Search

Your search keyword '"de la Torre, B"' showing total 288 results
Start Over Author "de la Torre, B"
288 results on '"de la Torre, B"'

1. Real-space imaging of {\sigma}-hole by means of Kelvin probe force microscopy with subatomic resolution

Author

Mallada1, B., Gallardo, A., Lamanec, M., de la Torre, B., Špirko, V., Hobza, P., and Jelinek, P.

Subjects
Condensed Matter - Materials Science
Abstract

An anisotropic charge distribution on individual atoms, such as e.g. {\sigma}-hole, may strongly affect material and structural properties of systems. Nevertheless, subatomic resolution of such anisotropic charge distributions represents a long-standing experimental challenge. In particular, the existence of the {\sigma}-hole on halogen atoms has been demonstrated only indirectly through determination of crystal structures of organic molecules containing halogens or via theoretical calculations. Nevertheless, its direct experimental visualization has not been reported yet. Here we demonstrate that Kelvin probe force microscopy, with a properly functionalized probe, can reach subatomic resolution imaging the {\sigma}-hole or a quadrupolar charge of carbon monoxide molecule. This achievement opens new way to characterize biological and chemical systems where anisotropic atomic charges play decisive role.

Published
2021

4. Tailoring topological order and {\pi}-conjugation to engineer quasi-metallic polymers

Author

Cirera, B., Sánchez-Grande, A., de la Torre, B., Santos, J., Edalatmanesh, S., Rodríguez-Sánchez, E., Lauwaet, K., Mallada-Faes, B., Zbořil, R., Miranda, R., Gröning, O., Jelínek, P., Martín, N., and Écija, D.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Materials Science
Abstract

Topological band theory provides a conceptual framework to predict or even engineer robust metallic states at the boundaries of topologically distinct phases. The bulk-boundary correspondence requires that a topological electronic phase transition between two insulators must proceed via closing of the electronic gap. Therefore, it can provide a conceptual solution to the instability of metallic phases in {\pi}-conjugated 1D polymers. In this work we predict and demonstrate that a clever design and on-surface synthesis of polymers consisting of 1D linearly bridged polyacene moieties, can position the resulting polymer near the topological transition from a trivial to a non-trivial quantum phase featuring a very narrow bandgap with in-gap zero-energy edge-states at the topologically non-trivial phase. We also reveal the fundamental connection between topological classes and electronic transformation of 1D {\pi}-conjugated polymers.

Published
2019
Full Text
View/download PDF

10. Generating antiaromaticity in polycyclic conjugated hydrocarbons by thermally selective skeletal rearrangements at interfaces

Author

Pérez-Elvira E., Barragán A., Chen Q., Soler-Polo D., Sánchez-Grande A., Vicent D.J., Lauwaet K., Santos J., Mutombo P., Mendieta-Moreno J.I., de la Torre B., Gallego J.M., Miranda, Rodolfo, Martín, Nazario, Jelínek P., Urgel J.I., Écija, David, Pérez-Elvira E., Barragán A., Chen Q., Soler-Polo D., Sánchez-Grande A., Vicent D.J., Lauwaet K., Santos J., Mutombo P., Mendieta-Moreno J.I., de la Torre B., Gallego J.M., Miranda, Rodolfo, Martín, Nazario, Jelínek P., Urgel J.I., and Écija, David

Published
2023

12. Dental Health and Mortality in People With End-Stage Kidney Disease Treated With Hemodialysis: A Multinational Cohort Study

Author

Raña, S., Serrano, M., Claros, S., Arias, M., Petracci, L., Arana, M., De Rosa, P., Gutierrez, A., Simon, M., Vergara, V., Tosi, M., Cernadas, M., Vilamajó, I., Gravac, D., Paulón, M., Penayo, L., Carrizo, G., Ghiani, M., Perez, G., Da Cruz, O., Galarce, D., Gravielle, M., Vescovo, E., Paparone, R., Mato Mira, C., Mojico, E., Hermida, O., Florio, D., Yucoswky, M., Labonia, W., Rubio, D., Di Napoli, G., Fernandez, A., Altman, H., Rodriguez, J., Serrano, S., Valle, G., Lobos, M., Acosta, V., Corpacci, G., Jofre, M., Gianoni, L., Chiesura, G., Capdevila, M., Montenegro, J., Bequi, J., Dayer, J., Gómez, A., Calderón, C., Abrego, E., Cechín, C., García, J., Corral, J., Natiello, M., Coronel, A., Muñiz, M., Muñiz, V., Bonelli, A., Sanchez, F., Maestre, S., Olivera, S., Camargo, M., Avalos, V., Geandet, E., Canteli, M., Escobar, A., Sena, E., Tirado, S., Peñalba, A., Neme, G., Cisneros, M., Oliszewski, R., Nascar, V., Daud, M., Mansilla, S., Paredes Álvarez, A., Gamín, L., Arijón, M., Coombes, M., Zapata, M., Boriceanu, C., Frantzen-Trendel, S., Albert, K., Csaszar, I., Kiss, E., Kosa, D., Orosz, A., Redl, J., Kovacs, L., Varga, E., Szabo, M., Magyar, K., Kriza, G., Zajko, E., Bereczki, A., Csikos, J., Kuti, A., Mike, A., Steiner, K., Nemeth, E., Tolnai, K., Toth, A., Vinczene, J., Szummer, Sz., Tanyi, E., Toth, R., Szilvia, M., Dambrosio, N., Paparella, G., Sambati, M., Donatelli, C., Pedone, F., Cagnazzo, V.A., Antinoro, R., Torsello, F., Saturno, C., Giannoccaro, G., Maldera, S., Boccia, E., Mantuano, M., Di Toro Mammarella, R., Meconizzi, M., Steri, P.F., Riccardi, C., Flammini, A., Moscardelli, L., Murgo, M., San Filippo, N., Pagano, S., Marino, G., Montalto, G., Cantarella, S., Salamone, B., Randazzo, G., Rallo, D., Maniscalco, A., Fici, M., Lupo, A., Pellegrino, P., Fichera, R., D’Angelo, A., Falsitta, N., Bochenska-Nowacka, E., Jaroszynski, A., Drabik, J., Birecka, M., Daniewska, D., Drobisz, M., Doskocz, K., Wyrwicz, G., Inchaustegui, L., Outerelo, C., Sousa Mendes, D., Mendes, A., Lopes, J., Barbas, J., Madeira, C., Fortes, A., Vizinho, R., Cortesão, A., Almeida, E., Bernat, A., De la Torre, B., Lopez, A., Martín, J., Cuesta, G., Rodriguez, R.M., Ros, F., Garcia, M., Orero, E., Ros, E., Caetano, A., MacGregor, K., Santos, M., Silva Pinheiro, S., Martins, L., Leitão, D., Izidoro, C., Bava, G., Bora, A., Gorena, H., Calderón, T., Dupuy, R., Alonso, N., Siciliano, V., Nagy, K., Bajusz, Ö., Pinke, I., Decsi, G., Gyergyoi, L., Jobba, Zs., Zalai, Zs., Zsedenyi, Á., Kiss, G., Pinter, M., Kereszturi, M., Petruzzi, M., De Benedittis, M., Szkutnik, J., Sieczkarek, J., Capelo, A., Garcia Gallart, M., Mendieta, C., Palmer, Suetonia C., Ruospo, Marinella, Wong, Germaine, Craig, Jonathan C., Petruzzi, Massimo, De Benedittis, Michele, Ford, Pauline, Johnson, David W., Tonelli, Marcello, Natale, Patrizia, Saglimbene, Valeria, Pellegrini, Fabio, Celia, Eduardo, Gelfman, Ruben, Leal, Miguel R., Torok, Marietta, Stroumza, Paul, Bednarek-Skublewska, Anna, Dulawa, Jan, Frantzen, Luc, Ferrari, Juan Nin, del Castillo, Domingo, Bernat, Amparo G., Hegbrant, Jorgen, Wollheim, Charlotta, Gargano, Letizia, Bots, Casper P., and Strippoli, Giovanni F.M.

Published
2015
Full Text
View/download PDF

15. Resolving Atomic-Scale Defects in Conjugated Polymers On-Surfaces

Author

Mallada B., Chen Q., Chutora T., Sánchez-Grande A., Cirera B., Santos J., Martín, Nazario, Écija, David, Jelínek P., de la Torre B., Mallada B., Chen Q., Chutora T., Sánchez-Grande A., Cirera B., Santos J., Martín, Nazario, Écija, David, Jelínek P., and de la Torre B.

Published
2022

16. Therapeutic vaccines against hepatocellular carcinoma in the immune checkpoint inhibitor era: time for neoantigens?

Author

Repáraz-Pernaut, D. (David), Aparicio-De-la-Torre, B. (Belén), Llopiz, D. (Diana), Hervas-Stubbs, S. (Sandra), and Sarobe, P. (Pablo)

Subjects
Neoantigens, Vaccines, Immune checkpoint inhibitors, Hepatocellular carcinoma, Immunotherapy, digestive system diseases
Abstract

Immune checkpoint inhibitors (ICI) have been used as immunotherapy for hepatocellular carcinoma (HCC) with promising but still limited results. Identification of immune elements in the tumor microenvironment of individual HCC patients may help to understand the correlations of responses, as well as to design personalized therapies for non-responder patients. Immune-enhancing strategies, such as vaccination, would complement ICI in those individuals with poorly infiltrated tumors. The prominent role of responses against mutated tumor antigens (neoAgs) in ICI-based therapies suggests that boosting responses against these epitopes may specifically target tumor cells. In this review we summarize clinical vaccination trials carried out in HCC, the available information on potentially immunogenic neoAgs in HCC patients, and the most recent results of neoAg-based vaccines in other tumors. Despite the low/intermediate mutational burden observed in HCC, data obtained from neoAg-based vaccines in other tumors indicate that vaccines directed against these tumor-specific antigens would complement ICI in a subset of HCC patients.

Published
2022

18. Determinación de Listeria monocytogenes en quesos frescos de producción artesanal que se expenden en los mercados del distrito de Ica, enero - marzo 2003

Author

Ana Espinoza M, Magali De La Torre B, Marianella Salinas F, and Víctor Sánchez P

Subjects
Listeriosis, Queso, Intoxicación alimentaria, Peru, Medicine, Medicine (General), R5-920
Abstract

Objetivo: Determinar la presencia de L. monocytogenes en quesos frescos de producción artesanal expendidos en los mercados de Ica durante el periodo enero - marzo de 2003. Material y Métodos: De la totalidad de los puestos que expenden queso fresco artesanal en los mercados Santo Domingo, Alejandro Toledo, San Antonio y Modelo, se evaluaron 74 muestras teniendo como unidad muestral 200 g según la Norma Técnica Peruana ISO 28329-1. El procesamiento, aislamiento e identificación se realizó de acuerdo con la metodología recomendada por el manual de bacteriología analítica de la Food and Drug Administration (FDA). Resultados: De las 74 muestras, 3 (4,05%) presentaban L. monocytogenes, y de ellas, una muestra correspondió al mercado Alejandro Toledo y 2 muestras al mercado Modelo. Se logró aislar 28 cepas de las cuales 6 (21,4%) correspondieron a L. monocytogenes, y 22 (78,6%) a otros microorganismos como Lactococcus lactis ss lactis, Enterococcus spp. y Bacillus spp. No se logró aislar L. monocytogenes en los mercados Santo Domingo y San Antonio; sin embargo, en el mercado Alejandro Toledo se aisló una cepa y en el mercado Modelo, se aislaron 5 cepas, lo cual demuestra la presencia significativa de L. monocytogenes sólo en el mercado Modelo. Conclusiones: Existe L. monocytogenes en quesos frescos de producción artesanal, representando un riesgo potencial para la población consumidora.

Published
2004

20. Green circular economy applied to peptide synthesis

Author

Al Musaimi, O, Al Shaer, D, De la Torre, B, and Albericio, F

Subjects
1101 Medical Biochemistry and Metabolomics, Organic Chemistry, 0305 Organic Chemistry
Abstract

While the focus of industry was once to cover people’s needs, it is now imperative to address how to minimize or even stop generating waste, either by decreasing the amount produced or by recycling and reusing it in the same or another synthetic flow. The closed-loop strategy has gained ground in the context of global resource depletion. In this regard, renewable and sustainable processes are required to benefit both the industrial economy and environment. Here we discuss several aspects related to the circular economy, and how this economic system correlates to green chemistry and its application to the peptide science field.

Published
2021

21. Real-space imaging of ��-hole by means of Kelvin probe force microscopy with subatomic resolution

Author

Mallada1, B., Gallardo, A., Lamanec, M., de la Torre, B., ��pirko, V., Hobza, P., and Jelinek, P.

Subjects
Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, Physics::Atomic Physics
Abstract

An anisotropic charge distribution on individual atoms, such as e.g. ��-hole, may strongly affect material and structural properties of systems. Nevertheless, subatomic resolution of such anisotropic charge distributions represents a long-standing experimental challenge. In particular, the existence of the ��-hole on halogen atoms has been demonstrated only indirectly through determination of crystal structures of organic molecules containing halogens or via theoretical calculations. Nevertheless, its direct experimental visualization has not been reported yet. Here we demonstrate that Kelvin probe force microscopy, with a properly functionalized probe, can reach subatomic resolution imaging the ��-hole or a quadrupolar charge of carbon monoxide molecule. This achievement opens new way to characterize biological and chemical systems where anisotropic atomic charges play decisive role.

Published
2021
Full Text
View/download PDF

22. On-Surface Synthesis of a Dicationic Diazahexabenzocoronene Derivative on the Au(111) Surface

Author

Biswas K., Urgel J.I., Xu K., Ma J., Sánchez-Grande A., Mutombo P., Gallardo A., Lauwaet K., Mallada B., de la Torre B., Matej A., Gallego J.M., Miranda, Rodolfo, Jelínek P., Feng X., Écija, David, Biswas K., Urgel J.I., Xu K., Ma J., Sánchez-Grande A., Mutombo P., Gallardo A., Lauwaet K., Mallada B., de la Torre B., Matej A., Gallego J.M., Miranda, Rodolfo, Jelínek P., Feng X., and Écija, David

Published
2021

23. Green circular economy applied to peptide synthesis

Author

Al Musaimi, O., Al Shaer, D., De la Torre, B., Albericio, Fernando, Al Musaimi, O., Al Shaer, D., De la Torre, B., and Albericio, Fernando

Abstract

While the focus of industry was once to cover people’s needs, it is now imperative to address how to minimize or even stop generating waste, either by decreasing the amount produced or by recycling and reusing it in the same or another synthetic flow. The closed-loop strategy has gained ground in the context of global resource depletion. In this regard, renewable and sustainable processes are required to benefit both the industrial economy and environment. Here we discuss several aspects related to the circular economy, and how this economic system correlates to green chemistry and its application to the peptide science field.

Published
2021

28. Tailoring topological order and π-conjugation to engineer quasi-metallic polymers

Author

Cirera B., Sánchez-Grande A., de la Torre B., Santos J., Edalatmanesh S., Rodríguez-Sánchez E., Lauwaet K., Mallada B., Zbo?il R., Miranda R., Gröning O., Jelínek P., Martín N., Ecija D. and This work was supported by the ERC Consolidator Grant ELECNANO (no. 766555), the EC FP7-PEOPLE-2011-COFUND AMAROUT II, the Spanish Ramón y Cajal programme (no. RYC-2012-11133), the Spanish Ministerio de Economía y Competitividad (projects FIS 2013-40667-P and FIS 2015-67287-P) and the Comunidad de Madrid (projects QUIMTRONIC-CM (Y2018/NMT-4783), MAD2D (S2013/ MIT-3007), NANOFRONTMAG (S2013/MT-2850) and PHOTOCARBON (S2013/ MIT-2841)). We also acknowledge support from the European Research Council (ERC-320441-Chirallcarbon) and the MINECO of Spain (projects CTQ2017-83531-R and CTQ2016-81911-REDT). IMDEA Nanociencia thanks support from the Severo Ochoa Programme for Centers of Excellence in R&D (MINECO, grant SEV-2016-0686). We also acknowledge support of MEYS CR LM2018110, GACR 18-09914S and Operational Programme Research, Development and Education financed by European Structural and Investment Funds and the Czech Ministry of Education, Youth and Sports (project no. CZ.02.1.01/0.0/0.0/16_019/0000754). P.J. acknowledges support from Praemium Academie of the Academy of Science of the Czech Republic. S.E. and B.M. are grateful for support from the Internal Student Grant of Palacký University Olomouc in Olomouc, Czech Republic (project no. IGA_PrF_2019_026). P.J. and S.E. acknowledge access to computing and storage facilities owned by parties and projects contributing to the Czech National Grid Infrastructure MetaCentrum provided under the programme Projects of Large Research, Development, and Innovations Infrastructures (CESNET LM2015042).

Published
2020

29. Diradical Organic One-Dimensional Polymers Synthesized on a Metallic Surface

Author

Sánchez-Grande A., Urgel J.I., Cahlík A., Santos J., Edalatmanesh S., Rodríguez-Sánchez E., Lauwaet K., Mutombo P., Nachtigallová D., Nieman R., Lischka H., de la Torre B., Miranda R., Gröning O., Martín N., Jelínek P., Écija D. and This work has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 766555), the Comunidad de Madrid [project QUIMTRONIC-CM (Y2018/NMT-4783), MAD2D and NanoMagCost] and the Spanish MINECO (projects FIS 2013-40667-P, FIS 2015-67287-P, SpOrQuMat, CTQ2018-102815-REDT, CTQ2017-83531-R and CTQ2016-81911-REDT). IMDEA Nanociencia thanks for support from the ?Severo Ochoa? Programme for Centers of Excellence in R&D (MINECO, Grant SEV-2016-0686). This work was also a part of the research project RVO (61388963) of the IOCB of the CAS (D.N.). We are grateful for support from the School of Pharmaceutical Science and Technology (SPST), Tianjin University, Tianjin, China, for computer time on the SPST computer cluster Arran. J.I.U thanks the JCB Atracci?n de Talento program from Comunidad de Madrid (contract no. IND-12535).

Published
2020

30. Tailoring π-conjugation and vibrational modes to steer on-surface synthesis of pentalene-bridged ladder polymers

Author

de la Torre B., Mat?j A., Sánchez-Grande A., Cirera B., Mallada B., Rodríguez-Sánchez E., Santos J., Mendieta-Moreno J.I., Edalatmanesh S., Lauwaet K., Otyepka M., Medve? M., Buendía Á., Miranda R., Martín N., Jelínek P., Écija D. and We acknowledge financial support from the Comunidad de Madrid [project QUIMTRONIC-CM (Y2018/NMT-4783)]. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 766555). MINECO of Spain (projects CTQ2017-83531-R and RED2018-102815-T) is also acknowledged. IMDEA Nanociencia thanks support from the 'Severo Ochoa' Program for Centers of Excellence in R&D (MINECO, Grant SEV-2016-0686). We also acknowledge support from Praemium Academie of the Academy of Science of the Czech Republic, GACR 18-09914S and Operational Program Research, Development and Education financed by European Structural and Investment Funds and the Czech Ministry of Education, Youth and Sports (Project No. CZ.02.1.01/0.0/0.0/16_019/0000754). A.M. and B.M. acknowledge the support from the Internal Student Grant Agency of the Palacký University in Olomouc, Czech Republic IGA_PrF_2020_022 and IGA PrF 2020_034.

Published
2020

31. Diradical Organic One-Dimensional Polymers Synthesized on a Metallic Surface

Author

Sánchez-Grande A., Urgel J.I., Cahlík A., Santos J., Edalatmanesh S., Rodríguez-Sánchez E., Lauwaet K., Mutombo P., Nachtigallová D., Nieman R., Lischka H., de la Torre B., Miranda, Rodolfo, Gröning O., Martín, Nazario, Jelínek P., Écija, David, Sánchez-Grande A., Urgel J.I., Cahlík A., Santos J., Edalatmanesh S., Rodríguez-Sánchez E., Lauwaet K., Mutombo P., Nachtigallová D., Nieman R., Lischka H., de la Torre B., Miranda, Rodolfo, Gröning O., Martín, Nazario, Jelínek P., and Écija, David

Published
2020

34. Eligible neonatal donors after circulatory determination of death (Maastricht type III): A national survey of level III NICUs.

Author

Caserío, Sonia, Arnaez, Juan, Izquierdo, R, Vega‐del‐Val, C, Moral, MT, Arriaga, M, Blanco, MD, Arca, G, Domingo, L, García‐Muñoz, F, Castañón, L, Valverde, E, Nuñez de la Torre, B, Barrio, AR, Torres, S, Benito, M, Rivero, M, Martín, B, Martínez, L, and Martinez, S

Subjects
PROOF & certification of death, CHILD patients, NEONATAL intensive care units, MEDICAL personnel
Abstract

Background: Organ donation continues to increase worldwide, but in general paediatric patients remain less likely to receive a transplant. The inclusion of neonates as donors after cDCD should be considered in an effort to increase donation rates. Methods: The survey for a cross‐sectional national study of potential cDCD neonatal donors (Maastricht type III) was sent to all 90 level III Spanish neonatal units to explore: 1) protocols, education, and specific opinions on donation and 2) potential cDCD that could have been eligible over a 2‐year period (2014–2015). Results: Forty‐five centers (50%) completed the survey, and 38/45 gave information about potential eligible donors. In 16% of the centers specific protocols on neonatal donation exist. All hospitals demanded more specific training, and 65% noted that the donation process could be a problem in the family's dismissal of the child. During the study period 46 805 neonates were admitted in the 38 centers, and 625 neonates died. Ninety‐five born at a gestational age ≥34 weeks and above 2000 gr died after an EoL decision, 38 (40%) and 13 (14%) of them due to neonatal encephalopathy and multiple congenital anomalies, respectively. There were 31 (33%) elegible infants who died in less than 120 min due to pathologies that did not contraindicate donation. Conclusions: Neonatal cDCD could help to reduce the gap between the supply of and demand for organs according to the potentially eligible patients emerging from this study. Training in EoL and donation processes should be provided to healthcare professionals. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

35. Tailoring topological order and ��-conjugation to engineer quasi-metallic polymers

Author

Cirera, B., S��nchez-Grande, A., de la Torre, B., Santos, J., Edalatmanesh, S., Rodr��guez-S��nchez, E., Lauwaet, K., Mallada-Faes, B., Zbo��il, R., Miranda, R., Gr��ning, O., Jel��nek, P., Mart��n, N., and ��cija, D.

Subjects
Mesoscale and Nanoscale Physics (cond-mat.mes-hall), Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences
Abstract

Topological band theory provides a conceptual framework to predict or even engineer robust metallic states at the boundaries of topologically distinct phases. The bulk-boundary correspondence requires that a topological electronic phase transition between two insulators must proceed via closing of the electronic gap. Therefore, it can provide a conceptual solution to the instability of metallic phases in ��-conjugated 1D polymers. In this work we predict and demonstrate that a clever design and on-surface synthesis of polymers consisting of 1D linearly bridged polyacene moieties, can position the resulting polymer near the topological transition from a trivial to a non-trivial quantum phase featuring a very narrow bandgap with in-gap zero-energy edge-states at the topologically non-trivial phase. We also reveal the fundamental connection between topological classes and electronic transformation of 1D ��-conjugated polymers.

Published
2019
Full Text
View/download PDF

36. On-Surface Synthesis of Gold Porphyrin Derivatives via a Cascade of Chemical Interactions: Planarization, Self-Metalation, and Intermolecular Coupling

Author

Cirera B., De La Torre B., Moreno D., Ondrá?ek M., Zbo?il R., Miranda R., Jelínek P., Écija D. and Work supported by the ERC Consolidator Grant ELECNANO (n° 766555), the EC FP7-PEOPLE-2011-COFUND AMAR-OUT II program, the Spanish Ramo? and Cajal Program (n° RYC-2012-11133), the Spanish Ministerio de Economiá y Competitividad (Projects FIS 2013-40667-P and FIS 2015- 67287-P), the Comunidad de Madrid [Projects Y2018/NMT-4783 (QUIMTRONIC-CM), S2013/MIT-3007 (MAD2D), and CMS2018/NMT-4321 (NANOMAGCOST)], and the IMDEA Foundation. P.J. and M.O. acknowledge support from Praemium Academie of the Academy of Sciences of the Czech Republic, MEYS LM2015087 and GACR 18-09914S, and Operational Programme Research, Development and Education financed by European Structural and Investment Funds and the Czech Ministry of Education, Youth and Sports (Projects SOLID21 - CZ.02.1.01/0.0/0.0/16_019/0000760 and CZ.02.1.01/0.0/0.0/16_019/0000754). IMDEA Nano-ciencia is grateful for support from the 'Severo Ochoa' Programme for Centers of Excellence in R&D (MINECO, Grant SEV-2016-0686). The authors acknowledge Willi Auwarter,? Francesco Allegretti, and Anthoula C. Papageorgiou for fruitful discussions.

Published
2019

37. On-Surface Synthesis of Ethynylene-Bridged Anthracene Polymers

Author

Sánchez-Grande A., de la Torre B., Santos J., Cirera B., Lauwaet K., Chutora T., Edalatmanesh S., Mutombo P., Rosen J., Zbo?il R., Miranda R., Björk J., Jelínek P., Martín N., Écija D. and This work was supported by the Comunidad de Madrid (Projects Y2018/NMT-4783 (QUIMTRONIC-CM), S2013/ MIT-3007 (MAD2D), and S2018/NMT (NANOMAGCOST-CM)), the European Research Council (ERC-320441-Chir-allcarbon and ERC-766555-ELECNANO), the Spanish Ramón y Cajal programme (No. RYC-2012-11133), and the MINECO of Spain (Projects FIS 2015-67287-P, CTQ2017-83531-R, and CTQ2016-81911-REDT). The IMDEA Nano-ciencia acknowledges support from the Severo Ochoa Programme for Centers of Excellence in R&D (MINECO, Grant SEV-2016-0686). P.J. acknowledges support from the Prae-mium Academie of the Academy of Science of the Czech Republic, MEYS LM2015087 and GACR 18–09914S, and the Operational Programme Research, Development, and Education financed by the European Structural and Investment Funds and the Czech Ministry of Education, Youth, and Sports (Project No. CZ.02.1.01/0.0/0.0/16 019/0000754). The authors acknowledge the support from the Czech Science Foundation under Project No. 19-27454X. J.B. and J.R. acknowledge financial support from the Swedish Research Council (642-2013-2080), the Swedish Strategic Research Area in Materials Science on Functional Materials at Link-çping University (Faculty Grant SFO-Mat-LiU No 2009 00971), and computational resources at the National Supercomputer Centre, Sweden, allocated by SNIC. The authors thank Dr. Oliver Grçning for fruitful discussions.

Published
2019

40. On-Surface Synthesis of Ethynylene-Bridged Anthracene Polymers

Author

Sánchez-Grande A., de la Torre B., Santos J., Cirera B., Lauwaet K., Chutora T., Edalatmanesh S., Mutombo P., Rosen J., Zbořil R., Miranda, Rodolfo, Björk J., Jelínek P., Martín, Nazario, Écija, David, Sánchez-Grande A., de la Torre B., Santos J., Cirera B., Lauwaet K., Chutora T., Edalatmanesh S., Mutombo P., Rosen J., Zbořil R., Miranda, Rodolfo, Björk J., Jelínek P., Martín, Nazario, and Écija, David

Published
2019

43. Data - Generating Antiaromaticity by Thermally-selective Skeletal Rearrangements at Interfaces

Author

Pérez-Elvira E., Barragán A., Chen Q., Soler-Polo D., Sánchez-Grande A., Vicent D. J., Lauwaet K., Santos J., Mutombo P., Mendieta-Moreno J. I., de la Torre B., Gallego J. M., Miranda, Rodolfo, Martín, Nazario, Jelínek P., Urgel J. I., Écija, David, Pérez-Elvira E., Barragán A., Chen Q., Soler-Polo D., Sánchez-Grande A., Vicent D. J., Lauwaet K., Santos J., Mutombo P., Mendieta-Moreno J. I., de la Torre B., Gallego J. M., Miranda, Rodolfo, Martín, Nazario, Jelínek P., Urgel J. I., and Écija, David

Abstract

STM-ncAFM from IMDEA Nanociencia Institute and CATRIN under ultra-high vacuum conditions at 4K, acquired between 2018 and 03.2023, *.txt *.jpg *.docx files, *.WSxM files can be opened with Origin

Published
2018

44. Immune response and partial protection against heterologous foot-and-mouth disease virus induced by dendrimer peptides in cattle

Author

Soria, I., Quattrocchi, V., Langellotti, C., Pérez-Filgueira, M., Pega, J., Gnazzo, V., Romera, S., Schammas, J., Bucafusco, D., Di Giacomo, S., De La Torre, B. G., Andreu, D., Sobrino, F., Blanco Lavilla, Esther, Zamorano, P., Soria, I., Quattrocchi, V., Langellotti, C., Pérez-Filgueira, M., Pega, J., Gnazzo, V., Romera, S., Schammas, J., Bucafusco, D., Di Giacomo, S., De La Torre, B. G., Andreu, D., Sobrino, F., Blanco Lavilla, Esther, and Zamorano, P.

Abstract

Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to induce solid protection in cattle. Dendrimeric peptides displaying two or four copies of a peptide corresponding to the B-cell epitope VP1 [136-154] of type O FMDV (O/UKG/11/2001) linked through thioether bonds to a single copy of the T-cell epitope 3A [21-35] (termed B2T and B4T, resp.) afforded protection in vaccinated pigs. In this work, we show that dendrimeric peptides B2T and B4T can elicit specific humoral responses in cattle and confer partial protection against the challenge with a heterologous type O virus (O1/Campos/Bra/58). This protective response correlated with the induction of specific T-cells as well as with an anamnestic antibody response upon virus challenge, as shown by the detection of virus-specific antibody-secreting cells (ASC) in lymphoid tissues distal from the inoculation point.

Published
2018

45. Immune response and partial protection against heterologous foot-and-Mouth disease virus induced by dendrimer peptides in cattle

Author

CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Economía y Competitividad (España), Soria, Ivana, Quattrocchi, V., Langellotti, C., Pérez-Filgueira, M., Pega, J., Gnazzo, V., Romera, S., Schammas, J., Bucafusco, D., Di Giacomo, S., De La Torre, B. G., Andreu, David, Sobrino Castelló, Francisco, Blanco Lavilla, Esther, Zamorano, Patricia, CSIC - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ministerio de Economía y Competitividad (España), Soria, Ivana, Quattrocchi, V., Langellotti, C., Pérez-Filgueira, M., Pega, J., Gnazzo, V., Romera, S., Schammas, J., Bucafusco, D., Di Giacomo, S., De La Torre, B. G., Andreu, David, Sobrino Castelló, Francisco, Blanco Lavilla, Esther, and Zamorano, Patricia

Abstract

Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to induce solid protection in cattle. Dendrimeric peptides displaying two or four copies of a peptide corresponding to the B-cell epitope VP1 [136–154] of type O FMDV (O/UKG/11/2001) linked through thioether bonds to a single copy of the T-cell epitope 3A [21–35] (termed BT and BT, resp.) afforded protection in vaccinated pigs. In this work, we show that dendrimeric peptides BT and BT can elicit specific humoral responses in cattle and confer partial protection against the challenge with a heterologous type O virus (O1/Campos/Bra/58). This protective response correlated with the induction of specific T-cells as well as with an anamnestic antibody response upon virus challenge, as shown by the detection of virus-specific antibody-secreting cells (ASC) in lymphoid tissues distal from the inoculation point.

Published
2018

47. Mortality reduction by post-dilution online-haemodiafiltration: a cause-specific analysis

Author

Nubé, Menso J., Peters, Sanne A E, Blankestijn, Peter J., Canaud, Bernard, Davenport, Andrew, Grooteman, Muriel P C, Asci, Gulay, Locatelli, Francesco, Maduell, Francisco, Morena, Marion, Ok, Ercan, Torres, Ferran, Bots, Michiel L., Moreso, Francesc, Pons, Mercedes, Ramos, Rosa, Mora-Macià, Josep, Carreras, Jordi, Soler, Jordi, Campistol, Josep M., Martinez-Castelao, Alberto, Insensé, B., Perez, C., Feliz, T., Barbetta, M., Soto, C., Mora, J., Juan, A., Ibrik, O., Foraster, A., Nin, J., Fernández, A., Arruche, M., Sánchez, C., Vidiella, J., Barbosa, F., Chiné, M., Hurtado, S., Llibre, J., Ruiz, A., Serra, M., Salvó, M., Poyuelo, T., Maduell, F., Carrera, M., Fontseré, N., Arias, M., Merín, A., Ribera, L., Galceran, J. M., Mòdol, J., Moliner, E., Ramirez, A., Aguilera, J., Alvarez, M., De La Torre, B., Molera, M., Casellas, J., Martín, G., Andres, E., Coll, E., Valles, M., Martínez, C., Castellote, E., Casals, J. M., Gabàs, J., Romero, M., Martinez-Castelao, A., Fulladosa, X., Ramirez-Arellano, M., Fulquet, M., Pelegrí, A., El Manouari, M., Ramos, N., Bartolomé, J., Sans, R., Fernández, E., Sarró, F., Compte, T., Marco, F., Mauri, R., Bronsoms, J., Arnaiz, J. A., Beleta, H., Pejenaute, A., Ríos, J., Lara, J., Ter Wee, P. M., Van Den Dorpel, M. A., Dorval, M., Lévesque, R., Koopman, M. G., Konings, C. J A M, Haanstra, W. P., Kooistra, M., Van Jaarsveld, B., Noordzij, T., Feith, G. W., Peltenburg, H. G., Van Buren, M., Offerman, J. J G, Hoogeveen, E. K., De Heer, F., Van De Ven, P. J., Kremer Hovinga, T. K., Bax, W. A., Groeneveld, J. O., Lavrijssen, A. T J, Schrander-Van Der Meer, A. M., Reichert, L. J M, Huussen, J., Rensma, P. L., Schrama, Y., Van Hamersvelt, H. W., Boer, W. H., Van Kuijk, W. H., Vervloet, M. G., Wauters, I. M P M J, Sekse, I., Toz, Huseyin, Ok, Ebru Sevinc, Kircelli, Fatih, Yilmaz, Mumtaz, Hur, Ender, Demirci, Meltem Sezis, Demirci, Cenk, Duman, Soner, Basci, Ali, Adam, Siddig Momin, Isik, Ismet Onder, Zengin, Murat, Suleymanlar, Gultekin, Yilmaz, Mehmet Emin, Ergin, Mehmet Ozkahya Pinar, Sagdic, Alfert, Kayali, Erkan, Boydak, Can, Colak, Taskin, Caliskan, Sihli, Kaplan, Hakan, Ulas, Hasibe, Kirbiyik, Sait, Berktas, Hakan, Dilbaz, Necati, Cristol, Jean Paul, Leray-Moragues, Hélène, Chenine, Leïla, Picot, Marie Christine, Jaussent, Audrey, Belloc, Claire, Lagarrigue, Mélodie, Chalabi, Lotfi, Debure, Alain, Ouziala, Messaoud, Lefevre, Jean Jacques, Thibaudin, Damien, Mohey, Hesham, Broyet, Christian, Afiani, Aida, Serveaux, Marie Odile, Patrier, Laure, Maurice, François, Rivory, Jean Pierre, Nicoud, Philippe, Durand, Claude, Normand, Michel, Seigneuric, Bruno, Magnant, Eric, Azzouz, Lynda, Islam, Mohamed Shariful, Vido, Sandor, Nzeyimana, Hilaire, Simonin, Danièle, Azymah, Yamina, Farah, Ibrahim, Coindre, Jean Philippe, Puyoo, Olivier, Chabannier, Marie Hélène, Ibos, Richard, Rouleau, Fabienne, Vela, Carlos, Joule, Josiane, Combarnous, François, Turc-Baron, Cécile, Ducret, Francis, Pointet, Philippe, Rey, Isabelle, Potier, Jacky, Bendini, Jean Christophe, Perrin, Franck, Kunz, Kristian, Lefrancois, Gaëlle, Colin, Angélique, Parahy, Sophie, Dancea, Irima, Coupel, Stéphanie, Testa, Angelo, Brunet, Philippe, Lebrun, Gaétan, Jaubert, Dominique, Delcroix, Catherine, Lavainne, Frédéric, Lefebvre, Anne, Guillodo, Marie Paule, Le Grignou, Dominique, Djema, Assia, Maaz, Mehadji, Chiron, Sylvie, Hoffmann, Maxime, Depraetre, Pascale, Haddj-Elmrabet, Atman, Joyeux, Véronique, Fleury, Dominique, Vrigneaud, Laurence, Lemaitre, Vincent, Aguilera, Didier, Guerraoui, Abdallah, Cremault, Alain, Laradi, Achour, Babinet, Francois, VU University Medical Center [Amsterdam], University of Oxford [Oxford], University Medical Center [Utrecht], Fresenius Medical Care Deutschland, University College of London [London] (UCL), Ege university, Alessandro Manzoni Hospital, Hospital Clinic Barcelona, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Universitat Autònoma de Barcelona (UAB), Ege Üniversitesi, Nephrology, ICaR - Circulation and metabolism, Herrada, Anthony, and University of Oxford

Subjects
Male, medicine.medical_specialty, 030232 urology & nephrology, Hemodiafiltration, 030204 cardiovascular system & hematology, haemodiafiltration, Convection, Lower risk, Sudden death, convection volume, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, haemo-diafiltration, 03 medical and health sciences, 0302 clinical medicine, Renal Dialysis, cardiovascular disease, Cause of Death, Internal medicine, Journal Article, medicine, Humans, Intensive care medicine, Aged, Proportional Hazards Models, Randomized Controlled Trials as Topic, Transplantation, integumentary system, business.industry, Mortality rate, Hazard ratio, Middle Aged, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, mortality, Confidence interval, 3. Good health, meta-analysis, Cardiovascular Diseases, Nephrology, Meta-analysis, Cardiology, Number needed to treat, Kidney Failure, Chronic, Female, business
Abstract

WOS: 000398117600023, PubMed ID: 28025382, Background. From an individual participant data (IPD) meta-analysis from four randomized controlled trials comparing haemodialysis (HD) with post-dilution online-haemodiafiltration (ol-HDF), previously it appeared that HDF decreases all-cause mortality by 14% (95% confidence interval 25; 1) and fatal cardiovascular disease (CVD) by 23% (39; 3). Significant differences were not found for fatal infections and sudden death. So far, it is unclear, however, whether the reduced mortality risk of HDF is only due to a decrease in CVD events and if so, which CVD in particular is prevented, if compared with HD. Methods. The IPD base was used for the present study. Hazard ratios and 95% confidence intervals for cause-specific mortality overall and in thirds of the convection volume were calculated using the Cox proportional hazard regression models. Annualized mortality and numbers needed to treat (NNT) were calculated as well. Results. Besides 554 patients dying from CVD, fatal infections and sudden death, 215 participants died from 'other causes', such as withdrawal from treatment and malignancies. In this group, the mortality risk was comparable between HD and ol-HDF patients, both overall and in thirds of the convection volume. Subdivision of CVD mortality in fatal cardiac, non-cardiac and unclassified CVD showed that ol-HDF was only associated with a lower risk of cardiac casualties [0.64 (0.61; 0.90)]. Annual mortality rates also suggest that the reduction in CVD death is mainly due to a decrease in cardiac fatalities, including both ischaemic heart disease and congestion. Overall, 32 and 75 patients, respectively, need to be treated by high-volume HDF (HV-HDF) to prevent one all-cause and one CVD death, respectively, per year. Conclusion. The beneficial effect of ol-HDF on all-cause and CVD mortality appears to be mainly due to a reduction in fatal cardiac events, including ischaemic heart disease as well as congestion. In HV-HDF, the NNT to prevent one CVD death is 75 per year., EuDial working group; European Nephrology and Dialysis Institute; Catalan Society of Nephrology; Fresenius Medical Care; Dutch Kidney Foundation [C02.2019]; Fresenius Medical Care, Netherlands; Gambro Lundia AB, Sweden; Dr E.E. Twiss Fund; International Society of Nephrology/Baxter Extramural Grant Program; Netherlands Organization for Health Research and DevelopmentNetherlands Organization for Health Research and Development [170882802]; national grant from the Health Ministry (Programme Hospitalier de Recherche Clinique, PHRC); Gambro through the Catalan Society of Nephrology; Roche Netherlands, The HDF Pooling project was designed, conducted and analysed independently of the financial contributors of the individual studies as listed below. Study data were collected and retained by the investigators and were not available for the financial contributors of the individual studies. S.A.E.P. and the meetings of the representatives of the combined authors of the four studies were financially supported by the EuDial working group. EuDial is an official working group of the European Renal Association-European Dialysis Transplant Association (ERA-EDTA, http://era-edta.org/eudial/European_Dialysis_Working_Group.html). No industry funding was received for any part of or activity related to the present analysis.; The Turkish HDF study was supported by European Nephrology and Dialysis Institute with an unrestricted grant. The study was performed in Fresenius Medical Care haemodialysis clinics in Turkey. ESHOL was supported by The Catalan Society of Nephrology and by grants from Fresenius Medical Care and Gambro through the Catalan Society of Nephrology. The CONTRAST study was supported by a grant from the Dutch Kidney Foundation (Nierstichting Nederland Grant C02.2019), and unrestricted grants from Fresenius Medical Care, Netherlands, and Gambro Lundia AB, Sweden. Additional support was received from the Dr E.E. Twiss Fund, Roche Netherlands, the International Society of Nephrology/Baxter Extramural Grant Program, and the Netherlands Organization for Health Research and Development (ZONMw Grant 170882802). The French HDF study was supported by a national grant from the Health Ministry (Programme Hospitalier de Recherche Clinique, PHRC) as a means to improve care and outcome of elderly chronic disease patients.

Published
2017
Full Text
View/download PDF

48. The VIMOS Public Extragalactic Redshift Survey (VIPERS)

Author

S. Rota, B. R. Granett, J. Bel, L. Guzzo, J. A. Peacock, M. J. Wilson, A. Pezzotta, S. de la Torre, B. Garilli, M. Bolzonella, M. Scodeggio, U. Abbas, C. Adami, D. Bottini, A. Cappi, O. Cucciati, I. Davidzon, P. Franzetti, A. Fritz, A. Iovino, J. Krywult, V. Le Brun, O. Le Fèvre, D. Maccagni, K. Małek, F. Marulli, W. J. Percival, M. Polletta, A. Pollo, L. A. M. Tasca, R. Tojeiro, D. Vergani, A.

Published
2017
Full Text
View/download PDF

49. Mortality reduction by post-dilution online-haemodiafiltration: A cause-specific analysis

Author

Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, MS Nefrologie, MS CGO, MS Medische Oncologie, Cancer, Projectafdeling VCI, Secretariaat en overig CTC, AIOS Anesthesiologie, Nubé, Menso J., Peters, Sanne A E, Blankestijn, Peter J., Canaud, Bernard, Davenport, Andrew, Grooteman, Muriel P C, Asci, Gulay, Locatelli, Francesco, Maduell, Francisco, Morena, Marion, Ok, Ercan, Torres, Ferran, Bots, Michiel L., Moreso, Francesc, Pons, Mercedes, Ramos, Rosa, Mora-Macià, Josep, Carreras, Jordi, Soler, Jordi, Campistol, Josep M., Martinez-Castelao, Alberto, Insensé, B., Perez, C., Feliz, T., Barbetta, M., Soto, C., Mora, J., Juan, A., Ibrik, O., Foraster, A., Nin, J., Fernández, A., Arruche, M., Sánchez, C., Vidiella, J., Barbosa, F., Chiné, M., Hurtado, S., Llibre, J., Ruiz, A., Serra, M., Salvó, M., Poyuelo, T., Maduell, F., Carrera, M., Fontseré, N., Arias, M., Merín, A., Ribera, L., Galceran, J. M., Mòdol, J., Moliner, E., Ramirez, A., Aguilera, J., Alvarez, M., De La Torre, B., Molera, M., Casellas, J., Martín, G., Andres, E., Coll, E., Valles, M., Martínez, C., Castellote, E., Casals, J. M., Gabàs, J., Romero, M., Martinez-Castelao, A., Fulladosa, X., Ramirez-Arellano, M., Fulquet, M., Pelegrí, A., El Manouari, M., Ramos, N., Bartolomé, J., Sans, R., Fernández, E., Sarró, F., Compte, T., Marco, F., Mauri, R., Bronsoms, J., Arnaiz, J. A., Beleta, H., Pejenaute, A., Ríos, J., Lara, J., Ter Wee, P. M., Van Den Dorpel, M. A., Dorval, M., Lévesque, R., Koopman, M. G., Konings, C. J A M, Haanstra, W. P., Kooistra, M., Van Jaarsveld, B., Noordzij, T., Feith, G. W., Peltenburg, H. G., Van Buren, M., Offerman, J. J G, Hoogeveen, E. K., De Heer, F., Van De Ven, P. J., Kremer Hovinga, T. K., Bax, W. A., Groeneveld, J. O., Lavrijssen, A. T J, Schrander-Van Der Meer, A. M., Reichert, L. J M, Huussen, J., Rensma, P. L., Schrama, Y., Van Hamersvelt, H. W., Boer, W. H., Van Kuijk, W. H., Vervloet, M. G., Wauters, I. M P M J, Sekse, I., Toz, Huseyin, Ok, Ebru Sevinc, Kircelli, Fatih, Yilmaz, Mumtaz, Hur, Ender, Demirci, Meltem Sezis, Demirci, Cenk, Duman, Soner, Basci, Ali, Adam, Siddig Momin, Isik, Ismet Onder, Zengin, Murat, Suleymanlar, Gultekin, Yilmaz, Mehmet Emin, Ergin, Mehmet Ozkahya Pinar, Sagdic, Alfert, Kayali, Erkan, Boydak, Can, Colak, Taskin, Caliskan, Sihli, Kaplan, Hakan, Ulas, Hasibe, Kirbiyik, Sait, Berktas, Hakan, Dilbaz, Necati, Cristol, Jean Paul, Leray-Moragues, Hélène, Chenine, Leïla, Picot, Marie Christine, Jaussent, Audrey, Belloc, Claire, Lagarrigue, Mélodie, Chalabi, Lotfi, Debure, Alain, Ouziala, Messaoud, Lefevre, Jean Jacques, Thibaudin, Damien, Mohey, Hesham, Broyet, Christian, Afiani, Aida, Serveaux, Marie Odile, Patrier, Laure, Maurice, François, Rivory, Jean Pierre, Nicoud, Philippe, Durand, Claude, Normand, Michel, Seigneuric, Bruno, Magnant, Eric, Azzouz, Lynda, Islam, Mohamed Shariful, Vido, Sandor, Nzeyimana, Hilaire, Simonin, Danièle, Azymah, Yamina, Farah, Ibrahim, Coindre, Jean Philippe, Puyoo, Olivier, Chabannier, Marie Hélène, Ibos, Richard, Rouleau, Fabienne, Vela, Carlos, Joule, Josiane, Combarnous, François, Turc-Baron, Cécile, Ducret, Francis, Pointet, Philippe, Rey, Isabelle, Potier, Jacky, Bendini, Jean Christophe, Perrin, Franck, Kunz, Kristian, Lefrancois, Gaëlle, Colin, Angélique, Parahy, Sophie, Dancea, Irima, Coupel, Stéphanie, Testa, Angelo, Brunet, Philippe, Lebrun, Gaétan, Jaubert, Dominique, Delcroix, Catherine, Lavainne, Frédéric, Lefebvre, Anne, Guillodo, Marie Paule, Le Grignou, Dominique, Djema, Assia, Maaz, Mehadji, Chiron, Sylvie, Hoffmann, Maxime, Depraetre, Pascale, Haddj-Elmrabet, Atman, Joyeux, Véronique, Fleury, Dominique, Vrigneaud, Laurence, Lemaitre, Vincent, Aguilera, Didier, Guerraoui, Abdallah, Cremault, Alain, Laradi, Achour, Babinet, Francois, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, MS Nefrologie, MS CGO, MS Medische Oncologie, Cancer, Projectafdeling VCI, Secretariaat en overig CTC, AIOS Anesthesiologie, Nubé, Menso J., Peters, Sanne A E, Blankestijn, Peter J., Canaud, Bernard, Davenport, Andrew, Grooteman, Muriel P C, Asci, Gulay, Locatelli, Francesco, Maduell, Francisco, Morena, Marion, Ok, Ercan, Torres, Ferran, Bots, Michiel L., Moreso, Francesc, Pons, Mercedes, Ramos, Rosa, Mora-Macià, Josep, Carreras, Jordi, Soler, Jordi, Campistol, Josep M., Martinez-Castelao, Alberto, Insensé, B., Perez, C., Feliz, T., Barbetta, M., Soto, C., Mora, J., Juan, A., Ibrik, O., Foraster, A., Nin, J., Fernández, A., Arruche, M., Sánchez, C., Vidiella, J., Barbosa, F., Chiné, M., Hurtado, S., Llibre, J., Ruiz, A., Serra, M., Salvó, M., Poyuelo, T., Maduell, F., Carrera, M., Fontseré, N., Arias, M., Merín, A., Ribera, L., Galceran, J. M., Mòdol, J., Moliner, E., Ramirez, A., Aguilera, J., Alvarez, M., De La Torre, B., Molera, M., Casellas, J., Martín, G., Andres, E., Coll, E., Valles, M., Martínez, C., Castellote, E., Casals, J. M., Gabàs, J., Romero, M., Martinez-Castelao, A., Fulladosa, X., Ramirez-Arellano, M., Fulquet, M., Pelegrí, A., El Manouari, M., Ramos, N., Bartolomé, J., Sans, R., Fernández, E., Sarró, F., Compte, T., Marco, F., Mauri, R., Bronsoms, J., Arnaiz, J. A., Beleta, H., Pejenaute, A., Ríos, J., Lara, J., Ter Wee, P. M., Van Den Dorpel, M. A., Dorval, M., Lévesque, R., Koopman, M. G., Konings, C. J A M, Haanstra, W. P., Kooistra, M., Van Jaarsveld, B., Noordzij, T., Feith, G. W., Peltenburg, H. G., Van Buren, M., Offerman, J. J G, Hoogeveen, E. K., De Heer, F., Van De Ven, P. J., Kremer Hovinga, T. K., Bax, W. A., Groeneveld, J. O., Lavrijssen, A. T J, Schrander-Van Der Meer, A. M., Reichert, L. J M, Huussen, J., Rensma, P. L., Schrama, Y., Van Hamersvelt, H. W., Boer, W. H., Van Kuijk, W. H., Vervloet, M. G., Wauters, I. M P M J, Sekse, I., Toz, Huseyin, Ok, Ebru Sevinc, Kircelli, Fatih, Yilmaz, Mumtaz, Hur, Ender, Demirci, Meltem Sezis, Demirci, Cenk, Duman, Soner, Basci, Ali, Adam, Siddig Momin, Isik, Ismet Onder, Zengin, Murat, Suleymanlar, Gultekin, Yilmaz, Mehmet Emin, Ergin, Mehmet Ozkahya Pinar, Sagdic, Alfert, Kayali, Erkan, Boydak, Can, Colak, Taskin, Caliskan, Sihli, Kaplan, Hakan, Ulas, Hasibe, Kirbiyik, Sait, Berktas, Hakan, Dilbaz, Necati, Cristol, Jean Paul, Leray-Moragues, Hélène, Chenine, Leïla, Picot, Marie Christine, Jaussent, Audrey, Belloc, Claire, Lagarrigue, Mélodie, Chalabi, Lotfi, Debure, Alain, Ouziala, Messaoud, Lefevre, Jean Jacques, Thibaudin, Damien, Mohey, Hesham, Broyet, Christian, Afiani, Aida, Serveaux, Marie Odile, Patrier, Laure, Maurice, François, Rivory, Jean Pierre, Nicoud, Philippe, Durand, Claude, Normand, Michel, Seigneuric, Bruno, Magnant, Eric, Azzouz, Lynda, Islam, Mohamed Shariful, Vido, Sandor, Nzeyimana, Hilaire, Simonin, Danièle, Azymah, Yamina, Farah, Ibrahim, Coindre, Jean Philippe, Puyoo, Olivier, Chabannier, Marie Hélène, Ibos, Richard, Rouleau, Fabienne, Vela, Carlos, Joule, Josiane, Combarnous, François, Turc-Baron, Cécile, Ducret, Francis, Pointet, Philippe, Rey, Isabelle, Potier, Jacky, Bendini, Jean Christophe, Perrin, Franck, Kunz, Kristian, Lefrancois, Gaëlle, Colin, Angélique, Parahy, Sophie, Dancea, Irima, Coupel, Stéphanie, Testa, Angelo, Brunet, Philippe, Lebrun, Gaétan, Jaubert, Dominique, Delcroix, Catherine, Lavainne, Frédéric, Lefebvre, Anne, Guillodo, Marie Paule, Le Grignou, Dominique, Djema, Assia, Maaz, Mehadji, Chiron, Sylvie, Hoffmann, Maxime, Depraetre, Pascale, Haddj-Elmrabet, Atman, Joyeux, Véronique, Fleury, Dominique, Vrigneaud, Laurence, Lemaitre, Vincent, Aguilera, Didier, Guerraoui, Abdallah, Cremault, Alain, Laradi, Achour, and Babinet, Francois

Published
2017

50. The effect of RU486 administered during the proliferative and secretory phase of the cycle on the bleeding pattern, hormonal parameters and the endometrium

Author

Swahn, M.L., Johannisson, E., Daniore, V., de la Torre, B., Bygdeman, M., Swahn, M.L., Johannisson, E., Daniore, V., de la Torre, B., and Bygdeman, M.

Abstract

Seventeen healthy women aged 24-45 years with regular menstrual periods, proven fertility and not using steroidal contraceptives or IUD were recruited for the study. The volunteers were followed during one control, one treatment and one follow-up cycle. Daily morning urine samples were obtained during the control and the treatment cycle. The samples were analysed with regard to pregnanediol glucuronide (P2-G), oestrone glucuronide (E1-G), oestradiol (E2), progesterone (P4), LH and creatinine. During the entire 3-month study the subjects kept a record of uterine bleeding and side effects. The subjects received 50 mg RU486 daily either on cycle days 7-10 (n = 7) or on cycle days 20-23 (n = 10). An endometrial biopsy was taken on cycle day 10 in the first group and on cycle days 21-28 in the second group of patients. Treatment during the proliferative phase caused significant prolongation of the cycle length due to a delay of the oestrogen and LH surge. However, once the oestrogen concentration started to increase, the remaining part of the cycle was normal. The length of the follow-up cycle was similar to that of the control cycle. The morphology of the endometrium did not differ from control samples taken from untreated women at the same time of the cycle. All ovulating women (n = 9) treated in the mid-luteal phase started to bleed on the 3rd to 4th day of the treatment. In four of these women the bleeding was scanty and followed by a menstrual-like bleeding at expected time, while in the remaining five volunteers the treatment bleeding was heavier and not followed by a new bleeding until a month later. The duration of the secretory phase was 16.5 ± 1.3 days in women with two bleeding episodes and 11.8 ± 1.9 days in women with one bleeding episode (P < 0.05). The hormonal parameters were similar in both groups up to the start of the treatment. In the patients with one bleeding episode, the treatment was associated with a reduction in progesterone concentration, while

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results