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2. Two new compounds from an Indonesian sponge Dysidea sp.

Author

Trianto, Agus, de Voodg, Nicole J., and Tanaka, Junichi

Subjects
*ANIMAL experimentation, *BIOLOGICAL products, *CELL culture, *HIGH performance liquid chromatography, *INVERTEBRATES, *MOLECULAR structure, *NUCLEAR magnetic resonance spectroscopy, *PHARMACEUTICAL chemistry, *RATS, *RESEARCH funding, *TOXICITY testing
Abstract

On our joint bioprospecting research on Indonesian marine invertebrates, we found moderate cytotoxicity on an extract of the sponge Dysidea sp. collected at Biak, West Papua. Separation of the extract provided two new compounds, biaketide (1) and debromoantazirine (2), along with four known molecules 3–6. The new structures were elucidated by spectroscopic analyses and by comparison with those reported. Compounds 1 and 2 showed moderate cytotoxicity against NBT-T2 cells with IC50 values of 8.3 and 4.7 μg ml− 1, respectively. [ABSTRACT FROM AUTHOR]

Published
2014
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