1. The Role of COVID-19 Vaccination in Serological and Infectious Response in the Xokós Indigenous Community.
- Author
-
Silva, Eloia Emanuelly Dias, Barreto, Marina dos Santos, Santos, Ronaldy Santana, Silva, Deise Maria Rego Rodrigues, Moura, Pedro Henrique Macedo, de Jesus, Pamela Chaves, de Souza, Jessiane Bispo, Guimarães, Adriana Gibara, Santana, Lucas Alves da Mota, and Borges, Lysandro Pinto
- Subjects
BOOSTER vaccines ,INDIGENOUS peoples of South America ,VIRAL antigens ,COVID-19 vaccines ,COVID-19 testing - Abstract
Objectives: This study aims to examine the serological and infectious characteristics of the Xokós indigenous community in Brazil, both prior to and following COVID-19 immunization; Methods: Immunofluorescence assays were employed to identify the SARS-CoV-2 viral antigen, while IgM and IgG antibody tests for COVID-19 were utilized to assess the participants' infectious and serological profiles in July 2020, before the commencement of the COVID-19 vaccination campaign, and in March 2022, during the booster dose vaccination campaign; Results: The majority of participants (n = 22) were female, with an average age of 42.20 years. The most prevalent comorbidity was hypertension (60%; n = 9), followed by hypertension associated with diabetes (20%; n = 3). No statistically significant correlation was found between the timing of vaccination and the levels of antigens or IgM. However, the prevalence of reactive antigens and IgM was 13.3% (n = 4) in the pre-vaccination group and 3.3% (n = 1) in the post-vaccination group. A statistically significant difference in IgG production was observed before and after vaccination (χ
2 (1) = 39.095, p < 0.01), as well as differences in IgG antibody detection before and after vaccination and in the vaccines used. Participants showed a higher probability of reactive IgG antibodies following vaccination; Conclusions: Our data demonstrate the beneficial effects of vaccination on the indigenous community, highlighting that continued immunization is a crucial step in protecting indigenous health and preventing severe outbreaks and deaths associated with the disease. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF