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6. Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis

Author

MS VPG/Gynaecologie, Child Health, MS Verloskunde, Arts-assistenten DV&B, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 4, CTI Vastert, Biostatistiek Onderzoek, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Gunning, Marlise N, Sir Petermann, Teresa, Crisosto, Nicolas, van Rijn, Bas B, de Wilde, Marlieke A, Christ, Jacob P, Uiterwaal, C S P M, de Jager, Wilco, Eijkemans, Marinus J C, Kunselman, Allen R, Legro, Richard S, Fauser, Bart C J M, MS VPG/Gynaecologie, Child Health, MS Verloskunde, Arts-assistenten DV&B, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 4, CTI Vastert, Biostatistiek Onderzoek, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Gunning, Marlise N, Sir Petermann, Teresa, Crisosto, Nicolas, van Rijn, Bas B, de Wilde, Marlieke A, Christ, Jacob P, Uiterwaal, C S P M, de Jager, Wilco, Eijkemans, Marinus J C, Kunselman, Allen R, Legro, Richard S, and Fauser, Bart C J M

Published
2020

7. Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis

Author

Gunning, Marlise N, primary, Sir Petermann, Teresa, primary, Crisosto, Nicolas, primary, van Rijn, Bas B, primary, de Wilde, Marlieke A, primary, Christ, Jacob P, primary, Uiterwaal, C S P M, primary, de Jager, Wilco, primary, Eijkemans, Marinus J C, primary, Kunselman, Allen R, primary, Legro, Richard S, primary, and Fauser, Bart C J M, primary

Published
2019
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8. Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis.

Author

Gunning, Marlise N, Petermann, Teresa Sir, Crisosto, Nicolas, Rijn, Bas B van, Wilde, Marlieke A de, Christ, Jacob P, Uiterwaal, C S P M, Jager, Wilco de, Eijkemans, Marinus J C, Kunselman, Allen R, Legro, Richard S, Fauser, Bart C J M, Sir Petermann, Teresa, van Rijn, Bas B, de Wilde, Marlieke A, and de Jager, Wilco

Subjects
META-analysis, WOMEN'S health, MATERNAL age, POLYCYSTIC ovary syndrome, HIGH density lipoproteins
Abstract

Background: Women diagnosed with polycystic ovary syndrome (PCOS) suffer from an unfavorable cardiometabolic risk profile, which is already established by child-bearing age.Objective and Rationale: The aim of this systematic review along with an individual participant data meta-analysis is to evaluate whether cardiometabolic features in the offspring (females and males aged 1-18 years) of women with PCOS (OPCOS) are less favorable compared to the offspring of healthy controls.Search Methods: PubMed, Embase and gray literature databases were searched by three authors independently (M.N.G., M.A.W and J.C.) (last updated on 1 February 2018). Relevant key terms such as 'offspring' and 'PCOS' were combined. Outcomes were age-specific standardized scores of various cardiometabolic parameters: BMI, blood pressure, glucose, insulin, lipid profile and the sum scores of various cardiometabolic features (metabolic sum score). Linear mixed models were used for analyses with standardized beta (β) as outcome.Outcomes: Nine relevant observational studies could be identified, which jointly included 1367 children: OPCOS and controls, originating from the Netherlands, Chile and the USA. After excluding neonates, duplicate records and follow-up screenings, a total of 885 subjects remained. In adjusted analyses, we observed that OPCOS (n = 298) exhibited increased plasma levels of fasting insulin (β = 0.21(95%CI: 0.01-0.41), P = 0.05), insulin-resistance (β = 0.21(95%CI: 0.01-0.42), P = 0.04), triglycerides (β = 0.19(95%CI: 0.02-0.36), P = 0.03) and high-density lipoprotein (HDL)-cholesterol concentrations (β = 0.31(95%CI: 0.08-0.54), P < 0.01), but a reduced birthweight (β = -116(95%CI: -195 to 38), P < 0.01) compared to controls (n = 587). After correction for multiple testing, however, differences in insulin and triglycerides lost their statistical significance. Interaction tests for sex revealed differences between males and females when comparing OPCOS versus controls. A higher 2-hour fasting insulin was observed among female OPCOS versus female controls (estimated difference for females (βf) = 0.45(95%CI: 0.07 to 0.83)) compared to the estimated difference between males ((βm) = -0.20(95%CI: -0.58 to 0.19)), with interaction-test: P = 0.03. Low-density lipoprotein-cholesterol differences in OPCOS versus controls were lower among females (βf = -0.39(95%CI: -0.62 to 0.16)), but comparable between male OPCOS and male controls (βm = 0.27(95%CI: -0.03 to 0.57)), with interaction-test: P < 0.01. Total cholesterol differences in OPCOS versus controls were also lower in females compared to the difference in male OPCOS and male controls (βf = -0.31(95%CI: -0.57 to 0.06), βm = 0.28(95%CI: -0.01 to 0.56), interaction-test: P = 0.01). The difference in HDL-cholesterol among female OPCOS versus controls (βf = 0.53(95%CI: 0.18-0.88)) was larger compared to the estimated mean difference among OPCOS males and the male controls (βm = 0.13(95%CI: -0.05-0.31), interaction-test: P < 0.01). Interaction test in metabolic sum score revealed a significant difference between females (OPCOS versus controls) and males (OPCOS versus controls); however, sub analyses performed in both sexes separately did not reveal a difference among females (OPCOS versus controls: βf = -0.14(95%CI: -1.05 to 0.77)) or males (OPCOS versus controls: βm = 0.85(95%CI: -0.10 to 1.79)), with P-value < 0.01.Wider Implications: We observed subtle signs of altered cardiometabolic health in OPCOS. Therefore, the unfavorable cardiovascular profile of women with PCOS at childbearing age may-next to a genetic predisposition-influence the health of their offspring. Sensitivity analyses revealed that these differences were predominantly observed among female offspring aged between 1 and 18 years. Moreover, studies with minimal risk of bias should elucidate the influence of a PCOS diagnosis in mothers on both sexes during fetal development and subsequently during childhood. [ABSTRACT FROM AUTHOR]

Published
2020
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9. Increased rates of complications in singleton pregnancies of women previously diagnosed with polycystic ovary syndrome predominantly in the hyperandrogenic phenotype

Author

de Wilde, Marlieke A., Lamain-de Ruiter, Marije, Veltman-Verhulst, Susanne M., Kwee, Anneke, Laven, Joop S., Lambalk, Cornelis B., Eijkemans, Marinus J.C., Franx, Arie, Fauser, Bart C.J.M., Koster, Maria P.H., de Wilde, Marlieke A., Lamain-de Ruiter, Marije, Veltman-Verhulst, Susanne M., Kwee, Anneke, Laven, Joop S., Lambalk, Cornelis B., Eijkemans, Marinus J.C., Franx, Arie, Fauser, Bart C.J.M., and Koster, Maria P.H.

Published
2017

10. Increased rates of complications in singleton pregnancies of women previously diagnosed with polycystic ovary syndrome predominantly in the hyperandrogenic phenotype

Author

MS VPG/Gynaecologie, Child Health, Eerstelijnsverloskundigen, Circulatory Health, MS Verloskunde, Other research (not in main researchprogram), Biostatistiek Onderzoek, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, DV&B-MT-Medisch, Brain, Groep Timmers, de Wilde, Marlieke A., Lamain-de Ruiter, Marije, Veltman-Verhulst, Susanne M., Kwee, Anneke, Laven, Joop S., Lambalk, Cornelis B., Eijkemans, Marinus J.C., Franx, Arie, Fauser, Bart C.J.M., Koster, Maria P.H., MS VPG/Gynaecologie, Child Health, Eerstelijnsverloskundigen, Circulatory Health, MS Verloskunde, Other research (not in main researchprogram), Biostatistiek Onderzoek, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, DV&B-MT-Medisch, Brain, Groep Timmers, de Wilde, Marlieke A., Lamain-de Ruiter, Marije, Veltman-Verhulst, Susanne M., Kwee, Anneke, Laven, Joop S., Lambalk, Cornelis B., Eijkemans, Marinus J.C., Franx, Arie, Fauser, Bart C.J.M., and Koster, Maria P.H.

Published
2017

11. Increased rates of complications in singleton pregnancies of women previously diagnosed with polycystic ovary syndrome predominantly in the hyperandrogenic phenotype

Author

de Wilde, Marlieke A., primary, Lamain-de Ruiter, Marije, additional, Veltman-Verhulst, Susanne M., additional, Kwee, Anneke, additional, Laven, Joop S., additional, Lambalk, Cornelis B., additional, Eijkemans, Marinus J.C., additional, Franx, Arie, additional, Fauser, Bart C.J.M., additional, and Koster, Maria P.H., additional

Published
2017
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12. Biomarker Profiles in Women with PCOS and PCOS Offspring; A Pilot Study

Author

Daan, Nadine M P, Koster, Maria P H, de Wilde, Marlieke A, Dalmeijer, Gerdien W, Evelein, Annemieke M V, Fauser, Bart C J M, de Jager, Wilco, Daan, Nadine M P, Koster, Maria P H, de Wilde, Marlieke A, Dalmeijer, Gerdien W, Evelein, Annemieke M V, Fauser, Bart C J M, and de Jager, Wilco

Published
2016

13. Biomarker Profiles in Women with PCOS and PCOS Offspring; A Pilot Study

Author

Child Health, MS VPG/Gynaecologie, Metabole ziekten patientenzorg, Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Practice, Arts-assistenten Kinderen, Brain, CTI Vastert, Infection & Immunity, Daan, Nadine M P, Koster, Maria P H, de Wilde, Marlieke A, Dalmeijer, Gerdien W, Evelein, Annemieke M V, Fauser, Bart C J M, de Jager, Wilco, Child Health, MS VPG/Gynaecologie, Metabole ziekten patientenzorg, Public Health Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Public Health Practice, Arts-assistenten Kinderen, Brain, CTI Vastert, Infection & Immunity, Daan, Nadine M P, Koster, Maria P H, de Wilde, Marlieke A, Dalmeijer, Gerdien W, Evelein, Annemieke M V, Fauser, Bart C J M, and de Jager, Wilco

Published
2016

15. Placental characteristics in women with polycystic ovary syndrome

Author

Koster, Maria P H, de Wilde, Marlieke A, Veltman-Verhulst, Susanne M, Houben, ML, Nikkels, Peter G J, van Rijn, Bas B, Fauser, Bart C J M, Koster, Maria P H, de Wilde, Marlieke A, Veltman-Verhulst, Susanne M, Houben, ML, Nikkels, Peter G J, van Rijn, Bas B, and Fauser, Bart C J M

Published
2015

16. The diagnostic process of cervical cancer; areas of good practice, and windows of opportunity

Author

Zaal, A., de Wilde, Marlieke, Duk, M.J., Graziosi, G.C.M., van Haaften, Maarten, von Mensdorff-Pouilly, S., van Diest, Paul J., Zweemer, RP, Peeters, Petra H.M., Verheijen, RHM, Zaal, A., de Wilde, Marlieke, Duk, M.J., Graziosi, G.C.M., van Haaften, Maarten, von Mensdorff-Pouilly, S., van Diest, Paul J., Zweemer, RP, Peeters, Petra H.M., and Verheijen, RHM

Published
2015

17. Placental characteristics in women with polycystic ovary syndrome

Author

Groep Timmers, Child Health, MS VPG/Gynaecologie, Integrale & Alg. Kindergen Patientenzorg, Pathologie Pathologen staf, Cancer, MS Verloskunde, Koster, Maria P H, de Wilde, Marlieke A, Veltman-Verhulst, Susanne M, Houben, ML, Nikkels, Peter G J, van Rijn, Bas B, Fauser, Bart C J M, Groep Timmers, Child Health, MS VPG/Gynaecologie, Integrale & Alg. Kindergen Patientenzorg, Pathologie Pathologen staf, Cancer, MS Verloskunde, Koster, Maria P H, de Wilde, Marlieke A, Veltman-Verhulst, Susanne M, Houben, ML, Nikkels, Peter G J, van Rijn, Bas B, and Fauser, Bart C J M

Published
2015

18. Insulin action in women with polycystic ovary syndrome and its relation to gestational diabetes

Author

Child Health, MS VPG/Gynaecologie, Biostatistiek Onderzoek, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, MS Verloskunde, De Wilde, Marlieke A., Goverde, Angelique J., Veltman-Verhulst, Susanne M., Eijkemans, Marinus J C, Franx, Arie, Fauser, Bart C J M, Koster, Maria P H, Child Health, MS VPG/Gynaecologie, Biostatistiek Onderzoek, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, MS Verloskunde, De Wilde, Marlieke A., Goverde, Angelique J., Veltman-Verhulst, Susanne M., Eijkemans, Marinus J C, Franx, Arie, Fauser, Bart C J M, and Koster, Maria P H

Published
2015

19. The diagnostic process of cervical cancer; areas of good practice, and windows of opportunity

Author

MS VPG/Gynaecologie, Child Health, MS Gynaecologische Oncologie, Pathologie, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Zaal, A., de Wilde, Marlieke, Duk, M.J., Graziosi, G.C.M., van Haaften, Maarten, von Mensdorff-Pouilly, S., van Diest, Paul J., Zweemer, RP, Peeters, Petra H.M., Verheijen, RHM, MS VPG/Gynaecologie, Child Health, MS Gynaecologische Oncologie, Pathologie, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Zaal, A., de Wilde, Marlieke, Duk, M.J., Graziosi, G.C.M., van Haaften, Maarten, von Mensdorff-Pouilly, S., van Diest, Paul J., Zweemer, RP, Peeters, Petra H.M., and Verheijen, RHM

Published
2015

20. Reply: Polycystic ovary syndrome and pregnancy.

Author

Palomba, Stefano, de Wilde, Marlieke A., Falbo, Angela, Koster, Maria P. H., Battista La Sala, Giovanni, Fauser, Bart C. J. M., deWilde, Marlieke A, and La Sala, Giovanni Battista

Subjects
*POLYCYSTIC ovary syndrome, *PREGNANCY complications, *GESTATIONAL diabetes, *HYPERTENSION in pregnancy, *RISK factors of preeclampsia, *HUMAN reproduction, *DISEASE risk factors, *DISEASE complications
Published
2016
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