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Background: Virus-associated febrile lower respiratory tract infections (fLRIs) during infancy have been identified as risk factors for persistent wheeze development. We hypothesized that variations in innate immune defense capacity during this period, as exemplified by production of type 1 and 3 interferons (T1/3IFNs), might be an underlying determinant of risk., Objective: We sought to investigate relationships between postnatal development of innate interferon response capacity and susceptibility to early infections and persistent wheeze., Methods: We studied a subset of subjects from a birth cohort at high risk for asthma/allergy and determined the capacity of cord blood cells (n = 151) to produce any of a panel of 17 T1/3IFNs in response to the viral mimic polyinosinic-polycytidylic acid using a sensitive PCR assay. We investigated relationships between neonatal interferon responses and lower respiratory tract infection history during infancy, wheezing history to 5 age years, and ensuing maturation of innate immune capacity by age 4 years (n = 160) and 10 years (n = 125)., Results: Although cohort subjects produced an average of 2.6 ± 0.3 of the 17 innate interferons tested at birth, 24% showed no T1/3IFN production. This nonproducer subgroup showed increased risk for infant fLRIs (odds ratio, 2.62; 95% CI, 1.14-6.06; P = .024) and persistent wheeze (odds ratio, 4.24; 95% CI, 1.60-11.24; P = .004) at age 5 years relative to those producing 1 or more T1/3IFNs, whereas risk for infant wheezy lower respiratory tract infections or "transient early wheeze" was unaffected. Moreover, infants who experienced fLRIs subsequently demonstrated accelerated development of T1/3IFN response capacity between 1 and 4 years of age., Conclusions: T1/3IFN response capacity appears strongly developmentally constrained at birth. Infants in whom this negative regulation is strongest manifest increased risk for severe respiratory tract infections during infancy and subsequent persistent wheeze., (Copyright © 2018. Published by Elsevier Inc.)

Blood pressure measurements obtained with the Dinamap 845XT Vital Signs monitor were compared with measurements obtained with a standard mercury sphygmomanometer and a London School of Hygiene mercury sphygmomanometer in a group of 31 normotensive and hypertensive subjects. The experimental design allowed reading to be taken with all 3 devices at approximately the same time. 12 sets of readings were obtained with each device in each subject. Although inter-device differences estimated from analysis of variance were small (less than 2 mmHg after allowing for calibration differences) differences between measurements taken simultaneously with the 3 devices were often substantial. Agreement between the two mercury sphygmomanometers was better than that between either sphygmomanometer and the Dinamap. This may be a reflection of fundamental differences between auscultatory and oscillometric measurements. Differences between devices were unrelated to blood pressure level. The observed variability within subjects was similar with each device.