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5. Clinical profile, management and outcomes of patients with cardiogenic shock undergoing transfer between centers in Spain

Author

Barrionuevo-Sánchez, M. Isabel, Ariza-Solé, Albert, Viana-Tejedor, Ana, del Prado, Náyade, Rosillo, Nicolás, Jorge-Pérez, Pablo, Sánchez-Salado, José Carlos, Lorente, Victòria, Alegre, Oriol, Llaó, Isaac, Martín-Asenjo, Roberto, Bernal, José Luis, Fernández-Pérez, Cristina, Corbí-Pascual, Miguel, Pascual, Júlia, Marcos, Marta, de la Cuerda, Francisco, Carmona, Jesús, Comin-Colet, Josep, and Elola, Francisco Javier

Published
2024
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6. Perfil clínico, abordaje y pronóstico del paciente con shock cardiogénico sometido a traslado interhospitalario en España

Author

Barrionuevo-Sánchez, M. Isabel, Ariza-Solé, Albert, Viana-Tejedor, Ana, del Prado, Náyade, Rosillo, Nicolás, Jorge-Pérez, Pablo, Sánchez-Salado, José Carlos, Lorente, Victòria, Alegre, Oriol, Llaó, Isaac, Martín-Asenjo, Roberto, Bernal, José Luis, Fernández-Pérez, Cristina, Corbí-Pascual, Miguel, Pascual, Júlia, Marcos, Marta, de la Cuerda, Francisco, Carmona, Jesús, Comin-Colet, Josep, and Elola, Francisco Javier

Published
2024
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13. Trends in cardiovascular care in the National Health System in Spain. Data from the RECALCAR project 2011-2020

Author

Cequier, Ángel, Bueno, Héctor, Macaya, Carlos, Bertomeu, Vicente, González-Juanatey, José R., Íñiguez, Andrés, Anguita, Manuel, Cruz, Ignacio, Calvo, David, Gómez-Doblas, Juan José, de la Torre Hernández, José M., del Prado, Náyade, Rodríguez Padial, Luis, Pérez-Villacastín, Julián, Bernal, José Luis, Fernández Pérez, Cristina, and Elola, Javier

Published
2023
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14. Evolución de la asistencia cardiovascular en el Sistema Nacional de Salud de España. Datos del proyecto RECALCAR 2011-2020

Author

Cequier, Ángel, Bueno, Héctor, Macaya, Carlos, Bertomeu, Vicente, González-Juanatey, José R., Íñiguez, Andrés, Anguita, Manuel, Cruz, Ignacio, Calvo, David, Gómez-Doblas, Juan José, de la Torre Hernández, José M., del Prado, Náyade, Rodríguez Padial, Luis, Pérez-Villacastín, Julián, Bernal, José Luis, Fernández Pérez, Cristina, and Elola, Javier

Published
2023
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17. Assessing Outcomes of Patients Subject to Intensive Care to Facilitate Organ Donation: A Spanish Multicenter Prospective Study

Author

Pérez-Blanco, Alicia, primary, Acevedo, María, additional, Padilla, María, additional, Gómez, Aroa, additional, Zapata, Luis, additional, Barber, María, additional, Martínez, Adolfo, additional, Calleja, Verónica, additional, Rivero, María C., additional, Fernández, Esperanza, additional, Velasco, Julio, additional, Flores, Eva M., additional, Quindós, Brígida, additional, Rodríguez, Sergio T., additional, Virgós, Beatriz, additional, Robles, Juan C., additional, Nebra, Agustín C., additional, Moya, José, additional, Trenado, Josep, additional, García, Nieves, additional, Vallejo, Ana, additional, Herrero, Eugenio, additional, García, Álvaro, additional, Rodríguez, Maria L., additional, García, Fernando, additional, Lara, Ramón, additional, Lage, Lucas, additional, Gil, Francisco J., additional, Guerrero, Francisco J., additional, Meilán, Ángela, additional, Del Prado, Nayade, additional, Fernández, Cristina, additional, Coll, Elisabeth, additional, and Domínguez-Gil, Beatriz, additional

Published
2024
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18. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Author

Datema, Mareen R., Zuidmeer-Jongejan, Laurian, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frédéric, Bures, Peter, Clausen, Michael, Dubakiene, Ruta, Gislason, David, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Knulst, André C., Kralimarkova, Tanya, Le, Thuy-My, Lovegrove, Alison, Marsh, Justin, Papadopoulos, Nikolaos G., Popov, Todor, del Prado, Náyade, Purohit, Ashok, Reese, Gerald, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Mills, Clare, Lidholm, Jonas, Hoffmann-Sommergruber, Karin, Fernández-Rivas, Montserrat, Ballmer-Weber, Barbara, and van Ree, Ronald

Published
2015
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19. 7. CARACTERÍSTICAS CLÍNICAS, ATENCIÓN HOSPITALARIA Y PRONÓSTICO DE LOS PACIENTES INGRESADOS POR MIOCARDIOPATÍA DILATADA EN LOS HOSPITALES ESPAÑOLES ENTRE 2016 Y 2020

Author

Fernández, Alberto Esteban, Sánchez, Manuel Anguita, Ramírez, Nicolás Rosillo, Gámez, María Anguita, del Prado, Náyade, Diego, Julia Gómez, Martínez, Teresa Morales, de Blas Ruiz, Carlos, Sobrino, José Luis Bernal, Pérez, Cristina Fernández, Cueva, Carolina Novo, Doblas, Juan José Gómez, Villacastín, Julián Pérez, Rozas, Inmaculada Fernández, and Somoza, Francisco Javier Elola

Published
2023
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26. 11. CARACTERÍSTICAS CLÍNICAS, ATENCIÓN HOSPITALARIA Y PRONÓSTICO DE LOS PACIENTES INGRESADOS POR AMILOIDOSIS CARDIACA EN LOS HOSPITALES ESPAÑOLES ENTRE 2016 Y 2020

Author

Fernández, Alberto Esteban, Sánchez, Manuel Anguita, del Prado, Náyade, Gámez, María Anguita, Ramírez, Nicolás Rosillo, Sobrino, José Luis Bernal, Pérez, Cristina Fernández, García, Nuria Acosta, Rubia, Raúl Gascueña, del Carmen Manzano Nieto, Mª, Doblas, Juan José Gómez, Villacastín, Julián Pérez, García, Sara Corredera, Rozas, Inmaculada Fernández, and Somoza, Francisco Javier Elola

Published
2023
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27. 11. PERFIL CLÍNICO, MANEJO Y PRONÓSTICO DEL PACIENTE CON SHOCK CARDIOGÉNICO SOMETIDO A TRASLADO INTERHOSPITALARIO EN ESPAÑA

Author

Sánchez, Marisa Barrionuevo, Solé, Albert Ariza, Tejedor, Ana Viana, del Prado, Náyade, Ramírez, Nicolás Rosillo, Salado, José Carlos Sánchez, Ferrando, Joan Isaac Llaó, Canals, Oriol Alegre, Sobrino, José Luis Bernal, Pérez, Cristina Fernández, Tordera, Victoria Lorente, Prieto, Remedios Sánchez, Mangas, Marta Marcos, Mayans, Julia Pascual, and Somoza, Francisco Javier Elola

Published
2023
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28. 2. IMPACTO DEL VOLUMEN Y LA DISPONIBILIDAD DE UNIDADES DE CUIDADOS INTENSIVOS CARDIACOS EN LA MORTALIDAD DE PACIENTES CON SHOCK CARDIOGÉNICO RELACIONADO CON INFARTO AGUDO DE MIOCARDIO TRATADOS EN CENTROS CON CAPACIDAD DE REVASCULARIZACIÓN

Author

Sánchez, Marisa Barrionuevo, Solé, Albert Ariza, Tejedor, Ana Viana, Ramírez, Nicolás Rosillo, del Prado, Náyade, Salado, José Carlos Sánchez, Tordera, Victoria Lorente, Canals, Oriol Alegre, Ferrando, Joan Isaac Llaó, Sobrino, José Luis Bernal, Pérez, Cristina Fernández, de la Cuerda Llorente, Francisco, Carmona, Jesús Carmona, Mayans, Julia Pascual, and Somoza, Francisco Javier Elola

Published
2023
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29. Bioanalytical Detection of Steroid Abuse in Sports Based on the Androgenic Activity Measurement

Author

Martín Escudero, M. Del Pilar, Muñoz Guerra, Jesus A., García Tenorio, Soledad Vargas, Serrano Garde, Ester, Soldevilla Navarro, Ana Belén, Cortes Carrillo, Nuria, Galindo Canales, Mercedes, del Prado, Nayade, Fuentes Ferrer, Manuel, Fernández Pérez, Cristina, Behnisch, Peter Alexander, Brouwer, Abraham, Martín Escudero, M. Del Pilar, Muñoz Guerra, Jesus A., García Tenorio, Soledad Vargas, Serrano Garde, Ester, Soldevilla Navarro, Ana Belén, Cortes Carrillo, Nuria, Galindo Canales, Mercedes, del Prado, Nayade, Fuentes Ferrer, Manuel, Fernández Pérez, Cristina, Behnisch, Peter Alexander, and Brouwer, Abraham

Abstract

The study was funded by grants awarded by the Spanish Ministry of Science and Innovation (DEP2016–78559-R; sub-program DEPO; DEP2012-40156) for competitive investigation., The anabolic androgenic steroids (AAS) are the most frequently consumed performance enhancing drugs (PED) in sports. In the anti-doping field, the detection of AAS is carried out by the analysis of the athlete’s urine using methodologies based on liquid/gas chromatography-mass spectrometry. Unfortunately, the detection of unknown compounds is not possible. BDS’s AR CALUX® bio detection technology was studied as an indirect method to detect the administration of a single dose of testosterone (T). Twelve T and placebo single dose administered men volunteers underwent a triple-blind crossover clinical trial. The UGT2B17 deletion was present among the volunteers and evenly distributed in heterozygous (ins/del), wild-type homozygous (ins/ins), and mutated homozygous (del/del) groups. A significant statistical difference in terms of bioluminescence was observed after the testosterone (T) administration for the three types of polymorphic groups. The ratio of means between the pre- and post-T administration periods, depending on the type of polymorphism, was in group ins/ins 3.31 (CI. 95%: 2.07–5.29), group ins/del 4.15 (CI 95%: 3.05–5.67), and group del/del 2.89 (CI 95%: 2.42–3.46). The results of the study are very promising, as they may offer us the possibility of designing a detection approach that, based on intra-individual monitoring of androgenic values, in the UGT2B17 deletion type., Ministerio de Ciencia e Innovación (España), Fac. de Medicina, TRUE, pub

Published
2021

30. Bioanalytical Detection of Steroid Abuse in Sports Based on the Androgenic Activity Measurement

Author

Martín-Escudero, Pilar, primary, Muñoz-Guerra, Jesus A., additional, García-Tenorio, Soledad Vargas, additional, Serrano-Garde, Ester, additional, Soldevilla-Navarro, Ana Belén, additional, Cortes-Carrillo, Nuria, additional, Galindo-Canales, Mercedes, additional, del Prado, Nayade, additional, Fuentes-Ferrer, Manuel, additional, Fernández-Pérez, Cristina, additional, Behnisch, Peter Alexander, additional, and Brouwer, Abraham, additional

Published
2021
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37. Impact of UGT2B17 gene deletion on the steroid profile of an athlete

Author

Martín-Escudero, Pilar, Muñoz-Guerra, Jesús, Del Prado, Nayade, Galindo Canales, Mercedes, Fuentes Ferrer, Manuel, Vargas, Soledad, Soldevilla, Ana B, Serrano-Garde, Ester, Miguel-Tobal, Francisco, Maestro de Las Casas, Marisa, and Fernandez-Pérez, Cristina

Subjects
UGT2B17 genotype, steroid profile, doping, Exercise
Abstract

The measurement of the testosterone to epitestosterone ratio (T/E ratio) in urine is often used as a marker for testosterone administration in the doping control field. This study examines the frequencies of the different expression forms of the UGT2B17 gene, and assesses their effects on this marker in volunteer subjects. The sample for this descriptive study was composed of male and female athletes aged between 16 and 55 years old who practiced different sports disciplines. All participants underwent a sports-medical physical examination, and subsequently provided 10 urine samples consecutively over a period of 48 h. The dependent variable examined was T/E and the main independent variable was the UGT2B17 gene polymorphism. During 1 year, 1410 urine samples were obtained from 141 athletes. The frequencies of the three genotypes were as follows: wt homozygotes (ins/ins) 48.2% (n = 68), mutant homozygotes (del/del) 12.1% (n = 17), and heterozygotes (ins/del) 39.7% (n = 56). Genotype distributions varied significantly (P

Published
2015

38. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey

Author

Infection & Immunity, MS Dermatologie/Allergologie, Datema, Mareen R., Zuidmeer-Jongejan, Laurian, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frederic, Bures, Peter, Clausen, Michael, Dubakiene, Ruta, Gislason, David, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Knulst, Andre C., Kralimarkova, Tanya, Le, Thuy-My, Lovegrove, Alison, Marsh, Justin, Papadopoulos, Nikolaos G., Popov, Todor, del Prado, Nayade, Purohit, Ashok, Reese, Gerald, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Mills, Clare, Lidholm, Jonas, Hoffmann-Sommergruber, Karin, Fernandez-Rivas, Montserrat, Ballmer-Weber, Barbara, van Ree, Ronald, Infection & Immunity, MS Dermatologie/Allergologie, Datema, Mareen R., Zuidmeer-Jongejan, Laurian, Asero, Riccardo, Barreales, Laura, Belohlavkova, Simona, de Blay, Frederic, Bures, Peter, Clausen, Michael, Dubakiene, Ruta, Gislason, David, Jedrzejczak-Czechowicz, Monika, Kowalski, Marek L., Knulst, Andre C., Kralimarkova, Tanya, Le, Thuy-My, Lovegrove, Alison, Marsh, Justin, Papadopoulos, Nikolaos G., Popov, Todor, del Prado, Nayade, Purohit, Ashok, Reese, Gerald, Reig, Isabel, Seneviratne, Suranjith L., Sinaniotis, Athanasios, Versteeg, Serge A., Vieths, Stefan, Zwinderman, Aeilko H., Mills, Clare, Lidholm, Jonas, Hoffmann-Sommergruber, Karin, Fernandez-Rivas, Montserrat, Ballmer-Weber, Barbara, and van Ree, Ronald

Published
2015

39. Impact of UGT2B17 gene deletion on the steroid profile of an athlete

Author

Martín-Escudero, Pilar, primary, Muñoz-Guerra, Jesús, additional, Del Prado, Nayade, additional, Galindo Canales, Mercedes, additional, Fuentes Ferrer, Manuel, additional, Vargas, Soledad, additional, Soldevilla, Ana B., additional, Serrano-Garde, Ester, additional, Miguel-Tobal, Francisco, additional, Maestro de las Casas, Marisa, additional, and Fernandez-Pérez, Cristina, additional

Published
2015
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40. Prognostic value of first fasting glucose measurement compared with admission glucose level in patients with acute coronary syndrome

Author

Vivas Balcones, Luis David, García Rubira, Juan Carlos, González Ferrer, Juan José, Núñez Gil, Ivan Javier, Del Prado, Nayade, Fernández Ortiz, Antonio Ignacio, Macaya, Carlos, Vivas Balcones, Luis David, García Rubira, Juan Carlos, González Ferrer, Juan José, Núñez Gil, Ivan Javier, Del Prado, Nayade, Fernández Ortiz, Antonio Ignacio, and Macaya, Carlos

Abstract

Estudio observacional unicéntrico que analizó 547 pacientes consecutivos ingresados por un síndrome coronario agudo. Se evaluaron los niveles de glucemia en varios puntos como fueron durante el ingreso y la primera glucemia en ayunas. El estudio concluyó que es la primera glucemia en ayunas y no al ingreso el parámetro que se relaciona con un factor de riesgo independiente de eventos cardiovasculares (muerte o reinfarto) durante la hospitalización., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2008

41. Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles.

Author

Datema MR, Lyons SA, Fernández-Rivas M, Ballmer-Weber B, Knulst AC, Asero R, Barreales L, Belohlavkova S, de Blay F, Clausen M, Dubakiene R, Fernández-Perez C, Fritsche P, Gislason D, Hoffmann-Sommergruber K, Jedrzejczak-Czechowicz M, Jongejan L, Kowalski ML, Kralimarkova TZ, Lidholm J, Papadopoulos NG, Popov TA, Del Prado N, Purohit A, Reig I, Seneviratne SL, Sinaniotis A, Vassilopoulou E, Versteeg SA, Vieths S, Welsing PMJ, Mills ENC, Le TM, Zwinderman AH, and van Ree R

Abstract

Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA). Objective: To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity. Methods: Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity. Results: Female sex, age at onset of PA, symptoms elicited by skin contact with peanut, family atopy, atopic dermatitis, house dust mite and latex allergy were independently associated with severe PA; birch pollen allergy with mild-to-moderate PA. The cross-validated AUC of all clinical background determinants combined (0.74) was significantly larger than the AUC of tests for sensitization to extract (0.63) or peanut components (0.54-0.64). Although larger skin prick test wheal size, and higher IgE to peanut extract, Ara h 1 and Ara h 2/6, were associated with severe PA, and higher IgE to Ara h 8 with mild-to-moderate PA, addition of these measurements of sensitization to the clinical background model did not significantly improve the AUC. Conclusions: Models combining clinical characteristics and IgE sensitization patterns can help establish the risk of severe reactions for peanut allergic patients, but clinical background determinants are most valuable for predicting severity of probable PA in an individual patient., Competing Interests: Outside of submitted work: MF-R reported grants and personal fees from Aimmune Therapeutics and Diater, personal fees from DBV, Allergy Therapeutics, GSK, HAL Allergy, Novartis, ThermoFisher Scientific, and SPRIM. BB-W reported personal fees from ThermoFisher Scientific. FB reported personal fees from Aimmune; grants from Stallergènes Greer, Chiesi, Mundipharma, Novartis, and Regeneron; and board membership for DVB, Stallergènes Greer, Novartis, ALK, Mundipharma, Boehringer, AstraZeneca, Medapharma, and Boston Scientific. JL was an employee of ThermoFisher Scientific. NP reported personal fees from Novartis, Nutricia, HAL Allergy BV, Menarine/Faes Farma, Sanofi, Mylan/Meda, Biomay, AstraZeneca, GSK, MSD, ASIT Biotech, Boehringer Ingelheim; and grants from Gerolymatos International SA, and Capricare. SV reported personal fees from Ärzteverband Deutscher Allergologen, Swiss Society for Allergy and Immunology, Schattauer Allergologie Handbuch, Elsevier Nahrungsmittelallergien und Intoleranzen, Karger Food Allergy: Molecular Basis and Clinical Practice, and Pharmacon. EM reported grants from Reacta Biotech; and was shareholder of Reacta Biotech Ltd. RR reported personal fees from HAL Allergy BV, Citeq BV, Angany Inc., and ThermoFisher Scientific. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Datema, Lyons, Fernández-Rivas, Ballmer-Weber, Knulst, Asero, Barreales, Belohlavkova, de Blay, Clausen, Dubakiene, Fernández-Perez, Fritsche, Gislason, Hoffmann-Sommergruber, Jedrzejczak-Czechowicz, Jongejan, Kowalski, Kralimarkova, Lidholm, Papadopoulos, Popov, Prado, Purohit, Reig, Seneviratne, Sinaniotis, Vassilopoulou, Versteeg, Vieths, Welsing, Mills, Le, Zwinderman and van Ree.)

Published
2021
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