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Postpartum depression (PPD) affects nearly 20% of postpartum women and has severe short- and long-term detrimental effects on their mental health. While there is ample evidence linking depression-related outcomes and individuals' socioeconomic status (SES), the examination of differences in PPD as a function of SES has received relatively little empirical attention, resulting in inconsistent empirical evidence. There are also no well-established systematic reviews on the linkage between SES and PPD. Thus, we conducted A PRISMA-compliant systematic review to comprehensively analyze the association of SES (as measured by long-established objective [e.g., income or education] and subjective measures) with PPD (as measured by widely validated scales). We performed a bibliographic search on CINAHL Complete, MEDLINE complete, and EBSCO Psychology and Behavioral Sciences Collection. Among the 201 articles retrieved, 16 met the eligibility criteria. Our results reveal that mothers with lower income and education levels (objective indicators of SES) were more likely to experience PPD. Notably, we also found that subjective SES, compared to objective SES, was more strongly associated with PPD. Overall, these findings indicate that low-SES mothers may be at increased risk of PPD compared to high-SES mothers, reflecting the need for more efficient early detection programs for PPD among low-SES mothers. [ABSTRACT FROM AUTHOR]

Background: While social disparities in depression are well-documented, the symptom experience across social positions remains less studied. Aims: This study examines the connections between depressive symptoms and self-recognizing a depressive episode, on the one hand, and clinical diagnosis, on the other hand, by three social position indicators. Methods: We analyzed baseline data from a population-based cohort of adults living in France, grouping participants by three indicators: education, financial difficulties, and occupation, and stratifying by sex. Utilizing a psychometric network approach, we estimated 24 networks. Nodes corresponded to the 20 CES-D items and 1 external variable, either 'Limitations due to depression' or 'Clinical depression'. Comparisons between socially disadvantaged and advantaged groups across the three social indicators were made in terms of network structures, global strength, and edge weights involving symptoms and both external nodes. Results: The study included data from 201,952 participants. Individuals in lower social positions exhibited higher rates of depressive-related variables. Four depressive symptoms emerged as crucial, being linked both to 'Clinical depression' and 'Limitations' across all social positions. Socially disadvantaged groups had denser networks. Some of the tests comparing network structures according to social position were significant, suggesting differences in the symptom activation chains. Connections between each external node and 'Felt depressed' and 'Could not get going' were non-invariant in educational and financial-based networks. Conclusions: Findings highlight four depressive symptoms, likely to play a key role in the experience of depression across all social positions. Other insights from specific symptoms could be used for improving depression care among disadvantaged populations. [ABSTRACT FROM AUTHOR]

Background: Given the increasing number of people achieving exceptionally long lifespans, there is an urgent need for a better understanding of mental health in centenarians. This study aimed to understand the prevalence of mental health conditions—depressive symptoms, anxiety, sleep disturbances, disinhibition, and aberrant motor behaviour—among centenarians in Switzerland. Methods: Data were collected from N = 169 participants via telephone interviews or paper questionnaires, either directly from centenarians or through proxy informants. Half the data were collected during a period when protective measures were imposed due to the COVID‐19 pandemic, and half were collected after the measures were lifted. Results: Mental health conditions were prevalent in our sample, particularly depressive symptoms (44.51%) and anxiety (42.17%). Significant positive associations were found between depressive symptoms and anxiety, and between disinhibition and aberrant motor behaviour. Furthermore, we identified statistical predictors for the occurrence of mental health conditions. Notably, institutionalised living increased the odds of depressive symptomatology, while those with higher education levels or an absence of cognitive impairment experienced more sleep disturbances. Finally, cognitive impairment was linked to increased disinhibition and aberrant motor behaviour. Conclusions: The high prevalence of mental health conditions underscores the need for proactive mental health care strategies in advanced old age. Moreover, it is vital to consider the interconnected nature of mental health conditions and to prioritise vulnerable groups, such as centenarians in institutional settings. [ABSTRACT FROM AUTHOR]

The experience of depressive manifestations and the presentation of symptoms in clinical settings may differ in men and women. Despite the extensive literature, it remains unclear how depressive manifestations interact at symptom levels in men and women. First, we aimed to describe and compare depressive networks by sex. Second, we examined symptom connections to Clinical depression and Functional Limitations as a proxy of self-recognition of a depressive episode. We estimated networks from the 20 CES-D items in men and women from a large population-based French cohort. We computed centrality measures and ran comparisons. Then, we re-estimated two networks in men and women separately, adding, on the one hand, Clinical Depression and, on the other hand, Limitations due to a depressive episode. Over 200,000 participants were included in this study. Women were twice as likely to have a previous diagnosis of depression. Sex-ratio was less pronounced (1,7:1) for Limitations due to depression. Centrality measures revealed similar symptom patterns. However, network structures differed between men and women. We found some symptom connections to Clinical depression and Limitations to be non-invariant according to sex. Cross-sectional data does not capture the direction of the connections between symptoms and an eventual diagnosis. We lacked data about the diagnosis's context and could not account for other factors influencing depressive symptomatology. Network structures differed, suggesting gender-specific mechanisms in activating symptoms and depressive states. Addressing central symptoms evoking depressed moods with tailored interventions may serve to tackle depressive states in men and women. • Men and women from the general population had different depressive network structures • We examined symptom connections to a previous diagnosis of depression and to self-reporting functional limitations • In men, crying could be a key symptom in recognizing depression, and symmetrically, in clinicians making a diagnosis [ABSTRACT FROM AUTHOR]

Background: Effective interventions are required to address tobacco smoking in people with depressive symptomatology. In this context, contingency management could be one useful therapeutic strategy. Objectives: This study is a systematic review of tobacco cessation interventions for smokers with depressive symptomatology including a contingency management component, evaluating their efficacy with regards to tobacco abstinence, depressive symptomatology, adherence to treatment and other variables related to tobacco use. For this purpose, a search was carried out in Pubmed, PsycINFO, Cochrane, Web of Science and ClinicalTrials.gov in September 2022. The quality of the studies was assessed using the Cochrane Risk of Bias tool. Results: Of the 208 articles identified, six were included in this review. Results: For the most part, the research included suggests that contingency management is an effective strategy for improving abstinence outcomes, adherence, and other smoking-related variables such as delay discounting and intensity of cigarette demand in smokers with depressive symptomatology. Conclusions: Although contingency management could be a promising intervention in tobacco smokers with depressive symptomatology, further research in this area is still required. [ABSTRACT FROM AUTHOR]

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Depression, suicidal behavior, excessive alcohol intake, and tobacco use are the main mental health problems in adolescents. To address these problems, it is necessary to understand the many factors associated with them, including parental factors. The aim of this study was to assess the associations between parental behavior and mental health problems in adolescents in Mexico. Data from the National Health and Nutrition Survey (ENSANUT) 2018–2019, representative for Mexico, were used. Households in which a parent–adolescent child pairing was identified (regardless of family type) were selected; n = 8758 households. The four outcomes of interest that were measured in the adolescents were: excessive alcohol intake, tobacco use, suicidal behavior, and depressive symptomatology. Logistic regression models using the adjusted odds ratio (AOR) and 95% confidence interval (95% CI) were estimated. Adolescents whose parents used alcohol or tobacco and reported depressive symptoms and suicidal behavior were more likely to present these behaviors themselves (AOR = 1.47, 95% CI: 1.17–1.85; AOR = 2.26, 95% CI: 1.51–3.39; AOR = 2.61, 95% CI: 1.88–3.61; AOR = 1.74, 95% CI: 1.16–2.61, respectively). Child sexual abuse was also strongly associated with the four outcomes of interest in adolescents (AOR = 1.89, 95% CI: 1.06–3.36 for excessive alcohol intake; AOR = 2.97, 95% CI: 1.49–5.91 for tobacco use; AOR = 5.15, 95% CI: 3.27–8.09 for depressive symptoms; AOR = 6.71, 95% CI: 4.25–10.59 for suicidal behavior). The family constitutes the central nucleus of care for children and adolescents; therefore, any effort to promote adolescent mental health must necessarily involve their parents and family. [ABSTRACT FROM AUTHOR]

Ketamine is a potential rapid-onset antidepressant characterized by sympathomimetic effects. However, the question of ketamine's use in treating adolescents' major depressive disorder (MDD) is still discussed. Thus, we aimed to study the acute effect of ketamine infusion treatment on sympathetic regulation using electrodermal activity (EDA) in addition to an assessment of depressive symptomatology in MDD adolescents. Twenty hospitalized adolescent girls with MDD (average age: 15.0 ± 1.46 yrs.) were examined before and two hours after a single intravenous infusion of ketamine. EDA was continuously recorded for 6 min, and depressive symptoms were assessed before and two hours after ketamine administration. The evaluated parameters included skin conductance level (SCL), nonspecific electrodermal responses (NS-SCRs), MADRS (questions no. 1–10, total score), and CDI (items A–E, total score). EDA parameters showed no significant changes after the ketamine treatment, and depressive symptoms were significantly reduced after the ketamine infusion. The analysis revealed a significant negative correlation between index SCL and CDI-A, CDI-E, and the total CDI score and between index NS-SCRs and MADRS no. 4 before the ketamine treatment. In conclusion, ketamine improved depressive symptomatology without a significant effect on EDA, indicating its potential safety and efficiency as an acute antidepressant intervention in adolescent MDD. [ABSTRACT FROM AUTHOR]

Objective: To analyze the validity of self and informant reports, depressive symptomatology, and some sociodemographic variables to predict the risk of cognitive decline at different follow-up times. Methods: A total of 337 participants over 50 years of age included in the CompAS and classified as Cognitively Unimpaired (CU), Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) groups were assessed at baseline and three follow-ups. A short version of the QAM was administered to assess the severity of subjective cognitive complaints (SCCs), and the GDS-15 was used to evaluate the depressive symptoms. At each follow-up assessment, participants were reclassified according to the stability, regression or progression of their conditions. Logistic regression analysis was used to predict which CU, SCD and MCI participants would remain stable, regress or progress at a 3rd follow-up by using self- and informant-reported complaints, depressive symptomatology, age and education at baseline and 2nd follow-ups as the predictive variables. Results: Overall, self-reported complaints predicted progression between the asymptomatic and presymptomatic stages. As the objective deterioration increased, i.e., when SCD progressed to MCI or dementia, the SCCs reported by informants proved the best predictors of progression. Depressive symptomatology was also a predictor of progression from CU to SCD and from SCD to MCI. Conclusion: A late increase in self-reported complaints make valid estimates to predict subjective decline at asymptomatic stages. However, an early increase in complaints reported by informants was more accurate in predicting objective decline from asymptomatic stages. Both, early and late decrease in selfreported complaints successfully predict dementia from prodromic stage. Only late decrease in self-reported complaints predict reversion from prodromic and pre-symptomatic stages. [ABSTRACT FROM AUTHOR]

Background: This study aimed to document recovery trajectories among adolescents with anorexia nervosa (AN) based on three markers of remission, namely changes in body weight, food restriction, and excessive exercise, and to identify predictors of these trajectories. Methods: One hundred twenty-six adolescent girls (14.7 ± 1.3 years) were recruited during initial assessment visits at specialized eating disorder (ED) programs in five University Health Centers across the province of Quebec, Canada. z-BMI and AN symptom severity (food restriction and excessive exercise) were assessed at initial assessment visits and subsequently reassessed at each quarterly follow-up over a 12-month period to identify recovery trajectories. Results: Considering the three markers of remission, three distinct trajectories emerged: Group 1, rapid responders; Group 2, gradual responders; and Group 3, unstable responders. At initial visits, a difference between groups was found regarding the type of treatment (p = 0.01) and weight suppression (p = 0.02). Group 1 had a higher number of youths hospitalized than Group 2 and Group 3, and a greater weight suppression than Group 3. Furthermore, individuals with atypical AN were more likely to belong to Group 2 than to Group 1 and Group 3 (p < 0.0001). Conclusions: This study contributes to a better understanding of the heterogeneity of recovery trajectories in adolescent girls with AN. [ABSTRACT FROM AUTHOR]

Background Subjective cognitive decline (SCD) has gained recent interest as a potential harbinger of neurodegenerative diseases such as Alzheimer's disease (AD) and cerebrovascular disease (CVD). In addition, SCD can be related to depressive symptomatology. However, the association between AD and CVD biomarkers, depressive symptomatology, and SCD is still unclear. We investigated the association of AD and CVD biomarkers and depressive symptomatology with SCD in individuals with subjective memory complaints (SCD-memory group) and individuals with subjective concentration complaints (SCD-concentration group). Methods We recruited a population-based cohort of 217 individuals (all aged 70 years, 53% female participants, 119 SCD-memory individuals, 23 SCD-concentration individuals, and 89 controls). AD and CVD were assessed through cerebrospinal fluid levels of the Aβ42/40 ratio and phosphorylated tau, and white matter signal abnormalities on magnetic resonance imaging, respectively. Associations between biomarkers, depressive symptomatology, and SCD were tested via logistic regression and correlation analyses. Results We found a significant association between depressive symptomatology with SCD-memory and SCD-concentration. Depressive symptomatology was not associated with AD and CVD biomarkers. Both the phosphorylated tau biomarker and depressive symptomatology predicted SCD-memory, and the Aβ42/40 ratio and depressive symptomatology predicted SCD-concentration. Conclusions The role of depressive symptomatology in SCD may differ depending on the stage within the spectrum of preclinical AD (as determined by amyloid-beta and tau positivity), and does not seem to reflect AD pathology. Our findings contribute to the emerging field of subclinical depressive symptomatology in SCD and clarify the association of different types of subjective complaints with distinct syndromic and biomarker profiles. [ABSTRACT FROM AUTHOR]

Depression is considered the most prevalent mood disorder in older people, generating a significant burden in the economic, personal and social spheres. It is established as a geriatric syndrome. The objective of the research was to determine the level of depressive symptoms and the associated factors in a group of older people from a rural context. This is a descriptive and cross-sectional study, with a population of older people, the type of sampling was non-probabilistic for convenience. Demographic factors evaluated according to self-report by the participant, family member or responsible caregiver were considered. Using a pre-designed and validated questionnaire, we inquired about age in years, gender, education, marital status, socioeconomic stratum level, employment status and economic dependency. Likewise, a history of chronic infectious diseases was found out. As instruments, the Yesavage scale was used, a self-report instrument, composed of 15 items that measure the presence of depressive symptoms through direct questions, the Minimental Test, a widely used instrument for the detection of global cognitive impairment, due to its speed and ease of scoring. The Life Questionnaire is a tool that evaluates performance in instrumental activities of daily living; To evaluate the use of living space, the Life Space Assessment (LSA) scale was chosen, a self-report measure requiring respondents to quantify how far and how often they have moved with or without assistance during the last four weeks. Latent class analysis was used to identify subgroups, according to patterns of depressive symptomatology. Results: 288 participants were included, aged between 60 and 93 years, with a higher proportion of women (57 %) from socioeconomic stratum 1 (99.7 %), with a low level of education (41 % with incomplete primary school). The average of the Yesavage scale was 10 (IR: 9 to 11). The analysis model presents four classes or subgroups of depressive symptom profiles with an entropy equal to 0.98. Classes 1, 2 and 3 show a predominance of depressive symptoms in the sample, with 3.81 %, 23.2 % and 21.6 %, respectively. The fourth class corresponds to moderate symptoms and would be present in 51.35 % of the sample. Regarding demographic characteristics, heterogeneity is observed at the level of the four subgroups. At the level of global cognitive performance, the results showed that it is one of the variables with the highest incidence in depressive symptoms in all groups. In relation to the total score in the VIDA questionnaire, compared to class 4, class 1 presented a SMD = -0.1 [95 % CI (-.716 - .51)], class 2 a SMD = .53 [95 % CI (-. .23 - .83)] and class 3 a SMD = -0.05 [95 % CI (-.33 - .24)]. On the LSA scale, compared to class 4, class 1 presented a SMD = -.62 [95 % CI (-1.233 - 0)], class 2 had a SMD = .42 [95 % CI (.12 - .72)] and class 3 a SMD = -.49 [95 % CI (-.78 - -.19)]. Regarding the Minimental Test, compared to class 4, class 1 presented a SMD = .62 [95 % CI (0 - 1.23)], class 2 a SMD = .46 [95 % CI (.16 - .76)] and class 3 a SMD = -.04 [95 % CI (-.33 - .25)]. It is concluded that the study shows significant associations between the presence of depressive symptoms in relation to demographic characteristics and cognitive performance, preferably; However, factors such as the use of living space and autonomy may present a bidirectional relationship with the analysis variable. [ABSTRACT FROM AUTHOR]

Friends are a vital source of social relations throughout the lifespan and across developmental stages. Our knowledge of how friendships develop over time, especially from childhood through adulthood, is limited. Furthermore, it is now recognized that this specific type of relationship influences health across the life course in unique ways. Using the Convoy Model of Social Relations as a guiding framework, this study charts the multiple and unique trajectories of friendship across adulthood and tests whether these trajectories influence health differentially by age. The sample for the study consisted of 553 adults from the longitudinal Social Relations Study. Respondents ranged in age from 13 to 77 at Wave 1 (1992), and included only those who reported a best friend in each wave, that is, Wave 2 (2005) and Wave 3 (2015). Approximately 65% of the respondents were women, and 24.5% were people of color. Latent growth curve analysis identified three trajectories of the presence of friends in one's network over time, two trajectories of positive friend quality, and three for negative quality. The most consistent findings are associated with positive friend relations over time. Gender was associated with friendship quality where women reported more positive friend relations over time, and increasing positive friend relations predicted better health 23 years later. These findings demonstrate that consistent and increasing positive friendships yield health benefits over time, whereas the presence of friends and negative quality does not have an effect. Overall, findings advance understanding of the long-term effects of social relations across the lifespan and life course. Public Significance Statement: This study suggests that there are distinct trajectories of friendship beginning in young and mid-adulthood indicated by proportion of friends in one's network and relationship quality. Identifying how personal and situational characteristics influence multiple dimensions of the friend relationship over time provides key information to guide social support-based interventions aimed at enriching developmental outcomes and maximizing well-being across the lifespan and life course. [ABSTRACT FROM AUTHOR]

This article aims to expand the knowledge about parental stress of the main caregivers of people with ASD in Uruguay. A cross-sectional study was carried out in which the Parenting Stress Index-Short Form, the Beach Center Family Quality of Life Survey and the Beck Depression Inventory-II were applied. 106 main caregivers participated, mostly mothers (87.4%), who reported high levels of stress. Depressive symptomatology was associated with the global level of parental stress and parental distress. An inverse relationship was found between family stress and family quality of life (QOLF); reported a satisfactory level of QOLF with low levels of emotional wellbeing. Inverse relationships were found between family interaction and parental role with the dysfunctional parent-child interaction factor. The results suggest integrating assessments on parental stress in interventions with people with ASD, considering the impact of emotional well-being on the quality of family life. [ABSTRACT FROM AUTHOR]

The main objective for this study is to analyze the impact of a positive reminiscence therapy program (REMPOS) in cognitive functioning and depressive symptomatology for older adults in different vital situations (healthy aging, mild cognitive impairment, and Alzheimer's disease). This is a transcultural comparative study (older people from Spain and Mexico). A randomized design with pre-posttest measurement and twelve groups was formulated, during a period of six months of intervention (3 in Mexico and 3 in Spain). The design had: 6 experimental groups with REMPOS intervention (3 in Mexico and 3 in Spain) during a period of six months and 6 control groups that received cognitive stimulation. While a key aspect of this study is the cross-cultural differences, an important part is to determine whether each experimental group had similar results in terms of the change in magnitude between the pre and post analysis. In general, intervention significantly improved cognitive function and decreased depressive symptoms. These findings provide further evidence about the efficacy of the REMPOS therapy between different types of aging and both geographical and cultural contexts (Spain and Mexico). [ABSTRACT FROM AUTHOR]

ObjectiveTo analyze the validity of self and informant reports, depressive symptomatology, and some sociodemographic variables to predict the risk of cognitive decline at different follow-up times.MethodsA total of 337 participants over 50 years of age included in the CompAS and classified as Cognitively Unimpaired (CU), Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) groups were assessed at baseline and three follow-ups. A short version of the QAM was administered to assess the severity of subjective cognitive complaints (SCCs), and the GDS-15 was used to evaluate the depressive symptoms. At each follow-up assessment, participants were reclassified according to the stability, regression or progression of their conditions. Logistic regression analysis was used to predict which CU, SCD and MCI participants would remain stable, regress or progress at a 3rd follow-up by using self- and informant-reported complaints, depressive symptomatology, age and education at baseline and 2nd follow-ups as the predictive variables.ResultsOverall, self-reported complaints predicted progression between the asymptomatic and presymptomatic stages. As the objective deterioration increased, i.e., when SCD progressed to MCI or dementia, the SCCs reported by informants proved the best predictors of progression. Depressive symptomatology was also a predictor of progression from CU to SCD and from SCD to MCI.ConclusionA late increase in self-reported complaints make valid estimates to predict subjective decline at asymptomatic stages. However, an early increase in complaints reported by informants was more accurate in predicting objective decline from asymptomatic stages. Both, early and late decrease in self-reported complaints successfully predict dementia from prodromic stage. Only late decrease in self-reported complaints predict reversion from prodromic and pre-symptomatic stages.

ObjectiveDepression in people with diabetes is associated with poorer health outcomes. Although web programs integrating cognitive-behavioral therapy with diabetes education have shown good results, no similar approach has been implemented in Spain. This aim of this study was to administer an Internet-based cognitive-behavioral therapy program (CBT) for the treatment of mild-moderate depressive symptomatology in individuals with type 1 diabetes (WEB_TDDI1 study) and evaluate the efficacy of this program.Research design and methodsA pre-post randomized controlled study was conducted. The sample comprised 65 people with type 1 diabetes and mild-moderate depressive symptoms: 35 treatment group (TG) and 30 control group (CG). The following effects of the nine-session program were analyzed: depression (Beck Depression Inventory Fast Screen, BDI-FS), metabolic variables (glycosilated hemoglobin, HbA1c), and other psychological variables including anxiety (State Trait Anxiety Inventory, STAI), fear of hypoglycemia (Fear of Hypoglycemia Questionnaire, FH-15), distress (Diabetes Distress Questionnaire (DDS), quality of life (Diabetes Quality of Life Questionnaire, DQOL),and treatment adherence (Diabetes Self-Care Inventory-Revised questionnaire, SCI-R).ResultsAt the end of the treatment program, only 28 people were evaluated (TG=8; CG=20). However, a significant reduction was found in both groups in BDI-FS and STAI-T scores, which was significantly greater in the TG. Significant improvements were also found in the TG in DQOL, FH-15, DDS and SCI-R scores. The percentage change in these variables was also statistically significant in the TG versus the CG. However, no significant results were found in HbA1c.ConclusionsThe Internet-based cognitive-behavioral therapy program for the treatment of mild-moderate depressive symptomatology in people with type 1 diabetes (WEB_TDDI1 study) is effective in reducing depressive symptomatology in the sample that completed the study. Positive results are also produced in other variables associated with depression in this population such as diabetes-related distress, trait anxiety, fear of hypoglycemia, quality of life, and adherence to diabetes treatment. Although new studies would be necessary to support the results of this platform, the results obtained are positive and support the use of this platform as an appropriate treatment for this population.Clinical trial registrationClinicalTrials.gov; identifier NCT03473704.

As part of a healthy diet, higher carotenoid intakes have been associated with a reduced risk of depression, mainly in adults, while prospective studies on plasma carotenoids in older adults are lacking. The aim of this study was to assess the prospective association between plasma carotenoids and the risk of Depressive Symptomatology (DS) in older adults. The study sample was based on the Three-City cohort of adults aged 65y+ free from DS at enrollment in 1999. Plasma carotenoids were measured at baseline. DS was assessed every 2–3 years over 17 years and defined by a Center for Epidemiologic Studies-Depression Scale score ≥ 16 and/or by antidepressant use. The association between plasma carotenoids or carotenoid/lipids (cholesterol and triglycerides) ratio and the risk for DS was assessed through multiple random-effect logistic regression. The study sample was composed of 1010 participants (mean age 74 y (±4.9), 58 % of women) followed-up during a median time of 13.4 years. Plasma zeaxanthin and ratios of zeaxanthin/lipids, lutein+zeaxanthin/lipids and β-carotene/lipids were independently associated with a significant reduced risk of DS over time (Odds ratio (OR) = 0.81, 95 % Confidence Interval (CI) [0.67;0.99], OR = 0.79 [0.67;0.98], OR = 0.79 [0.64;0.94] and OR = 0.80 [0.66;0.97] for +1 standard deviation of each exposure respectively). Plasma carotenoids were only available at study baseline. Focusing on circulating carotenoids and considering lipids levels, the present results suggested an association between higher levels of plasma zeaxanthin, combined lutein+zeaxanthin and β-carotene and a decreased risk of DS over time in older adults. • Nutrition is a promising approach in relation to depression in older adults. • Studies on circulating levels of carotenoid are lacking. • This study was based on prospective design, large sample size and long follow-up. • Higher plasma zeaxanthin or β-carotene reduced the risk of depressive symptomatology. • These results encouraged to eat a large variety of colorful fruits and vegetables. [ABSTRACT FROM AUTHOR]

The prevalence of depressive symptomatology in Indian women and the associated treatment gap are alarming and require interventions at a community level. Such interventions may succeed if the specific risk and protective factors are appropriately identified and addressed. Identifying such factors may suggest a Psychological Defensive Syndrome (PDS) against depressive symptomatology, and inculcating this PDS through specific interventions may help individuals manage depressive symptomatology. For evaluating the feasibility of such an idea, a two-phase research project was initiated, and the current paper presents findings of its first phase. The primary aim of the first phase was to explore the predictive relationship between depressive symptomatology and rumination, reappraisal, resilience, self-efficacy, neuroticism, and extraversion. A total of 671 women (Mage = 23.71) responded to standardized questionnaires in a semi-structured interview setting. The obtained data were subjected to correlational, regression, and path analysis. The findings support all the hypotheses; women, who reported less engagement in rumination and more in reappraisal, who scored low on neuroticism and high on extraversion, resilience and self-efficacy, showed less severe depressive symptoms than their counterparts. This pattern can be thought of as a PDS against depressive symptoms in Indian women. These results highlight the importance of addressing these factors in preventing and assuaging depressive symptomatology in Indian women. [ABSTRACT FROM AUTHOR]

Two cross-sectional survey studies were conducted to examine the relationships between minority stressors, protective factors and mental health outcomes in lesbian, gay and bisexual people (LGB) in the United Kingdom (UK). A convenience sample of 156 LGB people in the UK participated in Study 1. Multiple regression analyses showed that victimization and sexuality-related identity threat were positively associated with anxiety and that identity resilience, social support and degree of outness were negative correlates; and that rejection was positively associated with depression while identity resilience and social support were negative correlates. In Study 2, based on a convenience sample of 333 gay men, our structural equation model showed that ethnic minority status, lower identity resilience and higher identity threat were associated with greater distress; ethnic minority status was associated with less social support and more internalized homonegativity; being single was associated with less social support and more internalized homonegativity; identity resilience was positively associated with social support and negatively associated with internalized homonegativity; identity threat was associated with less social support and more internalized homonegativity; internalized homonegativity was negatively associated with social support; and social support was negatively associated with distress while internalized homonegativity was positively associated with distress. Findings show differential effects of particular stressors on particular mental health outcomes in LGB people and the significance of promoting identity resilience, social support and degree of outness as protective factors. [ABSTRACT FROM AUTHOR]

Depression is considered one of the main mental health issues in medical students. Previous studies have shown that medical students have a higher prevalence of depressive symptomatology than the general population and that said prevalence is higher during the medical internship stage compared to the rest of the training. In Mexico there are few reports on the prevalence rates of depressive symptomatology in medical students, particularly, during the medical internship. This work is a Descriptive-observational cross-sectional study and determines the prevalence of depressive symptomatology in medical students from a private university in Puebla city in Mexico undergoing the medical internship. The Center for Epidemiologic Studies Depression Scale Revised (CESD-R) was used as the main research instrument and validates 20 items in Mexican population. An online version of the CESD-R and a demographic questionnaire that includes a question about thoughts quitting career and/or internship, was applied to 204 students who were doing their undergraduate medical internship in February 2019. The sample was constituted by 71 men and 133 women with a mean age of 23.26 ± 1.28 years. For the total sample, 61.27 % were in their first month and 38.73 % in their sixth month of their internship stage; 70.59 % were carrying out their internship in a public hospital and 29.41 % in a private hospital. The results showed that the prevalence of subthreshold depression symptoms (> 16 points of the CESD-R) in the sample was 52.45% of which, 20.58 % were categorized under clinically significant depressive symptomatology with probable major depressive episode (MDE) and 31.86%, in the category of probable sub-threshold depression. Taking as reference the depressive symptoms established for the MDE criteria by DSM-V and its association with each item of the CESD-R, it is noted a prevalence of suicidal ideation from the total sample of 6.86 %. The most frequent depressive symptoms were sleep disturbances (66.17 %), depressive mood (dysphoria, 44.6 %) and fatigue (37.25 %). The proportion of the depressive mood was significantly higher in women than in men, 55.63 % and 23.94 %, respectively, as well as the persistence of fatigue or loss of energy, present in 43.6% of women and 25.35% of men. Whereas the prevalence of the sleep disturbances was greater in men 78.87 % than in women 59.39 %. The association of depressive symptomatology has been analyzed with thoughts about quitting career or internship and it was observed that 32.4% had thoughts about quitting career and/or internship in the last two weeks during the time of performing the questionnaire. The comparative analysis with the presence of depressive symptoms revealed significant differences as to the proportion between groups. Such thoughts were present in 32 of the 42 students with clinically significant depressive symptomatology and 24 of the 65 students with probable episode of sub-threshold depression. Through the analysis of odds ratio (OR), it was determined that the students with depressive symptomatology have 9.55 times greater predisposition to manifest thoughts about quitting career and/or internship. The prevalence of depressive symptoms in students undergoing the year of medical internship analyzed in this study was high and was associated with the idea of leaving the career and/or medical internship. These results support the need for research and implementation of new strategies to detect, prevent and treat depressive disorders in the next generations of medical internship students in the country. [ABSTRACT FROM AUTHOR]

Despite the advances in understanding the complex association between functional abilities and mental health in old age, studies have overlooked two important aspects. First, traditionally, research has employed cross-sectional designs, measuring limitations at a single time point. Second, most gerontological studies on this field have been conducted before the COVID-19 pandemic onset. This study aims to explore the association between diverse long-term functional ability trajectories across late adulthood and old age, and older people's mental health in Chile, before and after the COVID-19 pandemic onset. We use data from the population-representative and longitudinal 'Chilean Social Protection Survey', sequence analysis to reconstruct functional ability trajectory types from 2004 to 2018, and bivariate and multivariate analyses to measure their association with depressive symptoms in early 2020 (N = 891) and late 2020 (N = 672). We analyzed four age groups defined by their age at baseline (2004): people aged 46–50, 51–55, 56–60, and 61–65. Our findings indicate that erratic or equivocal patterns of functional limitations across time (with people transiting back and forth between low and high levels of limitations) show the worst mental health outcomes, both before and after the pandemic onset. Prevalence of people with depression increased after the COVID-19 onset in most groups, being particularly high among those with previous equivocal functional ability trajectories. The relationship between functional ability trajectories and mental health calls for a new paradigm, moving away from age as the main policy guide, and highlighting the need to adopt strategies to improve population-level functional status as an efficient policy to address the challenges of population aging. [ABSTRACT FROM AUTHOR]

Ketamine is a potential rapid-onset antidepressant characterized by sympathomimetic effects. However, the question of ketamine’s use in treating adolescents’ major depressive disorder (MDD) is still discussed. Thus, we aimed to study the acute effect of ketamine infusion treatment on sympathetic regulation using electrodermal activity (EDA) in addition to an assessment of depressive symptomatology in MDD adolescents. Twenty hospitalized adolescent girls with MDD (average age: 15.0 ± 1.46 yrs.) were examined before and two hours after a single intravenous infusion of ketamine. EDA was continuously recorded for 6 min, and depressive symptoms were assessed before and two hours after ketamine administration. The evaluated parameters included skin conductance level (SCL), nonspecific electrodermal responses (NS-SCRs), MADRS (questions no. 1–10, total score), and CDI (items A–E, total score). EDA parameters showed no significant changes after the ketamine treatment, and depressive symptoms were significantly reduced after the ketamine infusion. The analysis revealed a significant negative correlation between index SCL and CDI-A, CDI-E, and the total CDI score and between index NS-SCRs and MADRS no. 4 before the ketamine treatment. In conclusion, ketamine improved depressive symptomatology without a significant effect on EDA, indicating its potential safety and efficiency as an acute antidepressant intervention in adolescent MDD.

Many studies have examined risks factors that facilitated the transition from cognitive vulnerabilities to suicidal ideation. Few studies, however, have examined protective factors against this transition. This study aimed to investigate the buffering effect of different social support dimensions (from family, friends, and significant others) in the links from negative automatic thoughts to suicidal ideation and depressive symptomatology to suicidal ideation among Chinese college students. Also, we examined the mediating role of depressive symptomatology between negative automatic thoughts and suicidal ideation. 469 Chinese college students aged 17–23 were recruited and required to complete online questionnaires. The multidimensional Scale of Perceived Social Support (MSPSS) was used to assess perceived support from family, friends, and significant others. Beck Scale for Suicide Ideation-Chinese Version (BSI-CV), Automatic Thoughts Questionnaire (ATQ), and Self-rating Depression Scale (SDS) were used to evaluate suicidal ideation, negative automatic thoughts, and depressive symptomatology, respectively. Findings revealed that perceived family support could mediate the path between negative automatic thoughts and suicidal ideation, as well as the path between depressive symptomatology and suicidal ideation. However, both supports from friends and significant others could not buffer the adverse outcomes of negative automatic thoughts or depressive symptomatology on suicidal ideation. In addition, the relationship between negative automatic thoughts and suicidal ideation was partially mediated by depressive symptomatology in the present three mediation models. The findings of the current study highlight the potential value of different types of perceived social support against suicidal ideation among Chinese young adults. [ABSTRACT FROM AUTHOR]

The current study aimed at examining the potential role of self-compassion and self-judgment components on depressive symptomatology and psychological health in people with a diagnosis of chronic physical disease. The sample included 223 participants with a diagnosis of chronic physical disease, aged between 18 and 45 years, who completed an online survey. The tested model showed an excellent fit to the empirical data and path analysis results indicated that mindfulness, self-judgment, and isolation have a significant impact on depressive symptomatology (explaining 40% of its variance) and also on psychological health (explaining 45% of its variance). This study shed some light on the role of both self-compassion and self-judgment components, suggesting the importance of the promotion of mindfulness skills and the reduction of self-judgment and feelings of isolation in people with chronic physical disease. These findings seem to support the development of more effective interventions for the promotion of psychological health and reduction of depressive symptoms in people diagnosed with a chronic physical disease. [ABSTRACT FROM AUTHOR]

Background: Stress and depression have each been associated with relapse risk. In clinical practice, chronic alcohol use is often accompanied by poor emotional and self‐regulatory processes. Tonic and phasic changes in stress responsivity impact an individual's relapse risk to alcohol. A further complicating factor is the pervasive coexistence of depressive symptoms in those with Alcohol Use Disorder (AUD), where the contribution of depressive symptomatology to these processes is not well understood. Individuals with AUD (AD) (21 with and 12 without sub‐clinical depressive symptoms) and 37 social drinking controls (16 with and 21 without sub‐clinical depressive symptoms) as part of a more extensive study (Fox et al., 2019). All participants were exposed to two 5‐min personalized guided imagery conditions (stress and neutral) in a randomized and counterbalanced order across consecutive days. Alcohol craving, negative mood, Stroop performance, and plasma measures (cortisol, adrenocorticotrophic hormone, and salivary alpha‐amylase) were collected before and after imagery exposure. Results: Elevations in autonomic response (heart rate) to imagery (stress and neutral) were observed as a function of drinking (in both depressed and non‐depressed individuals with alcohol use disorder compared with depressed and non‐depressed social drinkers). Conversely, suppressed cortisol following stress was observed as a function of depressive symptomatology across both drinking groups. Individuals with comorbid AD and depressive symptoms demonstrated attenuated Adrenocorticotropic Hormone and poor Stroop performance compared with the other groups, indicating an interactive effect between drinking and depression on pituitary and inhibitory systems. Conclusion: Sub‐clinical depressive pathophysiology may be distinct from drinking severity and may alter relapse‐related stress adaptations during protracted abstinence from alcohol. [ABSTRACT FROM AUTHOR]

Introduction: Depressive symptomatology is often associated with the onset of dementia, although the exact form and directionality of this association is still unclear. The aim of this study is to investigate whether depressive symptomatology at the time of dementia diagnosis was predictive of cognitive, functional, and behavioral decline over 1 year. Methods: In a Rural and Remote Memory Clinic, 375 patients consecutively diagnosed with mild cognitive impairment, Alzheimer disease, or non-Alzheimer disease dementia completed the Center for Epidemiological Studies Depression Scale at first visit and 1-year follow-up to assess depressive symptomatology. The same cohort was evaluated for cognitive, functional, and behavioral decline through the completion of 5 clinical tests performed at the first visit and at 1-year follow-up. Results: Depressive symptomatology at time of dementia diagnosis did not predict cognitive or functional decline over 1 year, although increases in depressive symptomatology over 1 year significantly correlated with higher caregiver ratings of neuropsychiatric symptom severity and related distress over that time. Conclusion: Increasingly severe depressive symptomatology over 1 year correlated with greater caregiver distress. This study points the way for future studies delineating the relationship between depression, dementia progression, and caregiver distress. [ABSTRACT FROM AUTHOR]

Depression is a type of mood disorder that can impact individuals of any age. A variety of factors, including biological, psychological, and environmental factors, can contribute to the likelihood of developing depression. If the environment in which a person exists does not support its occurrence, the disorder may not manifest. The current research follows a retrospective, correlational approach, utilizing a non-probability sample of 557 high school students from public schools in Mexico City. This sample includes 181 males and 376 females, aged between 15 and 18 years, with an average age of 15.66 and a standard deviation of 0.68. The main objective of this research is to identify the variables that serve as risk factors for the development of depressive disorders in Mexican adolescents in high school. The data show that 78% of the adolescents in the total sample were at risk of depression, which is consistent with what has been reported by other researchers. The regression model shows that alcohol and drug consumption is associated with and influences the emergence and presence of depressive symptomatology and major depressive disorder. Adolescents with different sexual orientations than heterosexuals are twice as likely to suffer depression and emotional dysregulation. It was confirmed that the developmental stage and adolescence contributes as a context that favors the evolution of such a symptomatology. [ABSTRACT FROM AUTHOR]

Background: Depression remains among the most prevalent mental disorders, and it severely affects daily functioning and quality of life. There has been extensive research reporting on the impact of social relationships on depression, but much of this research has only considered isolated aspects of relationships. This study derived social network types based on the multiple components of social relationships, and then investigated their effects on depressive symptoms. Methods: Using samples of 620 adults (Mage = 53.52), Latent Profile Analysis (LPA) was conducted to uncover network types based on the structural (network size, contact frequency, marital status, and social engagement), functional (levels of support and conflict), and qualitative (satisfaction with relationships) aspects of social relationships. Multiple regressions were used to test if distinct network types directly impact on depressive symptoms and whether network types moderate the association of loneliness (perceived social isolation) with depressive symptoms. Results: LPA identified four distinct network types (diverse, family-focused, friend-focused, and restricted) and there were significant differences in depressive symptoms among four network types. Analysis using the BCH method showed that individuals in the restricted network type had the highest depressive symptoms, followed in order by individuals in the friend-focused, family-focused, and diverse network types. Regression results further indicated that an individual's network network type membership was significantly associated with depressive symptoms, and being in the diverse and family-focused network types alleviated the negative effect of loneliness on depressive symptoms. Conclusion: The results suggest that both quantitative and qualitative aspects of social relationships are important in buffering against the adverse effect of loneliness on depressive symptoms. These findings underscore the utility of taking a multi-dimensional approach to uncover heterogeneity in the social networks of adults and their implications on depression. [ABSTRACT FROM AUTHOR]

Objective. To estimate the prevalence of depressive symptomatology in Mexican adolescents and adults. Materials and methods. The Encuesta Nacional de Salud y Nutrición 2022 evaluated the prevalence of depressive symptomatology using the CESD-7 scale. In adolescents, we estimated the average score, and in adults the prevalence of depressive symptomatology according to preestablished cut-off points. Results. In adolescents the average score was 3.2. In adults, 16.7% had depressive symptomatology, with a higher prevalence in older adults (38.3%). We observed a higher prevalence among women, adults in the low well-being index, and older adult residents of rural areas. Conclusion. The prevalence of depressive symptomatology among adults has been stable from 2018-19 to date. However, the diagnosis and treatment of depression must be oriented to populations with a higher prevalence like women, adults with low well-being index, and residents of rural areas. [ABSTRACT FROM AUTHOR]

Osteoarthritis (OA) is a leading cause of disability among older adults. By 2050, approximately 60 million will suffer from arthritis adding up to a total societal cost of $65 billion. Chronic illnesses resulting in pain, and functional decline have been associated with depression in previous studies. A causal model was developed and tested using structural equation modeling that examined depression scores of 503 older (age 50-85), male Veterans with moderate to severe symptomatic OA of the knee\hip. The results of the structural equation modeling produced a final model of depressive symptomatology that fit the data well (Chi square = 12.23, DF = 11, p =.346; TLI =.99; CFI = 1.00; RMSEA =.02). The findings indicate the central role that OA severity (pain, stiffness, and functional difficulties) plays in the mental health of older Veterans in terms of the level of reported depressive symptoms. [ABSTRACT FROM AUTHOR]

Comorbid depression is a highly prevalent and debilitating condition in middle-aged and elderly adults, particularly when associated with obesity, diabetes, and sleep disturbances. In this context, there is a growing need to develop efficient screening methods for cases based on clinical health markers for these comorbidities and sleep data. Thus, our objective was to detect depressive symptoms in these subjects, considering general biomarkers of obesity and diabetes and variables related to sleep and physical exercise through a machine learning approach. We used the National Health and Nutrition Examination Survey (NHANES) 2015–2016 data. Eighteen variables on self-reported physical activity, self-reported sleep habits, sleep disturbance indicative, anthropometric measurements, sociodemographic characteristics and plasma biomarkers of obesity and diabetes were selected as predictors. A total of 2907 middle-aged and elderly subjects were eligible for the study. Supervised learning algorithms such as Lasso penalized Logistic Regression (LR), Random Forest (RF) and Extreme Gradient Boosting (XGBoost) were implemented. XGBoost provided greater accuracy and precision (87%), with a proportion of hits in cases with depressive symptoms above 80%. In addition, daytime sleepiness was the most significant predictor variable for predicting depressive symptoms. Sleep and physical activity variables, in addition to obesity and diabetes biomarkers, together assume significant importance to predict, with accuracy and precision of 87%, the occurrence of depressive symptoms in middle-aged and elderly individuals. • Sleep data facilitates the prediction of depressive symptoms in middle-aged and older adults. • Daytime sleepiness is an important predictor of depressive symptoms. • XGBoost outperforms other machine learning (ML) models in the prediction of depressive symptoms. • ML models to predict depressive symptoms facilitate the screening of depression. [ABSTRACT FROM AUTHOR]

Cognitive impairment can represent a predecessor to neuro-degenerative processes; however, evidence suggests that non-pharmacologic interventions such as reminiscence therapy (RT) and cognitive stimulation therapy (CST) can potentially stabilize or reverse this trend. Community-based settings are widely regarded as the key area of intervention by healthcare professionals in this field. Thus, this study aimed to assess the effects of an RT and a CST program in the cognition, depressive symptomatology, and quality of life (QoL) of older adults with cognitive decline who attend community support structures (CSS) in central Portugal. A quasi-experimental study with two arms (RT and CST program) was conducted for seven weeks. Participants were allocated to each arm based on the CSS they attended. Of the 109 older adults initially screened, 76 completed the intervention (50 in the RT program and 26 in the CST program). A pre- and post-intervention analysis showed statistically significant differences in older adults’ cognition, especially in their delayed recall ability, in both groups. Older adults in the RT program evidence improved QoL scores post-intervention. Both the RT and CST programs implemented throughout the study are beneficial to older adults’ cognitive performance, although results are more pronounced in the earlier stages of cognitive decline. Participation in the RT program was associated with improvements in older adults’ QoL scores.

Background: Preliminary evidence suggests beneficial effects of cognitive remediation in depression. An update of the current evidence is needed. The aim was to systematically assess the effectiveness of cognitive remediation in depression on three outcomes. Methods: The meta-analysis was pre-registered on PROSPERO (CRD42019124316). PubMed, PsycINFO, Embase and Cochrane Library were searched on 2 February 2019 and 8 November 2020 for peer-reviewed published articles. We included randomized and non-randomized clinical trials comparing cognitive remediation to control conditions in adults with primary depression. Random-effects models were used to calculate Hedges' g , and moderators were assessed using mixed-effects subgroup analyses and meta-regression. Main outcome categories were post-treatment depressive symptomatology (DS), cognitive functioning (CF) and daily functioning (DF). Results: We identified 5221 records and included 21 studies reporting on 24 comparisons, with 438 depressed patients receiving cognitive remediation and 540 patients in a control condition. We found a small effect on DS (g = 0.28, 95% CI 0.09–0.46, I 2 40%), a medium effect on CF (g = 0.60, 95% CI 0.37–0.83, I 2 44%) and a small effect on DF (g = 0.22, 95% CI 0.06–0.39, I 2 3%). There were no significant effects at follow-up. Confounding bias analyses indicated possible overestimation of the DS and DF effects in the original studies. Conclusions: Cognitive remediation in depression improves CF in the short term. The effects on DS and DF may have been overestimated. Baseline depressive symptom severity should be considered when administering cognitive remediation. [ABSTRACT FROM AUTHOR]

Current evidence suggests that some isolated polyphenols (PP) may exert promising effects for the risk of depression in young adults, however studies among older adults remain limited. The aim of the current study was to examine the prospective association between patterns of PP intake and the risk of depressive symptomatology (DS) in older adults. The study sample was based on the Three-City (3C) Bordeaux cohort of adults aged 65 years and over and without DS at the time of recruitment. The intakes of PP, summarised into 21 PP classes, were determined using a 24-h recall combined with the Phenol-Explorer database. In addition, the patterns of PP intake were identified by a Principal Component Analysis (PCA). DS was evaluated using the Center for Epidemiologic Studies Depression Scale (CES-D) over a period of 15 years with a reassessment every 2–3 years. The incident DS was reported for CES-D score ≥16 and/or the use of antidepressant treatment. The association between the patterns of PP intake at baseline and the risk of DS was computed using multivariate random-effect logistic regression models. Among the 1074 participants (mean age 75.7 y, SD 4.8 y), 423 (39.4%) developed a DS during the follow-up. Distinct patterns of PP intake were identified, explaining up to 50% of the variance. The two first patterns, mainly driven by stilbenes and dihydroflavonols and by hydroxyicnnamic acid and alkylmethoxyphenols respectively, were not associated with the odds of DS. Furthermore, a higher score on the third pattern, mainly driven by monomeric flavanols and theaflavins, was associated with a significant 27% lower risk of DS over time (Odd Ratio = 0.73, 95% Confidence Interval [0.55; 0.97]). This prospective study suggested that a pattern high in monomeric flavanols and theaflavins intakes, mainly provided by tea, was associated with a reduced risk of DS in older adults. These results provide promising evidence on combined PP intakes that would require further confirmation in other samples. [ABSTRACT FROM AUTHOR]

Objective: To analyze the association between diverse medical conditions and depressive symptoms in different profiles of dementia caregivers based on sex and kinship (wives, husbands, daughters, and sons).Methods: Individual interviews were conducted with 338 dementia family caregivers. Depressive symptoms were measured with the Spanish version of the Center for Epidemiologic Studies-Depression Scale. Medical conditions encompassed the following physical diseases: high cholesterol, osteoarthritis, hypertension, diabetes, cancer, and cardiovascular, brain, kidney, liver, and stomach diseases.Logistic regression analyses were carried out to identify determinants associated to thepresenceof depressive symptoms.Results: High cholesterol was the most frequent disease among caregivers.Significant differences among groups were found in depressive symptoms: between wives (50.60%) and husbands (28.40%),(p = 0.033), and between daughters (57.00%) and husbands (p = 0.001). Half of the sonsreported thepresenceof depressive symptoms. In daughters, depressive symptomatology was significantly more likely whether they presented a worse reaction to disruptive behaviors, a poor assessment of global deterioration of care recipient, and less perceived health status. Furthermore, daughters were 1.94 times more likely to experience depressive symptoms if they presented medical conditions (p = 0.017).Conclusions: Daughter caregivers that have depressive and physical diseases may be an especially vulnerable subgroup of caregivers that may not be the ideal population to provide care. Access to high-quality, evidence-based therapies focused on improving caregivers' physical health could have a positiveeffecton thepresenceof depressive symptoms, particularly in the case of daughter caregivers. [ABSTRACT FROM AUTHOR]

Abstract Background Depressive symptomatology is prevalent among female university students with adverse effects on their quality of life and academic performance. Previous research suggested associations between depressive symptomatology and oxytocin levels and between depressive symptomatology and Temperament Traits. Despite this evidence, to the best of our knowledge no research has studied the effects fboth oxytocin serum levels and temperament dimensions on depressivesymptoms in a healthy sample. The present study aimed to analyse the effect of oxytocin levels and temperament traits on depressive symptomatology in healthy female university students. Methods All participants completed the Beck Depression Inventory and the Adult Temperament Questionnaire. Blood samples were collected between 8 and 8H30 a.m. after 12 h of fasting and between 5 and 8 day of the menstrual cycle and serum oxytocin levels were quantified using a commercial enzyme-linked immunosorbent assay. A hierarchical multiple regression model using a stepwise method was conducted to identify predictors of depression. Results Forty-five women aged between 18 and 25 years old (19.37 ± 1.32 years) volunteered to participate in this study. Depressive symptomatology was negatively associated with oxytocin serum levels and "Negative affect" and positively associated with "Effortful control" and "Activation Control". In the final regression model, only oxytocin level was a predictor (B = − 0.090, p

Several foods from the Mediterranean Diet (MeDi) have already been characterized as beneficial for depression risk, while studies focusing on adherence to the overall MeDi are lacking among older adults at higher risk of depression. The aim of this study was to assess the association between MeDi adherence and the risk of depressive symptomatology (DS) in an older French cohort followed for 15 years. Participants from the Three-City Bordeaux cohort answered a food frequency questionnaire used to assess their MeDi adherence. The Center for Epidemiologic Studies Depression (CES-D) scale score of 16 or greater and/or use of antidepressant treatment ascertained at each visit defined incident DS. Random-effect logistic regression models were adjusted for potential confounders. Among 1018 participants, aged 75.6 years (SD 4.8 years) on average at baseline, 400 incident cases of DS were identified during the follow-up. Only when restricting the definition of DS to a CES-D score ≥ 16 was a borderline-significant trend towards a benefit of greater adherence to the MeDi with reduced odds of DS found (p-value = 0.053). In this large sample of older French adults, a potential benefit of greater adherence to the MeDi regarding the risk of DS would depend on the definition of DS. [ABSTRACT FROM AUTHOR]

The burden of depression is increasing worldwide, specifically in older adults. Unhealthy dietary patterns may partly explain this phenomenon. In the Spanish PREDIMED-Plus study, we explored (1) the cross-sectional association between the adherence to the Prime Diet Quality Score (PDQS), an a priori-defined high-quality food pattern, and the prevalence of depressive symptoms at baseline (cross-sectional analysis) and (2) the prospective association of baseline PDQS with changes in depressive symptomatology after 2 years of follow-up. After exclusions, we assessed 6612 participants in the cross-sectional analysis and 5523 participants in the prospective analysis. An energy-adjusted high-quality dietary score (PDQS) was assessed using a validated FFQ. The cross-sectional association between PDQS and the prevalence of depression or presence of depressive symptoms and the prospective changes in depressive symptoms were evaluated through multivariable regression models (logistic and linear models and mixed linear-effects models). PDQS was inversely associated with depressive status in the cross-sectional analysis. Participants in the highest quintile of PDQS (Q5) showed a significantly reduced odds of depression prevalence as compared to participants in the lowest quartile of PDQS (Q1) (OR (95 %) CI = 0·82 (0·68, 0·98))). The baseline prevalence of depression decreased across PDQS quintiles (Pfor trend = 0·015). A statistically significant association between PDQS and changes in depressive symptoms after 2-years follow-up was found (β (95 %) CI = −0·67 z-score (–1·17, −0·18). A higher PDQS was cross-sectionally related to a lower depressive status. Nevertheless, the null finding in our prospective analysis raises the possibility of reverse causality. Further prospective investigation is required to ascertain the association between PDQS and changes in depressive symptoms along time. [ABSTRACT FROM AUTHOR]

Objectives: This study aimed to identify the prevalence and correlates of depressive symptomatology among Vietnamese older people.Method: We used baseline survey data collected in 2018 from the Longitudinal Study of Ageing and Health in Vietnam (LSAHV) conducted across seven regions and comprising 6,050 people aged 60 years and over of whom 4962 completed the brief 11-item Center for Epidemiological Studies-Depression (CES-D) scale. Clinically significant depressive symptomatology was a CES-D score of 8.8 or higher. The association between demographic, physical, and mental factors with depressive symptomatology was examined using univariate and multivariable logistic regression.Results: The prevalence of depressive symptomatology was 31.3% (95% CI 29.8% - 32.9%). Depressive symptomatology was highest among people living in the Central Coast region (46.8%, 95% CI 44.5% - 49.2%). Factors associated with depressive symptomatology from the multivariable model included female sex (OR 1.3, 95% CI: 1.1-1.6), rural residence (OR 1.4, 95%CI: 1.1-1.7), not having a partner (OR 1.6, 95% CI: 1.3-1.9), low income (OR 1.8, 95% CI: 1.5-2.1), and health-limitations on activities (OR 1.3, 95% CI: 1.1-1.6). Poorer self-rated mental health (OR 2.1, 95% CI:1.8-2.5) or general health status (OR 1.5, 95% CI: 1.3-1.9) was associated with a higher prevalence of depressive symptomatology, as was poorer function with respect to different activities of daily living, and dissatisfaction with current life (OR 6.1, 95% CI: 4.4-8.4).Conclusions: Depressive symptomatology was frequent among older Vietnamese. Efforts to improve mental health in older persons in Vietnam, including prevention, early intervention and better medical care, appear warranted. [ABSTRACT FROM AUTHOR]

Depression is a type of mood disorder that can impact individuals of any age. A variety of factors, including biological, psychological, and environmental factors, can contribute to the likelihood of developing depression. If the environment in which a person exists does not support its occurrence, the disorder may not manifest. The current research follows a retrospective, correlational approach, utilizing a non-probability sample of 557 high school students from public schools in Mexico City. This sample includes 181 males and 376 females, aged between 15 and 18 years, with an average age of 15.66 and a standard deviation of 0.68. The main objective of this research is to identify the variables that serve as risk factors for the development of depressive disorders in Mexican adolescents in high school. The data show that 78% of the adolescents in the total sample were at risk of depression, which is consistent with what has been reported by other researchers. The regression model shows that alcohol and drug consumption is associated with and influences the emergence and presence of depressive symptomatology and major depressive disorder. Adolescents with different sexual orientations than heterosexuals are twice as likely to suffer depression and emotional dysregulation. It was confirmed that the developmental stage and adolescence contributes as a context that favors the evolution of such a symptomatology.

Background. Heart failure (HF) is a chronic disease whose symptoms and course produce significant physical limitations and psychological deterioration. hf patients with depression and anxiety perceive their quality of life as particularly impaired. Objective. The present study aimed to examine the efficacy of a cognitive-behavioral intervention via telephone to reduce depressive symptomatology in patients with HF. Method. Recording included depressive symptomatology (Beck BDI-II inventory), anxiety and depression (HADS), and physical and emotional quality of life in hf, (Minnesota). Additionally, a numerical visual scale was applied to assess perceived anxiety and a behavioral activation record. Procedure. Based on a pilot analysis of needs detection, the intervention assumed a modular structure. After reviewing conceptually, in depth, with the participants the topics of deep relaxation training, behavioral activation, problem-solving, dysfunctional thoughts, and relapse prevention; specific clinical techniques on these variables were implemented. Design. The study used a within-subjects design with a one-month follow-up. Results. The main findings show that the intervention was effective in relatively medically stable patients, with a lower effect in patients with exacerbated physical symptomatology. Perceived quality of life showed a trend towards improvement without statistically significant differences. Discussion. The treatment of depressive symptomatology in hf with this care format was feasible and easily accessible for participants in conditions of socioeconomic vulnerability. [ABSTRACT FROM AUTHOR]

Insulin resistance (IR) is linked to depressive disorders, and there is growing evidence that targeting IR may be beneficial in treating them. We examine the association between depressive symptoms and a direct measure of IR, and whether family history of type 2 diabetes (FHx-T2DM) or major depressive disorder (FHx-MDD) moderate this relationship. Cross-sectional data were collected from 96 primarily overweight/obese adults ages 25–50 without diabetes or clinical depression. Multiple regression and correlation analyses were used to assess the association between depressive symptoms and a direct measure of IR (steady-state plasma glucose) as well as moderating effects of FHx-T2DM or FHx-MDD. In the total sample, elevated depressive symptoms were positively associated with IR (p = 0.005). IR was associated with depressive symptoms in subjects with FHx-T2DM (p = 0.002) or FHx-MDD (p = 0.009) whereas BMI was associated with depressive symptoms in subjects without FHx-T2DM (p = 0.049) or FHx-MDD (p = 0.029). The odds of being in the top tertile of IR increased with elevated depressive symptoms alone (OR, 4.22; 95%CI, 1.15 to 17.33), presence of FHx-T2DM alone (OR, 3.42; 95%CI, 1.26 to 10.00), and presence of both FHx-T2DM and elevated depressive symptoms (OR, 10.08; 95%CI, 1.94 to 96.96). Our findings indicate that depressive symptoms are positively associated with a direct measure of IR in overweight/obese individuals without diabetes or clinical depression. This association is moderated by FHx-T2DM. Early identification of groups vulnerable to IR related to depressive symptomatology may be useful for determining personalized interventions that have the potential to reduce morbidity in later years. • Depressive symptoms were positively associated with a direct measure of insulin resistance in overweight/obese individuals without diabetes or clinical depression. • This association was moderated by family history of type 2 diabetes. • Subjects with family history of type 2 diabetes had increased odds of being in the top tertile of insulin resistance when they exhibited depressive symptoms. [ABSTRACT FROM AUTHOR]

Emotional neglect is said to be a risk factor for long lasting mental health problems in adolescents. This study aims to explore the experience and manifestation of emotional neglect in adolescents. Initially, 29 items were generated through open-ended interview approach from 25 participants (13 boys & 12 girls) aged 10-19 years. After content validation, a pilot study was carried out on a self-report measure of emotional neglect on a sample of 10 participants (5 boys and 5 girls). Lastly, a sample of 350 participants (boys = 45%, girls = 55%) aged 10-19 years (M=17.23; SD=1.02) were tested for psychometric properties of Emotional Neglect Scale (ENS) along with a Depressive Symptomatology Scale. Exploratory Factor Analysis generated two factors of Emotional Neglect Scale (ENS) dominance and control and lack of attention. ENS showed sound reliability and validity. The scale found to have good internal consistency, construct validity and reliability. Findings are discussed in the light of factorial structure in Pakistani cultural context. [ABSTRACT FROM AUTHOR]

In this work, we developed a machine learning model to predict depressive symptomatology (DS). The model achieved an AUC of 0.71 and a sensitivity of 74.8%. When developing the model, we applied a Bayesian network approach to select its predictors. This probabilistic approach facilitates the understanding of the relationships between predictors and DS. In consequence, we were able to identify that having balance problems and experiencing shortness of breath are directly related to DS. [ABSTRACT FROM AUTHOR]

The Patient Health Questionnaire-2 (PHQ-2) is the most commonly used ultra-brief depressive symptomatology pre-screening instrument. However, this analysis demonstrated the PHQ-2 is not superior to other PHQ-9 item pairings in this sample. 12 out of the 36 pairings had an equal or higher cross-validation area under the receiver operating characteristic curve than the PHQ-2. The two pairings of phq2&4 and phq2&8 performed best and suggest low energy or psychomotor retardation or agitation may be more discriminatory symptoms than anhedonia. Pairings were combined with machine learning models which are not restricted to the summation and greater-than-or-equal-to logic of the PHQ-2 thresholds. [ABSTRACT FROM AUTHOR]

Cognitive impairment can represent a predecessor to neuro-degenerative processes; however, evidence suggests that non-pharmacologic interventions such as reminiscence therapy (RT) and cognitive stimulation therapy (CST) can potentially stabilize or reverse this trend. Community-based settings are widely regarded as the key area of intervention by healthcare professionals in this field. Thus, this study aimed to assess the effects of an RT and a CST program in the cognition, depressive symptomatology, and quality of life (QoL) of older adults with cognitive decline who attend community support structures (CSS) in central Portugal. A quasi-experimental study with two arms (RT and CST program) was conducted for seven weeks. Participants were allocated to each arm based on the CSS they attended. Of the 109 older adults initially screened, 76 completed the intervention (50 in the RT program and 26 in the CST program). A pre- and post-intervention analysis showed statistically significant differences in older adults' cognition, especially in their delayed recall ability, in both groups. Older adults in the RT program evidence improved QoL scores post-intervention. Both the RT and CST programs implemented throughout the study are beneficial to older adults' cognitive performance, although results are more pronounced in the earlier stages of cognitive decline. Participation in the RT program was associated with improvements in older adults' QoL scores. [ABSTRACT FROM AUTHOR]

Background: Peer victimization is a problem that affects adolescents worldwide. Since so few studies have been made on the relationship between maturity and indirect peer victimization, the main objective of this study was to determine if maturity provides incremental validity beyond the personality traits when predicting indirect victimization. Another objective was to test a model of how all these variables are related to depressive symptomatology and life satisfaction. Method: 548 high school students completed five questionnaires. We performed correlations, multiple regression analysis and structural equation analysis. Results: The hierarchical regression analyses show that maturity has incremental validity in predicting indirect peer victimization. Two personality traits (emotional stability and agreeableness) and two maturity factors (identity and self-reliance) were major predictors of indirect peer victimization. The hierarchical regression analyses also show that major predictors were the same for girls and boys. The Structural Equation Model tested had a good fit, which suggests that indirect victimization increases depressive symptomatology and decreases life satisfaction. Conclusions: The results suggest that both personality traits and psychological maturity have to be taken into account when predicting indirect peer victimization. The study also shows the emotional suffering related to this victimization. [ABSTRACT FROM AUTHOR]