175 results on '"de los Ríos, Cristóbal"'
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2. Targeting neuronal calcium channels and GSK3β for Alzheimer’s disease with naturally-inspired Diels-Alder adducts
3. Therapeutic concentrations of varenicline increases exocytotic release of catecholamines from human and rat adrenal chromaffin cells in the presence of nicotine
4. Clay-based hybrids for controlled release of 7-azaindole derivatives as neuroprotective drugs in the treatment of Alzheimer's disease
5. Tetrabenazine Facilitates Exocytosis by Enhancing Calcium-Induced Calcium Release through Ryanodine Receptors
6. STRENGTHEN KNOWLEDGE IN TOXICOLOGY THROUGH A PRACTICAL EXPERIENCE
7. Retinal response to systemic inflammation differs between sexes and neurons
8. Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines
9. Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment
10. Design and synthesis of multipotent 3-aminomethylindoles and 7-azaindoles with enhanced protein phosphatase 2A-activating profile and neuroprotection
11. Substituent effect of N-benzylated gramine derivatives that prevent the PP2A inhibition and dissipate the neuronal Ca2+ overload, as a multitarget strategy for the treatment of Alzheimer’s disease
12. Ischemic brain injury: New insights on the protective role of melatonin
13. Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na+/Ca2+ exchanger
14. C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer's disease targeting tauopathies
15. Benzothiazepine CGP37157 and its 2′-isopropyl analogue modulate Ca2+ entry through CALHM1
16. Melatonin as Modulator for Sulfur and Nitrogen Mustard-Induced Inflammation, Oxidative Stress and DNA Damage: Molecular Therapeutics
17. Promising Molecular Targets in Pharmacological Therapy for Neuronal Damage in Brain Injury
18. Indole-3-carbinol induces cMYC and IAP-family downmodulation and promotes apoptosis of Epstein–Barr virus (EBV)-positive but not of EBV-negative Burkitt's lymphoma cell lines
19. Neuroprotective Effect of the Novel Compound ITH33/IQM9.21 Against Oxidative Stress and Na+ and Ca2+ Overload in Motor Neuron-like NSC-34 Cells
20. Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease
21. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine
22. Polyfunctionalized α-Phenyl-tert-butyl(benzyl)nitrones: Multifunctional Antioxidants for Stroke Treatment
23. Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists
24. Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice
25. Novel Purine Derivative ITH15004 Facilitates Exocytosis through a Mitochondrial Calcium-Mediated Mechanism
26. An okadaic acid fragment analogue prevents nicotine-induced resistance to cisplatin by recovering PP2A activity in non-small cell lung cancer cells
27. A review of metal-catalyzed molecular damage: protection by melatonin
28. Synthesis and Biological Assessment of 4,1-Benzothiazepines with Neuroprotective Activity on the Ca2+ Overload for the Treatment of Neurodegenerative Diseases and Stroke
29. Toxicology of Blister Agents: Is Melatonin a Potential Therapeutic Option?
30. (±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer’s Disease
31. In Silico Prediction of the Toxic Potential of Neuroprotective Bifunctional Molecules Based on Chiral N-Propargyl-1,2-amino Alcohol Derivatives
32. Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation
33. The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases
34. Synthesis of n-chloroquinolines and n-ethynylquinolines ( n=2, 4, 8): homo and heterocoupling reactions
35. Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca 2+ channels and nicotinic receptors
36. Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6
37. New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
38. Novel tacrine derivatives that block neuronal calcium channels
39. Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues
40. Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases
41. Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases
42. Analysis of Gene Expression Profiles of CR80, a Neuroprotective 1,8-Naphthyridine
43. Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration
44. Gramine Derivatives Targeting Ca2+ Channels and Ser/Thr Phosphatases: A New Dual Strategy for the Treatment of Neurodegenerative Diseases
45. New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H3Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
46. Ligands for Ser/Thr phosphoprotein phosphatases: a patent review (2005-2015)
47. Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9 H-benzo[5,6]chromeno[2,3- b]quinolin-13-amines
48. Synthesis and biological assessment of diversely substituted furo[2,3- b]quinolin-4-amine and pyrrolo[2,3- b]quinolin-4-amine derivatives, as novel tacrine analogues
49. Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer’s disease
50. Recent patents on calcium channel blockers: emphasis on CNS diseases
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