1. Lyotropic liquid crystal mesophases as transdermal delivery systems for lipophilic drugs: A comparative study.
- Author
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de Araujo GRS, Azevedo Lima OV, Barreto Neujahr JP, Matos SS, de Souza TA, Dos Santos AM, Chorilli M, de Souza Araujo AA, Duarte MC, da Cunha Gonsalves JKM, de Souza Nunes R, Dos Santos MRV, Vitorino Sarmento VH, and Moreira Lira AA
- Subjects
- Pharmaceutical Preparations, Scattering, Small Angle, X-Ray Diffraction, Administration, Cutaneous, Skin, Liquid Crystals chemistry
- Abstract
The present work aimed to evaluate different Liquid Crystal Mesophases (LCM) as transdermal drug delivery systems (TDDS) for nifedipine (NFD), a lipophilic drug model. The formulations composed of water, Citrus sinensis essential oil (CSEO), PPG-5-CETETH-20, and Olive oil ester PEG-7 were obtained and characterized by polarized light microscopy (PLM), rheology, small-angle x-ray scattering (SAXS), Fourier transform infrared coupled with an attenuated total reflection accessory (FTIR-ATR) and in vitro assays: bioadhesion, drug release, skin permeation, and retention tests. As a result, changes in component proportions led to several transparent viscous systems with an anisotropic profile. PLM and SAXS proved the presence of lamellar (S1), hexagonal (S3), and lamellar + hexagonal (S2) LCM, and rheology showed a high viscoelasticity profile. LCMs were able to adhere to the skin, and S2 achieved higher adhesion strength. NFD (5 mg/mL) has not modified the organization of LCMs. Results also showed that S3 promoted higher permeation and retention and higher disorganization of stratum corneum lipids, which is the main permeation-enhancing mechanism. Thus, the formulations obtained can carry and improve drug delivery through the skin and are promising TDDS for lipophilic drug administration, such as NFD., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)
- Published
- 2023
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