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2. EEG Dominant Frequency Peak Differentiates Between Alzheimer's Disease and Frontotemporal Lobar Degeneration.

Author

Goossens, Joery, Laton, Jorne, Van Schependom, Jeroen, Gielen, Jeroen, Struyfs, Hanne, Van Mossevelde, Sara, den Bossche, Tobi Van, Goeman, Johan, De Deyn, Peter Paul, Sieben, Anne, Martin, Jean-Jacques, Van Broeckhoven, Christine, van der Zee, Julie, Engelborghs, Sebastiaan, Nagels, Guy, and Van den Bossche, Tobi

Subjects
ELECTROENCEPHALOGRAPHY, FRONTOTEMPORAL lobar degeneration, ALZHEIMER'S disease diagnosis, DIAGNOSIS of dementia, DIFFERENTIAL diagnosis, ALZHEIMER'S disease, BRAIN, LONGITUDINAL method, RECEIVER operating characteristic curves, DIAGNOSIS
Abstract

We investigated the power of EEG as biomarker in differential diagnosis of Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). EEG was recorded from 106 patients with AD or FTLD, of which 37 had a definite diagnosis, and 40 controls. Dominant frequency peaks were extracted for all 19 channels, for each subject. The average frequency of the largest dominant frequency peaks (maxpeak) was significantly lower in AD than FTLD patients and controls. Based on ROC analysis, classification could be made with diagnostic accuracy of 78.9%. Our findings show that quantitative analysis of EEG maxpeak frequency is an easy and useful measure for differential dementia diagnosis. [ABSTRACT FROM AUTHOR]

Published
2017
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