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2. A Lassa virus live attenuated vaccine candidate that is safe and efficacious in guinea pigs

Author

Carey, Brian D., Yu, Shuiqing, Geiger, Jillian, Ye, Chengjin, Huzella, Louis M., Reeder, Rebecca J., Mehta, Monika, Hirsch, Shawn, Bernbaum, Rebecca, Cubitt, Beatrice, Pahar, Bapi, Anthony, Scott M., Marketon, Anthony, Bernbaum, John G., Tran, Julie P., Crozier, Ian, Martínez-Sobrido, Luis, Worwa, Gabriella, de la Torre, Juan Carlos, and Kuhn, Jens H.

Published
2024
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5. 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, Jens H, Adkins, Scott, Agwanda, Bernard R, Al Kubrusli, Rim, Alkhovsky, Sergey V, Amarasinghe, Gaya K, Avšič-Županc, Tatjana, Ayllón, María A, Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J, Basler, Christopher F, Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J, Bente, Dennis A, Bergeron, Éric, Bird, Brian H, Blair, Carol D, Blasdell, Kim R, Blystad, Dag-Ragnar, Bojko, Jamie, Borth, Wayne B, Bradfute, Steven, Breyta, Rachel, Briese, Thomas, Brown, Paul A, Brown, Judith K, Buchholz, Ursula J, Buchmeier, Michael J, Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H, Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N, Cheng, Qi, Chiaki, Yuya, Chiapello, Marco, Choi, Il-Ryong, Ciuffo, Marina, Clegg, J Christopher S, Crozier, Ian, Dal Bó, Elena, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L, Debat, Humberto, Dheilly, Nolwenn M, Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G, Digiaro, Michele, Dolnik, Olga, Drebot, Michael A, Drexler, J Felix, Dundon, William G, Duprex, W Paul, Dürrwald, Ralf, Dye, John M, Easton, Andrew J, Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W, Fooks, Anthony R, Forgia, Marco, Formenty, Pierre BH, Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R, Gaskin, Thomas, Gonzalez, Jean-Paul J, Griffiths, Anthony, Goldberg, Tony L, Groschup, Martin H, Günther, Stephan, Hall, Roy A, Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S, Hu, Tao, Hughes, Holly R, and Hüttner, Florian

Subjects
Biotechnology, Humans, Mononegavirales, Viruses, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

In March 2021, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by four families (Aliusviridae, Crepuscuviridae, Myriaviridae, and Natareviridae), three subfamilies (Alpharhabdovirinae, Betarhabdovirinae, and Gammarhabdovirinae), 42 genera, and 200 species. Thirty-nine species were renamed and/or moved and seven species were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2021

6. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

Author

Xian, Hongxu, Liu, Yuan, Rundberg Nilsson, Alexandra, Gatchalian, Raphaella, Crother, Timothy R, Tourtellotte, Warren G, Zhang, Yi, Aleman-Muench, German R, Lewis, Gavin, Chen, Weixuan, Kang, Sarah, Luevanos, Melissa, Trudler, Dorit, Lipton, Stuart A, Soroosh, Pejman, Teijaro, John, de la Torre, Juan Carlos, Arditi, Moshe, Karin, Michael, and Sanchez-Lopez, Elsa

Subjects
Biomedical and Clinical Sciences, Immunology, Acute Respiratory Distress Syndrome, Rare Diseases, Infectious Diseases, Coronaviruses, Lung, Emerging Infectious Diseases, 5.1 Pharmaceuticals, Good Health and Well Being, Adenosine Triphosphate, Animals, COVID-19, Cytokines, DNA, Mitochondrial, Humans, Inflammasomes, Interleukin-1beta, Lipopolysaccharides, Metformin, Mice, NLR Family, Pyrin Domain-Containing 3 Protein, Nucleoside-Phosphate Kinase, Pneumonia, Respiratory Distress Syndrome, SARS-CoV-2, ARDS, CMPK2, IL-1β, IL-6, NLRP3 inflammasome, inflammation, metformin, mitochondrial DNA
Abstract

Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how metformin inhibits inflammasome activation while exerting its anti-inflammatory effect. We show that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide (LPS)- and SARS-CoV-2-induced ARDS. By targeting electron transport chain complex 1 and independently of AMP-activated protein kinase (AMPK) or NF-κB, metformin blocked LPS-induced and ATP-dependent mitochondrial (mt) DNA synthesis and generation of oxidized mtDNA, an NLRP3 ligand. Myeloid-specific ablation of LPS-induced cytidine monophosphate kinase 2 (CMPK2), which is rate limiting for mtDNA synthesis, reduced ARDS severity without a direct effect on IL-6. Thus, inhibition of ATP and mtDNA synthesis is sufficient for ARDS amelioration.

Published
2021

8. 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, Jens H, Adkins, Scott, Alioto, Daniela, Alkhovsky, Sergey V, Amarasinghe, Gaya K, Anthony, Simon J, Avšič-Županc, Tatjana, Ayllón, María A, Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J, Bartonička, Tomáš, Basler, Christopher, Bavari, Sina, Beer, Martin, Bente, Dennis A, Bergeron, Éric, Bird, Brian H, Blair, Carol, Blasdell, Kim R, Bradfute, Steven B, Breyta, Rachel, Briese, Thomas, Brown, Paul A, Buchholz, Ursula J, Buchmeier, Michael J, Bukreyev, Alexander, Burt, Felicity, Buzkan, Nihal, Calisher, Charles H, Cao, Mengji, Casas, Inmaculada, Chamberlain, John, Chandran, Kartik, Charrel, Rémi N, Chen, Biao, Chiumenti, Michela, Choi, Il-Ryong, Clegg, J Christopher S, Crozier, Ian, da Graça, John V, Dal Bó, Elena, Dávila, Alberto MR, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L, Di Bello, Patrick L, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G, Digiaro, Michele, Dolja, Valerian V, Dolnik, Olga, Drebot, Michael A, Drexler, Jan Felix, Dürrwald, Ralf, Dufkova, Lucie, Dundon, William G, Duprex, W Paul, Dye, John M, Easton, Andrew J, Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Fernandes, Jorlan, Fooks, Anthony R, Formenty, Pierre BH, Forth, Leonie F, Fouchier, Ron AM, Freitas-Astúa, Juliana, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R, Gbakima, Aiah, Goldstein, Tracey, Gonzalez, Jean-Paul J, Griffiths, Anthony, Groschup, Martin H, Günther, Stephan, Guterres, Alexandro, Hall, Roy A, Hammond, John, Hassan, Mohamed, Hepojoki, Jussi, Hepojoki, Satu, Hetzel, Udo, Hewson, Roger, Hoffmann, Bernd, Hongo, Seiji, Höper, Dirk, Horie, Masayuki, Hughes, Holly R, Hyndman, Timothy H, Jambai, Amara, Jardim, Rodrigo, Jiāng, Dàohóng, Jin, Qi, and Jonson, Gilda B

Subjects
Biotechnology, Mononegavirales, Terminology as Topic, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

In March 2020, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. At the genus rank, 20 new genera were added, two were deleted, one was moved, and three were renamed. At the species rank, 160 species were added, four were deleted, ten were moved and renamed, and 30 species were renamed. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.

Published
2020

10. 2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, Jens H., Adkins, Scott, Alkhovsky, Sergey V., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Bandte, Martina, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Bigarré, Laurent, Blair, Carol D., Blasdell, Kim R., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Bruggmann, Rémy, Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Candresse, Thierry, Carson, Jeremy, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chiaki, Yuya, Crane, Anya, Crane, Mark, Dacheux, Laurent, Bó, Elena Dal, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Souza, William M., de Swart, Rik L., Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J. Felix, Duprex, W. Paul, Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Feuvrier, Claudette, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B. H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Godwin, Scott E., Gonzalez, Jean-Paul J., de Bellocq, Joëlle Goüy, Griffiths, Anthony, Groschup, Martin H., Günther, Stephan, Hammond, John, Hepojoki, Jussi, Hierweger, Melanie M., Hongō, Seiji, Horie, Masayuki, Horikawa, Hidenori, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy H., Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Karlin, David G., Klempa, Boris, Klingström, Jonas, Koch, Michel C., Kondō, Hideki, Koonin, Eugene V., Krásová, Jarmila, Krupovic, Mart, Kubota, Kenji, Kuzmin, Ivan V., Laenen, Lies, Lambert, Amy J., Lǐ, Jiànróng, Li, Jun-Min, Lieffrig, François, Lukashevich, Igor S., Luo, Dongsheng, Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., McCauley, John W., Mirazimi, Ali, Mohr, Peter G., Moody, Nick J. G., Morita, Yasuaki, Morrison, Richard N., Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Ochoa-Corona, Francisco M., Palacios, Gustavo, Pallandre, Laurane, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Pozet, Françoise, Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Rumbou, Artemis, Runstadler, Jonathan A., Rupp, Melanie, Sabanadzovic, Sead, Sasaya, Takahide, Schmidt-Posthaus, Heike, Schwemmle, Martin, Seuberlich, Torsten, Sharpe, Stephen R., Shi, Mang, Sironi, Manuela, Smither, Sophie, Song, Jin-Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Tesh, Robert B., Těšíková, Jana, Thornburg, Natalie J., Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tsunekawa, Kenta, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Yamasaki, Junki, Yanagisawa, Hironobu, Ye, Gongyin, Zhang, Yong-Zhen, and Økland, Arnfinn Lodden

Published
2022
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11. Taxonomy of the order Bunyavirales: update 2019

Author

Abudurexiti, Abulikemu, Adkins, Scott, Alioto, Daniela, Alkhovsky, Sergey V, Avšič-Županc, Tatjana, Ballinger, Matthew J, Bente, Dennis A, Beer, Martin, Bergeron, Éric, Blair, Carol D, Briese, Thomas, Buchmeier, Michael J, Burt, Felicity J, Calisher, Charles H, Cháng, Chénchén, Charrel, Rémi N, Choi, Il Ryong, Clegg, J Christopher S, de la Torre, Juan Carlos, de Lamballerie, Xavier, Dèng, Fēi, Di Serio, Francesco, Digiaro, Michele, Drebot, Michael A, Duàn, Xiǎoméi, Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Fulhorst, Charles F, Garrison, Aura R, Gāo, George Fú, Gonzalez, Jean-Paul J, Groschup, Martin H, Günther, Stephan, Haenni, Anne-Lise, Hall, Roy A, Hepojoki, Jussi, Hewson, Roger, Hú, Zhìhóng, Hughes, Holly R, Jonson, Miranda Gilda, Junglen, Sandra, Klempa, Boris, Klingström, Jonas, Kòu, Chūn, Laenen, Lies, Lambert, Amy J, Langevin, Stanley A, Liu, Dan, Lukashevich, Igor S, Luò, Tāo, Lǚ, Chuánwèi, Maes, Piet, de Souza, William Marciel, Marklewitz, Marco, Martelli, Giovanni P, Matsuno, Keita, Mielke-Ehret, Nicole, Minutolo, Maria, Mirazimi, Ali, Moming, Abulimiti, Mühlbach, Hans-Peter, Naidu, Rayapati, Navarro, Beatriz, Nunes, Márcio Roberto Teixeira, Palacios, Gustavo, Papa, Anna, Pauvolid-Corrêa, Alex, Pawęska, Janusz T, Qiáo, Jié, Radoshitzky, Sheli R, Resende, Renato O, Romanowski, Víctor, Sall, Amadou Alpha, Salvato, Maria S, Sasaya, Takahide, Shěn, Shū, Shí, Xiǎohóng, Shirako, Yukio, Simmonds, Peter, Sironi, Manuela, Song, Jin-Won, Spengler, Jessica R, Stenglein, Mark D, Sū, Zhèngyuán, Sūn, Sùróng, Táng, Shuāng, Turina, Massimo, Wáng, Bó, Wáng, Chéng, Wáng, Huálín, Wáng, Jūn, Wèi, Tàiyún, Whitfield, Anna E, Zerbini, F Murilo, Zhāng, Jìngyuàn, Zhāng, Lěi, Zhāng, Yànfāng, Zhang, Yong-Zhen, and Zhāng, Yújiāng

Subjects
Bunyaviridae, Genome, Viral, Phylogeny, RNA, Viral, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accepted by the International Committee on Taxonomy of Viruses (ICTV).

Published
2019

12. Taxonomy of the order Bunyavirales: second update 2018

Author

Maes, Piet, Adkins, Scott, Alkhovsky, Sergey V, Avšič-Županc, Tatjana, Ballinger, Matthew J, Bente, Dennis A, Beer, Martin, Bergeron, Éric, Blair, Carol D, Briese, Thomas, Buchmeier, Michael J, Burt, Felicity J, Calisher, Charles H, Charrel, Rémi N, Choi, Il Ryong, Clegg, J Christopher S, de la Torre, Juan Carlos, de Lamballerie, Xavier, DeRisi, Joseph L, Digiaro, Michele, Drebot, Mike, Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Fulhorst, Charles F, Garrison, Aura R, Gāo, George Fú, Gonzalez, Jean-Paul J, Groschup, Martin H, Günther, Stephan, Haenni, Anne-Lise, Hall, Roy A, Hewson, Roger, Hughes, Holly R, Jain, Rakesh K, Jonson, Miranda Gilda, Junglen, Sandra, Klempa, Boris, Klingström, Jonas, Kormelink, Richard, Lambert, Amy J, Langevin, Stanley A, Lukashevich, Igor S, Marklewitz, Marco, Martelli, Giovanni P, Mielke-Ehret, Nicole, Mirazimi, Ali, Mühlbach, Hans-Peter, Naidu, Rayapati, Nunes, Márcio Roberto Teixeira, Palacios, Gustavo, Papa, Anna, Pawęska, Janusz T, Peters, Clarence J, Plyusnin, Alexander, Radoshitzky, Sheli R, Resende, Renato O, Romanowski, Víctor, Sall, Amadou Alpha, Salvato, Maria S, Sasaya, Takahide, Schmaljohn, Connie, Shí, Xiǎohóng, Shirako, Yukio, Simmonds, Peter, Sironi, Manuela, Song, Jin-Won, Spengler, Jessica R, Stenglein, Mark D, Tesh, Robert B, Turina, Massimo, Wèi, Tàiyún, Whitfield, Anna E, Yeh, Shyi-Dong, Zerbini, F Murilo, Zhang, Yong-Zhen, Zhou, Xueping, and Kuhn, Jens H

Subjects
Animals, Arenaviridae, Arenaviridae Infections, Humans, Phylogeny, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

In October 2018, the order Bunyavirales was amended by inclusion of the family Arenaviridae, abolishment of three families, creation of three new families, 19 new genera, and 14 new species, and renaming of three genera and 22 species. This article presents the updated taxonomy of the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV).

Published
2019

16. DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection.

Author

Loureiro, María Eugenia, Zorzetto-Fernandes, Andre Luiz, Radoshitzky, Sheli, Chi, Xiaoli, Dallari, Simone, Marooki, Nuha, Lèger, Psylvia, Foscaldi, Sabrina, Harjono, Vince, Sharma, Sonia, Zid, Brian M, López, Nora, de la Torre, Juan Carlos, Bavari, Sina, and Zúñiga, Elina

Subjects
Cell Line, Humans, Arenavirus, Arenaviridae Infections, Interferon Type I, Viral Core Proteins, Virus Replication, DEAD-box RNA Helicases, Host-Pathogen Interactions, Immune Evasion, Virology, Microbiology, Immunology, Medical Microbiology
Abstract

Several arenaviruses cause hemorrhagic fever (HF) diseases that are associated with high morbidity and mortality in humans. Accordingly, HF arenaviruses have been listed as top-priority emerging diseases for which countermeasures are urgently needed. Because arenavirus nucleoprotein (NP) plays critical roles in both virus multiplication and immune-evasion, we used an unbiased proteomic approach to identify NP-interacting proteins in human cells. DDX3, a DEAD-box ATP-dependent-RNA-helicase, interacted with NP in both NP-transfected and virus-infected cells. Importantly, DDX3 deficiency compromised the propagation of both Old and New World arenaviruses, including the HF arenaviruses Lassa and Junin viruses. The DDX3 role in promoting arenavirus multiplication associated with both a previously un-recognized DDX3 inhibitory role in type I interferon production in arenavirus infected cells and a positive DDX3 effect on arenavirus RNA synthesis that was dependent on its ATPase and Helicase activities. Our results uncover novel mechanisms used by arenaviruses to exploit the host machinery and subvert immunity, singling out DDX3 as a potential host target for developing new therapies against highly pathogenic arenaviruses.

Published
2018

17. Intelligent Electric Drive Management for Plug-in Hybrid Buses

Author

Ruiz, Patricia, Arias, Aarón, Massobrio, Renzo, de la Torre, Juan Carlos, Seredynski, Marcin, Dorronsoro, Bernabé, Barbosa, Simone Diniz Junqueira, Editorial Board Member, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Kotenko, Igor, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Dorronsoro, Bernabé, editor, Ruiz, Patricia, editor, de la Torre, Juan Carlos, editor, Urda, Daniel, editor, and Talbi, El-Ghazali, editor

Published
2020
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19. Correction to: 2021 Taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

Author

Kuhn, Jens H., Adkins, Scott, Agwanda, Bernard R., Al Kubrusli, Rim, Alkhovsky, Sergey V., Amarasinghe, Gaya K., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Basler, Christopher F., Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J., Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol D., Blasdell, Kim R., Blystad, Dag-Ragnar, Bojko, Jamie, Borth, Wayne B., Bradfute, Steven, Breyta, Rachel, Briese, Thomas, Brown, Paul A., Brown, Judith K., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Cheng, Qi, Chiaki, Yuya, Chiapello, Marco, Choi, Il-Ryong, Ciuffo, Marina, Clegg, J. Christopher S., Crozier, Ian, Dal Bó, Elena, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Cicco, Emiliano, Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Dolnik, Olga, Drebot, Michael A., Drexler, J. Felix, Dundon, William G., Duprex, W. Paul, Dürrwald, Ralf, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Elbeaino, Toufic, Ergünay, Koray, Ferguson, Hugh W., Fooks, Anthony R., Forgia, Marco, Formenty, Pierre B. H., Fránová, Jana, Freitas-Astúa, Juliana, Fu, Jingjing, Fürl, Stephanie, Gago-Zachert, Selma, Gāo, George Fú, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas, Gonzalez, Jean-Paul J., Griffiths, Anthony, Goldberg, Tony L., Groschup, Martin H., Günther, Stephan, Hall, Roy A., Hammond, John, Han, Tong, Hepojoki, Jussi, Hewson, Roger, Hong, Jiang, Hong, Ni, Hongo, Seiji, Horie, Masayuki, Hu, John S., Hu, Tao, Hughes, Holly R., Hüttner, Florian, Hyndman, Timothy H., Ilyas, M., Jalkanen, Risto, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Kaukinen, Karia H., Kawate, Michael, Klempa, Boris, Klingström, Jonas, Kobinger, Gary, Koloniuk, Igor, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Langevin, Stanley L., Lee, Benhur, Lefkowitz, Elliot J., Leroy, Eric M., Li, Shaorong, Li, Longhui, Lǐ, Jiànróng, Liu, Huazhen, Lukashevich, Igor S., Maes, Piet, de Souza, William Marciel, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., Massart, Sebastien, McCauley, John W., Melzer, Michael, Mielke-Ehret, Nicole, Miller, Kristina M., Ming, Tobi J., Mirazimi, Ali, Mordecai, Gideon J., Mühlbach, Hans-Peter, Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R. T., Olmedo-Velarde, Alejandro, Palacios, Gustavo, Pallás, Vicente, Pályi, Bernadett, Papa, Anna, Paraskevopoulou, Sofia, Park, Adam C., Parrish, Colin R., Patterson, David A., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Payne, Susan, Peracchio, Carlotta, Pérez, Daniel R., Postler, Thomas S., Qi, Liying, Radoshitzky, Sheli R., Resende, Renato O., Reyes, Carina A., Rima, Bertus K., Luna, Gabriel Robles, Romanowski, Víctor, Rota, Paul, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sall, Amadou Alpha, Salvato, Maria S., Sang, Rosemary, Sasaya, Takahide, Schulze, Angela D., Schwemmle, Martin, Shi, Mang, Shí, Xiǎohóng, Shí, Zhènglì, Shimomoto, Yoshifumi, Shirako, Yukio, Siddell, Stuart G., Simmonds, Peter, Sironi, Manuela, Smagghe, Guy, Smither, Sophie, Song, Jin-Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Stone, David M., Sugano, Jari, Suttle, Curtis A., Tabata, Amy, Takada, Ayato, Takeuchi, Shigeharu, Tchouassi, David P., Teffer, Amy, Tesh, Robert B., Thornburg, Natalie J., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Torto, Baldwyn, Towner, Jonathan S., Tsuda, Shinya, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Uchida, Janice, Usugi, Tomio, Vaira, Anna Maria, Vallino, Marta, van den Hoogen, Bernadette, Varsani, Arvind, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Wang, Lin-Fa, Wang, Guoping, Wang, Yanxiang, Wang, Yaqin, Waqas, Muhammad, Wèi, Tàiyún, Wen, Shaohua, Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Wu, Jiangxiang, Xu, Lei, Yanagisawa, Hironobu, Yang, Caixia, Yang, Zuokun, Zerbini, F. Murilo, Zhai, Lifeng, Zhang, Yong-Zhen, Zhang, Song, Zhang, Jinguo, Zhang, Zhe, and Zhou, Xueping

Published
2021
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22. Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence.

Author

Cunningham, Cameron R, Champhekar, Ameya, Tullius, Michael V, Dillon, Barbara Jane, Zhen, Anjie, de la Fuente, Justin Rafael, Herskovitz, Jonathan, Elsaesser, Heidi, Snell, Laura M, Wilson, Elizabeth B, de la Torre, Juan Carlos, Kitchen, Scott G, Horwitz, Marcus A, Bensinger, Steven J, Smale, Stephen T, and Brooks, David G

Subjects
Dendritic Cells, T-Lymphocytes, Animals, Mice, Inbred C57BL, Mice, Knockout, Mice, Lymphocytic choriomeningitis virus, HIV, Tuberculosis, Virus Diseases, Lymphocytic Choriomeningitis, HIV Infections, Neoplasms, Disease Models, Animal, Interferons, Enzyme-Linked Immunosorbent Assay, Oligonucleotide Array Sequence Analysis, Flow Cytometry, Immune Tolerance, Real-Time Polymerase Chain Reaction, Inbred C57BL, Knockout, Disease Models, Animal, Virology, Microbiology, Immunology, Medical Microbiology
Abstract

Persistent viral infections are simultaneously associated with chronic inflammation and highly potent immunosuppressive programs mediated by IL-10 and PDL1 that attenuate antiviral T cell responses. Inhibiting these suppressive signals enhances T cell function to control persistent infection; yet, the underlying signals and mechanisms that program immunosuppressive cell fates and functions are not well understood. Herein, we use lymphocytic choriomeningitis virus infection (LCMV) to demonstrate that the induction and functional programming of immunosuppressive dendritic cells (DCs) during viral persistence are separable mechanisms programmed by factors primarily considered pro-inflammatory. IFNγ first induces the de novo development of naive monocytes into DCs with immunosuppressive potential. Type I interferon (IFN-I) then directly targets these newly generated DCs to program their potent T cell immunosuppressive functions while simultaneously inhibiting conventional DCs with T cell stimulating capacity. These mechanisms of monocyte conversion are constant throughout persistent infection, establishing a system to continuously interpret and shape the immunologic environment. MyD88 signaling was required for the differentiation of suppressive DCs, whereas inhibition of stimulatory DCs was dependent on MAVS signaling, demonstrating a bifurcation in the pathogen recognition pathways that promote distinct elements of IFN-I mediated immunosuppression. Further, a similar suppressive DC origin and differentiation was also observed in Mycobacterium tuberculosis infection, HIV infection and cancer. Ultimately, targeting the underlying mechanisms that induce immunosuppression could simultaneously prevent multiple suppressive signals to further restore T cell function and control persistent infections.

Published
2016

23. Suppression of Fcγ-receptor-mediated antibody effector function during persistent viral infection.

Author

Yamada, Douglas H, Elsaesser, Heidi, Lux, Anja, Timmerman, John M, Morrison, Sherie L, de la Torre, Juan Carlos, Nimmerjahn, Falk, and Brooks, David G

Subjects
B-Lymphocytes, Dendritic Cells, CD4-Positive T-Lymphocytes, Macrophages, Animals, Mice, Inbred C57BL, Mice, Knockout, Mice, Lymphocytic choriomeningitis virus, Lymphocytic Choriomeningitis, Receptors, IgG, Antigens, CD20, Immunologic Factors, Antibodies, Viral, Antigen-Antibody Complex, Lymphocyte Depletion, Lymphocyte Activation, Phagocytosis, Cross-Priming, Immune Tolerance, Immune Evasion, Antibodies, Monoclonal, Murine-Derived, Rituximab, Inbred C57BL, Knockout, Receptors, IgG, Antigens, CD20, Antibodies, Viral, Monoclonal, Murine-Derived, Emerging Infectious Diseases, Vaccine Related, Infectious Diseases, 2.1 Biological and endogenous factors, 2.2 Factors relating to physical environment, 5.1 Pharmaceuticals, Inflammatory and Immune System, Infection, Immunology
Abstract

Understanding how viruses subvert host immunity and persist is essential for developing strategies to eliminate infection. T cell exhaustion during chronic viral infection is well described, but effects on antibody-mediated effector activity are unclear. Herein, we show that increased amounts of immune complexes generated in mice persistently infected with lymphocytic choriomeningitis virus (LCMV) suppressed multiple Fcγ-receptor (FcγR) functions. The high amounts of immune complexes suppressed antibody-mediated cell depletion, therapeutic antibody-killing of LCMV infected cells and human CD20-expressing tumors, as well as reduced immune complex-mediated cross-presentation to T cells. Suppression of FcγR activity was not due to inhibitory FcγRs or high concentrations of free antibody, and proper FcγR functions were restored when persistently infected mice specifically lacked immune complexes. Thus, we identify a mechanism of immunosuppression during viral persistence with implications for understanding effective antibody activity aimed at pathogen control.

Published
2015

24. Functional impairment of “helpless” CD8+memory T cells is transient and driven by prolonged but finite cognate antigen presentation

Author

van der Heide, Verena, primary, Davenport, Bennett, additional, Cubitt, Beatrice, additional, Roudko, Vladimir, additional, Choo, Daniel, additional, Humblin, Etienne, additional, Jhun, Kevin, additional, Angeliadis, Krista, additional, Dawson, Travis, additional, Furtado, Glaucia, additional, Kamphorst, Alice, additional, Ahmed, Rafi, additional, de la Torre, Juan Carlos, additional, and Homann, Dirk, additional

Published
2024
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25. ICTV Virus Taxonomy Profile: Cruliviridae 2023

Author

Kuhn, Jens H., primary, Adkins, Scott, additional, Brown, Katherine, additional, de la Torre, Juan Carlos, additional, Digiaro, Michele, additional, Hughes, Holly R., additional, Junglen, Sandra, additional, Lambert, Amy J., additional, Maes, Piet, additional, Marklewitz, Marco, additional, Palacios, Gustavo, additional, Sasaya, Takahide, additional, Turina, Massimo, additional, and Zhang, Yong-Zhen, additional

Published
2023
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28. ICTV Virus Taxonomy Profile: Leishbuviridae 2023

Author

Adkins, Scott, primary, Brown, Katherine, additional, de la Torre, Juan Carlos, additional, Digiaro, Michele, additional, Hughes, Holly R., additional, Junglen, Sandra, additional, Lambert, Amy J., additional, Maes, Piet, additional, Marklewitz, Marco, additional, Palacios, Gustavo, additional, Sasaya, Takahide, additional, Turina, Massimo, additional, Zhang, Yong-Zhen, additional, and Kuhn, Jens H., additional

Published
2023
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31. Analysis of CD8⁺ T cell response during the 2013–2016 Ebola epidemic in West Africa

Author

Sakabe, Saori, Sullivan, Brian M., Hartnett, Jessica N., Robles-Sikisaka, Refugio, Gangavarapu, Karthik, Cubitt, Beatrice, Ware, Brian C., Kotliar, Dylan, Branco, Luis M., Goba, Augustine, Momoh, Mambu, Sandi, John Demby, Kanneh, Lansana, Grant, Donald S., Garry, Robert F., Andersen, Kristian G., de la Torre, Juan Carlos, Sabeti, Pardis C., Schieffelin, John S., and Oldstone, Michael B. A.

Published
2018

33. Finding the Most Influential Parameters of Coalitions in a PSO-CO Algorithm

Author

Ruiz, Patricia, Dorronsoro, Bernabé, de la Torre, Juan Carlos, Burguillo, Juan Carlos, Barbosa, Simone Diniz Junqueira, Series Editor, Chen, Phoebe, Series Editor, Filipe, Joaquim, Series Editor, Kotenko, Igor, Series Editor, Sivalingam, Krishna M., Series Editor, Washio, Takashi, Series Editor, Yuan, Junsong, Series Editor, Zhou, Lizhu, Series Editor, Medina, Jesús, editor, Ojeda-Aciego, Manuel, editor, Verdegay, José Luis, editor, Perfilieva, Irina, editor, Bouchon-Meunier, Bernadette, editor, and Yager, Ronald R., editor

Published
2018
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34. Analyzing the Influence of LLVM Code Optimization Passes on Software Performance

Author

de la Torre, Juan Carlos, Ruiz, Patricia, Dorronsoro, Bernabé, Galindo, Pedro L., Barbosa, Simone Diniz Junqueira, Series Editor, Chen, Phoebe, Series Editor, Filipe, Joaquim, Series Editor, Kotenko, Igor, Series Editor, Sivalingam, Krishna M., Series Editor, Washio, Takashi, Series Editor, Yuan, Junsong, Series Editor, Zhou, Lizhu, Series Editor, Medina, Jesús, editor, Ojeda-Aciego, Manuel, editor, Verdegay, José Luis, editor, Perfilieva, Irina, editor, Bouchon-Meunier, Bernadette, editor, and Yager, Ronald R., editor

Published
2018
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36. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Author

Gillespie, Eugene J, Ho, Chi-Lee C, Balaji, Kavitha, Clemens, Daniel L, Deng, Gang, Wang, Yao E, Elsaesser, Heidi J, Tamilselvam, Batcha, Gargi, Amandeep, Dixon, Shandee D, France, Bryan, Chamberlain, Brian T, Blanke, Steven R, Cheng, Genhong, de la Torre, Juan Carlos, Brooks, David G, Jung, Michael E, Colicelli, John, Damoiseaux, Robert, and Bradley, Kenneth A

Subjects
Biochemistry and Cell Biology, Biological Sciences, Infectious Diseases, Biodefense, Emerging Infectious Diseases, Rare Diseases, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Amines, Animals, Bacterial Toxins, Biological Transport, Caspase 1, Chromatography, Liquid, Endosomes, Flow Cytometry, HeLa Cells, High-Throughput Screening Assays, Humans, Macrophages, Magnetic Resonance Spectroscopy, Mass Spectrometry, Mice, Mice, Transgenic, Microscopy, Fluorescence, Molecular Structure, Phagocytosis, Semicarbazones, Small Molecule Libraries, Structure-Activity Relationship, Virus Internalization, Hela Cells
Abstract

Pathogenic microorganisms and toxins have evolved a variety of mechanisms to gain access to the host-cell cytosol and thereby exert virulent effects upon the host. One common mechanism of cellular entry requires trafficking to an acidified endosome, which promotes translocation across the host membrane. To identify small-molecule inhibitors that block this process, a library of 30,000 small molecules was screened for inhibitors of anthrax lethal toxin. Here we report that 4-bromobenzaldehyde N-(2,6-dimethylphenyl)semicarbazone, the most active compound identified in the screen, inhibits intoxication by lethal toxin and blocks the entry of multiple other acid-dependent bacterial toxins and viruses into mammalian cells. This compound, which we named EGA, also delays lysosomal targeting and degradation of the EGF receptor, indicating that it targets host-membrane trafficking. In contrast, EGA does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking, or phagosome permeabilization by Franciscella tularensis. Furthermore, EGA does not neutralize acidic organelles, demonstrating that its mechanism of action is distinct from pH-raising agents such as ammonium chloride and bafilomycin A1. EGA is a powerful tool for the study of membrane trafficking and represents a class of host-targeted compounds for therapeutic development to treat infectious disease.

Published
2013

37. Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials

Author

Postler, Thomas S., Clawson, Anna N., Amarasinghe, Gaya K., Basler, Christopher F., Bavari, Sbina, Benkő, Mária, Blasdell, Kim R., Briese, Thomas, Buchmeier, Michael J., Bukreyev, Alexander, Calisher, Charles H., Chandran, Kartik, Charrel, Rémi, Clegg, Christopher S., Collins, Peter L., de la Torre, Juan Carlos, DeRisi, Joseph L., Dietzgen, Ralf G., Dolnik, Olga, Dürrwald, Ralf, Dye, John M., Easton, Andrew J., Emonet, Sébastian, Formenty, Pierre, Fouchier, Ron A. M., Ghedin, Elodie, Gonzalez, Jean-Paul, Harrach, Balázs, Hewson, Roger, Horie, Masayuki, Jiāng, Dàohóng, Kobinger, Gary, Kondo, Hideki, Kropinski, Andrew M., Krupovic, Mart, Kurath, Gael, Lamb, Robert A., Leroy, Eric M., Lukashevich, Igor S., Maisner, Andrea, Mushegian, Arcady R., Netesov, Sergey V., Nowotny, Norbert, Patterson, Jean L., Payne, Susan L., Paweska, Janusz T., Peters, Clarence J., Radoshitzky, Sheli R., Rima, Bertus K., Romanowski, Victor, Rubbenstroth, Dennis, Sabanadzovic, Sead, Sanfaçon, Hélène, Salvato, Maria S., Schwemmle, Martin, Smither, Sophie J., Stenglein, Mark D., Stone, David M., Takada, Ayato, Tesh, Robert B., Tomonaga, Keizo, Tordo, Noël, Towner, Jonathan S., Vasilakis, Nikos, Volchkov, Viktor E., Wahl-Jensen, Victoria, Walker, Peter J., Wang, Lin-Fa, Varsani, Arvind, Whitfield, Anna E., Zerbini, F. Murilo, and Kuhn, Jens H.

Published
2017

40. Identification of In Vitro Inhibitors of Monkeypox Replication

Author

Chiem, Kevin, primary, Nogales, Aitor, additional, Lorenzo, Maria, additional, Morales Vasquez, Desarey, additional, Xiang, Yan, additional, Gupta, Yogesh K., additional, Blasco, Rafael, additional, de la Torre, Juan Carlos, additional, and Martínez-Sobrido, Luis, additional

Published
2023
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47. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

Author

Gavin, Amanda L., Huang, Deli, Huber, Christoph, Mårtensson, Annica, Tardif, Virginie, Skog, Patrick D., Blane, Tanya R., Thinnes, Therese C., Osborn, Kent, Chong, Hayley S., Kargaran, Farnaz, Kimm, Phoebe, Zeitjian, Armen, Sielski, Rachel L., Briggs, Megan, Schulz, Sebastian R., Zarpellon, Alessandro, Cravatt, Benjamin, Pang, Ee Shan, Teijaro, John, de la Torre, Juan Carlos, O’Keeffe, Meredith, Hochrein, Hubertus, Damme, Markus, Teyton, Luc, Lawson, Brian R., and Nemazee, David

Published
2018
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48. Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018

Author

Maes, Piet, Alkhovsky, Sergey V., Bào, Yīmíng, Beer, Martin, Birkhead, Monica, Briese, Thomas, Buchmeier, Michael J., Calisher, Charles H., Charrel, Rémi N., Choi, Il Ryong, Clegg, Christopher S., de la Torre, Juan Carlos, Delwart, Eric, DeRisi, Joseph L., Di Bello, Patrick L., Di Serio, Francesco, Digiaro, Michele, Dolja, Valerian V., Drosten, Christian, Druciarek, Tobiasz Z., Du, Jiang, Ebihara, Hideki, Elbeaino, Toufic, Gergerich, Rose C., Gillis, Amethyst N., Gonzalez, Jean-Paul J., Haenni, Anne-Lise, Hepojoki, Jussi, Hetzel, Udo, Hồ, Thiện, Hóng, Ní, Jain, Rakesh K., Jansen van Vuren, Petrus, Jin, Qi, Jonson, Miranda Gilda, Junglen, Sandra, Keller, Karen E., Kemp, Alan, Kipar, Anja, Kondov, Nikola O., Koonin, Eugene V., Kormelink, Richard, Korzyukov, Yegor, Krupovic, Mart, Lambert, Amy J., Laney, Alma G., LeBreton, Matthew, Lukashevich, Igor S., Marklewitz, Marco, Markotter, Wanda, Martelli, Giovanni P., Martin, Robert R., Mielke-Ehret, Nicole, Mühlbach, Hans-Peter, Navarro, Beatriz, Ng, Terry Fei Fan, Nunes, Márcio Roberto Teixeira, Palacios, Gustavo, Pawęska, Janusz T., Peters, Clarence J., Plyusnin, Alexander, Radoshitzky, Sheli R., Romanowski, Víctor, Salmenperä, Pertteli, Salvato, Maria S., Sanfaçon, Hélène, Sasaya, Takahide, Schmaljohn, Connie, Schneider, Bradley S., Shirako, Yukio, Siddell, Stuart, Sironen, Tarja A., Stenglein, Mark D., Storm, Nadia, Sudini, Harikishan, Tesh, Robert B., Tzanetakis, Ioannis E., Uppala, Mangala, Vapalahti, Olli, Vasilakis, Nikos, Walker, Peter J., Wáng, Guópíng, Wáng, Lìpíng, Wáng, Yànxiăng, Wèi, Tàiyún, Wiley, Michael R., Wolf, Yuri I., Wolfe, Nathan D., Wú, Zhìqiáng, Xú, Wénxìng, Yang, Li, Yāng, Zuòkūn, Yeh, Shyi-Dong, Zhāng, Yǒng-Zhèn, Zhèng, Yàzhōu, Zhou, Xueping, Zhū, Chénxī, Zirkel, Florian, and Kuhn, Jens H.

Published
2018
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