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3. Supreme Court Abandons Distinction Between Primary-Coverage Clauses And Preventive-Warranty Clauses. Good Riddance?

Author

Den Hollander, Wouter

Subjects
Clauses (Law) -- Laws, regulations and rules, Insurance law -- Interpretation and construction, Government regulation, Business, international
Abstract

The Dutch Supreme Court handed down an important decision (ECLI:NL:HR:2024:258) on 16 February 2024 on the restrictive standard of reasonableness and fairness with respect to insurance policies. The Supreme Court [...]

Published
2024

4. Accuracy of upper endoscopies with random biopsies to identify patients with gastric premalignant lesions who can safely be exempt from surveillance

Author

Mommersteeg, Michiel C., Nieuwenburg, Stella A. V., den Hollander, Wouter J., Holster, Lisanne, den Hoed, Caroline M., Capelle, Lisette G., Tang, Tjon J., Anten, Marie- Paule, Prytz-Berset, Ingrid, Witteman, Ellen M., ter Borg, Frank, Burger, Jordy P. W., Doukas, Michail, Bruno, Marco J., Peppelenbosch, Maikel P., Fuhler, Gwenny M., Kuipers, Ernst J., and Spaander, Manon C. W.

Published
2021
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5. Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.

Author

Castaño-Betancourt, Martha C, Evans, Dan S, Ramos, Yolande FM, Boer, Cindy G, Metrustry, Sarah, Liu, Youfang, den Hollander, Wouter, van Rooij, Jeroen, Kraus, Virginia B, Yau, Michelle S, Mitchell, Braxton D, Muir, Kenneth, Hofman, Albert, Doherty, Michael, Doherty, Sally, Zhang, Weiya, Kraaij, Robert, Rivadeneira, Fernando, Barrett-Connor, Elizabeth, Maciewicz, Rose A, Arden, Nigel, Nelissen, Rob GHH, Kloppenburg, Margreet, Jordan, Joanne M, Nevitt, Michael C, Slagboom, Eline P, Hart, Deborah J, Lafeber, Floris, Styrkarsdottir, Unnur, Zeggini, Eleftheria, Evangelou, Evangelos, Spector, Tim D, Uitterlinden, Andre G, Lane, Nancy E, Meulenbelt, Ingrid, Valdes, Ana M, and van Meurs, Joyce BJ

Subjects
Cartilage, Hip Joint, Humans, Osteoarthritis, Hip, Genetic Predisposition to Disease, Trehalase, Transforming Growth Factor alpha, Regulatory Sequences, Nucleic Acid, Genetic Heterogeneity, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Middle Aged, Female, Male, Receptor, Fibroblast Growth Factor, Type 3, Genome-Wide Association Study, Phosphatidylinositol 3-Kinases, Class Ia Phosphatidylinositol 3-Kinase, Osteoarthritis, Hip, Regulatory Sequences, Nucleic Acid, Polymorphism, Single Nucleotide, and over, Receptor, Fibroblast Growth Factor, Type 3, Genetics, Developmental Biology
Abstract

Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for cartilage thickness, in a discovery set of 13,013 participants from five different cohorts and replication in 8,227 individuals from seven independent cohorts. We identified five genome-wide significant (GWS, P≤5·0×10-8) SNPs annotated to four distinct loci. In addition, we found two additional loci that were significantly replicated, but results of combined meta-analysis fell just below the genome wide significance threshold. The four novel associated genetic loci were located in/near TGFA (rs2862851), PIK3R1 (rs10471753), SLBP/FGFR3 (rs2236995), and TREH/DDX6 (rs496547), while the other two (DOT1L and SUPT3H/RUNX2) were previously identified. A systematic prioritization for underlying causal genes was performed using diverse lines of evidence. Exome sequencing data (n = 2,050 individuals) indicated that there were no rare exonic variants that could explain the identified associations. In addition, TGFA, FGFR3 and PIK3R1 were differentially expressed in OA cartilage lesions versus non-lesioned cartilage in the same individuals. In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 and TREH) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human OA, which may serve as a new target for future therapies.

Published
2016

6. Secondhand smoke exposure in public outdoor spaces in the Netherlands: The stronger the smell, the more exposure to nicotine.

Author

Bommelé, Jeroen, Cremers, Hans, Den Hollander, Wouter, Troelstra, Sigrid, Geuke, Gemma, Dam, Wiebe, Willemse, Eefje, Hopman, Petra, Walters, Bethany Hipple, and Willemsen, Marc

Subjects
SMOKING prevention, RESEARCH funding, NICOTINE, HEALTH policy, DESCRIPTIVE statistics, PUBLIC spaces, SMELL, GAS chromatography, ENVIRONMENTAL exposure, MASS spectrometry, TOBACCO products, CONFIDENCE intervals, PASSIVE smoking
Abstract

INTRODUCTION While secondhand smoke exposure in outdoor spaces has been investigated before, no data on outdoor secondhand smoke exposure have been collected in the Netherlands. Such data could help policymakers gain support for smoke-free outdoor public spaces. METHODS Between May and November 2021, we visited 25 outdoor locations across the Netherlands. At each location, we conducted four measurements with smokers and one measurement without smokers. During each measurement, we counted the number of smokers present and we rated tobacco smell intensity on a five-point scale. Airborne nicotine and 3-ethenylpyridine (3-EP) data were collected through active sampling on thermal desorption tubes. The contents of these tubes were later analyzed using gas chromatography-mass spectrometry. Using linear mixed models, we investigated the association between levels of nicotine and the presence of smokers, the number of smokers, and the intensity of tobacco smell. We also investigated these association with levels of 3-EP. RESULTS Nicotine levels were higher when smokers were present (B=1.40; 95% CI: 0.69-2.11, p<0.001). For each additional smoker present, we measured higher levels of nicotine (B=0.23; 95% CI: 0.10-0.37, p=0.001). When the smell of tobacco smoke was noted to be stronger by the researchers, higher levels of nicotine were measured through sampling (B=0.85; 95% CI: 0.44-1.26, p<0.001). We found similar results for 3-EP levels. CONCLUSIONS This study showed that both nicotine and 3-EP are useful in quantifying levels of secondhand smoke in various outdoor locations. The level of nicotine exposure outdoors was positively associated with the number of smokers nearby. The intensity of the tobacco smell was also related to nicotine exposure: the stronger the smell of tobacco smoke, the more nicotine was measured in the air. [ABSTRACT FROM AUTHOR]

Published
2024
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7. The transcriptional landscape of age in human peripheral blood.

Author

Peters, Marjolein J, Joehanes, Roby, Pilling, Luke C, Schurmann, Claudia, Conneely, Karen N, Powell, Joseph, Reinmaa, Eva, Sutphin, George L, Zhernakova, Alexandra, Schramm, Katharina, Wilson, Yana A, Kobes, Sayuko, Tukiainen, Taru, NABEC/UKBEC Consortium, Ramos, Yolande F, Göring, Harald HH, Fornage, Myriam, Liu, Yongmei, Gharib, Sina A, Stranger, Barbara E, De Jager, Philip L, Aviv, Abraham, Levy, Daniel, Murabito, Joanne M, Munson, Peter J, Huan, Tianxiao, Hofman, Albert, Uitterlinden, André G, Rivadeneira, Fernando, van Rooij, Jeroen, Stolk, Lisette, Broer, Linda, Verbiest, Michael MPJ, Jhamai, Mila, Arp, Pascal, Metspalu, Andres, Tserel, Liina, Milani, Lili, Samani, Nilesh J, Peterson, Pärt, Kasela, Silva, Codd, Veryan, Peters, Annette, Ward-Caviness, Cavin K, Herder, Christian, Waldenberger, Melanie, Roden, Michael, Singmann, Paula, Zeilinger, Sonja, Illig, Thomas, Homuth, Georg, Grabe, Hans-Jörgen, Völzke, Henry, Steil, Leif, Kocher, Thomas, Murray, Anna, Melzer, David, Yaghootkar, Hanieh, Bandinelli, Stefania, Moses, Eric K, Kent, Jack W, Curran, Joanne E, Johnson, Matthew P, Williams-Blangero, Sarah, Westra, Harm-Jan, McRae, Allan F, Smith, Jennifer A, Kardia, Sharon LR, Hovatta, Iiris, Perola, Markus, Ripatti, Samuli, Salomaa, Veikko, Henders, Anjali K, Martin, Nicholas G, Smith, Alicia K, Mehta, Divya, Binder, Elisabeth B, Nylocks, K Maria, Kennedy, Elizabeth M, Klengel, Torsten, Ding, Jingzhong, Suchy-Dicey, Astrid M, Enquobahrie, Daniel A, Brody, Jennifer, Rotter, Jerome I, Chen, Yii-Der I, Houwing-Duistermaat, Jeanine, Kloppenburg, Margreet, Slagboom, P Eline, Helmer, Quinta, den Hollander, Wouter, Bean, Shannon, Raj, Towfique, Bakhshi, Noman, Wang, Qiao Ping, Oyston, Lisa J, Psaty, Bruce M, Tracy, Russell P, Montgomery, Grant W, and Turner, Stephen T

Subjects
NABEC/UKBEC Consortium, Humans, Gene Expression Profiling, DNA Methylation, Aging, European Continental Ancestry Group, Transcriptome, Biomarkers
Abstract

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.

Published
2015

8. Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Author

Copple, Ian M., den Hollander, Wouter, Callegaro, Giulia, Mutter, Fiona E., Maggs, James L., Schofield, Amy L., Rainbow, Lucille, Fang, Yongxiang, Sutherland, Jeffrey J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Fenwick, Stephen W., Goldring, Christopher E., van de Water, Bob, Stevens, James L., and Park, B. Kevin

Published
2019
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13. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Author

Teumer, Alexander, Chaker, Layal, Groeneweg, Stefan, Li, Yong, Di Munno, Celia, Barbieri, Caterina, Schultheiss, Ulla T., Traglia, Michela, Ahluwalia, Tarunveer S., Akiyama, Masato, Appel, Emil Vincent R., Arking, Dan E., Arnold, Alice, Astrup, Arne, Beekman, Marian, Beilby, John P., Bekaert, Sofie, Boerwinkle, Eric, Brown, Suzanne J., De Buyzere, Marc, Campbell, Purdey J., Ceresini, Graziano, Cerqueira, Charlotte, Cucca, Francesco, Deary, Ian J., Deelen, Joris, Eckardt, Kai-Uwe, Ekici, Arif B., Eriksson, Johan G., Ferrrucci, Luigi, Fiers, Tom, Fiorillo, Edoardo, Ford, Ian, Fox, Caroline S., Fuchsberger, Christian, Galesloot, Tessel E., Gieger, Christian, Gögele, Martin, De Grandi, Alessandro, Grarup, Niels, Greiser, Karin Halina, Haljas, Kadri, Hansen, Torben, Harris, Sarah E., van Heemst, Diana, den Heijer, Martin, Hicks, Andrew A., den Hollander, Wouter, Homuth, Georg, Hui, Jennie, Ikram, M. Arfan, Ittermann, Till, Jensen, Richard A., Jing, Jiaojiao, Jukema, J. Wouter, Kajantie, Eero, Kamatani, Yoichiro, Kasbohm, Elisa, Kaufman, Jean-Marc, Kiemeney, Lambertus A., Kloppenburg, Margreet, Kronenberg, Florian, Kubo, Michiaki, Lahti, Jari, Lapauw, Bruno, Li, Shuo, Liewald, David C. M., Lifelines Cohort Study, Lim, Ee Mun, Linneberg, Allan, Marina, Michela, Mascalzoni, Deborah, Matsuda, Koichi, Medenwald, Daniel, Meisinger, Christa, Meulenbelt, Ingrid, De Meyer, Tim, Meyer zu Schwabedissen, Henriette E., Mikolajczyk, Rafael, Moed, Matthijs, Netea-Maier, Romana T., Nolte, Ilja M., Okada, Yukinori, Pala, Mauro, Pattaro, Cristian, Pedersen, Oluf, Petersmann, Astrid, Porcu, Eleonora, Postmus, Iris, Pramstaller, Peter P., Psaty, Bruce M., Ramos, Yolande F. M., Rawal, Rajesh, Redmond, Paul, Richards, J. Brent, Rietzschel, Ernst R., Rivadeneira, Fernando, Roef, Greet, Rotter, Jerome I., Sala, Cinzia F., Schlessinger, David, Selvin, Elizabeth, Slagboom, P. Eline, Soranzo, Nicole, Sørensen, Thorkild I. A., Spector, Timothy D., Starr, John M., Stott, David J., Taes, Youri, Taliun, Daniel, Tanaka, Toshiko, Thuesen, Betina, Tiller, Daniel, Toniolo, Daniela, Uitterlinden, Andre G., Visser, W. Edward, Walsh, John P., Wilson, Scott G., Wolffenbuttel, Bruce H. R., Yang, Qiong, Zheng, Hou-Feng, Cappola, Anne, Peeters, Robin P., Naitza, Silvia, Völzke, Henry, Sanna, Serena, Köttgen, Anna, Visser, Theo J., and Medici, Marco

Published
2018
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16. Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

Author

den Hollander, Wouter, Boer, Cindy G, Hart, Deborah J, Yau, Michelle S, Ramos, Yolande F M, Metrustry, Sarah, Broer, Linda, Deelen, Joris, Cupples, L Adrienne, Rivadeneira, Fernando, Kloppenburg, Margreet, Peters, Marjolein, Spector, Tim D, Hofman, Albert, Slagboom, P Eline, Nelissen, Rob G H H, Uitterlinden, André G, Felson, David T, Valdes, Ana M, Meulenbelt, Ingrid, and van Meurs, Joyce J B

Published
2017
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19. The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment

Author

Callegaro, Giulia, primary, Kunnen, Steven J., additional, Trairatphisan, Panuwat, additional, Grosdidier, Solène, additional, Niemeijer, Marije, additional, den Hollander, Wouter, additional, Guney, Emre, additional, Piñero Gonzalez, Janet, additional, Furlong, Laura, additional, Webster, Yue W., additional, Saez-Rodriguez, Julio, additional, Sutherland, Jeffrey J., additional, Mollon, Jennifer, additional, Stevens, James L., additional, and van de Water, Bob, additional

Published
2021
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23. Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

Author

Bomer, Nils, den Hollander, Wouter, Ramos, Yolande F M, Bos, Steffan D, van der Breggen, Ruud, Lakenberg, Nico, Pepers, Barry A, van Eeden, Annelies E, Darvishan, Arash, Tobi, Elmar W, Duijnisveld, Bouke J, van den Akker, Erik B, Heijmans, Bastiaan T, van Roon-Mom, Willeke MC, Verbeek, Fons J, van Osch, Gerjo J V M, Nelissen, Rob G H H, Slagboom, P Eline, and Meulenbelt, Ingrid

Published
2015
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25. Pragmatic Quasi-Experimental Controlled Trial Evaluating the Outcomes of Blended CBT Compared to Face-to-Face CBT and Treatment as Usual for Adolescents with Depressive Disorders

Author

Rasing, Sanne P.a., Stikkelbroek, Yvonne A.j., Den Hollander, Wouter, Riper, Heleen, Deković, Maja, Nauta, Maaike H., Creemers, Daan H.m., Immink, Marianne C.p., Spuij, Mariken, Bodden, Denise H.m., Leerstoel Dekovic, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Clinical Psychology, APH - Global Health, APH - Mental Health, Psychiatry, Leerstoel Dekovic, Leerstoel Baar, Development and Treatment of Psychosocial Problems, and Clinical Psychology and Experimental Psychopathology

Subjects
Adult, Male, Adolescent, Cost-Benefit Analysis, medicine.medical_treatment, Health, Toxicology and Mutagenesis, lcsh:Medicine, Treatment as usual, CBT, Adolescents, Article, Blended treatment, law.invention, Young Adult, 03 medical and health sciences, Face-to-face, 0302 clinical medicine, Randomized controlled trial, SDG 3 - Good Health and Well-being, law, Humans, Medicine, Toxicology and Mutagenesis, 030212 general & internal medicine, Suicide Risk, Blended, Depression (differential diagnoses), Depressive Disorder, Major, Cognitive Behavioral Therapy, business.industry, Depression, Environmental and Occupational Health, lcsh:R, Public Health, Environmental and Occupational Health, Mental health, Pollution, 030227 psychiatry, Cognitive behavioral therapy, Treatment, Mental Health, Treatment Outcome, Health, Female, Public Health, business, Developmental Psychopathology, Clinical psychology
Abstract

Contains fulltext : 234365.pdf (Publisher’s version ) (Open Access) Depression is a major problem in youth mental health. Current treatment is on average effective, but adolescents are hesitant to seek help. Blended treatment could lower the barriers to seeking treatment. Evidence on effectiveness is, however, scarce. The present pragmatic quasi-experimental controlled trial aimed to compare the outcomes of blended cognitive behavioral therapy (CBT) to face-to-face CBT and treatment as usual. A total of 129 adolescents with clinical depression (82.2% female), aged 13-22 (M = 16.60, SD = 2.03) received blended CBT, face-to-face CBT or treatment as usual. Clinical diagnosis, depressive symptoms, and secondary outcomes were assessed at baseline, post-intervention, and six-months follow-up. Participants receiving blended CBT were, compared to participants receiving face-to-face CBT and treatment as usual, evenly likely to be in remission from their depressive disorder at post-intervention and at six-month follow-up. Depressive symptoms decreased significantly over time in all three conditions, and changes were not significantly different between conditions. Other secondary outcomes (suicide risk, internalizing and externalizing symptoms, severity of depression, and global functioning) did not differ between treatment conditions at post-intervention and six-month follow-up. Since there was no evidence for favorable outcomes for face-to-face therapies above blended CBT, blended CBT may also be an effective treatment format in clinical practice. 17 p.

Published
2021

28. The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment

Author

Callegaro, Giulia, primary, Kunnen, Steven J., additional, Trairatphisan, Panuwat, additional, Grosdidier, Solene, additional, Niemeijer, Marije, additional, den Hollander, Wouter, additional, Guney, Emre, additional, Gonzalez, Janet Pinero, additional, Furlong, Laura, additional, Webster, Yue W., additional, Saez-Rodriguez, Julio, additional, Sutherland, Jeffrey J., additional, Mollon, Jennifer, additional, Stevens, James L., additional, and van de Water, Bob, additional

Published
2021
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31. Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Author

Coutinho de Almeida, Rodrigo, primary, Mahfouz, Ahmed, additional, Mei, Hailiang, additional, Houtman, Evelyn, additional, den Hollander, Wouter, additional, Soul, Jamie, additional, Suchiman, Eka, additional, Lakenberg, Nico, additional, Meessen, Jennifer, additional, Huetink, Kasper, additional, Nelissen, Rob G H H, additional, Ramos, Yolande F M, additional, Reinders, Marcel, additional, and Meulenbelt, Ingrid, additional

Published
2020
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32. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Author

Ligthart, Symen, Vaez, Ahmad, Võsa, Urmo, Stathopoulou, Maria G, de Vries, Paul S, Prins, Bram P, Van der Most, Peter J, Tanaka, Toshiko, Naderi, Elnaz, Rose, Lynda M, Wu, Ying, Karlsson, Robert, Barbalic, Maja, Lin, Honghuang, Pool, René, Zhu, Gu, Macé, Aurélien, Sidore, Carlo, Trompet, Stella, Mangino, Massimo, Sabater-Lleal, Maria, Kemp, John P, Abbasi, Ali, Kacprowski, Tim, Verweij, Niek, Smith, Albert V, Huang, Tao, Marzi, Carola, Feitosa, Mary F, Lohman, Kurt K, Kleber, Marcus E, Milaneschi, Yuri, Mueller, Christian, Huq, Mahmudul, Vlachopoulou, Efthymia, Lyytikäinen, Leo-Pekka, Oldmeadow, Christopher, Deelen, Joris, Perola, Markus, Zhao, Jing Hua, Feenstra, Bjarke, LifeLines Cohort Study, Amini, Marzyeh, CHARGE Inflammation Working Group, Lahti, Jari, Schraut, Katharina E, Fornage, Myriam, Suktitipat, Bhoom, Chen, Wei-Min, Li, Xiaohui, Nutile, Teresa, Malerba, Giovanni, Luan, Jian'an, Bak, Tom, Schork, Nicholas, Del Greco M, Fabiola, Thiering, Elisabeth, Mahajan, Anubha, Marioni, Riccardo E, Mihailov, Evelin, Eriksson, Joel, Ozel, Ayse Bilge, Zhang, Weihua, Nethander, Maria, Cheng, Yu-Ching, Aslibekyan, Stella, Ang, Wei, Gandin, Ilaria, Yengo, Loïc, Portas, Laura, Kooperberg, Charles, Hofer, Edith, Rajan, Kumar B, Schurmann, Claudia, den Hollander, Wouter, Ahluwalia, Tarunveer S, Zhao, Jing, Draisma, Harmen HM, Ford, Ian, Timpson, Nicholas, Teumer, Alexander, Huang, Hongyan, Wahl, Simone, Liu, YongMei, Huang, Jie, Uh, Hae-Won, Geller, Frank, Joshi, Peter K, Yanek, Lisa R, Trabetti, Elisabetta, Lehne, Benjamin, Vozzi, Diego, Verbanck, Marie, Biino, Ginevra, Saba, Yasaman, Meulenbelt, Ingrid, O'Connell, Jeff R, Laakso, Markku, Giulianini, Franco, and Magnusson, Patrik KE

Subjects
Adult, Male, Bipolar Disorder, Adolescent, CHARGE Inflammation Working Group, Medical and Health Sciences, Body Mass Index, C-reactive protein, Young Adult, 80 and over, Mendelian randomization, Genetics, Humans, 2.1 Biological and endogenous factors, Aetiology, Child, Aged, Inflammation, Genetics & Heredity, genome-wide association study, system biology, Prevention, Inflammatory and immune system, DEPICT, Human Genome, Middle Aged, Mendelian Randomization Analysis, Biological Sciences, schizophrenia, Good Health and Well Being, Liver, Genetic Loci, Female, inflammatory disorders, Metabolic Networks and Pathways, Biomarkers, coronary artery disease, LifeLines Cohort Study
Abstract

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5× 10-8). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We identified 66 gene sets that were organized in two substantially correlated clusters, one mainly composed of immune pathways and the other characterized by metabolic pathways in the liver. Mendelian randomization analyses revealed a causal protective effect of CRP on schizophrenia and a risk-increasing effect on bipolar disorder. Our findings provide further insights into the biology of inflammation and could lead to interventions for treating inflammation and its clinical consequences.

Published
2018

33. Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage

Author

den Hollander, Wouter, primary, Pulyakhina, Irina, additional, Boer, Cindy, additional, Bomer, Nils, additional, van der Breggen, Ruud, additional, Arindrarto, Wibowo, additional, Couthino de Almeida, Rodrigo, additional, Lakenberg, Nico, additional, Sentner, Thom, additional, Laros, Jeroen F. J., additional, ‘t Hoen, Peter A. C., additional, Slagboom, Eline P. E., additional, Nelissen, Rob G. H. H., additional, van Meurs, Joyce, additional, Ramos, Yolande F. M., additional, and Meulenbelt, Ingrid, additional

Published
2019
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34. Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production

Author

van den Bosch, Martijn H J, primary, Ramos, Yolande F M, additional, den Hollander, Wouter, additional, Bomer, Nils, additional, Nelissen, Rob G H H, additional, Bovée, Judith V M G, additional, van den Berg, Wim B, additional, van Lent, Peter L E M, additional, Blom, Arjen B, additional, van der Kraan, Peter M, additional, and Meulenbelt, Ingrid, additional

Published
2019
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36. RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

Author

Coutinho de Almeida, Rodrigo, primary, Ramos, Yolande F M, additional, Mahfouz, Ahmed, additional, den Hollander, Wouter, additional, Lakenberg, Nico, additional, Houtman, Evelyn, additional, van Hoolwerff, Marcella, additional, Suchiman, H Eka D, additional, Rodríguez Ruiz, Alejandro, additional, Slagboom, P Eline, additional, Mei, Hailiang, additional, Kiełbasa, Szymon M, additional, Nelissen, Rob G H H, additional, Reinders, Marcel, additional, and Meulenbelt, Ingrid, additional

Published
2018
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37. Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Author

Copple, Ian M., primary, den Hollander, Wouter, additional, Callegaro, Giulia, additional, Mutter, Fiona E., additional, Maggs, James L., additional, Schofield, Amy L., additional, Rainbow, Lucille, additional, Fang, Yongxiang, additional, Sutherland, Jeffrey J., additional, Ellis, Ewa C., additional, Ingelman-Sundberg, Magnus, additional, Fenwick, Stephen W., additional, Goldring, Christopher E., additional, van de Water, Bob, additional, Stevens, James L., additional, and Park, B. Kevin, additional

Published
2018
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38. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Author

Ligthart, Symen, primary, Vaez, Ahmad, additional, Võsa, Urmo, additional, Stathopoulou, Maria G., additional, de Vries, Paul S., additional, Prins, Bram P., additional, Van der Most, Peter J., additional, Tanaka, Toshiko, additional, Naderi, Elnaz, additional, Rose, Lynda M., additional, Wu, Ying, additional, Karlsson, Robert, additional, Barbalic, Maja, additional, Lin, Honghuang, additional, Pool, René, additional, Zhu, Gu, additional, Macé, Aurélien, additional, Sidore, Carlo, additional, Trompet, Stella, additional, Mangino, Massimo, additional, Sabater-Lleal, Maria, additional, Kemp, John P., additional, Abbasi, Ali, additional, Kacprowski, Tim, additional, Verweij, Niek, additional, Smith, Albert V., additional, Huang, Tao, additional, Marzi, Carola, additional, Feitosa, Mary F., additional, Lohman, Kurt K., additional, Kleber, Marcus E., additional, Milaneschi, Yuri, additional, Mueller, Christian, additional, Huq, Mahmudul, additional, Vlachopoulou, Efthymia, additional, Lyytikäinen, Leo-Pekka, additional, Oldmeadow, Christopher, additional, Deelen, Joris, additional, Perola, Markus, additional, Zhao, Jing Hua, additional, Feenstra, Bjarke, additional, Amini, Marzyeh, additional, Lahti, Jari, additional, Schraut, Katharina E., additional, Fornage, Myriam, additional, Suktitipat, Bhoom, additional, Chen, Wei-Min, additional, Li, Xiaohui, additional, Nutile, Teresa, additional, Malerba, Giovanni, additional, Luan, Jian’an, additional, Bak, Tom, additional, Schork, Nicholas, additional, Del Greco M., Fabiola, additional, Thiering, Elisabeth, additional, Mahajan, Anubha, additional, Marioni, Riccardo E., additional, Mihailov, Evelin, additional, Eriksson, Joel, additional, Ozel, Ayse Bilge, additional, Zhang, Weihua, additional, Nethander, Maria, additional, Cheng, Yu-Ching, additional, Aslibekyan, Stella, additional, Ang, Wei, additional, Gandin, Ilaria, additional, Yengo, Loïc, additional, Portas, Laura, additional, Kooperberg, Charles, additional, Hofer, Edith, additional, Rajan, Kumar B., additional, Schurmann, Claudia, additional, den Hollander, Wouter, additional, Ahluwalia, Tarunveer S., additional, Zhao, Jing, additional, Draisma, Harmen H.M., additional, Ford, Ian, additional, Timpson, Nicholas, additional, Teumer, Alexander, additional, Huang, Hongyan, additional, Wahl, Simone, additional, Liu, YongMei, additional, Huang, Jie, additional, Uh, Hae-Won, additional, Geller, Frank, additional, Joshi, Peter K., additional, Yanek, Lisa R., additional, Trabetti, Elisabetta, additional, Lehne, Benjamin, additional, Vozzi, Diego, additional, Verbanck, Marie, additional, Biino, Ginevra, additional, Saba, Yasaman, additional, Meulenbelt, Ingrid, additional, O’Connell, Jeff R., additional, Laakso, Markku, additional, Giulianini, Franco, additional, Magnusson, Patrik K.E., additional, Ballantyne, Christie M., additional, Hottenga, Jouke Jan, additional, Montgomery, Grant W., additional, Rivadineira, Fernando, additional, Rueedi, Rico, additional, Steri, Maristella, additional, Herzig, Karl-Heinz, additional, Stott, David J., additional, Menni, Cristina, additional, Frånberg, Mattias, additional, St. Pourcain, Beate, additional, Felix, Stephan B., additional, Pers, Tune H., additional, Bakker, Stephan J.L., additional, Kraft, Peter, additional, Peters, Annette, additional, Vaidya, Dhananjay, additional, Delgado, Graciela, additional, Smit, Johannes H., additional, Großmann, Vera, additional, Sinisalo, Juha, additional, Seppälä, Ilkka, additional, Williams, Stephen R., additional, Holliday, Elizabeth G., additional, Moed, Matthijs, additional, Langenberg, Claudia, additional, Räikkönen, Katri, additional, Ding, Jingzhong, additional, Campbell, Harry, additional, Sale, Michele M., additional, Chen, Yii-Der I., additional, James, Alan L., additional, Ruggiero, Daniela, additional, Soranzo, Nicole, additional, Hartman, Catharina A., additional, Smith, Erin N., additional, Berenson, Gerald S., additional, Fuchsberger, Christian, additional, Hernandez, Dena, additional, Tiesler, Carla M.T., additional, Giedraitis, Vilmantas, additional, Liewald, David, additional, Fischer, Krista, additional, Mellström, Dan, additional, Larsson, Anders, additional, Wang, Yunmei, additional, Scott, William R., additional, Lorentzon, Matthias, additional, Beilby, John, additional, Ryan, Kathleen A., additional, Pennell, Craig E., additional, Vuckovic, Dragana, additional, Balkau, Beverly, additional, Concas, Maria Pina, additional, Schmidt, Reinhold, additional, Mendes de Leon, Carlos F., additional, Bottinger, Erwin P., additional, Kloppenburg, Margreet, additional, Paternoster, Lavinia, additional, Boehnke, Michael, additional, Musk, A.W., additional, Willemsen, Gonneke, additional, Evans, David M., additional, Madden, Pamela A.F., additional, Kähönen, Mika, additional, Kutalik, Zoltán, additional, Zoledziewska, Magdalena, additional, Karhunen, Ville, additional, Kritchevsky, Stephen B., additional, Sattar, Naveed, additional, Lachance, Genevieve, additional, Clarke, Robert, additional, Harris, Tamara B., additional, Raitakari, Olli T., additional, Attia, John R., additional, van Heemst, Diana, additional, Kajantie, Eero, additional, Sorice, Rossella, additional, Gambaro, Giovanni, additional, Scott, Robert A., additional, Hicks, Andrew A., additional, Ferrucci, Luigi, additional, Standl, Marie, additional, Lindgren, Cecilia M., additional, Starr, John M., additional, Karlsson, Magnus, additional, Lind, Lars, additional, Li, Jun Z., additional, Chambers, John C., additional, Mori, Trevor A., additional, de Geus, Eco J.C.N., additional, Heath, Andrew C., additional, Martin, Nicholas G., additional, Auvinen, Juha, additional, Buckley, Brendan M., additional, de Craen, Anton J.M., additional, Waldenberger, Melanie, additional, Strauch, Konstantin, additional, Meitinger, Thomas, additional, Scott, Rodney J., additional, McEvoy, Mark, additional, Beekman, Marian, additional, Bombieri, Cristina, additional, Ridker, Paul M., additional, Mohlke, Karen L., additional, Pedersen, Nancy L., additional, Morrison, Alanna C., additional, Boomsma, Dorret I., additional, Whitfield, John B., additional, Strachan, David P., additional, Hofman, Albert, additional, Vollenweider, Peter, additional, Cucca, Francesco, additional, Jarvelin, Marjo-Riitta, additional, Jukema, J. Wouter, additional, Spector, Tim D., additional, Hamsten, Anders, additional, Zeller, Tanja, additional, Uitterlinden, André G., additional, Nauck, Matthias, additional, Gudnason, Vilmundur, additional, Qi, Lu, additional, Grallert, Harald, additional, Borecki, Ingrid B., additional, Rotter, Jerome I., additional, März, Winfried, additional, Wild, Philipp S., additional, Lokki, Marja-Liisa, additional, Boyle, Michael, additional, Salomaa, Veikko, additional, Melbye, Mads, additional, Eriksson, Johan G., additional, Wilson, James F., additional, Penninx, Brenda W.J.H., additional, Becker, Diane M., additional, Worrall, Bradford B., additional, Gibson, Greg, additional, Krauss, Ronald M., additional, Ciullo, Marina, additional, Zaza, Gianluigi, additional, Wareham, Nicholas J., additional, Oldehinkel, Albertine J., additional, Palmer, Lyle J., additional, Murray, Sarah S., additional, Pramstaller, Peter P., additional, Bandinelli, Stefania, additional, Heinrich, Joachim, additional, Ingelsson, Erik, additional, Deary, Ian J., additional, Mägi, Reedik, additional, Vandenput, Liesbeth, additional, van der Harst, Pim, additional, Desch, Karl C., additional, Kooner, Jaspal S., additional, Ohlsson, Claes, additional, Hayward, Caroline, additional, Lehtimäki, Terho, additional, Shuldiner, Alan R., additional, Arnett, Donna K., additional, Beilin, Lawrence J., additional, Robino, Antonietta, additional, Froguel, Philippe, additional, Pirastu, Mario, additional, Jess, Tine, additional, Koenig, Wolfgang, additional, Loos, Ruth J.F., additional, Evans, Denis A., additional, Schmidt, Helena, additional, Smith, George Davey, additional, Slagboom, P. Eline, additional, Eiriksdottir, Gudny, additional, Morris, Andrew P., additional, Psaty, Bruce M., additional, Tracy, Russell P., additional, Nolte, Ilja M., additional, Boerwinkle, Eric, additional, Visvikis-Siest, Sophie, additional, Reiner, Alex P., additional, Gross, Myron, additional, Bis, Joshua C., additional, Franke, Lude, additional, Franco, Oscar H., additional, Benjamin, Emelia J., additional, Chasman, Daniel I., additional, Dupuis, Josée, additional, Snieder, Harold, additional, Dehghan, Abbas, additional, Alizadeh, Behrooz Z., additional, Boezen, H. Marike, additional, Navis, Gerjan, additional, Rots, Marianne, additional, Swertz, Morris, additional, Wolffenbuttel, Bruce H.R., additional, Wijmenga, Cisca, additional, Benjamin, Emelia, additional, Ahluwalia, Tarunveer Singh, additional, Meigs, James, additional, Tracy, Russell, additional, Ligthart, Symen, additional, Bis, Josh, additional, Pankratz, Nathan, additional, Rainer, Alex, additional, Wilson, James G., additional, Dupuis, Josee, additional, Prins, Bram, additional, Vaso, Urmo, additional, Stathopoulou, Maria, additional, Lehtimaki, Terho, additional, Jamshidi, Yalda, additional, Siest, Sophie, additional, Uitterlinden, Andre G., additional, Abdollahi, Mohammadreza, additional, Schnabel, Renate, additional, Schick, Ursula M., additional, Kraja, Aldi, additional, Hsu, Yi-Hsiang, additional, Tylee, Daniel S., additional, Zwicker, Alyson, additional, Uher, Rudolf, additional, Davey-Smith, George, additional, Hicks, Andrew, additional, van Duijn, Cornelia M., additional, Ward-Caviness, Cavin, additional, Rotter, J., additional, Rice, Ken, additional, Lange, Leslie, additional, de Geus, Eco, additional, Makela, Kari Matti, additional, Stacey, David, additional, Eriksson, Johan, additional, Frayling, Tim M., additional, and Slagboom, Eline P., additional

Published
2018
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41. Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions

Author

den Hollander, Wouter J, primary, Holster, I Lisanne, additional, den Hoed, Caroline M, additional, Capelle, Lisette G, additional, Tang, Tjon J, additional, Anten, Marie-Paule, additional, Prytz-Berset, Ingrid, additional, Witteman, Ellen M, additional, ter Borg, Frank, additional, Hartog, Gijsbert den, additional, Bruno, Marco J, additional, Peppelenbosch, Maikel Petrus, additional, Lesterhuis, Wilco, additional, Doukas, Michael, additional, Kuipers, Ernst J, additional, and Spaander, Manon C W, additional

Published
2018
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45. Helicobacter pyloricolonization and pregnancies complicated by preeclampsia, spontaneous prematurity, and small for gestational age birth

Author

den Hollander, Wouter J., primary, Schalekamp-Timmermans, Sarah, additional, Holster, I. Lisanne, additional, Jaddoe, Vincent W., additional, Hofman, Albert, additional, Moll, Henriëtte A., additional, Perez-Perez, Guillermo I., additional, Blaser, Martin J., additional, Steegers, Eric A. P., additional, and Kuipers, Ernst J., additional

Published
2016
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46. Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions.

Author

den Hollander, Wouter J., Holster, I. Lisanne, den Hoed, Caroline M., Capelle, Lisette G., Tang, Tjon J., Anten, Marie-Paule, Prytz-Berset, Ingrid, Witteman, Ellen M., ter Borg, Frank, den Hartog, Gijsbert, Bruno, Marco J., Peppelenbosch, Maikel Petrus, Lesterhuis, Wilco, Doukas, Michael, Kuipers, Ernst J., and Spaander, Manon C. W.

Subjects
ATROPHIC gastritis, PRECANCEROUS conditions
Published
2019
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50. Associations between joint effusion in the knee and gene expression levels in the circulation: a meta-analysis

Author

Peters, Marjolein J., primary, Ramos, Yolande F.M., additional, den Hollander, Wouter, additional, Schiphof, Dieuwke, additional, Hofman, Albert, additional, Uitterlinden, André G., additional, Oei, Edwin H.G., additional, Slagboom, P. Eline, additional, Kloppenburg, Margreet, additional, Bloem, Johan L., additional, Bierma-Zeinstra, Sita M.A., additional, Meulenbelt, Ingrid, additional, and van Meurs, Joyce B.J., additional

Published
2016
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