C. Ziegler, Paulo Mattos, Michael C. Stevens, Janita Bralten, Matt C. Gabel, Thomas Wolfers, Alasdair Vance, Leanne Tamm, Georg G. von Polier, Timothy J. Silk, Bernd Kardatzki, Jochen Seitz, Sabin Khadka, Ryan L. Muetzel, Marie F. Høvik, Damien A. Fair, Astri J. Lundervold, Eric Earl, Jeffery N. Epstein, Ramona Baur-Streubel, Paul Pauli, Yuliya N. Yoncheva, Jaap Oosterlaan, Gregor Kohls, Henning Tiemeier, Francisco X. Castellanos, Silvia Brem, Oscar Vilarroya, Pedro G.P. Rosa, Stephen V. Faraone, Klaus-Peter Lesch, Jan K. Buitelaar, Bob Oranje, Leyla Namazova-Baranova, A.A. Baranov, Andreas J. Fallgatter, Anna Calvo, Sara Ambrosino, Kathrin C. Zierhut, Yannis Paloyelis, Lizanne J. S. Schweren, APH - Personalized Medicine, ANS - Compulsivity, Impulsivity & Attention, Radiology and Nuclear Medicine, General Paediatrics, ARD - Amsterdam Reproduction and Development, APH - Mental Health, Child and Adolescent Psychiatry / Psychology, Department of Psychology, Education and Child Studies, Erasmus MC other, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, and Pediatric surgery

Subjects
Male, SYMPTOMS, CHILDREN, Audiology, physiopathology [Cerebral Cortex], 0302 clinical medicine, CONNECTIVITY, 130 000 Cognitive Neurology & Memory, diagnostic imaging [Cerebral Cortex], physiopathology [Attention Deficit Disorder with Hyperactivity], PARTICIPANTS, Young adult, Child, Child Behavior Checklist, Cerebral Cortex, education.field_of_study, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, Age Factors, 220 Statistical Imaging Neuroscience, Brain, Middle Aged, Magnetic Resonance Imaging, Psychiatry and Mental health, medicine.anatomical_structure, Cerebral cortex, Child, Preschool, Female, MRI, Adult, medicine.medical_specialty, Adolescent, DEFICIT HYPERACTIVITY DISORDER, Population, Neuroimaging, behavioral disciplines and activities, 150 000 MR Techniques in Brain Function, Article, Young Adult, 03 medical and health sciences, Sex Factors, All institutes and research themes of the Radboud University Medical Center, mental disorders, medicine, Journal Article, Attention deficit hyperactivity disorder, Humans, ddc:610, education, METAANALYSIS, Psychiatric Status Rating Scales, Fusiform gyrus, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], business.industry, ADULTS, pathology [Attention Deficit Disorder with Hyperactivity], medicine.disease, 030227 psychiatry, SIZE, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Endophenotype, RC0321, diagnostic imaging [Attention Deficit Disorder with Hyperactivity], pathology [Cerebral Cortex], business, 030217 neurology & neurosurgery
Abstract

Contains fulltext : 204879pub.pdf (Publisher’s version ) (Open Access) Contains fulltext : 204879pos.pdf (Author’s version postprint ) (Open Access) OBJECTIVE: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical characteristics related to ADHD using large-scale studies. METHODS: Cortical thickness and surface area (based on the Desikan-Killiany atlas) were compared between case subjects with ADHD (N=2,246) and control subjects (N=1,934) for children, adolescents, and adults separately in ENIGMA-ADHD, a consortium of 36 centers. To assess familial effects on cortical measures, case subjects, unaffected siblings, and control subjects in the NeuroIMAGE study (N=506) were compared. Associations of the attention scale from the Child Behavior Checklist with cortical measures were determined in a pediatric population sample (Generation-R, N=2,707). RESULTS: In the ENIGMA-ADHD sample, lower surface area values were found in children with ADHD, mainly in frontal, cingulate, and temporal regions; the largest significant effect was for total surface area (Cohen's d=-0.21). Fusiform gyrus and temporal pole cortical thickness was also lower in children with ADHD. Neither surface area nor thickness differences were found in the adolescent or adult groups. Familial effects were seen for surface area in several regions. In an overlapping set of regions, surface area, but not thickness, was associated with attention problems in the Generation-R sample. CONCLUSIONS: Subtle differences in cortical surface area are widespread in children but not adolescents and adults with ADHD, confirming involvement of the frontal cortex and highlighting regions deserving further attention. Notably, the alterations behave like endophenotypes in families and are linked to ADHD symptoms in the population, extending evidence that ADHD behaves as a continuous trait in the population. Future longitudinal studies should clarify individual lifespan trajectories that lead to nonsignificant findings in adolescent and adult groups despite the presence of an ADHD diagnosis.

Published
2019

4. The brain anatomy of attention-deficit/hyperactivity disorder in young adults - a magnetic resonance imaging study

Author

Tanyaporn Thampipop, James H. Fallon, Frithjof Kruggel, Jean-G. Gehricke, Sharina Dyan Alejo, L. Tugan Muftuler, and Erik Tatos

Subjects
Central Nervous System, Male, lcsh:Medicine, Brain mapping, Nervous System, Diagnostic Radiology, Superior temporal gyrus, 0302 clinical medicine, Materials Physics, Medicine and Health Sciences, Young adult, Gray Matter, lcsh:Science, Microstructure, Cerebral Cortex, Multidisciplinary, Physics, Radiology and Imaging, Superior longitudinal fasciculus, Brain, Magnetic Resonance Imaging, Frontal Lobe, medicine.anatomical_structure, Frontal lobe, Neurology, Physical Sciences, diagnosis, diagnostic imaging [Attention Deficit Disorder with Hyperactivity], Female, Anatomy, Clinical psychology, Research Article, Adult, medicine.medical_specialty, Imaging Techniques, Materials Science, Neuropsychiatric Disorders, Neuroimaging, Research and Analysis Methods, behavioral disciplines and activities, White matter, 03 medical and health sciences, Young Adult, Developmental Neuroscience, diagnostic imaging [Frontal Lobe], Diagnostic Medicine, Mental Health and Psychiatry, mental disorders, medicine, Attention deficit hyperactivity disorder, Adults, Humans, Psychiatry, business.industry, lcsh:R, diagnostic imaging [Gray Matter], Biology and Life Sciences, medicine.disease, 030227 psychiatry, Young Adults, Diffusion Magnetic Resonance Imaging, Attention Deficit Disorder with Hyperactivity, Neurodevelopmental Disorders, Age Groups, People and Places, Adhd, Population Groupings, lcsh:Q, business, 030217 neurology & neurosurgery, Neuroscience
Abstract

Background This is one of the first studies to examine the structural brain anatomy and connectivity associated with an ADHD diagnosis and child as well as adult ADHD symptoms in young adults. It was hypothesized that an adult ADHD diagnosis and in particular childhood symptoms, are associated with widespread changes in the brain macro- and microstructure, which can be used to develop a morphometric biomarker for ADHD. Methods Voxel-wise linear regression models were used to examine structural and diffusion-weighted MRI data in 72 participants (31 young adults with ADHD and 41 controls without ADHD) in relation to diagnosis and the number of self-reported child and adult symptoms. Results Findings revealed significant associations between ADHD diagnosis and widespread changes to the maturation of white matter fiber bundles and gray matter density in the brain, such as structural shape changes (incomplete maturation) of the middle and superior temporal gyrus, and fronto-basal portions of both frontal lobes. ADHD symptoms in childhood showed the strongest association with brain macro- and microstructural abnormalities. At the brain circuitry level, the superior longitudinal fasciculus (SLF) and cortico-limbic areas are dysfunctional in individuals with ADHD. The morphometric findings predicted an ADHD diagnosis correctly up to 83% of all cases. Conclusion An adult ADHD diagnosis and in particular childhood symptoms are associated with widespread micro- and macrostructural changes. The SLF and cortico-limbic findings suggest complex audio-visual, motivational, and emotional dysfunctions associated with ADHD in young adults. The sensitivity of the morphometric findings in predicting an ADHD diagnosis was sufficient, which indicates that MRI-based assessments are a promising strategy for the development of a biomarker.

Published
2017

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