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308 results on '"degli Uberti, E."'

1. Pegvisomant in acromegaly: an update

Author

Giustina, A., Arnaldi, G., Bogazzi, F., Cannavò, S., Colao, A., De Marinis, L., De Menis, E., Degli Uberti, E., Giorgino, F., Grottoli, S., Lania, A. G., Maffei, P., Pivonello, R., and Ghigo, E.

Published
2017
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2. Rare diseases in clinical endocrinology: a taxonomic classification system

Author

Marcucci, G., Cianferotti, L., Beck-Peccoz, P., Capezzone, M., Cetani, F., Colao, A., Davì, M. V., degli Uberti, E., Del Prato, S., Elisei, R., Faggiano, A., Ferone, D., Foresta, C., Fugazzola, L., Ghigo, E., Giacchetti, G., Giorgino, F., Lenzi, A., Malandrino, P., Mannelli, M., Marcocci, C., Masi, L., Pacini, F., Opocher, G., Radicioni, A., Tonacchera, M., Vigneri, R., Zatelli, M. C., and Brandi, M. L.

Published
2015
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7. Pegvisomant in acromegaly: Why, when, how

Author

Colao, A., Arnaldi, G., Beck-Peccoz, P., Cannavò, S., Cozzi, R., degli Uberti, E., De Marinis, L., De Menis, E., Ferone, D., Gasco, V., Giustina, A., Grottoli, S., Lombardi, G., Maffei, P., Martino, E., Minuto, F., Pivonello, R., and Ghigo, E.

Published
2007
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13. Correction to: Pegvisomant in acromegaly: an update (Journal of Endocrinological Investigation, (2017), 40, 6, (577-589), 10.1007/s40618-017-0614-1)

Author

Giustina, A., Arnaldi, G., Bogazzi, F., Cannavò, S., Colao, A., De Marinis, L., De Menis, E., Degli Uberti, E., Giorgino, F., Grottoli, S., Lania, A. G., Maffei, P., Pivonello, R., Ghigo, E., Giustina, A., Arnaldi, G., Bogazzi, F., Cannavò, S., Colao, A., De Marinis, L., De Menis, E., Degli Uberti, E., Giorgino, F., Grottoli, S., Lania, A. G., Maffei, P., Pivonello, R., and Ghigo, E.

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism
Published
2018

20. Acromegaly is associated with increased cancer risk: a survey in Italy

Author

Terzolo, Massimo, Reimondo, Giuseppe, Berchialla, Paola, FERRANTE, EMANUELE, Malchiodi, Elena, De Marinis, Laura, Pivonello, Rosario, Grottoli, Silvia, Losa, Marco, Cannavo, Salvatore, Ferone, Diego, Montini, Marcella, Bondanelli, Marta, De Menis, Ernesto, Martini, Chiara, Puxeddu, Efisio, Velardo, Antonino, Peri, Alessandro, Faustini-Fustini, Marco, Tita, Patrizia, Pigliaru, Francesca, Peraga, Giulia, Borretta, Giorgio, Scaroni, Carla, Bazzoni, Nicoletta, Bianchi, Antonio, Berton, Alessandro, Serban, Andreea Liliana, Baldelli, Roberto, Fatti, Letizia Maria, Colao, Annamaria, Arosio, Maura, Lombardi, G., TRIMARCHI, LORENZO, Degli Uberti, E. C., Ambrosio, M. R., Pagani, G., Attanasio, R., Kara, E., Mantero, F., Ceccato, F., Mortini, P., Razzore, P., Angeletti, G., Della Torre, D., Mariotti, S., Ghigo, E., Mainini, A. L., Appetecchia, M., Vigneri, R., Minuto, F., Nazzari, E., Cavagnini, F., Persani, L., Terzolo, Massimo, Reimondo, Giuseppe, Berchialla, Paola, Ferrante, Emanuele, Malchiodi, Elena, De Marinis, Laura, Pivonello, Rosario, Grottoli, Silvia, Losa, Marco, Cannavo, Salvatore, Ferone, Diego, Montini, Marcella, Bondanelli, Marta, De Menis, Ernesto, Martini, Chiara, Puxeddu, Efisio, Velardo, Antonino, Peri, Alessandro, Faustini-Fustini, Marco, Tita, Patrizia, Pigliaru, Francesca, Peraga, Giulia, Borretta, Giorgio, Scaroni, Carla, Bazzoni, Nicoletta, Bianchi, Antonio, Berton, Alessandro, Serban, Andreea Liliana, Baldelli, Roberto, Fatti, Letizia Maria, Colao, Annamaria, Arosio, Maura for the Italian Study Group of Acromegaly, Arosio, Maura, Lombardi, G., Trimarchi, Lorenzo, Degli Uberti, E. C., Ambrosio, M. R., Pagani, G., Attanasio, R., Kara, E., Mantero, F., Ceccato, F., Mortini, P., Razzore, P., Angeletti, G., Della Torre, D., Mariotti, S., Ghigo, E., Mainini, A. L., Appetecchia, M., Vigneri, R., Minuto, F., Nazzari, E., Cavagnini, F., and Persani, L.

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Colorectal cancer, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, NO, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Risk Factors, Neoplasms, Internal medicine, Gh IGF1, Acromegaly, Humans, Medicine, cancer, Family history, Thyroid cancer, Acromegaly cancer, Oncology, business.industry, GH, IGF1, acromegaly, Incidence, Risk Factor, Incidence (epidemiology), Cancer, Middle Aged, medicine.disease, Diabetes and Metabolism, Acromegaly, cancer, GH, IGF1, Italy, 030220 oncology & carcinogenesis, Neoplasm, Female, Cohort Studie, business, Kidney cancer, Human, Cohort study
Abstract

It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18–1.68, P P = 0.022), kidney cancer (SIR 2.87; 95% CI, 1.55–5.34, P P

Published
2017

21. Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH)

Author

Bonomi, M., Vezzoli, V., Krausz, C., Guizzardi, F., Vezzani, S., Simoni, M., Bassi, I., Duminuco, P., Di Iorgi, N., Giavoli, C., Pizzocaro, A., Russo, G., Moro, M., Fatti, L., Ferlin, A., Mazzanti, L., Zatelli, M. C., Cannavo, S., Isidori, A. M., Pincelli, A. I., Prodam, F., Mancini, A., Limone, P., Tanda, M. L., Gaudino, R., Salerno, M., Francesca, P., Maghnie, M., Maggi, M. C., Persani, L., Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P., Lombardi, V., Mandrile, G., Manieri, C., Mantovani, G., Marelli, S., Marzullo, M., Mencarelli, M. A., Migone, N., Motta, G., Neri, G., Padov, G., Parenti, G., Pasquino, B., Pia, A., Piantanida, E., Pignatti, E., Pilotta, A., Pivett, B., Pollazzon, M., Pontecorvi, A., Porcelli, P., Pozza, G. B., Pozzobon, G., Radetti, G., Razzore, P., Rocchett, L., Roncoron, R., Rossi, G., Sala, E., Salvatoni, A., Salvini, F., Secc, A., Segni, M., Selice, R., Sgaramella, P., Sileo, F., Sinisi, A. A., Sirchia, F., Spada, A., Tresoldi, A., Vigneri, R., Weber, G., Zucchini, S., Bassi I., Moro M., Pincelli A. I., Mancini A. (ORCID:0000-0002-7707-4564), Cappa M., Corbetta S., Corona G., Danesi L., Ghezzi M., Giusti M. (ORCID:0000-0001-5767-8785), Grugni G., Parenti G., Pontecorvi A. (ORCID:0000-0003-0570-6865), Sala E., Bonomi, M., Vezzoli, V., Krausz, C., Guizzardi, F., Vezzani, S., Simoni, M., Bassi, I., Duminuco, P., Di Iorgi, N., Giavoli, C., Pizzocaro, A., Russo, G., Moro, M., Fatti, L., Ferlin, A., Mazzanti, L., Zatelli, M. C., Cannavo, S., Isidori, A. M., Pincelli, A. I., Prodam, F., Mancini, A., Limone, P., Tanda, M. L., Gaudino, R., Salerno, M., Francesca, P., Maghnie, M., Maggi, M. C., Persani, L., Aimaretti, G., Altobell, M., Ambrosio, M. R., Andrioli, M., Angelett, G., Arecco, F., Arnald, G., Arosio, M., Balsamo, A., Baldassarr, M., Bartalena, L., Bazzon, N., Beccari, L., Beck-Peccoz, P., Bellastella, G., Bellizz, M., Benedicent, F., Bernasconi, S., Bizzarri, C., Bona, G., Bonadonna, S., Borrett, G., Boschetti, M., Brunani, A., Brunelli, V., Buz, F., Cacciatore, C., Cangiano, B., Cappa, M., Casalone, R., Cassio, A., Cavarzere, P., Cherubini, V., Ciampani, T., Cicognan, D., Cignarell, A., Cisternin, M., Colombo, P., Corbetta, S., Corciul, N., Corona, G., Cozzi, R., Crivellaro, C., Dalle Mule, I., Danesi, L., Eli, A. V. D., Degli Uberti, E., De Leo, S., Della Valle, E., De Marchi, M., Di Mambr, A., Fabbri, A., Foresta, C., Forti, G., Franceschi, A. R., Garolla, A., Ghezzi, M., Giacomozzi, C., Giusti, M., Grosso, E., Guabello, G., Guarneri, M. P., Grugni, G., Lanfranco, F., Lania, A., Lanzi, R., Larizza, L., Lenzi, A., Loche, S., Loli, P., Lombardi, V., Mandrile, G., Manieri, C., Mantovani, G., Marelli, S., Marzullo, M., Mencarelli, M. A., Migone, N., Motta, G., Neri, G., Padov, G., Parenti, G., Pasquino, B., Pia, A., Piantanida, E., Pignatti, E., Pilotta, A., Pivett, B., Pollazzon, M., Pontecorvi, A., Porcelli, P., Pozza, G. B., Pozzobon, G., Radetti, G., Razzore, P., Rocchett, L., Roncoron, R., Rossi, G., Sala, E., Salvatoni, A., Salvini, F., Secc, A., Segni, M., Selice, R., Sgaramella, P., Sileo, F., Sinisi, A. A., Sirchia, F., Spada, A., Tresoldi, A., Vigneri, R., Weber, G., Zucchini, S., Bassi I., Moro M., Pincelli A. I., Mancini A. (ORCID:0000-0002-7707-4564), Cappa M., Corbetta S., Corona G., Danesi L., Ghezzi M., Giusti M. (ORCID:0000-0001-5767-8785), Grugni G., Parenti G., Pontecorvi A. (ORCID:0000-0003-0570-6865), and Sala E.

Abstract

Objective: Isolated hypogonadotropic hypogonadism (IHH) is a rare disorder with pubertal delay, normal (normoosmic-IHH, nIHH) or defective sense of smell (Kallmann syndrome, KS). Other reproductive and nonreproductive anomalies might be present although information on their frequency are scanty, particularly according to the age of presentation. Design: Observational cohort study carried out between January 2008 and June 2016 within a national network of academic or general hospitals. Methods: We performed a detailed phenotyping of 503 IHH patients with: (1) manifestations of hypogonadism with low sex steroid hormone and low/normal gonadotropins; (2) absence of expansive hypothalamic/pituitary lesions or multiple pituitary hormone defects. Cohort was divided on IHH onset (PPO, pre-pubertal onset or AO, adult onset) and olfactory function: PPO-nIHH (n = 275), KS (n = 184), AO-nIHH (n = 36) and AO-doIHH (AO-IHH with defective olfaction, n = 8). Results: 90% of patients were classifed as PPO and 10% as AO. Typical midline and olfactory defects, bimanual synkinesis and familiarity for pubertal delay were also found among the AO-IHH. Mean age at diagnosis was signifcantly earlier and more frequently associated with congenital hypogonadism stigmata in patients with Kallmann's syndrome (KS). Synkinesis, renal and male genital tract anomalies were enriched in KS. Overweight/obesity are signifcantly associated with AO-IHH rather than PPO-IHH. Conclusions: Patients with KS are more prone to develop a severe and complex phenotype than nIHH. The presence of typical extra-gonadal defects and familiarity for PPO-IHH among the AO-IHH patients indicates a common predisposition with variable clinical expression. Overall, these fndings improve the understanding of IHH and may have a positive impact on the management of patients and their families.

Published
2018

22. Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH)

Author

Bonomi, Marco, primary, Vezzoli, Valeria, additional, Krausz, Csilla, additional, Guizzardi, Fabiana, additional, Vezzani, Silvia, additional, Simoni, Manuela, additional, Bassi, Ivan, additional, Duminuco, Paolo, additional, Di Iorgi, Natascia, additional, Giavoli, Claudia, additional, Pizzocaro, Alessandro, additional, Russo, Gianni, additional, Moro, Mirella, additional, Fatti, Letizia, additional, Ferlin, Alberto, additional, Mazzanti, Laura, additional, Zatelli, Maria Chiara, additional, Cannavò, Salvo, additional, Isidori, Andrea M, additional, Pincelli, Angela Ida, additional, Prodam, Flavia, additional, Mancini, Antonio, additional, Limone, Paolo, additional, Tanda, Maria Laura, additional, Gaudino, Rossella, additional, Salerno, Mariacarolina, additional, Francesca, Pregnolato, additional, Maghnie, Mohamad, additional, Maggi, Mario, additional, Persani, Luca, additional, _, _, additional, Aimaretti, G, additional, Altobelli, M, additional, Ambrosio, M R, additional, Andrioli, M, additional, Angeletti, G, additional, Arecco, F, additional, Arnaldi, G, additional, Arosio, M, additional, Balsamo, A, additional, Baldassarri, M, additional, Bartalena, L, additional, Bazzoni, N, additional, Beccaria, L, additional, Beck-Peccoz, P, additional, Bellastella, G, additional, Bellizzi, M, additional, Benedicenti, F, additional, Bernasconi, S, additional, Bizzarri, C, additional, Bona, G, additional, Bonadonna, S, additional, Borretta, G, additional, Boschetti, M, additional, Brunani, A, additional, Brunelli, V, additional, Buzi, F, additional, Cacciatore, C, additional, Cangiano, B, additional, Cappa, M, additional, Casalone, R, additional, Cassio, A, additional, Cavarzere, P, additional, Cherubini, V, additional, Ciampani, T, additional, Cicognani, D, additional, Cignarelli, A, additional, Cisternino, M, additional, Colombo, P, additional, Corbetta, S, additional, Corciulo, N, additional, Corona, G, additional, Cozzi, R, additional, Crivellaro, C, additional, Dalle Mule, I, additional, Danesi, L, additional, D’Elia, A V, additional, degli Uberti, E, additional, De Leo, S, additional, Della Valle, E, additional, De Marchi, M, additional, Di Iorgi, N, additional, Di Mambro, A, additional, Fabbri, A, additional, Foresta, C, additional, Forti, G, additional, Franceschi, A R, additional, Garolla, A, additional, Ghezzi, M, additional, Giacomozzi, C, additional, Giusti, M, additional, Grosso, E, additional, Guabello, G, additional, Guarneri, M P, additional, Grugni, G, additional, Isidori, A M, additional, Lanfranco, F, additional, Lania, A, additional, Lanzi, R, additional, Larizza, L, additional, Lenzi, A, additional, Loche, S, additional, Loli, P, additional, Lombardi, V, additional, Maggio, M C, additional, Mandrile, G, additional, Manieri, C, additional, Mantovani, G, additional, Marelli, S, additional, Marzullo, M, additional, Mencarelli, M A, additional, Migone, N, additional, Motta, G, additional, Neri, G, additional, Padova, G, additional, Parenti, G, additional, Pasquino, B, additional, Pia, A, additional, Piantanida, E, additional, Pignatti, E, additional, Pilotta, A, additional, Pivetta, B, additional, Pollazzon, M, additional, Pontecorvi, A, additional, Porcelli, P, additional, Pozzan, G B, additional, Pozzobon, G, additional, Radetti, G, additional, Razzore, P, additional, Rocchetti, L, additional, Roncoroni, R, additional, Rossi, G, additional, Sala, E, additional, Salvatoni, A, additional, Salvini, F, additional, Secco, A, additional, Segni, M, additional, Selice, R, additional, Sgaramella, P, additional, Sileo, F, additional, Sinisi, A A, additional, Sirchia, F, additional, Spada, A, additional, Tresoldi, A, additional, Vigneri, R, additional, Weber, G, additional, and Zucchini, S, additional

Published
2018
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24. Assessment of the awareness and management of sleep apnea syndrome in acromegaly. The COM.E.TA (Comorbidities Evaluation and Treatment in Acromegaly) Italian Study Group

Author

Menis, E., Giustina, A., Colao, A., Degli Uberti, E., Ghigo, E., Minuto, F., Bogazzi, F., Drigo, R., Cattaneo, A., Aimaretti, G., Ambrosio, M. R., Andreani, M., Angeletti, G., Celleno, R., Appetecchia, M. L., Baldelli, R., Armigliato, M., Arosio, M., Babini, A., Baldi, F., Balza, G., Bartalena, L., Tanda, M. L., Battista, C., Beck-Peccoz, P., Boffano, G. M., Martino, E., Borboni, P., Borretta, G., Baffoni, C., Boscaro, M., Arnaldi, G., Buschini, M., Salvatore Cannavo, Caramellino, A., Carani, C., Castelli, A., Pancotti, M., Cavagnini, F., Chiodera, P., Cataldo, S., Chiovato, L., Colombo, M., Crivellaro, C., D Ulizia, M., Mattè, S., Del Monte, P., Delitala, G., Masala, A., Fabbri, A., Piantoni, L., Faustini Fustini, M., Favro, S., Ferone, D., Fidotti, E., Valentini, F., Formoso, G., Frigato, F., Furlani, L., Gargiulo, P., Gasparoni, P., Gazzaruso, C., Giordano, C., Giorgino, F., Grandi, M., Pedersoli, S., Grimaldi, F., Grottoli, S., La Grotta, A., Lanzi, R., Limone, P., Razzore, P., Lio, S., Lo Cascio, V., Francia, G., Davì, M. V., Lo Coco, R., Macinini, E., Mantero, F., Scaroni, C., Marchetti, M., Mariotti, S., Pigliaru, F., Marzullo, P., Monachesi, M., Montini, M., Pagani, G., Muggeo, M., Castello, R., Mulas, G., Nassi, R., Vezzosi, C., Nizzoli, M., Orlandi, F., Pacini, F., Di Cairano, G., Palermo, M., Paoletta, A., Papini, E., Parillo, M., Parisi, G., Pasquali, R., Pagotto, U., Pavoncello, S., Perego, M. R., Peri, A., Piscopello, L., Pivonello, R., Raffa, M., Raggiunti, B., Roiter, I., Tamburrano, G., Terzolo, M., Testa, I., Testori, G., Cerruti, N., Toscano, V., Tota, N., Vailati, A., Lovati, E., Valcavi, R., Vincenzi, V., De Menis, E, Giustina, A, Colao, A, Degli Uberti, E, Ghigo, E, Minuto, F, Bogazzi, F, Drigo, R, Cattaneo, A, Aimaretti, G, Giordano, C, Giustina, Andrea, Italian Study Group, C. O. M. E. T. A., De Menis, E., Giustina, A., Colao, A., Degli Uberti, E., Ghigo, E., Minuto, F., Bogazzi, F., Drigo, R., Cattaneo, A., Aimaretti, G., Ambrosio, M.R., Andreani, M., Angeletti, G., Celleno, R., Appetecchia, M.L., Baldelli, R., Armigliato, M., Arosio, M., Babini, A., Baldi, F., Balza, G., Bartalena, L., Tanda, M.L., Battista, C., Beck-Peccoz, P., Boffano, G.M., Martino, E., Borboni, P., Borretta, G., Baffoni, C., Boscaro, M., Arnaldi, G., Buschini, M., Cannavò, S., Caramellino, A., Carani, C., Castelli, A., Pancotti, M., Cavagnini, F., Chiodera, P., Cataldo, S., Chiovato, L., Colombo, M., Crivellaro, C., D'Ulizia, M., De Mattè, S., Del Monte, P., Delitala, G., Masala, A., Fabbri, A., Piantoni, L., Faustini Fustini, M., Favro, S., Ferone, D., Fidotti, E., Valentini, F., Formoso, G., Frigato, F., Furlani, L., Gargiulo, P., Gasparoni, P., Gazzaruso, C., Giordano, C., Giorgino, F., Grandi, M., Pedersoli, S., Grimaldi, F., Grottoli, S., La Grotta, A., Lanzi, R., Limone, P., Razzore, P., Lio, S., Lo Cascio, V., Francia, G., Davì, M.V., Lo Coco, R., Macinini, E., Mantero, F., Scaroni, C., Marchetti, M., Mariotti, S., Pigliaru, F., Marzullo, P., Monachesi, M., Montini, M., Pagani, G., Muggeo, M., Castello, R., Mulas, G., Nassi, R., Vezzosi, C., Nizzoli, M., Orlandi, F., Pacini, F., Di Cairano, G., Palermo, M., Paoletta, A., Papini, E., Parillo, M., Parisi, G., Pasquali, R., Pagotto, U., Pavoncello, S., Perego, M.R., Peri, A., Piscopello, L., Pivonello, R., Raffa, M., Raggiunti, B., Roiter, I., Tamburrano, G., Terzolo, M., Testa, I., Testori, G., Cerruti, N., Toscano, V., Tota, N., Vailati, A., Lovati, E., Valcavi, R., Vincenzi, V., Colao, Annamaria, and C. O. M. E. T. A. Italian Study G. r. o. u., P.

Subjects
Male, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, Polysomnography, Comorbidity, somatostatin analogs, acromegaly, sleep apnea syndrome, Settore MED/13 - Endocrinologia, Somatostatin analog, Endocrinology, Sleep Apnea Syndromes, Quality of life, Acromegaly, Sleep apnea syndrome, Somatostatin analogs, Physicians, Surveys and Questionnaires, medicine, Prevalence, Humans, Continuous positive airway pressure, medicine.diagnostic_test, business.industry, Sleep apnea, Awareness, Focus Groups, sleep apnea, medicine.disease, Sleep Apnea, Italy, Physical therapy, COM.E.TA, Female, Clinical Competence, business
Abstract

In 2007 the Italian COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) study group started to assess the application in a clinical setting of the Versailles criteria for management of acromegaly complications by a first questionnaire focusing on cardiovascular co-morbidities. A further questionnaire on sleep apnea syndrome (SAS) was delivered by the COM.E.T.A. study group to 107 endocrine centers in Italy. The results of our survey suggest that SAS is a well-known comorbidity even if its estimated prevalence is lower than in the literature. Polysomnography is the preferred tool for diagnosis. Control of SAS is considered relevant both for quality of life and co-morbidities. Continuous positive airway pressure is the cornerstone of therapy, but patients' acceptance may be critical. Control of GH/IGF-I secretion is important to improve SAS. Management of SAS requires cooperation between specialists. ©2011, Editrice Kurtis.

Published
2011

25. Primary Empty Sella: why and when to investigate hypotalamic-pituitary function

Author

GIUSTINA , ANDREA, Aimaretti G, Bondanelli M, Buzi F, Cannavò S, Cirillo S, Colao A, De Marinis L, Ferone D, Gasperi M, Grottoli S, Porcelli T, Ghigo E, Degli Uberti E., Giustina, A, Aimaretti, G, Bondanelli, M, Buzi, F, Cannavo', S, Cirillo, Sossio, Colao, A, DE MARINIS, L, Ferone, D, Gasperi, M, Grottoli, S, Porcelli, T, Ghigo, E, DEGLI UBERTI, E., Giustina, Andrea, Cannavò, S, Cirillo, S, De Marinis, L, and Degli Uberti, E.

Published
2010

26. CDK-Inhibitors as New Therapeutic Treatment for Human Bronchial Carcinoids

Author

Benfini, K, Gentilin, E, Riva, E, Di Pasquale, C, Falletta, S, Gagliano, T, Schiavon, M, Cavallesco, G, Degli Uberti, E, and Zatelli, Mc

Subjects
Bronchial carcinoid, medical therapy, mTOR resistance, Bronchial carcinoid, medical therapy, mTOR resistance, CDK inhibitors, CDK inhibitors, NO
Published
2016

31. Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism

Author

De Bellis, A, Pane, E, Bellastella, G, Sinisi, Aa, Colella, C, Giordano, R, Giavoli, C, Lania, A, Ambrosio, Mr, Di Somma, C, Zatelli, Mc, Arvat, E, Colao, A, Bizzarro, A, Bellastella, A, Italian Autoimmune Hypophysitis Network Study Beck Peccoz, P, Betterle, C, Cannavo', Salvatore, Degli Uberti, E, Ghigo, E, Lombardi, G, Maghnie, M, Mantero, F, Spada, A, Falorni, A, Delvecchio, M, De Marinis, L, Martino, E, Rotondi, M, Chiovato, L., De Bellis, A, Pane, E, Bellastella, G, Sinisi, Aa, Colella, C, Giordano, R, Giavoli, C, Lania, A, Ambrosio, Mr, Di Somma, C, Zatelli, Mc, Arvat, E, Colao, A, Bizzarro, A, Bellastella, A, Beck-Peccoz, P, Betterle, C, Cannavò, S, Degli Uberti, E, Ghigo, E, Lombardi, G, Maghnie, M, Mantero, F, Spada, A, Falorni, A, Delvecchio, M, De Marinis, L, Martino, E, Rotondi, M, and Chiovato, L.

Subjects
Adult, Male, Human Growth Hormone, Hypothalamus, Autoimmunity, antipituitary and antihypothalamus antibodies, Hypopituitarism, Adrenocorticotropic Hormone, selective idiopathic hypopituitarism, Pituitary Gland, pituitary and hypothalamic autoimmunity, Humans, Female, Fluorescent Antibody Technique, Indirect, Autoantibodies, Hypophysectomy
Abstract

OBJECTIVE: Antipituitary (APA) but not antihypothalamus antibodies (AHA) have been investigated in patients with idiopathic hypopituitarism. This study searched for APA and AHA in some of these patients to investigate whether pituitary or hypothalamic autoimmunity could play a role in their pituitary dysfunction. DESIGN: Sixty-six patients with selective idiopathic hypopituitarism were studied: 27 with ACTH deficiency, 20 with GH deficiency and 19 with hypogonadotropic hypogonadism. Twenty patients with hypopituitarism secondary to hypophysectomy and 50 healthy subjects were enrolled as controls. MEASUREMENTS: Antipituitary and AHA were evaluated by indirect immunofluorescence in sera of patients and controls. Positive sera were retested by a four-layer double immunofluorescence to identify the cells targeted by these antibodies. RESULTS: Antipituitary were present at high titre in 4 of 27 patients with ACTH deficiency (14·8%), 4 of 20 with GH deficiency (26%) and 5 of 19 with hypogonadotropic hypogonadism (21%) and targeted, respectively, corticotrophs, somatotrophs and gonadotrophs. AHA were found at high titre only in 5 patients with ACTH deficiency (18·5%), mostly targeting corticotrophin-releasing hormone-secreting cells; none of these 5 patients resulted positive for antipituitary antibodies. Among the controls, only 1 hypophysectomized patient resulted APA positive at low titre. CONCLUSIONS: Our results suggest that in patients with selective idiopathic hypopituitarism, detection of APA or AHA could better characterize an autoimmune process involving the pituitary or hypothalamus, respectively. In particular, detection of antibodies targeting selectively ACTH-secreting or corticotrophin-releasing hormone-secreting cells may differentiate, respectively secondary from tertiary variants of autoimmune hypoadrenalism

Published
2011

32. Predictive role of the immunostaining pattern of immunofluorescence and the titers of antipituitary antibodies at presentation for the occurrence of autoimmune hypopituitarism in patients with autoimmune polyendocrine syndromes over a five-year follow-up

Author

Bellastella, G, Rotondi, M, Pane, E, Dello Iacovo, A, Pirali, B, Dalla Mora, L, Falorni, A, Sinisi, Aa, Bizzarro, A, Colao, A, Chiovato, L, De Bellis, A, Italian Autoimmune Hypophysitis Network Study, Ambrosio, Mr, Arvat, E, Beck Peccoz, P, Betterle, C, Cannavo', Salvatore, Degli Uberti, E, Giordano, R, Ghigo, E, Lombardi, G, Maghnie, M, Mantero, F, Persani, L, Spada, A, Santeusanio, F, Delvecchio, M., Bellastella, G., Rotondi, M., Pane, E., Dello Iacovo, A., Pirali, B., Dalla Mora, L., Falorni, A., Sinisi, ANTONIO AGOSTINO, Bizzarro, Antonio, Colao, Annamaria, Chiovato, L., DE BELLIS, Annamaria, Italian AutoimmuneHypophysitis Network, S. t. u. d. y., Bellastella, G, Rotondi, M, Pane, E, DELLO IACOVO, A, Pirali, B, DALLA MORA, L, Falorni, A, Sinisi, Aa, Bizzarro, A, Colao, A, Chiovato, L, DE BELLIS, A, Ambrosio, Mr, Arvat, E, BECK-PECOZ, P, Betterle, C, Cannavò, S, DEGLI UBERTI, E, Giordano, R, Ghigo, E, Lombardi, G, Maghnie, M, Mantero, F, Persani, L, Spada, A, Santeusanio, F, and DEL VECCHIO, M.

Subjects
Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, education, Clinical Biochemistry, Fluorescent Antibody Technique, Context (language use), Hypopituitarism, Immunofluorescence, medicine.disease_cause, Biochemistry, Statistics, Nonparametric, antipituitary antibodie, NO, Autoimmunity, Endocrinology, Anterior pituitary, autoimmune hypopituitarism, Pituitary Gland, Anterior, Predictive Value of Tests, Internal medicine, mental disorders, medicine, Humans, Polyendocrinopathies, Autoimmune, Autoantibodies, medicine.diagnostic_test, biology, business.industry, polyendocrine syndrome, Biochemistry (medical), medicine.disease, antipituitary antibodies, autoimmune polyendocrine syndromes, medicine.anatomical_structure, hypopituitarism, Autoimmune polyendocrine syndrome, immunofluorescence, antipituitary antibodies, poly-endocrine syndrome, biology.protein, Regression Analysis, Female, Antibody, business, Immunostaining, psychological phenomena and processes
Abstract

CONTEXT: Antipituitary antibodies (APA) are frequently present in patients with autoimmune polyendocrine syndrome (APS). DESIGN: The aim was to evaluate the predictive value of APA for the occurrence of hypopituitarism. A total of 149 APA-positive and 50 APA-negative patients with APS and normal pituitary function were longitudinally studied for 5 yr. METHODS: APA, by indirect immunofluorescence, and anterior pituitary function were assessed yearly in all patients. The risk for developing autoimmune pituitary dysfunction was calculated using survival and multivariate analysis. RESULTS: Hypopituitarism occurred in 28 of 149 (18.8%) APA-positive patients but in none of the 50 APA-negative patients. The immunostaining pattern in APA-positive patients involved either isolated pituitary cells [type 1 pattern; n=99 (66.4%)] or all pituitary cells [type 2 pattern; n=50 (33.6%)]. All patients developing pituitary dysfunction throughout the study span had a type 1 pattern. Kaplan-Meier curves for cumulative survival showed a significantly higher rate for developing hypopituitarism in relation to positive APA tests (P

Published
2010

33. High-dose intramuscular octreotide in patients with acromegaly inadequatelycontrolled on conventional somatostatin analogue therapy: a randomised controlledtrial

Author

Giustina A, Bonadonna S, Bugari G, Cozzi R, Cannavo S, de Marinis L, Degli Uberti E, Bogazzi F, Mazziotti G, Minuto F, Montini M, Ghigo E., COLAO, ANNAMARIA, Giustina, A, Bonadonna, S, Bugari, G, Colao, Annamaria, Cozzi, R, Cannavo, S, de Marinis, L, Degli Uberti, E, Bogazzi, F, Mazziotti, G, Minuto, F, Montini, M, and Ghigo, E.

Subjects
acromegaly, octreotide
Abstract

OBJECTIVE: In acromegaly, 25-50% of patients respond inadequately to conventional long-acting somatostatin analogue (SSA) therapy. Response may be improved by increasing SSA frequency or dose. This study evaluated the biochemical efficacy and safety of high-dose octreotide in patients with acromegaly. DESIGN: A 24-week prospective, multicentre, randomised, open-label trial conducted from 12 December 2005 to 23 October 2007 in patients with persistently uncontrolled acromegaly despite > or =6 month conventional SSA therapy. METHODS: Patients with > or =50% reduction in GH levels during previous SSA treatment were randomised to high-dose (60 mg/28 days) or high-frequency (30 mg/21 days) octreotide i.m. injection. Primary end-points were week 12 and 24 reduction in serum IGF1 and GH from baseline. Secondary end points included IGF1 normalisation and tumour shrinkage rates, and safety/tolerability evaluations. RESULTS: Significantly, more patients (10 out of 11) achieved week 24 IGF1 reduction in the high-dose than the high-frequency group (8 out of 15; P

Published
2009

34. GERMLINE PROKINETICIN RECEPTOR 2 (PROKR2) VARIANTS ASSOCIATED WITH CENTRAL HYPOGONADISM CAUSE DIFFERENTAL MODULATION OF DISTINCT INTRACELLULAR PATHWAYS

Author

Domenico Vladimiro Libri, Gunnar, Kleinau, Valeria, Vezzoli, Marta, Busnelli, Fabiana, Guizzardi, Antonio Agostino Sinisi, Angela Ida Pincelli, Antonio, Mancini, Gianni, Russo, Paolo Beck Peccoz, Sandro, Loche, Claudio, Crivellaro, Maghnie, Mohamad, Csilla, Krausz, Luca, Persani, Marco, Bonomi, Aimaretti, G., Altobelli, M., Arnaldi, G., Baldi, M., Bartalena, L., Beccaria, L., Bellastella, G., Bellizzi, M., Bona, G., Borretta, G., Buzi, F., Cannavo, S., Cappa, M., Cariboni, A., Ciampani, T., Cicognani, A., Cisternino, M., Corbetta, S., Corciulo, N., Corona, G., Cozzi, R., D'Elia, A. V., Degli Uberti, E., De Marchi, M., Forti, G., Di Iorgi, N., Isidori, Andrea, Fabbri, A., Ferlin, A., Foresta, C., Franceschi, R., Garolla, A., Gaudino, R., Giagulli, V., Grosso, E., Jannini, E., Lanfranco, F., Larizza, L., Lenzi, A., Lombardo, Francesco, Limone, P., Maggi, M., Maggi, R., Maggio, M. C., Mandrile, G., Marino, M., Mencarelli, M. A., Migone, N., Neri, G., Perroni, L., Pignatti, E., Pilotta, A., Pizzocaro, A., Pontecorvi, A., Pozzobon, G., Prodam, F., Radetti, G., Razzore, P., Salerno, M. C., Salvatoni, A., Salvini, F., Secco, A., Segni, Maria, Simoni, M., Vigneri, R., Weber, G., Libri, Dv, Kleinau, G, Vezzoli, V, Busnelli, M, Guizzardi, F, Sinisi, Antonio Agostino, Pincelli, Ai, Mancini, A, Russo, G, Beck Peccoz, P, Loche, S, Crivellaro, C, Maghnie, M, Krausz, C, Persani, L, Bonomi, M., Libri DV, Kleinau G, Vezzoli V, Busnelli M, Guizzardi F, Sinisi AA, Pincelli AI, Mancini A, Russo G, Beck-Peccoz P, Loche S, Crivellaro C, Maghnie M, Krausz C, Persani L, Bonomi M, Maggio MC, et al, Libri, Domenico Vladimiro, Kleinau, Gunnar, Vezzoli, Valeria, Busnelli, Marta, Guizzardi, Fabiana, Pincelli, Angela Ida, Mancini, Antonio, Russo, Gianni, Beck Peccoz, Paolo, Loche, Sandro, Crivellaro, Claudio, Maghnie, Mohamad, Krausz, Csilla, Persani, Luca, Bonomi, Marco, and Salerno, Mariacarolina

Subjects
Male, Kallmann syndrome, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Inositol Phosphate, medicine.disease_cause, Biochemistry, Hypogonadotropic hypogonadism, Germline, Receptors, G-Protein-Coupled, Cohort Studies, Endocrinology, Settore MED/38 - Pediatria Generale E Specialistica, Adolescent, Adult, Child, Cyclic AMP, Female, Genetic Association Studies, Humans, Hypogonadism, Inositol Phosphates, Middle Aged, Mutation, Missense, Receptors, Peptide, Signal Transduction, Young Adult, Germ-Line Mutation, Receptors, mutations, septo-optic dysplasia, Missense mutation, Receptor, Mutation, Prokineticin, Peptide, Human, medicine.medical_specialty, Adolescent, Adult, Child, Cohort Studies, Cyclic AMP, metabolism, Female, Genetic Association Studies, Germ-Line Mutation, Humans, Hypogonadism, epidemiology/genetics, Inositol Phosphates, metabolism, Male, Middle Aged, Missense, Receptors, G-Protein-Coupled, genetics, Receptors, genetics, Signal Transduction, genetics, Young Adult, Genetic Association Studie, Biology, Germline mutation, Internal medicine, medicine, Biochemistry (medical), Prokineticin receptor 2, medicine.disease, PROKR2, hypogonadism, prokineticin, Missense, Cohort Studie
Abstract

INTRODUCTION: Defects of prokineticin pathway affect the neuroendocrine control of reproduction, but their role in the pathogenesis of central hypogonadism remains undefined, and the functional impact of the missense PROKR2 variants has been incompletely characterized. MATERIAL AND METHODS: In a series of 246 idiopathic central hypogonadism patients, we found three novel (p.V158I, p.V334M, and p.N15TfsX30) and six already known (p.L173R, p.T260M, p.R268C, p.V274D, p.V331M, and p.H20MfsX23) germline variants in the PROKR2 gene. We evaluated the effects of seven missense alterations on two different prokineticin receptor 2 (PROKR2)-dependent pathways: inositol phosphate-Ca(2+) (Gq coupling) and cAMP (Gs coupling). RESULTS: PROKR2 variants were found in 16 patients (6.5%). Expression levels of variants p.V158I and p.V331M were moderately reduced, whereas they were markedly impaired in the remaining cases, except p.V334M, which was significantly overexpressed. The variants p.T260M, p.R268C, and p.V331M showed no remarkable changes in cAMP response (EC50) whereas the IP signaling appeared more profoundly affected. In contrast, cAMP accumulation cannot be stimulated through the p.L173R and p.V274D, but IP EC50 was similar to wt inp.L173R and increased by 10-fold in p.V274D. The variant p.V334M led to a 3-fold increase of EC50 for both cAMP and IP. CONCLUSION: Our study shows that single PROKR2 missense allelic variants can either affect both signaling pathways differently or selectively. Thus, the integrity of both PROKR2-dependent cAMP and IP signals should be evaluated for a complete functional testing of novel identified allelic variants.

Published
2014

35. Italian Study Group on Idiopathic Central Hypogonadism (ICH). Germline prokineticin receptor 2 (PROKR2) variants associated with central hypogonadism cause differental modulation of distinct intracellular pathways

Author

Libri, D. V., Kleinau, G., Vezzoli, V., Busnelli, M., Guizzardi, F., Sinisi, A. A., Pincelli, A. I., Mancini, A., Russo, G., Eccoz, P. Beck P., Loche, S., Crivellaro, C., Maghnie, M., Krausz, C., Persani, L., Bonomi, M., Aimaretti, G., Altobelli, M., Arnaldi, G., Baldi, M., Bartalena, Luigi, Beccaria, L., Bellastella, G., Bellizzi, M., Bona, G., Borretta, G., Buzi, F., Cannavò, S., Cappa, M., Cariboni, A., Ciampani, T., Cicognani, A., Cisternino, M., Corbetta, S., Corciulo, N., Corona, G., Cozzi, R., D’Elia, A. V., Degli Uberti, E., De Marchi, M., Forti, G., di Iorgi, N., Isidori, A., Fabbri, A., Ferlin, A., Foresta, C., Franceschi, R., Garolla, A., Gaudino, R., Giagulli, V., Grosso, E., Jannini, E., Lanfranco, F., Larizza, L., Lenzi, A., Lombardo, F., Limone, P., Maggi, M., Maggi, R., Maggio, M. C., Mandrile, G., Marino, M., Mencarelli, M. A., Migone, N., Neri, G., Perroni, L., Pignatti, E., Pilotta, A., Pizzocaro, A., Pontecorvi, A., Pozzobon, G., Prodam, F., Radetti, G., Razzore, P., Salerno, M. C., Salvatoni, Alessandro, Salvini, F., Secco, A., Segni, M., Simoni, M., Vigneri, R., and Weber, G.

Published
2014

36. First-line therapy of acromegaly: A statement of the A.L.I.C.E. (Acromegaly primary medical treatment Learning and Improvement with Continuous Medical Education) Study Group

Author

Colao, A., Martino, E., Cappabianca, P., Cozzi, R., Scanarini, M., Ghigo, E., Angeletti, G., Anile, C., Arnaldi, G., Arosio, M., Attanasio, R., Auriemma, R., Baldelli, R., Billeci, D., Borretta, G., Boscaro, M., Salvatore Cannavo, Cavagnini, F., Cirillo, S., D Arrigo, C., D Azzò, G., Marinis, L., Menis, E., Degli Uberti, E., Esposito, F., Ferone, D., Formoso, G., Gasco, V., Gasperi, M., Giordano, E., Giustina, A., Grottoli, S., La Notte, M., Lasio, G., Lombardi, G., Losa, M., Mantero, F., Mariotti, S., Marzullo, P., Mazzatenta, D., Minuto, F., Montini, M., Pacini, F., Pezzino, V., Pivonello, R., Ronchi, C., Sicolo, N., Sinisi, A., Spada, A., Tamburrano, G., Terzolo, M., Tita, P. M. B., Vigo, M. T., Colao, A., Martino, E., Cappabianca, P., Cozzi, R., Scanarini, M., Ghigo, E., Angeletti, G., Anile, C., Arnaldi, G., Arosio, M., Attanasio, R., Auriemma, R., Baldelli, R., Billeci, D., Borretta, G., Boscaro, M., Cannavò, S., Cavagnini, F., Cirillo, S., D'Arrigo, C., D'Azzò, G., De Marinis, L., De Menis, E., degli Uberti, E., Esposito, F., Ferone, D., Formoso, G., Gasco, V., Gasperi, M., Giordano, E., Giustina, A., Grottoli, S., La Notte, M., Lasio, G., Lombardi, G., Losa, M., Mantero, F., Mariotti, S., Marzullo, P., Mazzatenta, D., Minuto, F., Montini, M., Pacini, F., Pezzino, V., Pivonello, R., Ronchi, C., Sicolo, N., Sinisi, A., Spada, A., Tamburrano, G., Terzolo, M., Tita, P. M. B., and Vigo, M. T.

Subjects
Adenoma, medicine.medical_specialty, Pediatrics, Cabergoline, Medical treatment, business.industry, Statement (logic), Endocrinology, Diabetes and Metabolism, Guidelines, Guideline, medicine.disease, Acromegaly, Treatment, First line therapy, Endocrinology, Dopamine Agonists, Physical therapy, medicine, Ergolines, Humans, Somatostatin, business
Published
2006

37. First-line therapy of acromegaly: a statement of the A.L.I.C.E. (Acromegaly primary medical treatment Learning and Improvement with Continuous Medical Educcation) Studi Group

Author

COLAO A, MARTINO E, CAPPABIANCA P, COZZI R, SCANARINI M, GHIGO E, ANGELETTI G, ANILE C, ARNALDI G, AROSIO M, ATTANASIO R, AURIEMMA R, BALDELLI R, BILLECI D, BORRETTA G, BOSCARO M, CANNAV0' S, CAVAGNINI F, D'ARRIGO C, D'AZZO G, DE MARINIS L, DE MENIS E, DEGLI UBERTI E, ESPOSITO F, FERONE D, FORMOSO G, GASCO V, GASPERI M, GIORDANO E, GIUSTINA A, GROTTOLI S, LA NOTTE M, LASIO G, LOMBARDI G, LOSA M, MANTERO F, MARIOTTI S, MARZULLO P, MAZZATENTA D, MINUTO F, MONTINI M, PACINI F, PEZZINO V, PIVONELLO R, RONCHI C, SICOLO N, SINISI A, SPADA A, TAMBURRANO G, TERZOLO M, TITA PMB, VIGO MT, CIRILLO, Sossio, Colao, A, Martino, E, Cappabianca, P, Cozzi, R, Scanarini, M, Ghigo, E, Angeletti, G, Anile, C, Arnaldi, G, Arosio, M, Attanasio, R, Auriemma, R, Baldelli, R, Billeci, D, Borretta, G, Boscaro, M, Cannav0', S, Cavagnini, F, Cirillo, Sossio, D'Arrigo, C, D'Azzo, G, DE MARINIS, L, DE MENIS, E, DEGLI UBERTI, E, Esposito, F, Ferone, D, Formoso, G, Gasco, V, Gasperi, M, Giordano, E, Giustina, A, Grottoli, S, LA NOTTE, M, Lasio, G, Lombardi, G, Losa, M, Mantero, F, Mariotti, S, Marzullo, P, Mazzatenta, D, Minuto, F, Montini, M, Pacini, F, Pezzino, V, Pivonello, R, Ronchi, C, Sicolo, N, Sinisi, A, Spada, A, Tamburrano, G, Terzolo, M, Tita, Pmb, and Vigo, Mt

Published
2006

39. Timing of total thyroidectomy in RET gene carriers < 18 years of age

Author

Romei, C., Bottici, V., Opocher, G., Mian, C., Brandi, M. L., Giusti, F., Loli, P., Castellano, Maurizio, Cappelli, Carlo, Persani, L., Filetti, S., Fugazzola, L., Verga, U., degli Uberti, E., Zatelli, M. C., Colao, A., Faggiano, A., Creminini, N., Taccaliti, A., Boscaro, M., Giorgino, F., Orlandi, F., Elisei, R., and Itamen, Network

Subjects
Medullary thyroid cancer, RET mutation
Published
2013

40. INVOLVEMENT OF HYPOTHALAMUS AUTOIMMUNITY IN PATIENTS WITH AUTOIMMUNE HYPOPITUITARISM: ROLE OF ANTIBODIES TO HYPOTHALAMIC CELLS

Author

De Bellis, A, Sinisi, Aa, Pane, E, Dello Iacovo, A, Bellastella, G, Di Scala, G, Falorni, A, Giavoli, C, Gasco, V, Giordano, R, Ambrosio, Mr, Colao, A, Bizzarro, A, Bellastella, A, Italian Autoimmune Hypophysitis Network Group Arvat, E, Beck Peccoz, P, Betterle, C, Cannavo', Salvatore, Chiovato, L, Delvecchio, M, De Marinis, L, Degli Uberti, E, Ghigo, E, Maghnie, M, Mantero, F, Persani, L, Rotondi, M, Spada, A, Zatelli, M. C., DE BELLIS, Annamaria, Sinisi, Aa, Pane, E, Dello Iacovo, A, Bellastella, Giuseppe, Di Scala, G, Falorni, A, Giavoli, C, Gasco, V, Giordano, R, Ambrosio, Mr, Colao, A, Bizzarro, Antonio, and Bellastella, A.

Subjects
Adult, Male, medicine.medical_specialty, anticorpi anti-ipotalamo, Corticotropin-Releasing Hormone, Hypophysitis, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Context (language use), Hypopituitarism, Immunofluorescence, medicine.disease_cause, Biochemistry, Autoimmune Diseases, sindrome poliendocrina autoimmune, Autoimmunity, NO, Cohort Studies, Anticorpi anti-ipofisi, Endocrinology, Adrenocorticotropic Hormone, Antibody Specificity, Seroepidemiologic Studies, Internal medicine, medicine, Humans, antibodies, hypothalamus, health care economics and organizations, Autoantibodies, diabete insipido centrale, Subclinical infection, medicine.diagnostic_test, Human Growth Hormone, business.industry, Biochemistry (medical), medicine.disease, hypophysitis, Diabetes Insipidus, Neurogenic, Cross-Sectional Studies, Diabetes insipidus, Immunology, Autoimmune hypophysitis, Female, business
Abstract

Antipituitary antibodies (APA) but not antihypothalamus antibodies (AHA) are usually searched for in autoimmune hypopituitarism.Our objective was to search for AHA and characterize their hypothalamic target in patients with autoimmune hypopituitarism to clarify, on the basis of the cells stained by these antibodies, the occurrence of autoimmune subclinical/clinical central diabetes insipidus (CDI) and/or possible joint hypothalamic contribution to their hypopituitarism.We conducted a cross-sectional cohort study.Ninety-five APA-positive patients with autoimmune hypopituitarism, 60 without (group 1) and 35 with (group 2) lymphocytic hypophysitis, were studied in comparison with 20 patients with postsurgical hypopituitarism and 50 normal subjects.AHA by immunofluorescence and posterior pituitary function were evaluated; then AHA-positive sera were retested by double immunofluorescence to identify the hypothalamic cells targeted by AHA.AHA were detected at high titer in 12 patients in group 1 and in eight patients in group 2. They immunostained arginine vasopressin (AVP)-secreting cells in nine of 12 in group 1 and in four of eight in group 2. All AVP cell antibody-positive patients presented with subclinical/clinical CDI; in contrast, four patients with GH/ACTH deficiency but with APA staining only GH-secreting cells showed AHA targeting CRH- secreting cells.The occurrence of CDI in patients with lymphocytic hypophysitis seems due to an autoimmune hypothalamic involvement rather than an expansion of the pituitary inflammatory process. To search for AVP antibody in these patients may help to identify those of them prone to develop an autoimmune CDI. The detection of AHA targeting CRH-secreting cells in some patients with GH/ACTH deficiency but with APA targeting only GH-secreting cells indicates that an autoimmune aggression to hypothalamus is jointly responsible for their hypopituitarism.

Published
2012

41. Rare diseases in clinical endocrinology: a taxonomic classification system

Author

Marcucci, G., primary, Cianferotti, L., additional, Beck-Peccoz, P., additional, Capezzone, M., additional, Cetani, F., additional, Colao, A., additional, Davì, M. V., additional, degli Uberti, E., additional, Del Prato, S., additional, Elisei, R., additional, Faggiano, A., additional, Ferone, D., additional, Foresta, C., additional, Fugazzola, L., additional, Ghigo, E., additional, Giacchetti, G., additional, Giorgino, F., additional, Lenzi, A., additional, Malandrino, P., additional, Mannelli, M., additional, Marcocci, C., additional, Masi, L., additional, Pacini, F., additional, Opocher, G., additional, Radicioni, A., additional, Tonacchera, M., additional, Vigneri, R., additional, Zatelli, M. C., additional, and Brandi, M. L., additional

Published
2014
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42. Apoplessie in una casistica di adenomi ipofisari

Author

Lapparelli, Marcello, Sarubbo, Silvio, Ambrosio, Maria Rosaria, Degli Uberti, E., Ceruti, S., Granieri, Enrico Gavino Giuseppe, Cavazzini, L., and Cavallo, Michele Alessandro

Published
2009

43. Frequenza delle mutazioni di RET in una casistica italiana di famiglie affette da MEN2: uno studio multicentrico

Author

Elisei, R., Mariotti, S., Fugazzola, L., Taccaliti, A., Pacini, F., Opocher, G., Castellano, Maurizio, Degli Uberti, E., Ceccherini, I., Cremonini, N., Seregni, E., Orlandi, F., Ferolla, P., Colao, A., Puxeddu, E., Giorgino, F., Loli, P., Bondi, F., Romei, C., Cosci, B., Pinna, G., Persani, L., Boscaro, M., Castagna, M. G., Milan, C., Cappelli, Carlo, Zatelli, M. C., and Pinchera, A.

Subjects
medullary cancer, RET
Published
2008

44. Circadian rhythms of atrial natriuretic peptide, renin, aldosterone, cortisol, blood pressure and heart rate in normal and hypertensive subjects

Author

M. Ferlini, Parti M, Angelo Margutti, Francesco Portaluppi, degli Uberti E, L Montanari, Maria Teresa Zanella, Giorgio Trasforini, Cavallini R, and Bagni B

Subjects
Male, Cosinor analysis, Sodium balance, medicine.medical_specialty, Hydrocortisone, Physiology, Heart rate, Rennin, Essential hypertension, Plasma renin activity, Cortisol, chemistry.chemical_compound, Atrial natriuretic peptide, Internal medicine, Renin, Internal Medicine, medicine, Humans, Adult hospitalized humans, Circadian rhythm, Aldosterone, Chronobiology, business.industry, Middle Aged, Blood pressure, medicine.disease, Endocrinology, chemistry, Hypertension, cardiovascular system, Female, Cardiology and Cardiovascular Medicine, business, Atrial Natriuretic Factor, hormones, hormone substitutes, and hormone antagonists, circulatory and respiratory physiology, Blood sampling
Abstract

The occurrence and extent of a circadian rhythm in the circulating concentrations of atrial natriuretic peptide (ANP) are still matters of controversy. Only a few data are available in humans relating the time structure of plasma ANP levels with the circadian patterns of other hormones and cardiovascular variables. In a group of hospitalized normal volunteers (six men and four women, 16-76 years old), and in a group of hospitalized hypertensives (seven men and three women, 18-76 years old), we investigated the circadian variability of ANP and its temporal relationship with the circadian rhythms of blood pressure (BP) and heart rate (HR), and plasma renin activity (PRA), plasma aldosterone (PA) and plasma cortisol (PC) levels, by using a chronobiological inferential statistic method. At the end of a synchronizing period of 1 week (the diet and daily schedule were standardized), the subjects underwent automatic BP and HR monitoring, and blood sampling for 24 h. A statistically significant mean circadian rhythm was demonstrated for ANP, BP, HR, PRA, PA and PC in both normal and hypertensive subjects. The mean circadian acrophase of ANP (calculated to occur at around 04.00 h) anticipated the corresponding acrophases of the other hormones; BP and HR rhythms appeared to be in antiphase with ANP rhythm, i.e. the peak of BP and HR rhythms more or less coincided with the trough in ANP rhythm. A significant increase in the daily levels (assessed by the circadian mesor) of ANP was present in hypertensive subjects when compared with normal controls. In essential hypertension the circadian rhythm of ANP was set at higher circulating levels, but otherwise it was similar to the circadian rhythm found in normals. ANP mesors correlated significantly with renin and aldosterone mesors in normal subjects but not in hypertensive patients. ANP appears to anticipate awakening in its circadian periodic rise. On the basis of the considerable acrophase asynchronism, it seems possible to exclude any causal relations between the periodic changes of ANP and the rhythmic fluctuations of the other hormones that we studied. In contrast, important relations may be hypothesized between ANP levels and BP and HR values, on the basis of their antiphase rhythms.

Published
1990

45. Chromogranin A as a marker of neuroendocrine neoplasia: an Italian Multicenter Study

Author

Zatelli, M. C., DELLE FAVE, Gianfranco, Torta, M., Leon, A., Ambrosio, M. R., Gion, M., Tomassetti, P., De Braud, F., Delle, Fave, G., Dogliotti, L., Degli Uberti, E. C., Italian Cromanet Working Group, Zatelli M., Torta M., Leon A., Ambrosio M., Gion M., Tomassetti P., De Braud F., Delle Fave G., Dogliotti L., and degli Uberti E.C.

Subjects
Adult, Male, endocrine system, Cancer Research, medicine.medical_specialty, Pathology, Endocrinology, Diabetes and Metabolism, Enzyme-Linked Immunosorbent Assay, Neuroendocrine tumors, Gastroenterology, Endocrinology, Internal medicine, Positive predicative value, Active disease, medicine, Biomarkers, Tumor, Humans, In patient, Gastrointestinal Neoplasms, Neuroendocrine neoplasia, biology, business.industry, Chromogranin A, Middle Aged, medicine.disease, Pancreatic Neoplasms, Neuroendocrine Tumors, Oncology, Multicenter study, Italy, biology.protein, Female, business
Abstract

Elevated circulating chromogranin A (CgA) levels are found in neuroendocrine tumors (NETs), but the diagnostic usefulness of this marker is still debatable. To assess the role of CgA for the diagnosis of gastroenteropancreatic (GEP) NETs and the identification of metastatic patients, an Italian multicenter observational study has been performed. CgA was evaluated in 202 GEP NET patients by IRMA and ELISA. The cutoffs for diagnosis and presence of metastases were identified by receiver-operating characteristic (ROC) curve. We found good correlation between IRMA and ELISA. The ROC analysis identified a cutoff of 53 ng/ml for IRMA and 16 U/l for ELISA as discriminating between controls and patients with active disease (sensitivity 71.3 and 84%; specificity 71 and 85% respectively). Metastases were present in 123 patients, having significantly higher CgA levels than patients without metastases. ROC analysis identified a cutoff of 146 ng/ml for IRMA and 67.3 U/l for ELISA as discriminating between patients with and without metastases (sensitivity 57 and 63.3%; specificity 55.6 and 71.4% respectively). For pancreatic NETs positive and negative predictive values were 84 and 78% respectively (90% specificity and 68% sensitivity). We found lower CgA levels in patients with extensive metastatic spread than in those with liver metastases only. These data assess the role of CgA evaluation in GEP NETs, and demonstrate that higher CgA levels associate with metastatic disease, confirming that CgA levels can provide a helpful practical biochemical marker for the clinical management of NETs, but with low sensitivity and specificity.

Published
2007

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