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To standardize the market conduct of electricity sales companies and elevate the power market management level， it is essential to conduct a credit evaluation of these companies. Therefore， based on Box-plot and orthogonalization methods， a credit evaluation model based on an enhanced discrete Hopfield neural network （DHNN） is proposed. Firstly， factors influencing the credit levels of electricity sales companies are analyzed， and a credit evaluation index system， which includes 11 indicators such as basic information， foundational management， contract management， and transaction management， is established. The weights for these indicators are determined using the Delphi method. Secondly， outliers in the indicators of electricity sales companies are addressed to derive optimal credit scores， enabling an objective assessment of their credit levels. Finally， the feasibility of the proposed model is verified through case studies. The results indicate that the model can objectively and accurately evaluate the credit levels of electricity sales companies.

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SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, which exhibited large red shifts after conversion. With the conjugates, SARM1 activation was visualized in live cells following elevation of endogenous NMN or treatment with a cell-permeant NMN-analog. In neurons, imaging documented mouse SARM1 activation preceded vincristine-induced axonal degeneration by hours. Library screening identified a derivative of nisoldipine (NSDP) as a covalent inhibitor of SARM1 that reacted with the cysteines, especially Cys311 in its ARM domain and blocked its NMN-activation, protecting axons from degeneration. The Cryo-EM structure showed that SARM1 was locked into an inactive conformation by the inhibitor, uncovering a potential neuroprotective mechanism of dihydropyridines., Competing Interests: WL, KH, YC, QW, WZ, YH, SW, SC, ZZ, XX, YD, CL, HL, HZ No competing interests declared, YZ Two Chinese patents (202010528147.3; 202011359354.7) are in the process of application., (© 2021, Li et al.)