44 results on '"de la Cruz-Cosme C"'
Search Results
2. Tiempo puerta-aguja entre neurólogo presencial y localizado en ictus isquémico tratado con alteplasa. Estudio PRISA
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Gallardo-Tur, A., Carazo-Barrios, L., and de la Cruz-Cosme, C.
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- 2022
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3. Validation of a basic neurosonology laboratory for detecting cervical carotid artery stenosis
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de la Cruz Cosme, C., Dawid Milner, M.S., Ojeda Burgos, G., Gallardo Tur, A., Márquez Martínez, M., and Segura, T.
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- 2019
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4. Validación de un laboratorio básico de neurosonología para la detección de estenosis carotídea cervical
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de la Cruz Cosme, C., Dawid Milner, M.S., Ojeda Burgos, G., Gallardo Tur, A., Márquez Martínez, M., and Segura, T.
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- 2019
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5. Tetraventricular diffused germinoma in an adult: relevance of biopsy in germinal cell tumours of the nervous system: P1710
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De la Cruz Cosme, C., Ramírez, Moreno V., Castro, Serrano V., Cuevas, Aguilar R., Fernández, Campos J., and Acebal, Romero M.
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- 2010
6. Signo del punto ('dot sign') en rama perisilviana de la arteria cerebral media
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null Pablo Cabezudo García and null Carlos De la Cruz Cosme - C. H. E. Virgen De La Victoria
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- 2014
7. Pseudo-subarachnoid haemorrhage. A need for clinical-radiological diagnostic criteria
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de la Cruz-Cosme, C., Barbieri, G., and Vallejo-Baez, A.
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- 2010
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8. Pseudohemorragia subaracnoidea. Necesidad de criterios diagnósticos clínico-radiológicos
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de la Cruz-Cosme, C., Barbieri, G., and Vallejo-Baez, A.
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- 2010
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9. Síndrome confusional en paciente con hiponatremia severa
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Ojeda Burgos, G., Cuenca, A., de la Cruz Cosme, C., Pérez, E., Vicioso, L., Aguilar, R., and Rivas, E.
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- 2008
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10. Patología psicógena en la planta de neurología. Revisión de los últimos 10 años de hospitalización en un servicio de tercer nivel
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Avanesi-Molina E, de la Cruz-Cosme C, Romero-Acebal M, and Barbieri G
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Tratamiento farmacologico ,business.industry ,Medicine ,Neurology (clinical) ,General Medicine ,business ,Humanities - Abstract
Introduccion. Los trastornos psicogenos son frecuentes en la practica neurologica, y, en ocasiones, obligan a hospitalizar al paciente para descartar una patologia organica potencialmente grave. Objetivo. Conocer el perfil de los pacientes con diagnostico al alta de trastorno psicogeno que ingresan en la planta de neurologia de un hospital espanol. Pacientes y metodos. Se revisaron los informes de alta de neurologia de los ultimos 10 anos, se seleccionaron los pacientes que tenian un diagnostico de `no organicidad´ y se recogieron hasta un total de 28 variables demograficas, epidemiologicas y clinicas. Resultados. Sesenta y cuatro pacientes (el 1% de los hospitalizados) tenian diagnostico de psicogenicidad, con una edad media de 40 anos. La proporcion de sexos era de 1 a 1, y la estancia media, de 10 dias. Los sintomas mixtos eran los mas habituales (50%), seguidos de los motores aislados (22%). Los posibles diagnosticos neurologicos de ictus isquemico y enfermedad desmielinizante fueron la mayoria de los casos. Solo se consulto un 25% a psiquiatria durante el ingreso. En un 11% de los casos hubo historia posterior de intento de autolisis y en ocho casos (12,5%) se llego a un diagnostico ambulatorio de organicidad gracias al seguimiento evolutivo (`error´ en el diagnostico provisional al alta). Conclusion. Este trabajo dibuja por vez primera en nuestro medio el perfil del paciente psicogeno que ingresa en la planta de neurologia, y examina su manejo hospitalario y su seguimiento ambulatorio. Se recuerda la necesidad de no menospreciar esta patologia y de generar una via ordenada para su manejo, siempre multidisciplinar y con el protagonismo del neurologo y el psiquiatra.
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- 2011
11. Early Occupational Therapy Intervention post-stroke (EOTIPS): A randomized controlled trial.
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García-Pérez P, Rodríguez-Martínez MC, Gallardo-Tur A, Blanco-Reina E, de la Cruz-Cosme C, and Lara JP
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- Humans, Female, Male, Aged, Middle Aged, Prospective Studies, Spain, Treatment Outcome, Occupational Therapy methods, Stroke Rehabilitation methods, Quality of Life, Stroke complications, Stroke therapy, Stroke psychology
- Abstract
Background: Occupational therapy (OT) is an effective evidence-based intervention that positively influences stroke patients'independence recovery, leading to new opportunities for better quality of life outcomes., Objectives: To explore the effectiveness of an early OT intervention program (EOTIPS) in the process of hospital to home discharge after stroke in Spain., Material and Methods: We conducted a prospective, randomized controlled clinical trial that included 60 adults who suffered a stroke and were discharged home. Participants assigned to the experimental group (n = 30) were included in EOTIPS and compared with a control group (n = 30). Evaluations assessed quality of life (Stroke and Aphasia Quality of Life Scale [SAQOL-39]), functional independence (Modified Rankin Scale [mRS], Barthel Index [BI] and Stroke Impact Scale-16 [SIS-16]), perceptual-cognitive skills (Montreal Cognitive Assessment [MoCA]), upper limb function (Fugl Meyer Assessment [FMA]), mobility (Berg Balance Scale [BBS] and Timed Up & Go [TUG]), communication skills (Communicative Activity Log [CAL]) and mood disorders (Beck Depression Inventory-II [BDI-II] and Hamilton Anxiety Scale [HAM-A]); they were completed within two weeks post-stroke and after three months follow-up. Statistical analysis included intent-to-treat analysis, considering all participants (dropouts as failures), and efficacy analysis, considering only end-of-treatment participants., Results: Participants in the intervention group showed a significant better evolution in the main outcome measure of quality of life (SAQOL-39 p = .029), as well as for independence (mRSp = .004), perceptual-cognitive skills (MoCA p = .012)and symptoms of depression (BDI-II p = .011) compared to the control group., Conclusions: EOTIPS was effective in improving quality of life, as well as enhancing perceptual-cognitive skills, independence and reducing levels of depression for patients who suffered a stroke in a Spanish cohort and could be considered as an applicable non-pharmacologic therapeutic tool that can lead to patients' positive outcomes after stroke. This study was registered on ClinicalTrials.gov with the identifier NCT04835363., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 García-Pérez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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12. Early Occupational Therapy Intervention Programme and Coping Strategies and Burden in Caregivers of People with Sub-Acute Stroke: A Randomised Controlled Trial.
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García-Pérez P, Rodríguez-Martínez MC, Gallardo-Tur A, Blanco-Reina E, de la Cruz-Cosme C, and Lara JP
- Abstract
Caregivers of people who have suffered a stroke experience a great burden and may use disengagement coping strategies. We studied the influence of an early occupational therapy intervention programme in the process of hospital-to-home discharge after stroke (EOTIPS) in a Spanish cohort that improved patients' quality of life and caregivers' burden and coping strategies. EOTIPS was delivered by a single occupational therapist. We conducted a prospective randomised controlled trial that included 60 adults who suffered a stroke, of which 91.6% had a caregiver who agreed to be involved in their care ( n = 55). Evaluations assessed the caregivers' burden and coping strategies within two weeks post-stroke and after a three-month follow-up. Statistical analyses included intent-to-treat analysis (considering dropouts as failures) and efficacy analysis, considering only end-of-treatment participants. The caregivers in the intervention group showed a significantly better evolution in the main outcome measure of burden ( p = 0.019), as well as in the coping strategies of social support ( p = 0.037) and social withdrawal ( p ≤ 0.001), compared with the control group. EOTIPS was effective in improving the caregivers' burden and two coping strategies, and it could be considered as an applicable tool that can minimise the risk of suffering burden.
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- 2024
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13. Effects of Type 2 Diabetes on the Neuropsychological Profile in Mild Cognitive Impairment.
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Reyes Bueno JA, Sánchez-Guijo G, Ráez PD, García-Arnés JA, Garzón-Maldonado FJ, Castro VS, de la Cruz-Cosme C, Alba-Linero C, Gutiérrez-Bedmar M, and García-Casares N
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- Humans, Male, Female, Aged, Cross-Sectional Studies, Middle Aged, Aged, 80 and over, Attention physiology, Cognitive Dysfunction psychology, Cognitive Dysfunction diagnosis, Cognitive Dysfunction etiology, Neuropsychological Tests, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 psychology, Executive Function physiology
- Abstract
Background: Diabetes is one of the main risk factors for developing mild cognitive impairment (MCI) and Alzheimer's disease. Most studies have demonstrated a worse performance in executive function, verbal fluency, and information processing speed in patients with diabetes., Objective: To assess the cognitive functioning of persons with type 2 diabetes and amnesic mild cognitive impairment (aMCI-T2DM) compared to persons with aMCI without diabetes and persons without diabetes or aMCI as controls, to understand the role of diabetes in the neuropsychological profile., Methods: Cross-sectional study involving a sample of 83 patients, ranging in age from 61 to 85 years and divided into three groups: aMCI-T2DM (27 patients), aMCI (29 patients), Controls (27 individuals). All the participants undertook an exhaustive neuropsychological assessment (auditory-verbal and visual memory, attention, information processing speed, language, executive function, and depression)., Results: Both groups of aMCI patients performed significantly worse than the controls in all the neuropsychological tests. A significant linear tendency (p trend < 0.05) was found between groups, with the aMCI-T2DM group presenting worse results in global cognition assessed by the Mini-Mental State Examination and Montreal Cognitive Assessment; Rey-Osterrieth Complex Figure Test; Auditory Verbal Learning Test; Trail Making Test A and B, Verbal Fluency Test, and Hamilton Depression Rating Scale., Conclusions: aMCI patients with or without diabetes showed worse cognitive function compared to persons without diabetes or aMCI. Additionally, aMCI patients without T2DM presented a different cognitive profile than aMCI patients with T2DM, which tended towards presenting worse cognitive functions such as global cognition, memory, attention, executive function, and language.
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- 2024
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14. Structural and Functional Retinal Changes in Patients with Mild Cognitive Impairment with and without Diabetes.
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Santos-Ortega Á, Alba-Linero C, Urbinati F, Rocha-de-Lossada C, Orti R, Reyes-Bueno JA, Garzón-Maldonado FJ, Serrano V, de Rojas-Leal C, de la Cruz-Cosme C, España-Contreras M, Rodríguez-Calvo-de-Mora M, and García-Casares N
- Abstract
Our objective is to analyze retinal changes using optical coherence tomography angiography (OCT-A) in patients with mild cognitive impairment (MCI) to characterize structural and vascular alterations. This cross-sectional study involved 117 eyes: 39 eyes from patients with MCI plus diabetes (DM-MCI), 39 eyes from patients with MCI but no diabetes (MCI); and 39 healthy control eyes (C). All patients underwent a visual acuity measurement, a structural OCT, an OCT-A, and a neuropsychological examination. Our study showed a thinning of retinal nerve fiber layer thickness (RNFL) and a decrease in macular thickness when comparing the MCI-DM group to the C group ( p = 0.008 and p = 0.016, respectively). In addition, an increase in arteriolar thickness ( p = 0.016), a reduction in superficial capillary plexus density ( p = 0.002), and a decrease in ganglion cell thickness ( p = 0.027) were found when comparing the MCI-DM group with the MCI group. Diabetes may exacerbate retinal vascular changes when combined with mild cognitive impairment.
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- 2023
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15. Effects of GLP-1 receptor agonists on neurological complications of diabetes.
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García-Casares N, González-González G, de la Cruz-Cosme C, Garzón-Maldonado FJ, de Rojas-Leal C, Ariza MJ, Narváez M, Barbancho MÁ, García-Arnés JA, and Tinahones FJ
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- Humans, Hypoglycemic Agents pharmacology, Hypoglycemic Agents therapeutic use, Liraglutide pharmacology, Liraglutide therapeutic use, Glucagon-Like Peptide-1 Receptor therapeutic use, Glucagon-Like Peptide 1, Diabetes Mellitus, Type 2 drug therapy, Cardiovascular Diseases, Stroke, Diabetes Complications drug therapy
- Abstract
Emerging evidence suggests that treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) could be an interesting treatment strategy to reduce neurological complications such as stroke, cognitive impairment, and peripheral neuropathy. We performed a systematic review to examine the evidence concerning the effects of GLP-1 RAs on neurological complications of diabetes. The databases used were Pubmed, Scopus and Cochrane. We selected clinical trials which analysed the effect of GLP-1 RAs on stroke, cognitive impairment, and peripheral neuropathy. We found a total of 19 studies: 8 studies include stroke or major cardiovascular events, 7 involve cognitive impairment and 4 include peripheral neuropathy. Semaglutide subcutaneous and dulaglutide reduced stroke cases. Liraglutide, albiglutide, oral semaglutide and efpeglenatide, were not shown to reduce the number of strokes but did reduce major cardiovascular events. Exenatide, dulaglutide and liraglutide improved general cognition but no significant effect on diabetic peripheral neuropathy has been reported with GLP-1 RAs. GLP-1 RAs are promising drugs that seem to be useful in the reduction of some neurological complications of diabetes. However, more studies are needed., (© 2023. The Author(s).)
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- 2023
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16. Retinal Neurodegeneration Measured With Optical Coherence Tomography and Neuroimaging in Alzheimer Disease: A Systematic Review.
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Carazo-Barrios L, Cabrera-Maestre A, Alba-Linero C, Gutiérrez-Bedmar M, Garzón-Maldonado FJ, Serrano V, de la Cruz-Cosme C, and García-Casares N
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- Humans, Tomography, Optical Coherence methods, Retina diagnostic imaging, Retina pathology, Neuroimaging methods, Biomarkers, Alzheimer Disease diagnostic imaging, Cognitive Dysfunction diagnostic imaging
- Abstract
Background: Optical coherence tomography (OCT) has enabled several retinal alterations to be detected in patients with Alzheimer disease (AD), alterations that could be potential biomarkers. However, the relationship between the retina and other biomarkers of AD has been underresearched. We gathered and analyzed the literature about the relationship between retinal and cerebral alterations detected via neuroimaging in patients with AD, mild cognitive impairment (MCI), and preclinical AD., Methods: This systematic review followed the PRISMA Statement guidelines through the 27 items on its checklist. We searched in PubMed, BVS, Scopus, and the Cochrane Library, using the keywords: Alzheimer's disease, optical coherence tomography, white matter, cortex, atrophy, cortical thickness, neuroimaging, magnetic resonance imaging, and positron emission tomography. We included articles that studied the retina in relation to neuroimaging in patients with AD, MCI, and preclinical AD. We excluded studies without OCT, without neuroimaging, clinical cases, opinion articles, systematic reviews, and animal studies., Results: Of a total of 35 articles found, 23 were finally included. Although mixed results were found, most of these corroborate the relationship between retinal and brain disorders., Conclusions: More rigorous research is needed in the field, including homogenized, longitudinal, and prolonged follow-up studies, as well as studies that include all stages of AD. This will enable better understanding of the retina and its implications in AD, leading to the discovery of retinal biomarkers that reflect brain alterations in AD patients in an accessible and noninvasive manner., Competing Interests: The authors report no conflicts of interest., (Copyright © 2022 by North American Neuro-Ophthalmology Society.)
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- 2023
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17. [Impact of COVID-19 lockdown on patients with idiopathic intracranial hypertension in Spain].
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Carazo-Barrios L, Gallardo-Tur A, Aguilar-Monge A, Heras-González ML, Sempere-Fernández JF, Hamad-Cueto O, Heras-Pérez JA, and de la Cruz-Cosme C
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- Humans, Female, Quality of Life, Spain epidemiology, Pandemics, Cross-Sectional Studies, Dizziness, Diplopia, Communicable Disease Control, Anxiety epidemiology, Anxiety etiology, Headache epidemiology, Headache etiology, Depression epidemiology, Depression psychology, COVID-19 epidemiology, COVID-19 psychology, Pseudotumor Cerebri epidemiology
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Introduction: The nationwide lockdown implemented in Spain in March 2020 in response to the 2019 coronavirus disease pandemic (COVID-19) could have had an effect on the clinical situation, disease management and access to care in patients with idiopathic intracranial hypertension., Patients and Methods: A cross-sectional observational study was conducted by means of an online survey. The frequency and impact of headache, visual symptoms, dizziness, cognitive symptoms, diplopia, anxiety and depression on patients' quality of life were recorded. Disease treatment and delays experienced in accessing care were recorded. Participants were grouped according to the time elapsed since diagnosis., Results: A total of 112 patients participated in the study (103 women). The average time since disease onset was 6.25 years. Headache, anxiety and depression were responsible for considerable impact in the period prior to lockdown. The impact of headache was not aggravated during lockdown, but anxiety and depression did become significantly worse. Recently diagnosed participants reported higher rates of anxiety, depression, dizziness and diplopia; chronically diagnosed participants reported a higher frequency of cognitive symptoms., Conclusions: The clinical situation of the participants deteriorated during lockdown, although the differences were smaller than previously thought. This was probably because the baseline situation was more severe than expected. Further studies are needed to clarify the medium and long-term impact of the COVID-19 pandemic on patients with idiopathic intracranial hypertension.
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- 2023
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18. Cerebral hyperperfusion syndrome in the emergency department.
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Ortigosa Arrabal MP, Delgado Gil V, and de la Cruz Cosme C
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- Emergency Service, Hospital, Humans, Syndrome, Nervous System Diseases
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- 2022
19. Express improvement of acute stroke care accessibility in large regions using a centralized telestroke network.
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Barragán-Prieto A, Pérez-Sánchez S, Moniche F, Moyano RV, Delgado F, Martínez-Sánchez P, Moya M, Oropesa JM, Mínguez-Castellanos A, Villegas I, Álvarez Soria MJ, Tamayo Toledo JA, de la Cruz Cosme C, Canto Neguillo R, Herrerías Esteban JM, Montero Cobos DJ, Moreno Muñoz JA, González A, and Montaner J
- Abstract
Introduction: Acute ischemic stroke therapy has improved in recent decades, decreasing the rates of disability and death among stroke patients. Unfortunately, all health care systems have geographical disparities in infrastructure for stroke patients. A centralized telestroke network might be a low-cost strategy to reduce differences in terms of geographical barriers, equitable access, and quality monitoring across different hospitals., Aims: We aimed to quantify changes in stroke patients' geographic access to specialized evaluation by neurologists and to intravenous acute stroke reperfusion treatments following the rapid implementation of a centralized telestroke network in the large region of Andalusia (8.5 million inhabitants)., Methods: We conducted an observational study using spatial and analytical methods to examine how a centralized telestroke network influences the quality and accessibility of stroke care for a large region., Results: In the pre-implementation period, 5,005,477 (59.72% of the Andalusian population) had access to specialized stroke care in less than 30 min. After the 5-month process of implementing the telestroke network, 7,832,988 (93.5%) inhabitants had an access time of less than 30 min, bridging the gap in acute stroke care in rural hospitals., Conclusions: A centralized telestroke network may be an efficient tool to reduce the differences in stroke care access and quality monitoring across different hospitals, especially in large regions with low population density., Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© European Stroke Organisation 2022.)
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- 2022
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20. Door-to-needle times for patients with ischaemic stroke treated with alteplase by on-site and off-site on-duty neurologists. PRISA study.
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Gallardo-Tur A, Carazo-Barrios L, and de la Cruz-Cosme C
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- Humans, Female, Child, Aged, Male, Tissue Plasminogen Activator therapeutic use, Fibrinolytic Agents therapeutic use, Neurologists, Prospective Studies, Thrombolytic Therapy, Stroke drug therapy, Brain Ischemia drug therapy, Ischemic Stroke drug therapy
- Abstract
Background: Hospital on-call neurology shifts are frequently on-site, but some on-call services may be off-site or mixed. Intravenous tissue plasminogen activator (tPA) is one of the main reperfusion treatments for acute ischaemic stroke (AIS). This study assesses door-to-needle times (DNT) when the neurologist is on-site or off-site., Methods: We performed a prospective, observational study from 2012 to 2017, including patients with AIS and treated with tPA. Data were collected on sex, age, door-to-scan time, scan-to-needle time, and DNT. The on-duty neurologist was on-site from 08:00 to 20:00, and on call but off-site from 20:00 to 8:00. Three groups were formed: on-site, off-site, and off-site with resident present., Results: Our sample included 138 patients. The mean age was 69.7 years, and 45.7% of patients were women. Ninety-six patients were admitted during the on-site shift, 25 during the off-site shift, and 17 during the off-site-resident present shift. Patients admitted during the on-site and off-site shifts presented DNTs of 59 and 72minutes, respectively (P=.003). DNTs were 59, 74, and 68minutes (P=.001), respectively, for the on-site, off-site, and off-site-resident present shifts; the difference between DNTs for on-site and off-site shifts was statistically significant. No differences were observed between DNTs according to time of day (morning, afternoon, or night), or between weekdays and weekends., Conclusion: DNT is influenced by whether the on-duty neurologist is on- or off-site at the time of code stroke activation. The presence of a neurology resident can reduce DNT., (Copyright © 2019 Sociedad Española de Neurología. Publicado por Elsevier España, S.L.U. All rights reserved.)
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- 2022
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21. Interventions within the Scope of Occupational Therapy in the Hospital Discharge Process Post-Stroke: A Systematic Review.
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García-Pérez P, Lara JP, Rodríguez-Martínez MDC, and de la Cruz-Cosme C
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Stroke is one of the main causes of disability in adulthood. Its rehabilitation is a complex process that requires a multidisciplinary team of specialised professionals. The main goal of this review was to determine the impact of occupational therapy intervention post-stroke on the home discharge process. A systematic search was carried out of the following databases: Pubmed, Web of Science, PsycINFO, Scopus, Otseeker, and Dialnet. A screening was performed taking into account the type of article, including exclusively RCT, and type of intervention, only including interventions within the scope of occupational therapy that take place during the process of hospital discharge post-stroke. A total of 2285 citations were identified in the search from which 13 articles met the inclusion criteria. Comparisons of the groups indicated that early occupational therapy intervention during the process of hospital discharge can be effective in terms of functional recovery and can lead to the caregiver seeing improvements in self-efficacy and fatigue. In addition, the inclusion of a caregiver in the intervention influences the patient's adherence to treatment, leading to a reduction in the cost of treatment and rehabilitation.
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- 2022
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22. [Knowledge on stroke in Spanish population. A systematic review].
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Romero-Bravo M, de la Cruz-Cosme C, Barbancho MA, and García-Casares N
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- Health Knowledge, Attitudes, Practice, Humans, Risk Factors, Emergency Medical Services, Hypertension epidemiology, Stroke epidemiology
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Objectives: To analyze by means of a systematic review the general knowledge about strokes of the Spanish population., Materials and Methods: A systematic review is performed following PRISMA guidelines and with data from PubMed, Scopus and EMBASE. All studies carried out in Spain, centred around the knowledge of strokes are compiled (terminology, pathophysiology, signs and symptoms, risk factors, treatment, and willingness to make use of the Emergency Services). From the 4,627 articles collected, 21 were ultimately included in this review., Results: In Spain, the term stroke is less known than others such as embolism or cerebrovascular accident. Loss of strength is the most widely recognized symptom, whereas arterial hypertension is the most widely identified risk factor. The least known symptom and risk factor are visual impairment and diabetes mellitus, respectively. When faced with a suspected stroke, the attitude of most respondents is adequate as they decide to go to the hospital or call the Emergency Services. However, in rural areas or in cases in which the symptoms suddenly stop, a greater number of participants choose to go to their family physician. The main sources of information of the participants are their family members and their doctors., Conclusions: General knowledge about strokes is scarce among the general population. Nonetheless, the attitude of most of the participants is adequate as they choose to contact specialized Emergency Services.
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- 2022
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23. The cognitive and psychiatric subacute impairment in severe Covid-19.
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Serrano-Castro PJ, Garzón-Maldonado FJ, Casado-Naranjo I, Ollero-Ortiz A, Mínguez-Castellanos A, Iglesias-Espinosa M, Baena-Palomino P, Sánchez-Sanchez V, Sánchez-Pérez RM, Rubi-Callejon J, Estévez-María JC, Galeano-Bilbao B, Romero-Imbroda J, Sobrino B, Arrabal-Gomez C, Oliver-Martos B, Muñoz-Becerra L, Requena N, González Álvarez de Sotomayor MDM, Estivill-Torrus G, Suarez J, Ciano-Petersen NL, Pons-Pons G, Reyes-Bueno JA, Cabezudo-Garcia P, Aguilar-Castillo MJ, De la Cruz Cosme C, Duque-Holguera M, Cuartero-Rodriguez E, Vilches-Carrillo RM, Carrera-Muñoz I, Carnero-Pardo C, Ramirez-Garcia T, Oropesa JM, Dominguez-Mayoral A, Pelaez-Viñas N, Valiente L, and de Fonseca FR
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- COVID-19 virology, Humans, SARS-CoV-2 isolation & purification, Severity of Illness Index, COVID-19 psychology, Cognition Disorders psychology, Mental Disorders psychology
- Abstract
Neurologic impairment persisting months after acute severe SARS-CoV-2 infection has been described because of several pathogenic mechanisms, including persistent systemic inflammation. The objective of this study is to analyze the selective involvement of the different cognitive domains and the existence of related biomarkers. Cross-sectional multicentric study of patients who survived severe infection with SARS-CoV-2 consecutively recruited between 90 and 120 days after hospital discharge. All patients underwent an exhaustive study of cognitive functions as well as plasma determination of pro-inflammatory, neurotrophic factors and light-chain neurofilaments. A principal component analysis extracted the main independent characteristics of the syndrome. 152 patients were recruited. The results of our study preferential involvement of episodic and working memory, executive functions, and attention and relatively less affectation of other cortical functions. In addition, anxiety and depression pictures are constant in our cohort. Several plasma chemokines concentrations were elevated compared with both, a non-SARS-Cov2 infected cohort of neurological outpatients or a control healthy general population. Severe Covid-19 patients can develop an amnesic and dysexecutive syndrome with neuropsychiatric manifestations. We do not know if the deficits detected can persist in the long term and if this can trigger or accelerate the onset of neurodegenerative diseases., (© 2022. The Author(s).)
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- 2022
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24. Correlation between retinal nerve fibre layer thickness and white matter lesions in Alzheimer's disease.
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Carazo-Barrios L, Archidona-Arranz A, Claros-Ruiz A, García-Basterra I, Garzón-Maldonado FJ, Serrano-Castro V, Gutiérrez-Bedmar M, Barbancho MÁ, De la Cruz Cosme C, García-Campos JM, and García-Casares N
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- Cross-Sectional Studies, Humans, Nerve Fibers, Retina diagnostic imaging, Alzheimer Disease diagnostic imaging, White Matter diagnostic imaging
- Abstract
Objectives: Early diagnosis in Alzheimer's disease (AD) is crucial in order to implement new therapeutic strategies. The retina is embryologically related to the brain. Thus, the possible usefulness of optical coherence tomography (OCT) in the early detection of AD is currently being studied. Our aim was to study the relationship between retinal nerve fiber layer (RNFL) thickness and AD., Methods: We undertook an observational, analytical, cross-sectional study with consecutive sampling of 32 patients with AD or mild cognitive impairment and a group of healthy controls (C). The total number of eyes studied was 64. An ophthalmological and a comprehensive neuropsychological evaluation were performed in all participants. Quantification of white matter lesions and study of atrophy of the hippocampus by cerebral magnetic resonance were also performed., Results: We observed a significant linear trend towards a thinning of RNFL as the degree of cognitive deterioration increased, in the superior and temporal quadrants of the retina. A significant correlation was also noted between the mean thickness of the RNFL of the left temporal quadrant and occipital white matter lesions (r = -0.579, p = 0.038)., Conclusions: OCT could be a safe, rapid noninvasive tool providing useful biomarkers in the early detection of cognitive deterioration and AD., (© 2020 John Wiley & Sons Ltd.)
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- 2021
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25. [Familial cavernous malformation secondary to a novel genetic mutation].
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Carazo-Barrios L, Gallardo-Tur A, and de la Cruz-Cosme C
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- Aged, Female, Humans, Central Nervous System Neoplasms genetics, Hemangioma, Cavernous, Central Nervous System genetics, Mutation
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- 2020
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26. Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke.
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de la Cruz-Cosme C, Dawid-Milner MS, Ojeda-Burgos G, Gallardo-Tur A, and Segura T
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- Aged, Brain Ischemia diagnostic imaging, Brain Ischemia etiology, Carotid Artery, Internal diagnostic imaging, Cerebrovascular Circulation, Female, Hemodynamics, Humans, Male, Middle Aged, Prospective Studies, Cerebral Small Vessel Diseases diagnostic imaging, Cerebral Small Vessel Diseases etiology, Stroke diagnostic imaging, Stroke etiology, Ultrasonography, Doppler, Transcranial
- Abstract
Introduction and Goal: Lacunar stroke is defined as an <1.5 cm diameter infarct located in the territory of a perforating artery, that is not accessible for direct study using conventional imaging techniques. Diagnosis requires exclusion of other causes. It usually occurs in the context of chronic cerebral small vessel disease, which can be suspected during the neurosonography study in the form of high pulsatility [PI] or resistance index [RI]. Clinical research was performed to confirm that PI and RI correlate with cerebral small vessel lesion burden and to determine whether these parameters are useful for supporting a lacunar origin (LO) in acute stroke., Material and Methods: We prospectively recorded internal carotid artery resistivity and the Fazekas score for all patients with acute ischemic stroke who met inclusion but not exclusion criteria over a 6-month period., Results: The study population comprised 74 patients. A correlation was observed between the Fazekas score and resistivity. Both parameters predicted a LO, with an area under the curve of .78 and .696, respectively. The optimal cut-offs were PI = .96/RI = .58 for screening (sensitivity, 96%) and PI = 1.46/RI = .83 for confirmation (specificity, 89%)., Conclusions: Doppler ultrasound is a useful technique for determining the LO of acute stroke., (Copyright © 2018. Published by Elsevier Inc.)
- Published
- 2018
- Full Text
- View/download PDF
27. [Bilateral acquired Brown syndrome].
- Author
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de la Cruz-Cosme C, Gallardo-Tur A, and Ortigosa-Arrabal MP
- Subjects
- Adult, Female, Humans, Magnetic Resonance Imaging, Syndrome, Ocular Motility Disorders diagnostic imaging, Ocular Motility Disorders pathology
- Published
- 2017
28. [Factors associated with long-term prognosis after ischemic stroke treated with fibrinolytic agents].
- Author
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Gallardo Tur A, García Casares N, de la Cruz Cosme C, Jiménez Parras M, Temboury Ruiz F, Rosell Vergara E, Márquez Martínez M, and Fernández Fernández Ó
- Abstract
Objectives: To analyze the variables associated with better functional outcome 3 months after ischemic stroke treated with fibrinolytic agents., Material and Methods: The cases of 63 patients with characteristics leading to activation of a stroke code were analyzed retrospectively. The patients received fibrinolytic therapy in a referral hospital for the western district of Malaga, Spain. We recorded the time until start of fibrinolytic therapy, severity according to the National Institute of Health Stroke Scale (NIHSS) at baseline and at 24 hours, and functional outcome at 3 months according to the modified Rankin Scale., Results: Data for 63 patients with a mean (SD) age of 65 (11) years were included. The mean time until start of fibrinolytic therapy was 151 (42) minutes. The mean NIHSS scores were 15.5 (4.8) points at baseline and 9.1 (7.13) at 24 hours. The mean change in score at 24 hours was 6.3 (5.8) points. The findings of correlation analysis between scores on the modified Rankin scale and other variables were as follows: NIHSS score at 24 hours, ρ = 0.73; P < .01; NIHSS at baseline, ρ = 0.34; P = .01); age, ρ = 0.41; P = .001); time until start of fibrinolysis, ρ = 0.21; P = .09); change in NIHSS score at 24 hours, ρ = -0.61; P = .001)., Conclusion: The prognosis for the functional recovery of patients given intravenous fibrinolytic therapy after stroke depends on such factors as age, time treatment is started, severity, and the patient's status at 24 hours. The last factor is the one that is most strongly related to prognosis.
- Published
- 2015
29. Transient global amnesia associated with an acute infarction at the cingulate gyrus.
- Author
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Gallardo-Tur A, Romero-Godoy J, de la Cruz Cosme C, and Arboix A
- Abstract
Background. Transient global amnesia (TGA) is a syndrome of sudden, unexplained isolated short-term memory loss. In the majority of TGA cases, no causes can be identified and neuroimaging, CSF studies and EEG are usually normal. We present a patient with TGA associated with a small acute infarct at the cingulate gyrus. Case Report. The patient, a 62 year-old man, developed two episodes of TGA. He had hypertension and hypercholesterolemia. He was found to have an acute ischemic stroke of small size (15 mm of maximal diameter) at the right cerebral cingulate gyrus diagnosed on brain magnetic resonance imaging. No lesions involving other limbic system structures such as thalamus, fornix, corpus callosum, or hippocampal structures were seen. The remainder of the examination was normal. Conclusion. Unilateral ischemic lesions of limbic system structures may result in TGA. We must bear in mind that TGA can be an associated clinical disorder of cingulate gyrus infarct.
- Published
- 2014
- Full Text
- View/download PDF
30. [Severe asymptomatic carotid stenosis: a neurological perspective].
- Author
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de la Cruz-Cosme C and Segura T
- Subjects
- Aged, Anticoagulants therapeutic use, Clinical Trials as Topic, Combined Modality Therapy, Disease Management, Disease Progression, Endarterectomy, Carotid, Humans, Middle Aged, Multicenter Studies as Topic, Neuroimaging, Practice Guidelines as Topic, Prevalence, Risk Factors, Stroke etiology, Stroke prevention & control, Ultrasonography, Vasospasm, Intracranial etiology, Asymptomatic Diseases, Carotid Stenosis complications, Carotid Stenosis diagnostic imaging, Carotid Stenosis epidemiology, Carotid Stenosis surgery
- Abstract
Asymptomatic carotid stenosis is a relatively frequent pathology, although when considering the possibility of managing it surgically, there is still an important amount of disagreement concerning the criteria to be taken into account. This study conducts a broad examination of the condition, from its concept and epidemiology to the studies that triggered the boom in its surgical treatment during the nineties. The research also reviews the tools available for a better selection of cases that could potentially benefit most from surgery, the presence of silent brain lesions, the severity of the stenosis, its progression, the characteristics of the plaque, colaterality and vasoreactivity studies, the detection of micro-emboli, the presence of risk factors independently associated to the symptomatic conversion of the stenosis, and other elements that have recently been reported either clinically or experimentally. Finally, the article outlines the current state of the surgical technique and the advances being made in its pharmacological treatment. This review is not intended to be a set of clinical practice guidelines, but to offer a global integrating overview of the management of high-grade asymptomatic carotid stenosis.
- Published
- 2012
31. Atypical Vascular Involvement in a Case of Behçet's Disease.
- Author
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Rodríguez Morata A, Hidalgo Conde A, de la Cruz Cosme C, Gómez Ramírez S, and Gómez Medialdea R
- Abstract
Introduction. Behçet's disease (BD) is a form of vasculitis of unknown etiology which is rare in our environment. It is characterized by a variety of clinical manifestations and usually affects young adults. Recurrent oral and genital ulcers are a characteristic and extremely frequent symptom, but mortality is linked with more significant symptoms such as aortic pseudoaneurysm, pulmonary pseudoaneurysm, and cerebral venous thrombosis. Patient and Method. We present a case of a young male with atypical BD and severe polyvascular involvement (previous cerebral venous thrombosis and current peripheral venous thrombosis, acute ischemia, and peripheral arterial pseudoaneurysm) who required urgent surgical intervention due to a symptomatic external iliac pseudoaneurysm. Result. The pseudoaneurysm was successfully treated, we performed an iliofemoral bypass, and we treated it with steroids and immunosuppressive therapy. Conclusions. These rare clinical manifestations highlight the importance of considering BD in young patients, even in usual cases of vascular intervention, whether arterial or venous in nature.
- Published
- 2012
- Full Text
- View/download PDF
32. [Psychogenic pathology in the neurology unit. A review of the hospital admissions over the last 10 years in a third-level service].
- Author
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de la Cruz-Cosme C, Barbieri G, Avanesi-Molina E, and Romero-Acebal M
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Nervous System Diseases physiopathology, Nervous System Diseases psychology, Psychiatry, Somatoform Disorders diagnosis, Somatoform Disorders therapy, Young Adult, Hospital Units, Hospitalization, Neurology, Somatoform Disorders physiopathology, Somatoform Disorders psychology
- Abstract
Introduction: Psychogenic disorders are frequently seen in neurological practice and sometimes make it necessary to hospitalise the patient in order to rule out a potentially severe organic pathology., Aim: To determine the profile of patients with a discharge diagnosis of psychogenic disorder that are admitted to the neurology unit of a Spanish hospital., Patients and Methods: The neurology unit discharge abstracts from the last 10 years were reviewed and the patients who were diagnosed with 'non-organicity' were selected; a total of 28 demographic, epidemiological and clinical variables were also collected., Results: A total of 64 patients (1% of those admitted to hospital), with a mean age of 40 years, had a diagnosis of psychogenicity. The proportion between sexes was one to one and the mean length of stay in hospital was 10 days. Mixed symptoms were the most usual (50%), followed by isolated motor symptoms (22%). Most cases consisted of possible neurological diagnoses of ischaemic stroke and demyelinating disease. Only 25% of cases consulted psychiatry during hospitalisation. In 11% of cases there was a later history of suicide attempts and in eight cases (12.5%) an ambulatory diagnosis of organicity was reached thanks to the developmental follow-up ('error' in the provisional diagnosis on discharge)., Conclusions: This study traces, for the first time in our setting, the profile of the psychogenic patient who is admitted to the neurology unit and examines their hospital management and their outpatient follow-up. We highlight the need not to underestimate this pathological condition and to generate an ordered way of managing it, which should always be multidisciplinary with the leading roles played by the neurologist and the psychiatrist.
- Published
- 2011
33. Percheron artery syndrome: variability in presentation and differential diagnosis.
- Author
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de la Cruz-Cosme C, Márquez-Martínez M, Aguilar-Cuevas R, Romero-Acebal M, and Valdivielso-Felices P
- Subjects
- Adult, Aged, Aged, 80 and over, Cerebrovascular Circulation, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Syndrome, Cerebral Arteries pathology, Cerebral Infarction diagnosis, Cerebral Infarction pathology, Thalamus blood supply
- Abstract
Introduction: Synchronous bilateral paramedian thalamic stroke (SBPTS), usually equated to Percheron artery infarction, is considered to be uncommon and difficult to diagnose clinically. Its characterization is based on the original description plus a few small series., Aim: To characterize SBPTS clinically by collecting cases and identifying the key difficulties for an early diagnosis., Patients and Methods: Six cases at our centre plus another 115 located by systematic literature search and critical reading of articles fulfilled the criteria for SBPTS. An analysis was made of the variables age, gender, vascular risk factors, aetiology, alterations and fluctuations of consciousness, need for intubation, cognitive-behavioural disorders, pupillary changes, other neurological focal disorders and brainstem involvement on imaging studies., Results: Of note in our series were disorders of consciousness (n=5), their fluctuations (n=3) and the diagnostic delay (seven days, with MRI in four patients). In only one case was a bilateral thalamic lesion seen on the initial CT. Joint analysis of all the cases showed a mean age of 61 years, a predominance of men (58%), the presence of vascular risk factors in 77%, a mainly cardioembolic aetiology (34% among those that were specified), sensory involvement in 75% (intubation in 7% and fluctuations in 16.5%), cognitive-behavioural disorders in 43%, oculomotor in 73%, pupillary in 31%, other in 67% and specified brainstem lesion in 37%., Conclusions: The SBPTS syndrome has a variable presentation with a low sensitivity on the initial CT, requiring brain MRI for typification. This explains the diagnostic difficulty and the fact that its frequency is probably underestimated., (© 2011 Revista de Neurología)
- Published
- 2011
34. [Pseudo-subarachnoid haemorrhage. A need for clinical-radiological diagnostic criteria].
- Author
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de la Cruz-Cosme C, Barbieri G, and Vallejo-Baez A
- Subjects
- Adult, Brain Death, Fatal Outcome, Humans, Hypoxia-Ischemia, Brain diagnosis, Hypoxia-Ischemia, Brain diagnostic imaging, Male, Radiography, Subarachnoid Hemorrhage diagnosis, Subarachnoid Hemorrhage diagnostic imaging
- Published
- 2010
35. [Germinoma with tetraventricular extension: the importance of biopsy studies in germinal tumours in the nervous system].
- Author
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de la Cruz-Cosme C, Moreno-Ramírez V, Serrano-Castro V, Aguilar-Cuevas R, Campos-Fernández J, and Romero-Acebal M
- Subjects
- Biopsy, Humans, Male, Young Adult, Cerebral Ventricle Neoplasms pathology, Germinoma pathology
- Published
- 2010
36. [Déjerine-Roussy syndrome of an ischaemic origin in an adolescent with patent foramen ovale].
- Author
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de la Cruz-Cosme C, Márquez-Martínez M, Hamad-Cueto O, Rodríguez-Bailón I, Heras-Pérez JA, and Romero-Acebal M
- Subjects
- Adolescent, Behcet Syndrome pathology, Behcet Syndrome physiopathology, Cerebral Infarction pathology, Hippocampus pathology, Humans, Male, Risk Factors, Thalamic Diseases pathology, Thalamic Diseases physiopathology, Thalamus pathology, Cerebral Infarction etiology, Foramen Ovale, Patent complications, Thalamic Diseases etiology
- Abstract
Introduction: Déjerine-Roussy syndrome, or thalamic syndrome, is characterised by transient mild hemiparesis, hemichoreoathetosis, hemihypoesthesia, hyperalgesia, allodynia and hemiataxia with astereognosia that varies in intensity, and it appears in the presence of lesions in the posterior nuclei of the thalamus. It can be produced by strategic cerebral infarction, reported in elderly patients with vascular risk factors. Patent foramen ovale has been suggested as a risk factor for ischaemic stroke in young people, especially when associated to aneurysm of the auricular septum and above all to a procoagulating status., Case Report: An 18-year-old male with a family history of Behçet's disease, who presented right-side thalamic and hippocampal cerebral infarction; following an exhaustive study, patent foramen ovale with septal aneurysm was found as the only risk factor. At that time he did not satisfy criteria for Behçet's disease, and thorough systemic screening did not reveal direct or indirect signs of venous thrombosis. Percutaneous closure of the foramen was performed., Conclusions: This is the first reported case of Déjerine-Roussy syndrome as a manifestation of cryptogenic cerebral infarction associated to patent foramen ovale in an adolescent. Taken as a whole, the clinical and complementary data enable us to reconstruct the pathophysiological sequence that position foramen ovale with an associated septal 'aneurysm' as the only detectable risk factor, which, when linked to the stress of the patient and the family, triggered its early closure.
- Published
- 2009
37. [Amyotrophic lateral sclerosis syndrome-plus and consumption of cassava (Manihot). Is this a new presentation of the neurotoxic motor-neuron syndrome?].
- Author
-
de la Cruz Cosme C, Medialdea Natera P, and Romero Acebal M
- Subjects
- Amyotrophic Lateral Sclerosis pathology, Animals, Brain pathology, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Amyotrophic Lateral Sclerosis chemically induced, Diet, Manihot adverse effects, Motor Neurons drug effects, Motor Neurons pathology, Neurotoxicity Syndromes pathology, Neurotoxicity Syndromes physiopathology
- Published
- 2009
38. [Thalamic lacunar infarction with pure sensitive syndrome with atrial myxoma presentation].
- Author
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de la Cruz Cosme C, Heras Pérez JA, García Casares N, Aguilar Cuevas R, and Romero Acebal M
- Subjects
- Female, Humans, Magnetic Resonance Imaging, Middle Aged, Syndrome, Brain Infarction pathology, Heart Atria pathology, Heart Neoplasms pathology, Myxoma pathology, Thalamus pathology
- Published
- 2008
39. [Miller Fisher syndrome as the presenting symptom of Wernicke's encephalopathy].
- Author
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de la Cruz-Cosme C, Padilla-Parrado F, García-Casares N, Heras-Pérez JA, Sempere-Fernández J, Serrano-Castro V, and Romero-Acebal M
- Subjects
- Aged, Female, Humans, Wernicke Encephalopathy diagnosis, Miller Fisher Syndrome etiology, Wernicke Encephalopathy complications
- Abstract
Introduction: Wernicke's encephalopathy is an acute neuropsychiatric syndrome resulting from a thiamine deficit, which is defined by the characteristic triad of confusion, ophthalmoparesis and ataxia, although rare presentations have been reported that delay its diagnosis. Miller Fisher syndrome is characterised by the triad ophthalmoparesis, ataxia and areflexia and is considered to be a variant of Guillain-Barré syndrome; its differential diagnosis includes Wernicke's encephalopathy., Case Report: A 75-year-old female with chronic digestive disorders, who developed an acute picture of bilateral internuclear ophthalmoplegia, ataxia and areflexia, with proteinocytologic dissociation in cerebrospinal fluid; accordingly, an initial diagnosis of Miller Fisher syndrome was proposed. Results of the neurophysiological studies were normal; anti-GQ1b antibodies were negative; and magnetic resonance imaging of the brain suggested Wernicke's encephalopathy. The response to thiamine was spectacular., Conclusions: The similarities in the distribution of the lesions of the two conditions, in the signs and symptoms and the lab findings, as well as the influence of certain misleading factors (hyponatremia, advanced age), went to make up a typical syndrome that favoured a wrong presumptive aetiological diagnosis. This was corrected at an early stage, however, in light of the results of certain diagnostic tests and after observing the therapeutic response. In addition to being an atypical presentation for Wernicke's encephalopathy, this case highlights the fact that for there to be an agreement between the syndromic and aetiological diagnoses it is necessary to carry out a correct differential diagnosis based on details from the patient's history, on appropriate complementary tests and on the follow-up study of how the patients progress, even when we come across typical syndromes that are usually related to a predominant aetiopathogenesis.
- Published
- 2008
40. [Diagnosis of cerebral aspergillosis by neuroimaging].
- Author
-
de la Cruz-Cosme C, Ojeda-Burgos G, García-Casares N, Hamad-Cueto O, and Ruiz-Morales J
- Subjects
- Adult, Humans, Male, Magnetic Resonance Imaging, Neuroaspergillosis diagnosis
- Published
- 2008
41. [Thalamic dementia secondary to acute bilateral paramedian thalamic infarcts after occlusion of the artery of Percheron].
- Author
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García-Casares N, Garzón-Maldonado FJ, and de la Cruz-Cosme C
- Subjects
- Acute Disease, Adult, Humans, Male, Arterial Occlusive Diseases complications, Cerebral Arterial Diseases complications, Cerebral Infarction complications, Dementia etiology, Thalamus blood supply
- Abstract
Introduction: The anterior and medial part of the thalamus is the responsible of multiples cognitive functions through the thalamus-cortical connections. A bilateral thalamic infarction can cause a secondary dementia and these are related to a thalamocortical deafferentation with a partial recovery. We report a case of sudden onset dementia caused by bilateral thalamus lesions., Case Report: A 42 smoker male, that suddenly had an acute confusional syndrome with altered language, bradypsychia, right hemiparesis and right hemisensory loss. Cranial magnetic resonance imaging showed a bilateral thalamic stroke probably due to a variant talamus irrigation (artery of Percheron type 2). From this date, in three months, the patient had attention deficit, impairment of memory retention, apathy, initiative deficit, depressive syndrome and mood changes. All these symptoms improving partially in the following six months., Conclusions: The thalamic stroke can cause a thalamic dementia, commonly bilateral and preferable located in the anterior and medial nuclei. In our case, cranial SPECT showed frontal hypocaptation for diaschisis phenomenon.
- Published
- 2008
42. [Confusional syndrome in a patient with severe hyponatremia].
- Author
-
Ojeda Burgos G, Cuenca A, de la Cruz Cosme C, Pérez E, Vicioso L, Aguilar R, and Rivas E
- Subjects
- Confusion etiology, Fatal Outcome, Humans, Hyponatremia complications, Male, Middle Aged, Myelinolysis, Central Pontine complications, Severity of Illness Index, Myelinolysis, Central Pontine diagnosis
- Published
- 2008
- Full Text
- View/download PDF
43. [Frontal absences: a case report].
- Author
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de la Cruz-Cosme C, Pérez-Errazquin F, Márquez-Martínez M, Chamorro-Muñoz MI, and Romero-Acebal M
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Electroencephalography, Humans, Male, Epilepsy, Absence physiopathology
- Published
- 2007
44. [Rapidly progressing cognitive impairment as the presenting symptom of a bithalamic tumour].
- Author
-
de la Cruz-Cosme C, Salinas-Iñigo ME, García-Casares N, Pérez-Errazquin F, and Hamad-Cueto O
- Subjects
- Aged, 80 and over, Disease Progression, Female, Humans, Tomography, X-Ray Computed, Brain Neoplasms complications, Brain Neoplasms diagnosis, Brain Neoplasms pathology, Cognition Disorders etiology, Thalamic Diseases complications, Thalamic Diseases diagnosis, Thalamic Diseases pathology, Thalamic Nuclei pathology
- Published
- 2007
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