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20 results on '"de Vries, Joost C."'

1. Computational modelling of peritoneal dialysis: an overview

Author

Swapnasrita, Sangita, de Vries, Joost C, Öberg, Carl M, Carlier, Aurélie MF, and Gerritsen, Karin GF

Subjects
Quantitative Biology - Quantitative Methods
Abstract

Peritoneal dialysis (PD) is becoming more popular as a result of a rising interest in home dialysis, lower intrusion in social life and longer preservation of residual kidney function. However, PD has several important drawbacks: small solute clearance is relatively low compared to hemodialysis and technique survival is limited. Application of continuous flow, sorbent-based dialysate regeneration and novel glucose-sparing PD solutions are some solutions proposed to address the limitations of PD. To optimize and personalize current and novel PD therapies, patient peritoneal characteristics interacting with PD techniques need to be studied together and separately as they interplay. However, considering the multitude of parameters, it would be difficult, expensive, and time consuming to optimize all parameter settings only with the help of clinical trials. Mathematical modelling is an exciting tool to dissect these interacting processes and comprehend PD techniques better at a patient specific level. In this review, we look at the history of computational PD models, explore the many ways a computational PD model can be constructed and review the various existing PD models that can be used to optimize and personalize PD treatment., Comment: 58 pages, 5 figures

Published
2023

2. Coccolithophore ecology, with a special focus on their life cycle and standing stocks

Author

De Vries, Joost C., Monteiro, Fanny, and Andrews, Oliver

Subjects
coccolithophores, ecology, standing stocks, haplo-diplontic, SDM, Machine Learning, inorganic carbon, Coccolithus pelagicus, Coccolithus braarudii
Abstract

Coccolithophores play an important role in regulating the climate through their influence on the organic and inorganic carbon pumps. Coccolithophores' influence on the ocean carbon pumps depends on their ecology, our understanding of which is currently limited to a few species. My thesis thus aims at improving our knowledge of coccolithophore ecology by investigating the nature and function of the coccolithophore life cycle (haploid versus diploid phases) and quantifying the global standing stocks of the most common coccolithophore species. I used a trait-based framework and a multidisciplinary approach that combines statistical analysis, lab experiments, machine learning and numerical modelling. Using statistical analysis, I quantify the niche occupied by haploid and diploid coccolithophores, showing that the coccolithophore life cycle expands coccolithophore niche by ≈ 18%. Additionally, using lab experiments and numerical modelling, I demonstrate that a trade-off between nutrient storage and maximum growth is a critical bottom-up control of Coccolithus pelagicus life stages' distribution. Finally, using machine learning approaches, I estimate that two genera account for the majority of coccolithophore's global organic carbon standing stock and that mid-to-low latitude regions contribute similarly to high-latitude regions. This thesis provides novel insights into the ecology of the coccolithophore life cycle and the species that dominate coccolithophore biomass, and furthermore lays the groundwork for future coccolithophore research by identifying some of the key coccolithophore species and traits. My thesis also successfully applied novel multidisciplinary approaches leading the way to improve the ecology of marine plankton in general.

Published
2023

5. Coccolithophore ecology : with a special focus on their life cycle and standing stocks

Author

De Vries, Joost C and De Vries, Joost C

Abstract

Coccolithophores play an important role in regulating the climate through their influence on the organic and inorganic carbon pumps. Coccolithophores’ influence on the ocean carbon pumps depends on their ecology, our understanding of which is currently limited to a few species. My thesis thus aims at improving our knowledge of coccolithophore ecology by investigating the nature and function of the coccolithophore life cycle (haploid versus diploid phases) and quantifying the global standing stocks of the most common coccolithophore species. I used a trait-based framework and a multidisciplinary approach that combines statistical analysis, lab experiments, machine learning and numerical modelling. Using statistical analysis, I quantify the niche occupied by haploid and diploid coccolithophores, showing that the coccolithophore life cycle expands coccolithophore niche by ≈ 18%. Additionally, using lab experiments and numerical modelling, I demonstrate that a trade-off between nutrient storage and maximum growth is a critical bottom-up control of Coccolithus pelagicus life stages’ distribution. Finally, using machine learning approaches, I estimate that two genera account for the majority of coccolithophore’s global organic carbon standing stock and that mid-to-low latitude regions contribute similarly to high-latitude regions. This thesis provides novel insights into the ecology of the coccolithophore life cycle and the species that dominate coccolithophore biomass, and furthermore lays the groundwork for future coccolithophore research by identifying some of the key coccolithophore species and traits. My thesis also successfully applied novel multidisciplinary approaches leading the way to improve the ecology of marine plankton in general.

Published
2023

6. A Uremic Pig Model for Peritoneal Dialysis

Author

de Vries, Joost C., primary, van Gelder, Maaike K., additional, Monninkhof, Anneke S., additional, Ahmed, Sabbir, additional, Hazenbrink, Diënty H. M., additional, Nguyen, Tri Q., additional, de Kort, Gèrard A. P., additional, Vonken, Evert-Jan P. A., additional, Vaessen, Koen R. D., additional, Joles, Jaap A., additional, Verhaar, Marianne C., additional, and Gerritsen, Karin G. F., additional

Published
2022
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8. A Uremic Pig Model for Peritoneal Dialysis

Author

MS Nefrologie, Nefro Vasculaire Geneeskunde, Pathologie Pathologen staf, Circulatory Health, MS Radiologie, Regenerative Medicine and Stem Cells, de Vries, Joost C., van Gelder, Maaike K., Monninkhof, Anneke S., Ahmed, Sabbir, Hazenbrink, Diënty H.M., Nguyen, Tri Q., de Kort, Gèrard A.P., Vonken, Evert Jan P.A., Vaessen, Koen R.D., Joles, Jaap A., Verhaar, Marianne C., Gerritsen, Karin G.F., MS Nefrologie, Nefro Vasculaire Geneeskunde, Pathologie Pathologen staf, Circulatory Health, MS Radiologie, Regenerative Medicine and Stem Cells, de Vries, Joost C., van Gelder, Maaike K., Monninkhof, Anneke S., Ahmed, Sabbir, Hazenbrink, Diënty H.M., Nguyen, Tri Q., de Kort, Gèrard A.P., Vonken, Evert Jan P.A., Vaessen, Koen R.D., Joles, Jaap A., Verhaar, Marianne C., and Gerritsen, Karin G.F.

Published
2022

9. Evidence on continuous flow peritoneal dialysis: A review

Author

MS Nefrologie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, de Vries, Joost C, van Gelder, Maaike K, Cappelli, Gianni, Bajo Rubio, Maria A, Verhaar, Marianne C, Gerritsen, Karin G F, MS Nefrologie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, de Vries, Joost C, van Gelder, Maaike K, Cappelli, Gianni, Bajo Rubio, Maria A, Verhaar, Marianne C, and Gerritsen, Karin G F

Published
2022

10. A Uremic Goat Model Created by Subtotal Renal Artery Embolization and Gentamicin

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, MS Radiologie, Pathologie Pathologen staf, Regenerative Medicine and Stem Cells, van Gelder, Maaike K, de Vries, Joost C, Ahmed, Sabbir, Monninkhof, Anneke S, de Kort, Gérard A P, Vonken, Evert-Jan P A, Hazenbrink, Diënty H M, Vaessen, Koen R D, Nguyen, Tri Q, Verhaar, Marianne C, Joles, Jaap A, Gerritsen, Karin G F, Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, MS Radiologie, Pathologie Pathologen staf, Regenerative Medicine and Stem Cells, van Gelder, Maaike K, de Vries, Joost C, Ahmed, Sabbir, Monninkhof, Anneke S, de Kort, Gérard A P, Vonken, Evert-Jan P A, Hazenbrink, Diënty H M, Vaessen, Koen R D, Nguyen, Tri Q, Verhaar, Marianne C, Joles, Jaap A, and Gerritsen, Karin G F

Published
2021

11. A Uremic Goat Model Created by Subtotal Renal Artery Embolization and Gentamicin

Author

van Gelder, Maaike K., primary, de Vries, Joost C., additional, Ahmed, Sabbir, additional, Monninkhof, Anneke S., additional, de Kort, Gérard A. P., additional, Vonken, Evert-Jan P. A., additional, Hazenbrink, Diënty H. M., additional, Vaessen, Koen R. D., additional, Nguyen, Tri Q., additional, Verhaar, Marianne C., additional, Joles, Jaap A., additional, and Gerritsen, Karin G. F., additional

Published
2021
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12. Evaluation of a system for sorbent-assisted peritoneal dialysis in a uremic pig model

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, van Gelder, Maaike K, de Vries, Joost C, Simonis, Frank, Monninkhof, Anneke S, Hazenbrink, Diënty H M, Ligabue, Giulia, Giovanella, Silvia, Joles, Jaap A, Verhaar, Marianne C, Bajo Rubio, Maria A, Selgas, Rafael, Cappelli, Gianni, Gerritsen, Karin G F, Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Regenerative Medicine and Stem Cells, van Gelder, Maaike K, de Vries, Joost C, Simonis, Frank, Monninkhof, Anneke S, Hazenbrink, Diënty H M, Ligabue, Giulia, Giovanella, Silvia, Joles, Jaap A, Verhaar, Marianne C, Bajo Rubio, Maria A, Selgas, Rafael, Cappelli, Gianni, and Gerritsen, Karin G F

Published
2020

14. Heparin Forms Polymers with Cell-free DNA Which Elongate Under Shear in Flowing Blood

Author

MS Nefrologie, CDL Research analisten, CDL Contact activatie, Poli Van Creveldkliniek Medisch, Circulatory Health, CTI Leusen, CDL Staf Research, de Vries, Joost C, Barendrecht, Arjan D, Clark, Chantal C, Urbanus, Rolf T, Boross, Peter, de Maat, Steven, Maas, Coen, MS Nefrologie, CDL Research analisten, CDL Contact activatie, Poli Van Creveldkliniek Medisch, Circulatory Health, CTI Leusen, CDL Staf Research, de Vries, Joost C, Barendrecht, Arjan D, Clark, Chantal C, Urbanus, Rolf T, Boross, Peter, de Maat, Steven, and Maas, Coen

Published
2019

20. Evaluation of a system for sorbent-assisted peritoneal dialysis in a uremic pig model.

Author

van Gelder MK, de Vries JC, Simonis F, Monninkhof AS, Hazenbrink DHM, Ligabue G, Giovanella S, Joles JA, Verhaar MC, Bajo Rubio MA, Selgas R, Cappelli G, and Gerritsen KGF

Subjects
Animals, Anion Exchange Resins chemistry, Anion Exchange Resins standards, Catheters standards, Chlorides blood, Chlorides urine, Creatinine urine, Female, Peritoneal Dialysis instrumentation, Phosphates blood, Phosphates urine, Potassium blood, Potassium urine, Swine, Urea blood, Urea urine, Peritoneal Dialysis methods, Uremia therapy
Abstract

A system for sorbent-assisted peritoneal dialysis (SAPD) has been developed that continuously recirculates dialysate via a tidal mode using a single-lumen peritoneal catheter with the regeneration of spent dialysate by means of sorbents. SAPD treatment may improve plasma clearance by the maintenance of a high plasma-to-dialysate concentration gradient and by increasing the mass transfer area coefficient (MTAC) of solutes. The system is designed for daily 8-hr treatment (12 kg, nighttime system). A wearable system (2.3 kg, daytime system) may further enhance the clearance of phosphate and organic waste solutes during the day. Uremic pigs (n = 3) were treated with the day- (n = 3) and nighttime system (n = 15) for 4-8 hr per treatment. Plasma clearance (Cl), MTAC, and total mass transport (MT) of urea, creatinine, phosphate, and potassium were compared with a static dwell (n = 28). Cl, MTAC, and MT of urea, creatinine, phosphate, and potassium were low in the pig as compared to humans due to the pig's low peritoneal transport status and could be enhanced only to a limited extent by SAPD treatment compared with a static dwell (nighttime system: Cl urea: ×1.5 (p = .029), Cl creatinine: ×1.7 (p = .054), Cl phosphate: ×1.5 (p = .158), Cl potassium: ×1.6 (p = .011); daytime system: Cl creatinine: ×2.7 (p = .040), Cl phosphate: ×2.2 (p = .039)). Sorbent-assisted peritoneal dialysis treatment in a uremic pig model is safe and enhances small solute clearance as compared to a static dwell. Future studies in humans or animal species with higher peritoneal transport should elucidate whether our SAPD system enhances clearance to a clinically relevant extent as compared to conventional PD., (© 2020 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)

Published
2020
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