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1. Rubrics: Best Practices

Author

de Boer, Ivo, de Vegt, Femmie, Pluk, Helma, Latijnhouwers, Mieke, Crooks, Steven M., Editor-in-Chief, Cheon, Jongpil, Editorial Board Member, de Jong, Peter G. M., Editorial Board Member, Mullins, David W., Editorial Board Member, Oostendorp, Thom F., Editorial Board Member, de Boer, Ivo, de Vegt, Femmie, Pluk, Helma, and Latijnhouwers, Mieke

Published
2021
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2. Rubrics: A Start

Author

de Boer, Ivo, de Vegt, Femmie, Pluk, Helma, Latijnhouwers, Mieke, Crooks, Steven M., Editor-in-Chief, Cheon, Jongpil, Editorial Board Member, de Jong, Peter G. M., Editorial Board Member, Mullins, David W., Editorial Board Member, Oostendorp, Thom F., Editorial Board Member, de Boer, Ivo, de Vegt, Femmie, Pluk, Helma, and Latijnhouwers, Mieke

Published
2021
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3. Perspectives on Rubrics

Author

de Boer, Ivo, de Vegt, Femmie, Pluk, Helma, Latijnhouwers, Mieke, Crooks, Steven M., Editor-in-Chief, Cheon, Jongpil, Editorial Board Member, de Jong, Peter G. M., Editorial Board Member, Mullins, David W., Editorial Board Member, Oostendorp, Thom F., Editorial Board Member, de Boer, Ivo, de Vegt, Femmie, Pluk, Helma, and Latijnhouwers, Mieke

Published
2021
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8. High prevalence of impaired awareness of hypoglycemia and severe hypoglycemia among people with insulin-treated type 2 diabetes: The Dutch Diabetes Pearl Cohort

Author

MS Interne Geneeskunde, Circulatory Health, Van Meijel, Lian A., De Vegt, Femmie, Abbink, Evertine J., Rutters, Femke, Schram, Miranda T., Van Der Klauw, Melanie M., Wolffenbuttel, Bruce H.R., Siegelaar, Sarah, Devries, J. Hans, Sijbrands, Eric J.G., Özcan, Behiye, De Valk, Harold W., Silvius, Bianca, Schaper, Nicolaas, Stehouwer, Coen D.A., Elders, Petra J.M., Tack, Cornelis J., De Galan, Bastiaan E., MS Interne Geneeskunde, Circulatory Health, Van Meijel, Lian A., De Vegt, Femmie, Abbink, Evertine J., Rutters, Femke, Schram, Miranda T., Van Der Klauw, Melanie M., Wolffenbuttel, Bruce H.R., Siegelaar, Sarah, Devries, J. Hans, Sijbrands, Eric J.G., Özcan, Behiye, De Valk, Harold W., Silvius, Bianca, Schaper, Nicolaas, Stehouwer, Coen D.A., Elders, Petra J.M., Tack, Cornelis J., and De Galan, Bastiaan E.

Published
2020

13. High prevalence of impaired awareness of hypoglycemia and severe hypoglycemia among people with insulin-treated type 2 diabetes: The Dutch Diabetes Pearl Cohort

Author

van Meijel, Lian A, primary, de Vegt, Femmie, additional, Abbink, Evertine J, additional, Rutters, Femke, additional, Schram, Miranda T, additional, van der Klauw, Melanie M, additional, Wolffenbuttel, Bruce H R, additional, Siegelaar, Sarah, additional, DeVries, J Hans, additional, Sijbrands, Eric J G, additional, Özcan, Behiye, additional, de Valk, Harold W, additional, Silvius, Bianca, additional, Schaper, Nicolaas, additional, Stehouwer, Coen D A, additional, Elders, Petra J M, additional, Tack, Cornelis J, additional, and de Galan, Bastiaan E, additional

Published
2020
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14. Trends and projections in the incidence of oesophageal cancer in the Netherlands: An age‐period‐cohort analysis from 1989 to 2041.

Author

de Vegt, Femmie, Gommers, Jessie J. J., Groenewoud, Hans, Siersema, Peter D., Verbeek, André L. M., Peters, Yonne, and Broeders, Mireille J. M.

Subjects
ESOPHAGEAL cancer, SQUAMOUS cell carcinoma, DIAGNOSIS, LOG-linear models, WESTERN countries
Abstract

In Western populations, the incidence of oesophageal squamous cell carcinoma (OSCC) has been declining, whereas the incidence of oesophageal adenocarcinoma (OAC) has been increasing. Our study examines temporal trends in the incidence of oesophageal cancer in the Netherlands between 1989 and 2016, in addition to predicting future trends through 2041. Data from the Netherlands Cancer Registry and Statistics Netherlands were collected to obtain incidence trends of OSCC and OAC for the period 1989 to 2016. Age‐period‐cohort (APC) modelling was used to estimate the contribution of age, calendar period and birth cohort on the observed incidence trends. To predict the future numbers of new cases of both OSCC and OAC from 2017 to 2041, log‐linear APC models were fitted to the trends of 1989 to 2016. The age‐standardised incidence rates of OSCC have decreased slightly for men and increased slightly for women. In contrast, a marked increase in the incidence of OAC was observed, ranging from 2.8 per 100 000 persons in 1989 to 10.1 in 2016. This increase in OAC incidence was more prominent in men, and it will result in an increased risk of OAC for successive generations. Future projections indicate that the incidence of OAC will further increase to 13.1 per 100 000 persons in 2037 to 2041, meaning that there will be 13 259 cases of OAC in 2037 to 2041, as compared to 9386 diagnoses in 2017 to 2021. The changing epidemiologic trends in oesophageal cancer in the Netherlands should be reflected in the development of prevention, early detection and treatment strategies. What's new? The incidence of esophageal adenocarcinoma (OAC) is on the rise in Western countries. Better understanding of this trend could facilitate critical improvements in OAC prevention, early detection, and treatment strategies. Here, the authors investigated trends in OAC incidence from 1989 to 2016 for successive birth cohorts in the Netherlands. OAC incidence was found to have increased significantly since 1989, with risk rising most noticeably in men. Analyses through 2037‐2041 predict continued growth in OAC cases. The findings highlight the importance of promoting measures to prevent esophageal cancer, particularly those aimed at controlling modifiable risk factors, such as obesity and smoking. [ABSTRACT FROM AUTHOR]

Published
2022
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15. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Author

Thorgeirsson, Thorgeir E., Geller, Frank, Sulem, Patrick, Rafnar, Thorunn, Wiste, Anna, Magnusson, Kristinn P., Manolescu, Andrei, Thorleifsson, Gudmar, Stefansson, Hreinn, Ingason, Andres, Stacey, Simon N., Bergthorsson, Jon T., Thorlacius, Steinunn, Gudmundsson, Julius, Jonsson, Thorlakur, Jakobsdottir, Margret, Saemundsdottir, Jona, Olafsdottir, Olof, Gudmundsson, Larus J., Bjornsdottir, Gyda, Kristjansson, Kristleifur, Skuladottir, Halla, Isaksson, Helgi J., Gudbjartsson, Tomas, Jones, Gregory T., Mueller, Thomas, Gottsäter, Anders, Flex, Andrea, Aben, Katja K. H., de Vegt, Femmie, Mulders, Peter F. A., Isla, Dolores, Vidal, Maria J., Asin, Laura, Saez, Berta, Murillo, Laura, Blondal, Thorsteinn, Kolbeinsson, Halldor, Stefansson, Jon G., Hansdottir, Ingunn, Runarsdottir, Valgerdur, Pola, Roberto, Lindblad, Bengt, van Rij, Andre M., Dieplinger, Benjamin, Haltmayer, Meinhard, Mayordomo, Jose I., Kiemeney, Lambertus A., Matthiasson, Stefan E., Oskarsson, Hogni, Tyrfingsson, Thorarinn, Gudbjartsson, Daniel F., Gulcher, Jeffrey R., Jonsson, Steinn, Thorsteinsdottir, Unnur, Kong, Augustine, and Stefansson, Kari

Published
2008
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16. Relatie tussen leefstijl en kanker; onderwerp van gesprek in de spreekkamer?

Author

Evers, Jelle, Swankhuisen, Christine, Kiemeney, Bart, Hoogerbrugge, Nicoline, de Vegt, Femmie, Health Technology & Services Research, and TechMed Centre

Subjects
n/a OA procedure
Abstract

Doel: Dit onderzoek verkent in hoeverre er draagvlak is onder zorgprofessionals voor het ondersteunen van kankerpatiënten bij leefstijlveranderingen, aan de hand van 3 vragen: (a) Wat is de invloed van leefstijl op kanker volgens zorgprofessionals? (b) Beschouwen zorgprofessionals het als hun taak om kankerpatiënten te ondersteunen bij leefstijlveranderingen? (c) Beïnvloedt de eigen leefstijl van zorgprofessionals de gesprekken die zij met kankerpatiënten voeren over leefstijl? Opzet: Vragenlijstonderzoek. Methode: 1550 zorgprofessionals uit Nijmegen en omgeving ontvingen in januari 2015 een digitale vragenlijst over de relatie tussen leefstijl en kanker. De vragenlijst werd ingevuld door 562 zorgprofessionals (respons: 36%), van wie er 404 (72%) met kankerpatiënten werkten. Deze groep bestond uit 170 medisch specialisten, 62 huisartsen en 172 verpleegkundigen en praktijkondersteuners. Resultaten: Zorgprofessionals onderkenden de invloed van leefstijl op het ontstaan van kanker. Vrijwel alle professionals (98%) waren het erover eens dat een gezonde leefstijl het welbevinden van kankerpatiënten in zekere mate beïnvloedt. Circa twee derde van alle zorgprofessionals vond dat leefstijl ‘meestal’ of ‘altijd’ moet worden besproken met kankerpatiënten en iets meer dan de helft van alle zorgprofessionals gaf aan dit ook te doen. Zorgprofessionals hebben behoefte aan evidencebased kennis over de relatie tussen leefstijl en kanker, voorlichtingsmateriaal en extra consulttijd om kankerpatiënten te ondersteunen bij leefstijlveranderingen. De leefstijl van zorgprofessionals lijkt ook van invloed: bij zorgprofessionals die niet aan leefstijlnormen voldoen, kwam leefstijl minder vaak aan bod in de spreekkamer. Conclusie: Er lijkt draagvlak te zijn onder zorgprofessionals om leefstijl te bespreken met kankerpatiënten en om hen te ondersteunen bij leefstijlveranderingen.

Published
2019

21. Prevalence of Impaired Awareness of Hypoglycemia and Severe Hypoglycemia among People with Type 2 Diabetes Treated with Insulin—The Dutch Diabetes Pearl Cohort

Author

Bianca Silvius, Nathalie Masurel, Femke Rutters, Bastiaan E. de Galan, De Vegt Femmie, C.J.J. Tack, Lian A. van Meijel, J. Hans DeVries, Hanno Pijl, Evertine J. Abbink, Jacqueline M. Dekker, Bruce H. R. Wolffenbuttel, Frits Holleman, Behiye Özcan, Epidemiology and Data Science, AII - Inflammatory diseases, APH - Aging & Later Life, APH - Health Behaviors & Chronic Diseases, Dermatology, and ACS - Diabetes & metabolism

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Recurrent hypoglycemia, Type 2 diabetes, Hypoglycemia, medicine.disease, Interquartile range, Diabetes mellitus, Cohort, Internal Medicine, medicine, Adverse effect, business
Abstract

Aim: Most people with type 2 diabetes eventually require insulin treatment because of progressive loss of beta-cell function. The most common adverse effect of insulin therapy is hypoglycemia. Recurrent hypoglycemia may lead to impaired awareness of hypoglycemia (IAH) and a consequently high risk for severe hypoglycemia. The aim of this study was to determine the prevalence of IAH and severe hypoglycemia in a large cohort of people with insulin-treated type 2 diabetes. Methods: The Dutch Diabetes Pearl is a contemporary cohort of people with type 2 diabetes from primary, secondary and tertiary medical centers in the Netherlands. We collected data from people on insulin therapy who had completed the validated Dutch version of the Clarke questionnaire on IAH, where 3 out of 5 points indicate IAH. Descriptive statistics, T-tests and Chi-square tests were performed. Results: Our study included 1923 patients of whom 59% were men. Median age was 62.1 years (interquartile range 55.1-68.3), median diabetes duration was 13.9 years (8.8-20.1) and median HbA1c was 7.6 % (7.0-8.5). 2individuals (10.8%) were classified as having IAH; these people were more likely to be non-Caucasian and have a lower educational level, and less likely to have a partner. Severe hypoglycemia was reported in 617 patients (32.1%) and severe hypoglycemia requiring medical intervention in the past year in 166 patients (8.6%). People with severe hypoglycemia were more likely to be non-Caucasian, to have a lower educational level, to have a history of cardiovascular events and neuropathic pain, and to use over 10 different types of drugs. No significant associations between HbA1c-levels and IAH or severe hypoglycemia were observed. Conclusion: IAH and severe hypoglycemia are common in people with type 2 diabetes treated with insulin. Non- Caucasian ethnicity, lower educational level, and being single may be risk factors for IAH in patients with type 2 diabetes. Disclosure L. van Meijel: None. F. de Vegt: None. C. Tack: Advisory Panel; Self; Merck Sharp & Dohme Corp., Novo Nordisk A/S, AstraZeneca. Research Support; Self; AstraZeneca. Speaker's Bureau; Self; Novo Nordisk A/S. E.J. Abbink: None. F. Rutters: None. J.M. Dekker: None. B.H. Wolffenbuttel: None. F. Holleman: Other Relationship; Self; Sanofi-Aventis, Bioton, AstraZeneca. J. DeVries: Research Support; Self; Dexcom, Inc., Medtronic, Novo Nordisk A/S. Advisory Panel; Self; Novo Nordisk A/S. Speaker's Bureau; Self; Novo Nordisk A/S, Roche Diabetes Care Health and Digital Solutions. Advisory Panel; Self; Sanofi. Research Support; Self; Senseonics. Speaker's Bureau; Self; Senseonics. Advisory Panel; Self; Zealand Pharma A/S. N. Masurel: None. H. Pijl: None. B. Ozcan: None. B. Silvius: None. B.E. de Galan: Research Support; Self; AstraZeneca, Sanofi. Advisory Panel; Self; Novo Nordisk A/S.

Published
2018

23. Alcohol Consumption and Mortality Risk in Categories of Glucose Tolerance. The Hoorn Study

Author

DEKKER, JACQUELINE M., DE VEGT, FEMMIE, GROENEVELD, WILLEM JAN, NIJPELS, GIEL, STEHOUWER, COEN D. A., BOUTER, LEX M., and HEINE, ROBERT J.

Subjects
Drinking of alcoholic beverages -- Health aspects, Diabetics -- Health aspects, Diabetes -- Care and treatment, Health
Abstract

Light to moderate alcohol consumption is associated with lower mortality risk compared to nondrinkers. It is also known that moderate alcohol intake is associated with higher insulin sensitivity. Therefore we [...]

Published
2000

24. Hyperglycemia is Associated with All-Cause and Cardiovascular Mortality in a Non-Diabetic Elderly Population: The Hoorn Study

Author

DE VEGT, FEMMIE, DEKKER, JACQUELINE M, STEHOUWER, COEN D A, NIJPELS, GIEL, BOUTER, LEX M, and HEINE, ROBERT J

Subjects
Diabetes -- Research, Health
Abstract

Glycemic level has been shown to be associated with all-cause and scardiovascular (CVD) mortality in diabetic subjects. Whether this association also exists in the general population is still controversial. We [...]

Published
1999

26. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Author

Berndt, Sonja I., Gustafsson, Stefan, Maegi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jian'an, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L., Neale, Benjamin M., Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L., Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E., Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E., Koenig, Inke R., Kristiansson, Kati, Kutalik, Zoltn, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L., Medina-Gomez, Carolina, Mueller-Nurasyid, Martina, Ngwa, Julius S., Nolte, Ilja M., Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J., Preuss, Michael, Rose, Lynda M., Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J., Surakka, Ida, Teumer, Alexander, Trip, Mieke D., Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V., Vandenput, Liesbeth, Waite, Lindsay L., Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W., Atalay, Mustafa, Attwood, Antony P., Balmforth, Anthony J., Basart, Hanneke, Beilby, John, Bonnycastle, Lori L., Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Connell, John M., Cookson, William O., de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M., Farrall, Martin, Ferrario, Marco M., Ferrieres, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V., Grallert, Harald, Groenberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S., Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L., Heath, Andrew C., Hebebrand, Johannes, Homuth, Georg, Hu, Frank B., Hunt, Sarah E., Hyppoenen, Elina, Iribarren, Carlos, Jacobs, Kevin B., Jansson, John-Olov, Jula, Antti, Kahonen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimaki, Mika, Koenig, Wolfgang, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H., Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A., Magnusson, Patrik K., Manunta, Paolo, Marek, Diana, März, Winfried, Leach, Irene Mateo, McKnight, Barbara, Medland, Sarah E., Mihailov, Evelin, Milani, Lili, Montgomery, Grant W., Mooser, Vincent, Muehleisen, Thomas W., Munroe, Patricia B., Musk, Arthur W., Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A., Ong, Ken K., Oostra, Ben A., Palmer, Colin N. A., Palotie, Aarno, Peden, John F., Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P., Prokopenko, Inga, Puetter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E., Sambrook, Jennifer G., Sanders, Alan R., Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stancakova, Alena, Stark, Klaus, Stephens, Jonathan C., Stirrups, Kathleen, Stolk, Ronald P., Stumvoll, Michael, Swift, Amy J., Theodoraki, Eirini V., Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M., van Meurs, Joyce B. J., Vermeulen, Sita H., Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gerard, Wang, Zhaoming, Widen, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Winkelmann, Bernhard R., Witteman, Jacqueline C. M., Wolffenbuttel, Bruce H. R., Wong, Andrew, Wright, Alan F., Zillikens, M. Carola, Amouyel, Philippe, Boehm, Bernhard O., Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Chanock, Stephen J., Cupples, L. Adrienne, Cusi, Daniele, Dedoussis, George V., Erdmann, Jeanette, Eriksson, Johan G., Franks, Paul W., Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Hengstenberg, Christian, Hicks, Andrew A., Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G., Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Joeckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Kuh, Diana, Laakso, Markku, Lehtimaki, Terho, Levinson, Douglas F., Martin, Nicholas G., Metspalu, Andres, Morris, Andrew D., Nieminen, Markku S., Njolstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J., Ouwehand, Willem H., Palmer, Lyle J., Penninx, Brenda, Power, Chris, Province, Michael A., Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Ridker, Paul M., Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J., Snieder, Harold, Sorensen, Thorkild I. A., Spector, Timothy D., Stefansson, Kari, Tonjes, Anke, Tuomilehto, Jaakko, Uitterlinden, Andre G., Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Wilson, James F., Abecasis, Goncalo R., Assimes, Themistocles L., Barroso, Ines, Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Frayling, Timothy, Groop, Leif C., Haritunian, Talin, Heid, Iris M., Hunter, David, Kaplan, Robert C., Karpe, Fredrik, Moffatt, Miriam F., Mohlke, Karen L., O'Connell, Jeffrey R., Pawitan, Yudi, Schadt, Eric E., Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P., Thorsteinsdottir, Unnur, van Duijn, Cornelia M., Visscher, Peter M., Di Blasio, Anna Maria, Hirschhorn, Joel N., Lindgren, Cecilia M., Morris, Andrew P., Meyre, David, Scherag, Andr, McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Loos, Ruth J. F., Ingelsson, Erik, Berndt, Sonja I., Gustafsson, Stefan, Maegi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jian'an, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L., Neale, Benjamin M., Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L., Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E., Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E., Koenig, Inke R., Kristiansson, Kati, Kutalik, Zoltn, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L., Medina-Gomez, Carolina, Mueller-Nurasyid, Martina, Ngwa, Julius S., Nolte, Ilja M., Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J., Preuss, Michael, Rose, Lynda M., Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J., Surakka, Ida, Teumer, Alexander, Trip, Mieke D., Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V., Vandenput, Liesbeth, Waite, Lindsay L., Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W., Atalay, Mustafa, Attwood, Antony P., Balmforth, Anthony J., Basart, Hanneke, Beilby, John, Bonnycastle, Lori L., Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Connell, John M., Cookson, William O., de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M., Farrall, Martin, Ferrario, Marco M., Ferrieres, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V., Grallert, Harald, Groenberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S., Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L., Heath, Andrew C., Hebebrand, Johannes, Homuth, Georg, Hu, Frank B., Hunt, Sarah E., Hyppoenen, Elina, Iribarren, Carlos, Jacobs, Kevin B., Jansson, John-Olov, Jula, Antti, Kahonen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimaki, Mika, Koenig, Wolfgang, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H., Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A., Magnusson, Patrik K., Manunta, Paolo, Marek, Diana, März, Winfried, Leach, Irene Mateo, McKnight, Barbara, Medland, Sarah E., Mihailov, Evelin, Milani, Lili, Montgomery, Grant W., Mooser, Vincent, Muehleisen, Thomas W., Munroe, Patricia B., Musk, Arthur W., Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A., Ong, Ken K., Oostra, Ben A., Palmer, Colin N. A., Palotie, Aarno, Peden, John F., Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P., Prokopenko, Inga, Puetter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E., Sambrook, Jennifer G., Sanders, Alan R., Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stancakova, Alena, Stark, Klaus, Stephens, Jonathan C., Stirrups, Kathleen, Stolk, Ronald P., Stumvoll, Michael, Swift, Amy J., Theodoraki, Eirini V., Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M., van Meurs, Joyce B. J., Vermeulen, Sita H., Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gerard, Wang, Zhaoming, Widen, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Winkelmann, Bernhard R., Witteman, Jacqueline C. M., Wolffenbuttel, Bruce H. R., Wong, Andrew, Wright, Alan F., Zillikens, M. Carola, Amouyel, Philippe, Boehm, Bernhard O., Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Chanock, Stephen J., Cupples, L. Adrienne, Cusi, Daniele, Dedoussis, George V., Erdmann, Jeanette, Eriksson, Johan G., Franks, Paul W., Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Hengstenberg, Christian, Hicks, Andrew A., Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G., Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Joeckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Kuh, Diana, Laakso, Markku, Lehtimaki, Terho, Levinson, Douglas F., Martin, Nicholas G., Metspalu, Andres, Morris, Andrew D., Nieminen, Markku S., Njolstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J., Ouwehand, Willem H., Palmer, Lyle J., Penninx, Brenda, Power, Chris, Province, Michael A., Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Ridker, Paul M., Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J., Snieder, Harold, Sorensen, Thorkild I. A., Spector, Timothy D., Stefansson, Kari, Tonjes, Anke, Tuomilehto, Jaakko, Uitterlinden, Andre G., Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Wilson, James F., Abecasis, Goncalo R., Assimes, Themistocles L., Barroso, Ines, Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Frayling, Timothy, Groop, Leif C., Haritunian, Talin, Heid, Iris M., Hunter, David, Kaplan, Robert C., Karpe, Fredrik, Moffatt, Miriam F., Mohlke, Karen L., O'Connell, Jeffrey R., Pawitan, Yudi, Schadt, Eric E., Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P., Thorsteinsdottir, Unnur, van Duijn, Cornelia M., Visscher, Peter M., Di Blasio, Anna Maria, Hirschhorn, Joel N., Lindgren, Cecilia M., Morris, Andrew P., Meyre, David, Scherag, Andr, McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Loos, Ruth J. F., and Ingelsson, Erik

Abstract

Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.

Published
2013
Full Text
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27. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Author

Berndt, Sonja I, Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F, Justice, Anne E, Monda, Keri L, Croteau-Chonka, Damien C, Day, Felix R, Esko, Tõnu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U, Luan, Jian'an, Randall, Joshua C, Vedantam, Sailaja, Willer, Cristen J, Winkler, Thomas, Wood, Andrew R, Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L, Neale, Benjamin M, Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L, Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E, Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E, König, Inke R, Kristiansson, Kati, Kutalik, Zoltán, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L, Medina-Gomez, Carolina, Müller-Nurasyid, Martina, Ngwa, Julius S, Nolte, Ilja M, Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J, Preuss, Michael, Rose, Lynda M, Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J, Surakka, Ida, Teumer, Alexander, Trip, Mieke D, Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V, Vandenput, Liesbeth, Waite, Lindsay L, Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W, Atalay, Mustafa, Attwood, Antony P, Balmforth, Anthony J, Basart, Hanneke, Beilby, John, Bonnycastle, Lori L, Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I, Chines, Peter S, Collins, Francis S, Connell, John M, Cookson, William O, de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M, Farrall, Martin, Ferrario, Marco M, Ferrières, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V, Grallert, Harald, Grönberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S, Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L, Heath, Andrew C, Hebebrand, Johannes, Homuth, Georg, Hu, Frank B, Hunt, Sarah E, Hyppönen, Elina, Iribarren, Carlos, Jacobs, Kevin B, Jansson, John-Olov, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimäki, Mika, Koenig, Wolfgang, Kraja, Aldi T, Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H, Lakka, Timo A, Langenberg, Claudia, Launer, Lenore J, Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A, Magnusson, Patrik K, Manunta, Paolo, Marek, Diana, März, Winfried, Mateo Leach, Irene, McKnight, Barbara, Medland, Sarah E, Mihailov, Evelin, Milani, Lili, Montgomery, Grant W, Mooser, Vincent, Mühleisen, Thomas W, Munroe, Patricia B, Musk, Arthur W, Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A, Ong, Ken K, Oostra, Ben A, Palmer, Colin N A, Palotie, Aarno, Peden, John F, Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P, Prokopenko, Inga, Pütter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E, Sambrook, Jennifer G, Sanders, Alan R, Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stan?áková, Alena, Stark, Klaus, Stephens, Jonathan C, Stirrups, Kathleen, Stolk, Ronald P, Stumvoll, Michael, Swift, Amy J, Theodoraki, Eirini V, Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M, van Meurs, Joyce B J, Vermeulen, Sita H, Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gérard, Wang, Zhaoming, Widén, Elisabeth, Wild, Sarah H, Willemsen, Gonneke, Winkelmann, Bernhard R, Witteman, Jacqueline C M, Wolffenbuttel, Bruce H R, Wong, Andrew, Wright, Alan F, Zillikens, M Carola, Amouyel, Philippe, Boehm, Bernhard O, Boerwinkle, Eric, Boomsma, Dorret I, Caulfield, Mark J, Chanock, Stephen J, Cupples, L Adrienne, Cusi, Daniele, Dedoussis, George V, Erdmann, Jeanette, Eriksson, Johan G, Franks, Paul W, Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B, Hengstenberg, Christian, Hicks, Andrew A, Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G, Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M, Kiemeney, Lambertus A, Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Levinson, Douglas F, Martin, Nicholas G, Metspalu, Andres, Morris, Andrew D, Nieminen, Markku S, Njølstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J, Ouwehand, Willem H, Palmer, Lyle J, Penninx, Brenda, Power, Chris, Province, Michael A, Psaty, Bruce M, Qi, Lu, Rauramaa, Rainer, Ridker, Paul M, Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J, Snieder, Harold, Sørensen, Thorkild I A, Spector, Timothy D, Stefansson, Kari, Tönjes, Anke, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J, Watkins, Hugh, Wichmann, H-Erich, Wilson, James, Abecasis, Goncalo R, Assimes, Themistocles L, Barroso, Inês, Boehnke, Michael, Borecki, Ingrid B, Deloukas, Panos, Fox, Caroline S, Frayling, Timothy, Groop, Leif C, Haritunian, Talin, Heid, Iris M, Hunter, David, Kaplan, Robert C, Karpe, Fredrik, Moffatt, Miriam F, Mohlke, Karen L, O'Connell, Jeffrey R, Pawitan, Yudi, Schadt, Eric E, Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P, Thorsteinsdottir, Unnur, van Duijn, Cornelia M, Visscher, Peter M, Di Blasio, Anna Maria, Hirschhorn, Joel N, Lindgren, Cecilia M, Morris, Andrew P, Meyre, David, Scherag, André, McCarthy, Mark I, Speliotes, Elizabeth K, North, Kari E, Loos, Ruth J F, Ingelsson, Erik, Berndt, Sonja I, Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F, Justice, Anne E, Monda, Keri L, Croteau-Chonka, Damien C, Day, Felix R, Esko, Tõnu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U, Luan, Jian'an, Randall, Joshua C, Vedantam, Sailaja, Willer, Cristen J, Winkler, Thomas, Wood, Andrew R, Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L, Neale, Benjamin M, Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L, Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E, Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E, König, Inke R, Kristiansson, Kati, Kutalik, Zoltán, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L, Medina-Gomez, Carolina, Müller-Nurasyid, Martina, Ngwa, Julius S, Nolte, Ilja M, Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J, Preuss, Michael, Rose, Lynda M, Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J, Surakka, Ida, Teumer, Alexander, Trip, Mieke D, Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V, Vandenput, Liesbeth, Waite, Lindsay L, Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W, Atalay, Mustafa, Attwood, Antony P, Balmforth, Anthony J, Basart, Hanneke, Beilby, John, Bonnycastle, Lori L, Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I, Chines, Peter S, Collins, Francis S, Connell, John M, Cookson, William O, de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M, Farrall, Martin, Ferrario, Marco M, Ferrières, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V, Grallert, Harald, Grönberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S, Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L, Heath, Andrew C, Hebebrand, Johannes, Homuth, Georg, Hu, Frank B, Hunt, Sarah E, Hyppönen, Elina, Iribarren, Carlos, Jacobs, Kevin B, Jansson, John-Olov, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimäki, Mika, Koenig, Wolfgang, Kraja, Aldi T, Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H, Lakka, Timo A, Langenberg, Claudia, Launer, Lenore J, Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A, Magnusson, Patrik K, Manunta, Paolo, Marek, Diana, März, Winfried, Mateo Leach, Irene, McKnight, Barbara, Medland, Sarah E, Mihailov, Evelin, Milani, Lili, Montgomery, Grant W, Mooser, Vincent, Mühleisen, Thomas W, Munroe, Patricia B, Musk, Arthur W, Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A, Ong, Ken K, Oostra, Ben A, Palmer, Colin N A, Palotie, Aarno, Peden, John F, Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P, Prokopenko, Inga, Pütter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E, Sambrook, Jennifer G, Sanders, Alan R, Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stan?áková, Alena, Stark, Klaus, Stephens, Jonathan C, Stirrups, Kathleen, Stolk, Ronald P, Stumvoll, Michael, Swift, Amy J, Theodoraki, Eirini V, Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M, van Meurs, Joyce B J, Vermeulen, Sita H, Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gérard, Wang, Zhaoming, Widén, Elisabeth, Wild, Sarah H, Willemsen, Gonneke, Winkelmann, Bernhard R, Witteman, Jacqueline C M, Wolffenbuttel, Bruce H R, Wong, Andrew, Wright, Alan F, Zillikens, M Carola, Amouyel, Philippe, Boehm, Bernhard O, Boerwinkle, Eric, Boomsma, Dorret I, Caulfield, Mark J, Chanock, Stephen J, Cupples, L Adrienne, Cusi, Daniele, Dedoussis, George V, Erdmann, Jeanette, Eriksson, Johan G, Franks, Paul W, Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B, Hengstenberg, Christian, Hicks, Andrew A, Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G, Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M, Kiemeney, Lambertus A, Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Levinson, Douglas F, Martin, Nicholas G, Metspalu, Andres, Morris, Andrew D, Nieminen, Markku S, Njølstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J, Ouwehand, Willem H, Palmer, Lyle J, Penninx, Brenda, Power, Chris, Province, Michael A, Psaty, Bruce M, Qi, Lu, Rauramaa, Rainer, Ridker, Paul M, Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J, Snieder, Harold, Sørensen, Thorkild I A, Spector, Timothy D, Stefansson, Kari, Tönjes, Anke, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J, Watkins, Hugh, Wichmann, H-Erich, Wilson, James, Abecasis, Goncalo R, Assimes, Themistocles L, Barroso, Inês, Boehnke, Michael, Borecki, Ingrid B, Deloukas, Panos, Fox, Caroline S, Frayling, Timothy, Groop, Leif C, Haritunian, Talin, Heid, Iris M, Hunter, David, Kaplan, Robert C, Karpe, Fredrik, Moffatt, Miriam F, Mohlke, Karen L, O'Connell, Jeffrey R, Pawitan, Yudi, Schadt, Eric E, Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P, Thorsteinsdottir, Unnur, van Duijn, Cornelia M, Visscher, Peter M, Di Blasio, Anna Maria, Hirschhorn, Joel N, Lindgren, Cecilia M, Morris, Andrew P, Meyre, David, Scherag, André, McCarthy, Mark I, Speliotes, Elizabeth K, North, Kari E, Loos, Ruth J F, and Ingelsson, Erik

Published
2013

28. Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics

Author

Hu, Yi-Juan, primary, Berndt, Sonja I., additional, Gustafsson, Stefan, additional, Ganna, Andrea, additional, Hirschhorn, Joel, additional, North, Kari E., additional, Ingelsson, Erik, additional, Lin, Dan-Yu, additional, Mägi, Reedik, additional, Wheeler, Eleanor, additional, Feitosa, Mary F., additional, Justice, Anne E., additional, Monda, Keri L., additional, Croteau-Chonka, Damien C., additional, Day, Felix R., additional, Esko, Tõnu, additional, Fall, Tove, additional, Ferreira, Teresa, additional, Gentilini, Davide, additional, Jackson, Anne U., additional, Luan, Jian’an, additional, Randall, Joshua C., additional, Vedantam, Sailaja, additional, Willer, Cristen J., additional, Winkler, Thomas W., additional, Wood, Andrew R., additional, Workalemahu, Tsegaselassie, additional, Hu, Yi-Juan, additional, Lee, Sang Hong, additional, Liang, Liming, additional, Min, Josine L., additional, Neale, Benjamin M., additional, Thorleifsson, Gudmar, additional, Yang, Jian, additional, Albrecht, Eva, additional, Amin, Najaf, additional, Bragg-Gresham, Jennifer L., additional, Cadby, Gemma, additional, den Heijer, Martin, additional, Eklund, Niina, additional, Fischer, Krista, additional, Goel, Anuj, additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E., additional, Jarick, Ivonne, additional, Johansson, Åsa, additional, Johnson, Toby, additional, Kanoni, Stavroula, additional, Kleber, Marcus E., additional, König, Inke R., additional, Kristiansson, Kati, additional, Kutalik, Zoltán, additional, Lamina, Claudia, additional, Lecoeur, Cecile, additional, Li, Guo, additional, Mangino, Massimo, additional, McArdle, Wendy L., additional, Medina-Gomez, Carolina, additional, Müller-Nurasyid, Martina, additional, Ngwa, Julius S., additional, Nolte, Ilja M., additional, Paternoster, Lavinia, additional, Pechlivanis, Sonali, additional, Perola, Markus, additional, Peters, Marjolein J., additional, Preuss, Michael, additional, Rose, Lynda M., additional, Shi, Jianxin, additional, Shungin, Dmitry, additional, Smith, Albert Vernon, additional, Strawbridge, Rona J., additional, Surakka, Ida, additional, Teumer, Alexander, additional, Trip, Mieke D., additional, Tyrer, Jonathan, additional, Van Vliet-Ostaptchouk, Jana V., additional, Vandenput, Liesbeth, additional, Waite, Lindsay L., additional, Zhao, Jing Hua, additional, Absher, Devin, additional, Asselbergs, Folkert W., additional, Atalay, Mustafa, additional, Attwood, Antony P., additional, Balmforth, Anthony J., additional, Basart, Hanneke, additional, Beilby, John, additional, Bonnycastle, Lori L., additional, Brambilla, Paolo, additional, Bruinenberg, Marcel, additional, Campbell, Harry, additional, Chasman, Daniel I., additional, Chines, Peter S., additional, Collins, Francis S., additional, Connell, John M., additional, Cookson, William, additional, de Faire, Ulf, additional, de Vegt, Femmie, additional, Dei, Mariano, additional, Dimitriou, Maria, additional, Edkins, Sarah, additional, Estrada, Karol, additional, Evans, David M., additional, Farrall, Martin, additional, Ferrario, Marco M., additional, Ferrières, Jean, additional, Franke, Lude, additional, Frau, Francesca, additional, Gejman, Pablo V., additional, Grallert, Harald, additional, Grönberg, Henrik, additional, Gudnason, Vilmundur, additional, Hall, Alistair S., additional, Hall, Per, additional, Hartikainen, Anna-Liisa, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L., additional, Heath, Andrew C., additional, Hebebrand, Johannes, additional, Homuth, Georg, additional, Hu, Frank B., additional, Hunt, Sarah E., additional, Hyppönen, Elina, additional, Iribarren, Carlos, additional, Jacobs, Kevin B., additional, Jansson, John-Olov, additional, Jula, Antti, additional, Kähönen, Mika, additional, Kathiresan, Sekar, additional, Kee, Frank, additional, Khaw, Kay-Tee, additional, Kivimaki, Mika, additional, Koenig, Wolfgang, additional, Kraja, Aldi T., additional, Kumari, Meena, additional, Kuulasmaa, Kari, additional, Kuusisto, Johanna, additional, Laitinen, Jaana H., additional, Lakka, Timo A., additional, Langenberg, Claudia, additional, Launer, Lenore J., additional, Lind, Lars, additional, Lindström, Jaana, additional, Liu, Jianjun, additional, Liuzzi, Antonio, additional, Lokki, Marja-Liisa, additional, Lorentzon, Mattias, additional, Madden, Pamela A., additional, Magnusson, Patrik K., additional, Manunta, Paolo, additional, Marek, Diana, additional, März, Winfried, additional, Leach, Irene Mateo, additional, McKnight, Barbara, additional, Medland, Sarah E., additional, Mihailov, Evelin, additional, Milani, Lili, additional, Montgomery, Grant W., additional, Mooser, Vincent, additional, Mühleisen, Thomas W., additional, Munroe, Patricia B., additional, Musk, Arthur W., additional, Narisu, Narisu, additional, Navis, Gerjan, additional, Nicholson, George, additional, Nohr, Ellen A., additional, Ong, Ken K., additional, Oostra, Ben A., additional, Palmer, Colin N.A., additional, Palotie, Aarno, additional, Peden, John F., additional, Pedersen, Nancy, additional, Peters, Annette, additional, Polasek, Ozren, additional, Pouta, Anneli, additional, Pramstaller, Peter P., additional, Prokopenko, Inga, additional, Pütter, Carolin, additional, Radhakrishnan, Aparna, additional, Raitakari, Olli, additional, Rendon, Augusto, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Saaristo, Timo E., additional, Sambrook, Jennifer G., additional, Sanders, Alan R., additional, Sanna, Serena, additional, Saramies, Jouko, additional, Schipf, Sabine, additional, Schreiber, Stefan, additional, Schunkert, Heribert, additional, Shin, So-Youn, additional, Signorini, Stefano, additional, Sinisalo, Juha, additional, Skrobek, Boris, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Stark, Klaus, additional, Stephens, Jonathan C., additional, Stirrups, Kathleen, additional, Stolk, Ronald P., additional, Stumvoll, Michael, additional, Swift, Amy J., additional, Theodoraki, Eirini V., additional, Thorand, Barbara, additional, Tregouet, David-Alexandre, additional, Tremoli, Elena, additional, Van der Klauw, Melanie M., additional, van Meurs, Joyce B.J., additional, Vermeulen, Sita H., additional, Viikari, Jorma, additional, Virtamo, Jarmo, additional, Vitart, Veronique, additional, Waeber, Gérard, additional, Wang, Zhaoming, additional, Widén, Elisabeth, additional, Wild, Sarah H., additional, Willemsen, Gonneke, additional, Winkelmann, Bernhard R., additional, Witteman, Jacqueline C.M., additional, Wolffenbuttel, Bruce H.R., additional, Wong, Andrew, additional, Wright, Alan F., additional, Zillikens, M. Carola, additional, Amouyel, Philippe, additional, Boehm, Bernhard O., additional, Boerwinkle, Eric, additional, Boomsma, Dorret I., additional, Caulfield, Mark J., additional, Chanock, Stephen J., additional, Cupples, L. Adrienne, additional, Cusi, Daniele, additional, Dedoussis, George V., additional, Erdmann, Jeanette, additional, Eriksson, Johan G., additional, Franks, Paul W., additional, Froguel, Philippe, additional, Gieger, Christian, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Harris, Tamara B., additional, Hengstenberg, Christian, additional, Hicks, Andrew A., additional, Hingorani, Aroon, additional, Hinney, Anke, additional, Hofman, Albert, additional, Hovingh, Kees G., additional, Hveem, Kristian, additional, Illig, Thomas, additional, Jarvelin, Marjo-Riitta, additional, Jöckel, Karl-Heinz, additional, Keinanen-Kiukaanniemi, Sirkka M., additional, Kiemeney, Lambertus A., additional, Kuh, Diana, additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Levinson, Douglas F., additional, Martin, Nicholas G., additional, Metspalu, Andres, additional, Morris, Andrew D., additional, Nieminen, Markku S., additional, Njølstad, Inger, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine J., additional, Ouwehand, Willem H., additional, Palmer, Lyle J., additional, Penninx, Brenda, additional, Power, Chris, additional, Province, Michael A., additional, Psaty, Bruce M., additional, Qi, Lu, additional, Rauramaa, Rainer, additional, Ridker, Paul M., additional, Ripatti, Samuli, additional, Salomaa, Veikko, additional, Samani, Nilesh J., additional, Snieder, Harold, additional, Sørensen, Thorkild I.A., additional, Spector, Timothy D., additional, Stefansson, Kari, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Uitterlinden, André G., additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, Vollenweider, Peter, additional, Wallaschofski, Henri, additional, Wareham, Nicholas J., additional, Watkins, Hugh, additional, Wichmann, H.-Erich, additional, Wilson, James F., additional, Abecasis, Goncalo R., additional, Assimes, Themistocles L., additional, Barroso, Inês, additional, Boehnke, Michael, additional, Borecki, Ingrid B., additional, Deloukas, Panos, additional, Fox, Caroline S., additional, Frayling, Timothy, additional, Groop, Leif C., additional, Haritunian, Talin, additional, Heid, Iris M., additional, Hunter, David, additional, Kaplan, Robert C., additional, Karpe, Fredrik, additional, Moffatt, Miriam, additional, Mohlke, Karen L., additional, O’Connell, Jeffrey R., additional, Pawitan, Yudi, additional, Schadt, Eric E., additional, Schlessinger, David, additional, Steinthorsdottir, Valgerdur, additional, Strachan, David P., additional, Thorsteinsdottir, Unnur, additional, van Duijn, Cornelia M., additional, Visscher, Peter M., additional, Di Blasio, Anna Maria, additional, Hirschhorn, Joel N., additional, Lindgren, Cecilia M., additional, Morris, Andrew P., additional, Meyre, David, additional, Scherag, André, additional, McCarthy, Mark I., additional, Speliotes, Elizabeth K., additional, North, Kari E., additional, and Loos, Ruth J.F., additional

Published
2013
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29. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Author

Berndt, Sonja I, primary, Gustafsson, Stefan, additional, Mägi, Reedik, additional, Ganna, Andrea, additional, Wheeler, Eleanor, additional, Feitosa, Mary F, additional, Justice, Anne E, additional, Monda, Keri L, additional, Croteau-Chonka, Damien C, additional, Day, Felix R, additional, Esko, Tõnu, additional, Fall, Tove, additional, Ferreira, Teresa, additional, Gentilini, Davide, additional, Jackson, Anne U, additional, Luan, Jian'an, additional, Randall, Joshua C, additional, Vedantam, Sailaja, additional, Willer, Cristen J, additional, Winkler, Thomas W, additional, Wood, Andrew R, additional, Workalemahu, Tsegaselassie, additional, Hu, Yi-Juan, additional, Lee, Sang Hong, additional, Liang, Liming, additional, Lin, Dan-Yu, additional, Min, Josine L, additional, Neale, Benjamin M, additional, Thorleifsson, Gudmar, additional, Yang, Jian, additional, Albrecht, Eva, additional, Amin, Najaf, additional, Bragg-Gresham, Jennifer L, additional, Cadby, Gemma, additional, den Heijer, Martin, additional, Eklund, Niina, additional, Fischer, Krista, additional, Goel, Anuj, additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E, additional, Jarick, Ivonne, additional, Johansson, Åsa, additional, Johnson, Toby, additional, Kanoni, Stavroula, additional, Kleber, Marcus E, additional, König, Inke R, additional, Kristiansson, Kati, additional, Kutalik, Zoltán, additional, Lamina, Claudia, additional, Lecoeur, Cecile, additional, Li, Guo, additional, Mangino, Massimo, additional, McArdle, Wendy L, additional, Medina-Gomez, Carolina, additional, Müller-Nurasyid, Martina, additional, Ngwa, Julius S, additional, Nolte, Ilja M, additional, Paternoster, Lavinia, additional, Pechlivanis, Sonali, additional, Perola, Markus, additional, Peters, Marjolein J, additional, Preuss, Michael, additional, Rose, Lynda M, additional, Shi, Jianxin, additional, Shungin, Dmitry, additional, Smith, Albert Vernon, additional, Strawbridge, Rona J, additional, Surakka, Ida, additional, Teumer, Alexander, additional, Trip, Mieke D, additional, Tyrer, Jonathan, additional, Van Vliet-Ostaptchouk, Jana V, additional, Vandenput, Liesbeth, additional, Waite, Lindsay L, additional, Zhao, Jing Hua, additional, Absher, Devin, additional, Asselbergs, Folkert W, additional, Atalay, Mustafa, additional, Attwood, Antony P, additional, Balmforth, Anthony J, additional, Basart, Hanneke, additional, Beilby, John, additional, Bonnycastle, Lori L, additional, Brambilla, Paolo, additional, Bruinenberg, Marcel, additional, Campbell, Harry, additional, Chasman, Daniel I, additional, Chines, Peter S, additional, Collins, Francis S, additional, Connell, John M, additional, Cookson, William O, additional, de Faire, Ulf, additional, de Vegt, Femmie, additional, Dei, Mariano, additional, Dimitriou, Maria, additional, Edkins, Sarah, additional, Estrada, Karol, additional, Evans, David M, additional, Farrall, Martin, additional, Ferrario, Marco M, additional, Ferrières, Jean, additional, Franke, Lude, additional, Frau, Francesca, additional, Gejman, Pablo V, additional, Grallert, Harald, additional, Grönberg, Henrik, additional, Gudnason, Vilmundur, additional, Hall, Alistair S, additional, Hall, Per, additional, Hartikainen, Anna-Liisa, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L, additional, Heath, Andrew C, additional, Hebebrand, Johannes, additional, Homuth, Georg, additional, Hu, Frank B, additional, Hunt, Sarah E, additional, Hyppönen, Elina, additional, Iribarren, Carlos, additional, Jacobs, Kevin B, additional, Jansson, John-Olov, additional, Jula, Antti, additional, Kähönen, Mika, additional, Kathiresan, Sekar, additional, Kee, Frank, additional, Khaw, Kay-Tee, additional, Kivimäki, Mika, additional, Koenig, Wolfgang, additional, Kraja, Aldi T, additional, Kumari, Meena, additional, Kuulasmaa, Kari, additional, Kuusisto, Johanna, additional, Laitinen, Jaana H, additional, Lakka, Timo A, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lind, Lars, additional, Lindström, Jaana, additional, Liu, Jianjun, additional, Liuzzi, Antonio, additional, Lokki, Marja-Liisa, additional, Lorentzon, Mattias, additional, Madden, Pamela A, additional, Magnusson, Patrik K, additional, Manunta, Paolo, additional, Marek, Diana, additional, März, Winfried, additional, Leach, Irene Mateo, additional, McKnight, Barbara, additional, Medland, Sarah E, additional, Mihailov, Evelin, additional, Milani, Lili, additional, Montgomery, Grant W, additional, Mooser, Vincent, additional, Mühleisen, Thomas W, additional, Munroe, Patricia B, additional, Musk, Arthur W, additional, Narisu, Narisu, additional, Navis, Gerjan, additional, Nicholson, George, additional, Nohr, Ellen A, additional, Ong, Ken K, additional, Oostra, Ben A, additional, Palmer, Colin N A, additional, Palotie, Aarno, additional, Peden, John F, additional, Pedersen, Nancy, additional, Peters, Annette, additional, Polasek, Ozren, additional, Pouta, Anneli, additional, Pramstaller, Peter P, additional, Prokopenko, Inga, additional, Pütter, Carolin, additional, Radhakrishnan, Aparna, additional, Raitakari, Olli, additional, Rendon, Augusto, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Saaristo, Timo E, additional, Sambrook, Jennifer G, additional, Sanders, Alan R, additional, Sanna, Serena, additional, Saramies, Jouko, additional, Schipf, Sabine, additional, Schreiber, Stefan, additional, Schunkert, Heribert, additional, Shin, So-Youn, additional, Signorini, Stefano, additional, Sinisalo, Juha, additional, Skrobek, Boris, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Stark, Klaus, additional, Stephens, Jonathan C, additional, Stirrups, Kathleen, additional, Stolk, Ronald P, additional, Stumvoll, Michael, additional, Swift, Amy J, additional, Theodoraki, Eirini V, additional, Thorand, Barbara, additional, Tregouet, David-Alexandre, additional, Tremoli, Elena, additional, Van der Klauw, Melanie M, additional, van Meurs, Joyce B J, additional, Vermeulen, Sita H, additional, Viikari, Jorma, additional, Virtamo, Jarmo, additional, Vitart, Veronique, additional, Waeber, Gérard, additional, Wang, Zhaoming, additional, Widén, Elisabeth, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Winkelmann, Bernhard R, additional, Witteman, Jacqueline C M, additional, Wolffenbuttel, Bruce H R, additional, Wong, Andrew, additional, Wright, Alan F, additional, Zillikens, M Carola, additional, Amouyel, Philippe, additional, Boehm, Bernhard O, additional, Boerwinkle, Eric, additional, Boomsma, Dorret I, additional, Caulfield, Mark J, additional, Chanock, Stephen J, additional, Cupples, L Adrienne, additional, Cusi, Daniele, additional, Dedoussis, George V, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Franks, Paul W, additional, Froguel, Philippe, additional, Gieger, Christian, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Harris, Tamara B, additional, Hengstenberg, Christian, additional, Hicks, Andrew A, additional, Hingorani, Aroon, additional, Hinney, Anke, additional, Hofman, Albert, additional, Hovingh, Kees G, additional, Hveem, Kristian, additional, Illig, Thomas, additional, Jarvelin, Marjo-Riitta, additional, Jöckel, Karl-Heinz, additional, Keinanen-Kiukaanniemi, Sirkka M, additional, Kiemeney, Lambertus A, additional, Kuh, Diana, additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Levinson, Douglas F, additional, Martin, Nicholas G, additional, Metspalu, Andres, additional, Morris, Andrew D, additional, Nieminen, Markku S, additional, Njølstad, Inger, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine J, additional, Ouwehand, Willem H, additional, Palmer, Lyle J, additional, Penninx, Brenda, additional, Power, Chris, additional, Province, Michael A, additional, Psaty, Bruce M, additional, Qi, Lu, additional, Rauramaa, Rainer, additional, Ridker, Paul M, additional, Ripatti, Samuli, additional, Salomaa, Veikko, additional, Samani, Nilesh J, additional, Snieder, Harold, additional, Sørensen, Thorkild I A, additional, Spector, Timothy D, additional, Stefansson, Kari, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Uitterlinden, André G, additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, Vollenweider, Peter, additional, Wallaschofski, Henri, additional, Wareham, Nicholas J, additional, Watkins, Hugh, additional, Wichmann, H-Erich, additional, Wilson, James F, additional, Abecasis, Goncalo R, additional, Assimes, Themistocles L, additional, Barroso, Inês, additional, Boehnke, Michael, additional, Borecki, Ingrid B, additional, Deloukas, Panos, additional, Fox, Caroline S, additional, Frayling, Timothy, additional, Groop, Leif C, additional, Haritunian, Talin, additional, Heid, Iris M, additional, Hunter, David, additional, Kaplan, Robert C, additional, Karpe, Fredrik, additional, Moffatt, Miriam F, additional, Mohlke, Karen L, additional, O'Connell, Jeffrey R, additional, Pawitan, Yudi, additional, Schadt, Eric E, additional, Schlessinger, David, additional, Steinthorsdottir, Valgerdur, additional, Strachan, David P, additional, Thorsteinsdottir, Unnur, additional, van Duijn, Cornelia M, additional, Visscher, Peter M, additional, Di Blasio, Anna Maria, additional, Hirschhorn, Joel N, additional, Lindgren, Cecilia M, additional, Morris, Andrew P, additional, Meyre, David, additional, Scherag, André, additional, McCarthy, Mark I, additional, Speliotes, Elizabeth K, additional, North, Kari E, additional, Loos, Ruth J F, additional, and Ingelsson, Erik, additional

Published
2013
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34. Correction: Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones—Role of Age and Comorbid Diseases

Author

Gudbjartsson, Daniel F., primary, Holm, Hilma, additional, Indridason, Olafur S., additional, Thorleifsson, Gudmar, additional, Edvardsson, Vidar, additional, Sulem, Patrick, additional, de Vegt, Femmie, additional, d'Ancona, Frank C. H., additional, den Heijer, Martin, additional, Wetzels, Jack F. M., additional, Franzson, Leifur, additional, Rafnar, Thorunn, additional, Kristjansson, Kristleifur, additional, Bjornsdottir, Unnur S., additional, Eyjolfsson, Gudmundur I., additional, Kiemeney, Lambertus A., additional, Kong, Augustine, additional, Palsson, Runolfur, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional

Published
2010
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36. Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones—Role of Age and Comorbid Diseases

Author

Gudbjartsson, Daniel F., primary, Holm, Hilma, additional, Indridason, Olafur S., additional, Thorleifsson, Gudmar, additional, Edvardsson, Vidar, additional, Sulem, Patrick, additional, de Vegt, Femmie, additional, d'Ancona, Frank C. H., additional, den Heijer, Martin, additional, Franzson, Leifur, additional, Rafnar, Thorunn, additional, Kristjansson, Kristleifur, additional, Bjornsdottir, Unnur S., additional, Eyjolfsson, Gudmundur I., additional, Kiemeney, Lambertus A., additional, Kong, Augustine, additional, Palsson, Runolfur, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional

Published
2010
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37. Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density

Author

Thorleifsson, Gudmar, primary, Holm, Hilma, additional, Edvardsson, Vidar, additional, Walters, G Bragi, additional, Styrkarsdottir, Unnur, additional, Gudbjartsson, Daniel F, additional, Sulem, Patrick, additional, Halldorsson, Bjarni V, additional, de Vegt, Femmie, additional, d'Ancona, Frank C H, additional, den Heijer, Martin, additional, Franzson, Leifur, additional, Christiansen, Claus, additional, Alexandersen, Peter, additional, Rafnar, Thorunn, additional, Kristjansson, Kristleifur, additional, Sigurdsson, Gunnar, additional, Kiemeney, Lambertus A, additional, Bodvarsson, Magnus, additional, Indridason, Olafur S, additional, Palsson, Runolfur, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional

Published
2009
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38. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

Author

Rafnar, Thorunn, primary, Sulem, Patrick, additional, Stacey, Simon N, additional, Geller, Frank, additional, Gudmundsson, Julius, additional, Sigurdsson, Asgeir, additional, Jakobsdottir, Margret, additional, Helgadottir, Hafdis, additional, Thorlacius, Steinunn, additional, Aben, Katja K H, additional, Blöndal, Thorarinn, additional, Thorgeirsson, Thorgeir E, additional, Thorleifsson, Gudmar, additional, Kristjansson, Kristleifur, additional, Thorisdottir, Kristin, additional, Ragnarsson, Rafn, additional, Sigurgeirsson, Bardur, additional, Skuladottir, Halla, additional, Gudbjartsson, Tomas, additional, Isaksson, Helgi J, additional, Einarsson, Gudmundur V, additional, Benediktsdottir, Kristrun R, additional, Agnarsson, Bjarni A, additional, Olafsson, Karl, additional, Salvarsdottir, Anna, additional, Bjarnason, Hjordis, additional, Asgeirsdottir, Margret, additional, Kristinsson, Kari T, additional, Matthiasdottir, Sigurborg, additional, Sveinsdottir, Steinunn G, additional, Polidoro, Silvia, additional, Höiom, Veronica, additional, Botella-Estrada, Rafael, additional, Hemminki, Kari, additional, Rudnai, Peter, additional, Bishop, D Timothy, additional, Campagna, Marcello, additional, Kellen, Eliane, additional, Zeegers, Maurice P, additional, de Verdier, Petra, additional, Ferrer, Ana, additional, Isla, Dolores, additional, Vidal, Maria Jesus, additional, Andres, Raquel, additional, Saez, Berta, additional, Juberias, Pablo, additional, Banzo, Javier, additional, Navarrete, Sebastian, additional, Tres, Alejandro, additional, Kan, Donghui, additional, Lindblom, Annika, additional, Gurzau, Eugene, additional, Koppova, Kvetoslava, additional, de Vegt, Femmie, additional, Schalken, Jack A, additional, van der Heijden, Henricus F M, additional, Smit, Hans J, additional, Termeer, René A, additional, Oosterwijk, Egbert, additional, van Hooij, Onno, additional, Nagore, Eduardo, additional, Porru, Stefano, additional, Steineck, Gunnar, additional, Hansson, Johan, additional, Buntinx, Frank, additional, Catalona, William J, additional, Matullo, Giuseppe, additional, Vineis, Paolo, additional, Kiltie, Anne E, additional, Mayordomo, José I, additional, Kumar, Rajiv, additional, Kiemeney, Lambertus A, additional, Frigge, Michael L, additional, Jonsson, Thorvaldur, additional, Saemundsson, Hafsteinn, additional, Barkardottir, Rosa B, additional, Jonsson, Eirikur, additional, Jonsson, Steinn, additional, Olafsson, Jon H, additional, Gulcher, Jeffrey R, additional, Masson, Gisli, additional, Gudbjartsson, Daniel F, additional, Kong, Augustine, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional

Published
2009
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43. Cardiovascular events in type 2 diabetes: comparison with nondiabetic individuals without and with prior cardiovascular disease.

Author

Becker, Annemarie, Bos, Griët, de Vegt, Femmie, Kostense, Piet J, Dekker, Jacqueline M, Nijpels, Giel, Heine, Robert J, Bouter, Lex M, and Stehouwer, Coen D.A

Abstract

Aims We questioned whether prior cardiovascular disease has the same impact on risk of cardiovascular events as type 2 diabetes, and whether this differed between men and women.Methods and results To address these issues we compared the 10-year risk of cardiovascular events among 208 Caucasian individuals with diabetes to that of 2253 Caucasian individuals without diabetes, in a population-based cohort study. Gender significantly modified the association between type 2 diabetes and cardiovascular events (p=0.01). The hazard ratio of cardiovascular events associated with the presence of diabetes was higher in women (adjusted hazard ratio, 1.8; 95% CI, 1.2 to 2.7) than in men (adjusted hazard ratio, 1.3; 0.9 to 2). As compared to men without diabetes but with prior cardiovascular disease, risk of cardiovascular events was significantly lower in men with diabetes but without prior cardiovascular disease (adjusted hazard ratio, 0.5; 0.3 to 0.9). In contrast, this risk was equal in women with diabetes but without prior cardiovascular disease and women without diabetes but with prior cardiovascular disease (adjusted hazard ratio, 1.0; 0.6 to 1.7; P for interaction between gender and diabetes=0.05).Conclusions Women with diabetes but without prior cardiovascular disease have a risk of cardiovascular events that is similar to that of women without diabetes but with prior cardiovascular disease, whereas in men the presence of prior cardiovascular disease conferred a higher risk. These data emphasise the necessity of aggressive treatment of cardiovascular risk factors in women with type 2 diabetes. [ABSTRACT FROM PUBLISHER]

Published
2003
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44. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Author

Berndt, Sonja I., Gustafsson, Stefan, Mägi, Reedik, Ganna, Andrea, Wheeler, Eleanor, Feitosa, Mary F., Justice, Anne E., Monda, Keri L., Croteau-Chonka, Damien C., Day, Felix R., Esko, Tõnu, Fall, Tove, Ferreira, Teresa, Gentilini, Davide, Jackson, Anne U., Luan, Jian’an, Randall, Joshua C., Vedantam, Sailaja, Willer, Cristen J., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Hu, Yi-Juan, Lee, Sang Hong, Liang, Liming, Lin, Dan-Yu, Min, Josine L., Neale, Benjamin M., Thorleifsson, Gudmar, Yang, Jian, Albrecht, Eva, Amin, Najaf, Bragg-Gresham, Jennifer L., Cadby, Gemma, den Heijer, Martin, Eklund, Niina, Fischer, Krista, Goel, Anuj, Hottenga, Jouke-Jan, Huffman, Jennifer E., Jarick, Ivonne, Johansson, Åsa, Johnson, Toby, Kanoni, Stavroula, Kleber, Marcus E., König, Inke R., Kristiansson, Kati, Kutalik, Zoltán, Lamina, Claudia, Lecoeur, Cecile, Li, Guo, Mangino, Massimo, McArdle, Wendy L., Medina-Gomez, Carolina, Müller-Nurasyid, Martina, Ngwa, Julius S., Nolte, Ilja M., Paternoster, Lavinia, Pechlivanis, Sonali, Perola, Markus, Peters, Marjolein J., Preuss, Michael, Rose, Lynda M., Shi, Jianxin, Shungin, Dmitry, Smith, Albert Vernon, Strawbridge, Rona J., Surakka, Ida, Teumer, Alexander, Trip, Mieke D., Tyrer, Jonathan, Van Vliet-Ostaptchouk, Jana V., Vandenput, Liesbeth, Waite, Lindsay L., Zhao, Jing Hua, Absher, Devin, Asselbergs, Folkert W., Atalay, Mustafa, Attwood, Antony P., Balmforth, Anthony J., Basart, Hanneke, Beilby, John, Bonnycastle, Lori L., Brambilla, Paolo, Bruinenberg, Marcel, Campbell, Harry, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Connell, John M., Cookson, William, de Faire, Ulf, de Vegt, Femmie, Dei, Mariano, Dimitriou, Maria, Edkins, Sarah, Estrada, Karol, Evans, David M., Farrall, Martin, Ferrario, Marco M., Ferrières, Jean, Franke, Lude, Frau, Francesca, Gejman, Pablo V., Grallert, Harald, Grönberg, Henrik, Gudnason, Vilmundur, Hall, Alistair S., Hall, Per, Hartikainen, Anna-Liisa, Hayward, Caroline, Heard-Costa, Nancy L., Heath, Andrew C., Hebebrand, Johannes, Homuth, Georg, Hu, Frank B., Hunt, Sarah E., Hyppönen, Elina, Iribarren, Carlos, Jacobs, Kevin B., Jansson, John-Olov, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Kee, Frank, Khaw, Kay-Tee, Kivimaki, Mika, Koenig, Wolfgang, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Laitinen, Jaana H., Lakka, Timo A., Langenberg, Claudia, Launer, Lenore J., Lind, Lars, Lindström, Jaana, Liu, Jianjun, Liuzzi, Antonio, Lokki, Marja-Liisa, Lorentzon, Mattias, Madden, Pamela A., Magnusson, Patrik K., Manunta, Paolo, Marek, Diana, März, Winfried, Mateo Leach, Irene, McKnight, Barbara, Medland, Sarah E., Mihailov, Evelin, Milani, Lili, Montgomery, Grant W., Mooser, Vincent, Mühleisen, Thomas W., Munroe, Patricia B., Musk, Arthur W., Narisu, Narisu, Navis, Gerjan, Nicholson, George, Nohr, Ellen A., Ong, Ken K., Oostra, Ben A., Palmer, Colin N.A., Palotie, Aarno, Peden, John F., Pedersen, Nancy, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P., Prokopenko, Inga, Pütter, Carolin, Radhakrishnan, Aparna, Raitakari, Olli, Rendon, Augusto, Rivadeneira, Fernando, Rudan, Igor, Saaristo, Timo E., Sambrook, Jennifer G., Sanders, Alan R., Sanna, Serena, Saramies, Jouko, Schipf, Sabine, Schreiber, Stefan, Schunkert, Heribert, Shin, So-Youn, Signorini, Stefano, Sinisalo, Juha, Skrobek, Boris, Soranzo, Nicole, Stančáková, Alena, Stark, Klaus, Stephens, Jonathan C., Stirrups, Kathleen, Stolk, Ronald P., Stumvoll, Michael, Swift, Amy J., Theodoraki, Eirini V., Thorand, Barbara, Tregouet, David-Alexandre, Tremoli, Elena, Van der Klauw, Melanie M., van Meurs, Joyce B.J., Vermeulen, Sita H., Viikari, Jorma, Virtamo, Jarmo, Vitart, Veronique, Waeber, Gérard, Wang, Zhaoming, Widén, Elisabeth, Wild, Sarah H., Willemsen, Gonneke, Winkelmann, Bernhard R., Witteman, Jacqueline C.M., Wolffenbuttel, Bruce H.R., Wong, Andrew, Wright, Alan F., Zillikens, M. Carola, Amouyel, Philippe, Boehm, Bernhard O., Boerwinkle, Eric, Boomsma, Dorret I., Caulfield, Mark J., Chanock, Stephen J., Cupples, L. Adrienne, Cusi, Daniele, Dedoussis, George V., Erdmann, Jeanette, Eriksson, Johan G., Franks, Paul W., Froguel, Philippe, Gieger, Christian, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B., Hengstenberg, Christian, Hicks, Andrew A., Hingorani, Aroon, Hinney, Anke, Hofman, Albert, Hovingh, Kees G., Hveem, Kristian, Illig, Thomas, Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Kuh, Diana, Laakso, Markku, Lehtimäki, Terho, Levinson, Douglas F., Martin, Nicholas G., Metspalu, Andres, Morris, Andrew D., Nieminen, Markku S., Njølstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J., Ouwehand, Willem H., Palmer, Lyle J., Penninx, Brenda, Power, Chris, Province, Michael A., Psaty, Bruce M., Qi, Lu, Rauramaa, Rainer, Ridker, Paul M., Ripatti, Samuli, Salomaa, Veikko, Samani, Nilesh J., Snieder, Harold, Sørensen, Thorkild I.A., Spector, Timothy D., Stefansson, Kari, Tönjes, Anke, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Vollenweider, Peter, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H.-Erich, Wilson, James F., Abecasis, Goncalo R., Assimes, Themistocles L., Barroso, Inês, Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Frayling, Timothy, Groop, Leif C., Haritunian, Talin, Heid, Iris M., Hunter, David, Kaplan, Robert C., Karpe, Fredrik, Moffatt, Miriam, Mohlke, Karen L., O’Connell, Jeffrey R., Pawitan, Yudi, Schadt, Eric E., Schlessinger, David, Steinthorsdottir, Valgerdur, Strachan, David P., Thorsteinsdottir, Unnur, van Duijn, Cornelia M., Visscher, Peter M., Di Blasio, Anna Maria, Hirschhorn, Joel N., Lindgren, Cecilia M., Morris, Andrew P., Meyre, David, Scherag, André, McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Loos, Ruth J.F., and Ingelsson, Erik

Abstract

Approaches exploiting extremes of the trait distribution may reveal novel loci for common traits, but it is unknown whether such loci are generalizable to the general population. In a genome-wide search for loci associated with upper vs. lower 5th percentiles of body mass index, height and waist-hip ratio, as well as clinical classes of obesity including up to 263,407 European individuals, we identified four new loci (IGFBP4, H6PD, RSRC1, PPP2R2A) influencing height detected in the tails and seven new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3, ZZZ3) for clinical classes of obesity. Further, we show that there is large overlap in terms of genetic structure and distribution of variants between traits based on extremes and the general population and little etiologic heterogeneity between obesity subgroups.

Published
2014
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45. [The relationship between lifestyle and cancer; topic of conversation in the consultation room?]

Author

Swankhuisen C, Evers J, Kiemeney LALM, Hoogerbrugge N, and de Vegt F

Subjects
Adult, Female, General Practitioners, Healthy Lifestyle, Humans, Male, Middle Aged, Professional Role, Surveys and Questionnaires, Attitude of Health Personnel, Life Style, Neoplasms psychology, Physician-Patient Relations
Abstract

Objective: This survey explores the degree of consensus amongst healthcare professionals for the support of cancer patients' lifestyle management, based on three questions posed to them: a) what do they know about the relation between lifestyle and cancer?; b) do they consider lifestyle support for cancer patients part of their professional role?; c) does their own lifestyle influence the lifestyle management consultations they may have with cancer patients? Design Survey study., Method: A digital questionnaire with questions concerning lifestyle and cancer was sent to 1550 healthcare professionals in and around Nijmegen. The questionnaire was filled out by 562 healthcare professionals (36% response rate), of whom 404 (72%) were involved in cancer patient care. This cohort of responders consisted of 170 medical specialists, 62 general practitioners, and 172 nurses and allied health professionals., Results: Healthcare professionals acknowledge the influence of lifestyle on the development of cancer. Almost all healthcare professionals (98%) agree on the positive effects of a healthy lifestyle on the well-being of cancer patients. Approximately two-thirds of all responders believe that lifestyle support should 'usually' or 'always' form part of cancer care; about fifty percent report to implement this in clinical practice. Healthcare professionals require evidence-based knowledge concerning the relationship between lifestyle and cancer, patient information materials, and additional consultation time to support lifestyle management involving cancer patients. The healthcare professionals' own lifestyle appears to have an influence: in those responders who do not adhere to a healthy lifestyle themselves, lifestyle was also covered less in consultations., Conclusion: This explorative survey shows that lifestyle support of cancer patients is deemed an important topic amongst healthcare professionals.

Published
2019

46. [Patients on the move: validated methods to quantify physical activity].

Author

Bakker EA, Eijsvogels TM, de Vegt F, Busser GS, Hopman MT, and Verbeek A

Subjects
Body Water diagnostic imaging, Calorimetry, Indirect, Exercise physiology, Humans, Monitoring, Physiologic methods, Netherlands, Physical Fitness physiology, Radionuclide Imaging, Reproducibility of Results, Energy Metabolism physiology, Observation methods, Sedentary Behavior, Surveys and Questionnaires standards
Abstract

Physical activity is an important component in the maintenance and improvement of general health; physical inactivity is, however, an increasing problem in the Netherlands. Requests for advice on physical activity are increasing within the healthcare. Assessment of an individual's physical activity pattern is required to provide tailored advice. There are a number of methods for measuring physical activity; these are divided into subjective and objective methods. Subjective measures include physical activity questionnaires and diaries. Objective measures include indirect calorimetry, measurement with doubly labelled water, heart-rate monitoring and the use of an accelerometer or pedometer. The choice of method depends predominantly on the aim of the measurement, and the availability of personnel, time and financial resources. In clinical practice a validated questionnaire is usually the preferred method, but when measuring effects this should be combined with an objective measurement instrument.

Published
2015

47. Entering a new era of body indices: the feasibility of a body shape index and body roundness index to identify cardiovascular health status.

Author

Maessen MF, Eijsvogels TM, Verheggen RJ, Hopman MT, Verbeek AL, and de Vegt F

Subjects
Body Mass Index, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Humans, Odds Ratio, Population Surveillance, Prevalence, Risk Factors, Surveys and Questionnaires, Waist Circumference, Anthropometry, Cardiovascular System, Health Status
Abstract

Background: The Body Mass Index (BMI) and Waist Circumference (WC) are well-used anthropometric predictors for cardiovascular diseases (CVD), but their validity is regularly questioned. Recently, A Body Shape Index (ABSI) and Body Roundness Index (BRI) were introduced as alternative anthropometric indices that may better reflect health status., Objective: This study assessed the capacity of ABSI and BRI in identifying cardiovascular diseases and cardiovascular disease risk factors and determined whether they are superior to BMI and WC., Design and Methods: 4627 Participants (54±12 years) of the Nijmegen Exercise Study completed an online questionnaire concerning CVD health status (defined as history of CVD or CVD risk factors) and anthropometric characteristics. Quintiles of ABSI, BRI, BMI, and WC were used regarding CVD prevalence. Odds ratios (OR), adjusted for age, sex, and smoking, were calculated per anthropometric index., Results: 1332 participants (27.7%) reported presence of CVD or CVD risk factors. The prevalence of CVD increased across quintiles for BMI, ABSI, BRI, and WC. Comparing the lowest with the highest quintile, adjusted OR (95% CI) for CVD were significantly different for BRI 3.2 (1.4-7.2), BMI 2.4 (1.9-3.1), and WC 3.0 (1.6-5.6). The adjusted OR (95% CI) for CVD risk factors was for BRI 2.5 (2.0-3.3), BMI 3.3 (1.6-6.8), and WC 2.0 (1.6-2.5). No association was observed for ABSI in both groups., Conclusions: BRI, BMI, and WC are able to determine CVD presence, while ABSI is not capable. Nevertheless, the capacity of BRI as a novel body index to identify CVD was not superior compared to established anthropometric indices like BMI and WC.

Published
2014
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48. [Aftercare in oncology--greater role for the general practitioner].

Author

de Vegt F, van Dijck JA, van de Lisdonk EH, and Verbeek AL

Subjects
Disease-Free Survival, Humans, Neoplasms epidemiology, Netherlands epidemiology, Patient-Centered Care, Physician-Patient Relations, Practice Patterns, Physicians', Prevalence, Aftercare, Continuity of Patient Care, Delivery of Health Care standards, General Practitioners standards, Neoplasms therapy, Physician's Role
Abstract

Patients who undergo curative treatment for cancer continue to be medically monitored for a number of years. Scheduled aftercare, mainly aimed at early detection of locoregional cancer recurrences, distant metastases and secondary primary tumours, takes place chiefly in the second line, but is expected to shift to the first line. Figures from the Nijmegen Continuous Morbidity Registration show that an average (Dutch) general practitioner, caring for about 2500 patients, has in his practice 90 patients who have or have had cancer. This number will increase due to the increasing prevalence of cancer. In addition, extra consultations for each cancer patient will increase the demand for GP care.

Published
2011

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