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2. P44 - Colorectal cancer screening participation in childhood cancer survivors: a report from the French Childhood Cancer Survivors Study (FCCSS)

Author

Ouanounou, J., primary, Bejarano-Quisoboni, D., additional, Bougas, N., additional, Allodji, R., additional, Vu-Bezin, G., additional, Souchard, V., additional, Fayech, C., additional, Dumas, A., additional, Journy, N., additional, Demoor-Goldschmidt, C., additional, Pacquement, H., additional, Pluchart, C., additional, Bondiau, PY., additional, Quintin, C., additional, Dufour, C., additional, Valteau-Couanet, D., additional, De Vathaire, F., additional, and Fresneau, B., additional

Published
2024
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5. Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers

Author

Sugier, P, Lucotte, E, Domenighetti, C, Law, M, Iles, M, Brown, K, Amos, C, Mckay, J, Hung, R, Karimi, M, Bacq-Daian, D, Boland-Auge, A, Olaso, R, Deleuze, J, Lesueur, F, Ostroumova, E, Kesminiene, A, de Vathaire, F, Guenel, P, Sreelatha, A, Schulte, C, Grover, S, May, P, Bobbili, D, Radivojkov-Blagojevic, M, Lichtner, P, Singleton, A, Hernandez, D, Edsall, C, Mellick, G, Zimprich, A, Pirker, W, Rogaeva, E, Lang, A, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, J, Chartier-Harlin, M, Mutez, E, Brockmann, K, Deutschlander, A, Hadjigeorgiou, G, Dardiotis, E, Stefanis, L, Simitsi, A, Valente, E, Petrucci, S, Straniero, L, Zecchinelli, A, Pezzoli, G, Brighina, L, Ferrarese, C, Annesi, G, Quattrone, A, Gagliardi, M, Matsuo, H, Nakayama, A, Hattori, N, Nishioka, K, Chung, S, Kim, Y, Kolber, P, van de Warrenburg, B, Bloem, B, Aasly, J, Toft, M, Pihlstrom, L, Guedes, L, Ferreira, J, Bardien, S, Carr, J, Tolosa, E, Ezquerra, M, Pastor, P, Diez-Fairen, M, Wirdefeldt, K, Pedersen, N, Ran, C, Belin, A, Puschmann, A, Rodstrom, E, Clarke, C, Morrison, K, Tan, M, Krainc, D, Burbulla, L, Farrer, M, Kruger, R, Gasser, T, Sharma, M, Truong, T, Elbaz, A, Sugier P. -E., Lucotte E. A., Domenighetti C., Law M. H., Iles M. M., Brown K., Amos C., McKay J. D., Hung R. J., Karimi M., Bacq-Daian D., Boland-Auge A., Olaso R., Deleuze J. -F., Lesueur F., Ostroumova E., Kesminiene A., de Vathaire F., Guenel P., Sreelatha A. A. K., Schulte C., Grover S., May P., Bobbili D. R., Radivojkov-Blagojevic M., Lichtner P., Singleton A. B., Hernandez D. G., Edsall C., Mellick G. D., Zimprich A., Pirker W., Rogaeva E., Lang A. E., Koks S., Taba P., Lesage S., Brice A., Corvol J. -C., Chartier-Harlin M. -C., Mutez E., Brockmann K., Deutschlander A. B., Hadjigeorgiou G. M., Dardiotis E., Stefanis L., Simitsi A. M., Valente E. M., Petrucci S., Straniero L., Zecchinelli A., Pezzoli G., Brighina L., Ferrarese C., Annesi G., Quattrone A., Gagliardi M., Matsuo H., Nakayama A., Hattori N., Nishioka K., Chung S. J., Kim Y. J., Kolber P., van de Warrenburg B. P. C., Bloem B. R., Aasly J., Toft M., Pihlstrom L., Guedes L. C., Ferreira J. J., Bardien S., Carr J., Tolosa E., Ezquerra M., Pastor P., Diez-Fairen M., Wirdefeldt K., Pedersen N., Ran C., Belin A. C., Puschmann A., Rodstrom E. Y., Clarke C. E., Morrison K. E., Tan M., Krainc D., Burbulla L. F., Farrer M. J., Kruger R., Gasser T., Sharma M., Truong T., Elbaz A., Sugier, P, Lucotte, E, Domenighetti, C, Law, M, Iles, M, Brown, K, Amos, C, Mckay, J, Hung, R, Karimi, M, Bacq-Daian, D, Boland-Auge, A, Olaso, R, Deleuze, J, Lesueur, F, Ostroumova, E, Kesminiene, A, de Vathaire, F, Guenel, P, Sreelatha, A, Schulte, C, Grover, S, May, P, Bobbili, D, Radivojkov-Blagojevic, M, Lichtner, P, Singleton, A, Hernandez, D, Edsall, C, Mellick, G, Zimprich, A, Pirker, W, Rogaeva, E, Lang, A, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, J, Chartier-Harlin, M, Mutez, E, Brockmann, K, Deutschlander, A, Hadjigeorgiou, G, Dardiotis, E, Stefanis, L, Simitsi, A, Valente, E, Petrucci, S, Straniero, L, Zecchinelli, A, Pezzoli, G, Brighina, L, Ferrarese, C, Annesi, G, Quattrone, A, Gagliardi, M, Matsuo, H, Nakayama, A, Hattori, N, Nishioka, K, Chung, S, Kim, Y, Kolber, P, van de Warrenburg, B, Bloem, B, Aasly, J, Toft, M, Pihlstrom, L, Guedes, L, Ferreira, J, Bardien, S, Carr, J, Tolosa, E, Ezquerra, M, Pastor, P, Diez-Fairen, M, Wirdefeldt, K, Pedersen, N, Ran, C, Belin, A, Puschmann, A, Rodstrom, E, Clarke, C, Morrison, K, Tan, M, Krainc, D, Burbulla, L, Farrer, M, Kruger, R, Gasser, T, Sharma, M, Truong, T, Elbaz, A, Sugier P. -E., Lucotte E. A., Domenighetti C., Law M. H., Iles M. M., Brown K., Amos C., McKay J. D., Hung R. J., Karimi M., Bacq-Daian D., Boland-Auge A., Olaso R., Deleuze J. -F., Lesueur F., Ostroumova E., Kesminiene A., de Vathaire F., Guenel P., Sreelatha A. A. K., Schulte C., Grover S., May P., Bobbili D. R., Radivojkov-Blagojevic M., Lichtner P., Singleton A. B., Hernandez D. G., Edsall C., Mellick G. D., Zimprich A., Pirker W., Rogaeva E., Lang A. E., Koks S., Taba P., Lesage S., Brice A., Corvol J. -C., Chartier-Harlin M. -C., Mutez E., Brockmann K., Deutschlander A. B., Hadjigeorgiou G. M., Dardiotis E., Stefanis L., Simitsi A. M., Valente E. M., Petrucci S., Straniero L., Zecchinelli A., Pezzoli G., Brighina L., Ferrarese C., Annesi G., Quattrone A., Gagliardi M., Matsuo H., Nakayama A., Hattori N., Nishioka K., Chung S. J., Kim Y. J., Kolber P., van de Warrenburg B. P. C., Bloem B. R., Aasly J., Toft M., Pihlstrom L., Guedes L. C., Ferreira J. J., Bardien S., Carr J., Tolosa E., Ezquerra M., Pastor P., Diez-Fairen M., Wirdefeldt K., Pedersen N., Ran C., Belin A. C., Puschmann A., Rodstrom E. Y., Clarke C. E., Morrison K. E., Tan M., Krainc D., Burbulla L. F., Farrer M. J., Kruger R., Gasser T., Sharma M., Truong T., and Elbaz A.

Abstract

Background: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. Objective: We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors. Methods: We used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses. Results: We confirmed a previously reported positive genetic correlation of PD with melanoma (Gcorr = 0.16 [0.04; 0.28]) and reported an additional significant positive correlation of PD with prostate cancer (Gcorr = 0.11 [0.03; 0.19]). There was a significant inverse association between the PRS for ovarian cancer and PD (odds ratio [OR] = 0.89 [0.84; 0.94]). Conversely, the PRS of PD was positively associated with breast cancer (OR = 1.08 [1.06; 1.10]) and inversely associated with ovarian cancer (OR = 0.95 [0.91; 0.99]). The association between PD and ovarian cancer was mostly driven b

Published
2023

11. Identification of rare variants involved in the risk of second cancer following radiotherapy and chemotherapy treatment of pediatric cancers

Author

Ducos, C., primary, Brice, F., additional, Rosselli, F., additional, Vu-Bezin, G., additional, Schwartz, B., additional, Allodji, R., additional, Marenne, G., additional, Ludwig, T., additional, Boland-Augé, A., additional, Blanché, H., additional, El-Fayech, C., additional, Rubino, C., additional, Diallo, I., additional, de Vathaire, F., additional, Benhamou, S., additional, and Haddy, N., additional

Published
2023
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13. CO12.1 - A case-control study to identify potential genetic biomarkers related to cardiac diseases occurrence in childhood cancer survivors

Author

Aba, N., primary, Belhechmi, S., additional, Fresneau, B., additional, El-Fayech, C., additional, Rubino, C., additional, Allodji, R., additional, Morel, E., additional, de la Grange, P., additional, Jolly, A., additional, Koscielny, S., additional, Vu-Bezin, G., additional, de Vathaire, F., additional, Teuff, G. Le, additional, and Haddy, N., additional

Published
2023
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29. Healthcare system barriers of breast and thyroid screening for childhood and young adulthood cancer survivors in France A qualitative study of the DeNaCaPST programme at one year

Author

Filhon B, G. Truc, Bernier, Charlotte Demoor-Goldschmidt, Dezellus A, Reguerre Y, Supiot S, de Vathaire F, Hélène Sudour-Bonnange, Bondiau, Briandet C, Céline Vigneron, Caroline Oudot, M Poirée Py, Gaudichon J, Line Claude, Padovani L, Agnès Dumas, Christine Kerr, Claire Berger, I. Guichard, and Coze C

Subjects
medicine.medical_specialty, Thyroid screening, business.industry, Family medicine, medicine, Cancer, Young adult, General Agricultural and Biological Sciences, business, medicine.disease, Qualitative research, Healthcare system
Abstract

Purpose Childhood, adolescent and young adult cancer survivors (CAYACS) who were treated by radiotherapy have a significant risk of developing subsequent malignancies, particularly breast and thyroid cancers when the field of irradiation concerned these organs. Advice regarding their increased risk of developing secondary breast (SBC) and thyroid (STC) cancer are recommended to ensure risk-stratified life-long follow-up care including appropriate screening. In France, a national program called DeNaCaPST was started to promote this care. We aimed to explore the perspectives of medical practitioners (MP) on the healthcare system factors that limited inclusion in this programme. Methods Data of the DeNaCAPST programme regarding organisation were studied, including data from a qualitative survey done among MP. Results Seventeen months after the DeNaCaPST programme started, 84.6% of the French regions had participating centres/hospitals, along with one overseas territory. The main barriers to screening highlighted by MP were: 1) inconvenient and under-resourced healthcare professionals to perform these consultations, (2) difficulty determining which CAYACS need SBC and/or STC screening, (3) difficulty organising the network of professionals from paediatric to adult health services. Conclusions Despite a slow inclusion speed and a suboptimal geographical coverage, changes are underway and should allow for several improvements and interesting perspectives for this study. CAYACS lost to follow-up are difficult to invite for a consultation. The absence of real long-term follow-up care is a real barrier to promoting such screening, which must involve a transition care between the paediatric oncologists who know who are at risk and why and the adult medical professionals who have the knowledge to do the screening. The involvement and empowerment of CAYACS is necessary to promote patient-centred healthcare solutions and seems feasible.

Published
2019

32. Late excess mortality in survivors of childhood and adolescent cancer: Results from the PanCareSurFup Study

Author

Schmidtmann, I, Byrne, J, Rashid, H, Grabow, D, Hagberg, O, Bardi, E, De Vathaire, F, Falck Winther, J, Gudmundsdottir, T, Haupt, R, Hawkins, MM, Jakab, Z, Jankovic, M, Kaatsch, P, Kremer, LMC, Kuehni, CE, Lähteenmäki, PM, Ronckers, CM, Sacerdote, C, Skinner, R, Terenziani, M, Zadravec Zaletel, L, Hjorth, L, Schmidtmann, I, Byrne, J, Rashid, H, Grabow, D, Hagberg, O, Bardi, E, De Vathaire, F, Falck Winther, J, Gudmundsdottir, T, Haupt, R, Hawkins, MM, Jakab, Z, Jankovic, M, Kaatsch, P, Kremer, LMC, Kuehni, CE, Lähteenmäki, PM, Ronckers, CM, Sacerdote, C, Skinner, R, Terenziani, M, Zadravec Zaletel, L, and Hjorth, L

Published
2019

36. Risk Factors of Small Final Height in Survivors of Childhood Cancer, Importance of the Irradiation Dose at the Hypophysis Gland

Author

Demoor-Goldschmidt, C., primary, Allodji, R., additional, Journy, N., additional, Rubino, C., additional, Zrafi, W., additional, Veres, C., additional, Diallo, I., additional, Thomas-Teinturier, C., additional, Bolle, S., additional, Berchery, D., additional, Haddy, N., additional, Pacquement, H., additional, Fresneau, B., additional, and De Vathaire, F., additional

Published
2019
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41. Long-term survivors of childhood cancer: cure and care—the Erice Statement (2006) revised after 10 years (2016)

Author

Jankovic, M, Haupt, R, Spinetta, J, Beck, J, Byrne, J, Calaminus, G, Lackner, H, Biondi, A, Oeffinger, K, Hudson, M, Skinner, R, Reaman, G, van der Pal, H, Kremer, L, Den Hartogh, J, Michel, G, Frey, E, Bardi, E, Hawkins, M, Rizvi, K, Terenziani, M, Valsecchi, M, Bode, G, Jenney, M, de Vathaire, F, Garwicz, S, Levitt, G, Grabow, D, Kuehni, C, Schrappe, M, Hjorth, L, Jankovic, Momcilo, Haupt, Riccardo, Spinetta, John J., Beck, Joern D., Byrne, Julianne, Calaminus, Gabriele, Lackner, Herwig, Biondi, Andrea, Oeffinger, Kevin, Hudson, Melissa, Skinner, Roderick, Reaman, Gregory, van der Pal, Helena, Kremer, Leontien, Den Hartogh, Jaap, Michel, Gisela, Frey, Eva, Bardi, Edit, Hawkins, Michael, Rizvi, Katie, Terenziani, Monica, Valsecchi, Maria Grazia, Bode, Gerlind, Jenney, Meriel, de Vathaire, Florent, Garwicz, Stanislaw, Levitt, Gill A., Grabow, Desiree, Kuehni, Claudia E., Schrappe, Martin, Hjorth, Lars, Jankovic, M, Haupt, R, Spinetta, J, Beck, J, Byrne, J, Calaminus, G, Lackner, H, Biondi, A, Oeffinger, K, Hudson, M, Skinner, R, Reaman, G, van der Pal, H, Kremer, L, Den Hartogh, J, Michel, G, Frey, E, Bardi, E, Hawkins, M, Rizvi, K, Terenziani, M, Valsecchi, M, Bode, G, Jenney, M, de Vathaire, F, Garwicz, S, Levitt, G, Grabow, D, Kuehni, C, Schrappe, M, Hjorth, L, Jankovic, Momcilo, Haupt, Riccardo, Spinetta, John J., Beck, Joern D., Byrne, Julianne, Calaminus, Gabriele, Lackner, Herwig, Biondi, Andrea, Oeffinger, Kevin, Hudson, Melissa, Skinner, Roderick, Reaman, Gregory, van der Pal, Helena, Kremer, Leontien, Den Hartogh, Jaap, Michel, Gisela, Frey, Eva, Bardi, Edit, Hawkins, Michael, Rizvi, Katie, Terenziani, Monica, Valsecchi, Maria Grazia, Bode, Gerlind, Jenney, Meriel, de Vathaire, Florent, Garwicz, Stanislaw, Levitt, Gill A., Grabow, Desiree, Kuehni, Claudia E., Schrappe, Martin, and Hjorth, Lars

Abstract

Purpose: The number of persons who have successfully completed treatment for a cancer diagnosed during childhood and who have entered adulthood is increasing over time, and former patients will become aging citizens. Methods: Ten years ago, an expert panel met in Erice, Italy, to produce a set of principles concerning the cure and care of survivors of childhood and adolescent cancer. The result was the Erice Statement (Haupt et al. Eur J Cancer 43(12):1778–80, 2007) that was translated into nine languages. Ten years on, it was timely to review, and possibly revise, the Erice Statement in view of the changes in paediatric oncology and the number and results of international follow-up studies conducted during the intervening years. Results: The long-term goal of the cure and care of a child with cancer is that he/she becomes a resilient and autonomous adult with optimal health-related quality of life, accepted in society at the same level as his/her age peers. “Cure” refers to cure from the original cancer, regardless of any potential for, or presence of, remaining disabilities or side effects of treatment. The care of a child with cancer should include complete and honest information for parents and the child. Conclusions and implication for cancer survivors: Some members of the previous expert panel, as well as new invited experts, met again in Erice to review the Erice Statement, producing a revised version including update and integration of each of the ten points. In addition, a declaration has been prepared, by the Childhood Cancer International Survivors Network in Dublin on October 2016 (see Annex 1).

Published
2018

42. Facteurs de risque des accidents vasculaires cérébraux survenant après radiothérapie pour un cancer de l’enfant : résultats du projets européen CerebRad

Author

de Vathaire, F., primary, Allodji, R., additional, Journy, N., additional, Portmans, P., additional, Mazal, A., additional, Deutsch, É., additional, Bolle, S., additional, Lefkopoulos, D., additional, Fresneau, B., additional, Zrafi, W., additional, Veres, C., additional, Vu-Bezin, G., additional, Haddy, N., additional, and Diallo, I., additional

Published
2018
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43. Impact on testicular function of a single ablative activity of 3.7 GBq radioactive iodine for differentiated thyroid carcinoma

Author

Bourcigaux, N, primary, Rubino, C, additional, Berthaud, I, additional, Toubert, M E, additional, Donadille, B, additional, Leenhardt, L, additional, Petrot-Keller, I, additional, Brailly-Tabard, S, additional, Fromigué, J, additional, de Vathaire, F, additional, Simon, T, additional, Siffroi, J P, additional, Schlumberger, M, additional, Bouchard, P, additional, and Christin-Maitre, S, additional

Published
2018
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44. PO-0842: Proton Therapy in children, adolescents and young adults: Patterns of care survey in Europe

Author

Journy, N., primary, Kleinerman, R., additional, Alapetite, C., additional, Bernier-Chastagner, V., additional, Dendale, R., additional, Bolle, S., additional, Doyen, J., additional, Gurtner, K., additional, Habrand, J.L., additional, Helfre, S., additional, Hoyer, M., additional, Krause, M., additional, Maduro, J., additional, Nyström, P.W., additional, Rombi, B., additional, Timmermann, B., additional, De Vathaire, F., additional, Weber, D.C., additional, Indelicato, D., additional, and Berrington de Gonzalez, A., additional

Published
2018
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45. OC-0600: Long term risk of stroke after childhood cancer radiotherapy

Author

De Vathaire, F., primary, El - Fayech, C., additional, Haddy, N., additional, Allodji, R., additional, Veres, C., additional, Llanas, D., additional, Journy, N., additional, Souchard, V., additional, Rubino, C., additional, Pacquement, H., additional, Teinturier, C., additional, Fresneau, B., additional, Vu-Bezin, G., additional, Bolle, S., additional, Mazal, A., additional, Poortmans, P., additional, Deutsch, E., additional, and Diallo, I., additional

Published
2018
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47. Impacts testiculaires du traitement par iode radioactif chez des hommes ayant un cancer thyroïdien : étude SAPIRA

Author

Bourcigaux, N., primary, Rubino, C., additional, Berthaud, I., additional, Donadille, B., additional, Toubert, M.E., additional, Leenhardt, L., additional, Corone, C., additional, Keller, I. Petrot, additional, Brailly, S., additional, Beaufaron, J., additional, De Vathaire, F., additional, Simon, T., additional, Siffroi, J.P., additional, Sclumberger, M., additional, Bouchard, P., additional, and Maitre, S. Christin, additional

Published
2017
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48. Abstract P2-06-04: Breast cancer after Hodgkin lymphoma: Influence of endogenous and exogenous gonadal hormones on the radiation dose-response relationship

Author

Krul, IM, primary, Opstal - van Winden, AWJ, additional, Aleman, BMP, additional, Janus, CPM, additional, van Eggermond, AM, additional, de Bruin, ML, additional, Hauptmann, M, additional, Krol, ADG, additional, Schaapveld, M, additional, Broeks, A, additional, Kooijman, KR, additional, Fase, S, additional, Lybeert, ML, additional, Zijlstra, JM, additional, van der Maazen, RWM, additional, Kesminiene, A, additional, Diallo, I, additional, de Vathaire, F, additional, Russell, NS, additional, and van Leeuwen, FE, additional

Published
2017
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49. Investigating the heterogeneity of alkylating agents’ efficacy and toxicity between sexes: A systematic review and meta-analysis of randomized trials comparing cyclophosphamide and ifosfamide (MAIAGE study)

Author

Fresneau, Brice, primary, Hackshaw, A., additional, Hawkins, D.S., additional, Paulussen, M., additional, Anderson, J.R., additional, Judson, I., additional, Litière, S., additional, Dirksen, U., additional, Lewis, I., additional, van den Berg, H., additional, Gaspar, N., additional, Gelderblom, H., additional, Whelan, J., additional, Boddy, A.V., additional, Wheatley, K., additional, Pignon, J.P., additional, De Vathaire, F., additional, Le Deley, M.C., additional, and Le Teuff, G., additional

Published
2017
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