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134 results on '"de Santi, M. M."'

13. Fractal analysis in human pathology

Author

Luzi, Pietro, Bianciardi, Giorgio, Miracco, Clelia, DE SANTI, M. M., DEL VECCHIO, MARIA TERESA, and Tosi, Piero

Subjects
neoplasia, Fractal analysis, Human pathology
Published
1998

35. Histological and ultra-structural effects of rapid muscle expansion through intramuscular administration of carbon dioxide: an intra-operative study in an animal model.

Author

NISI, G., PACELLA, E., CAMPANA, M., MAZZEO, F., BRANDI, C., DE SANTI, M. M., MALAGNINO, V., TANGANELLI, P., PACELLA, F., and D'NIELLO, C.

Abstract

INTRODUCTION: Carbon dioxide (CO2) therapy refers to trans-cutaneous or subcutaneous administration of CO2 for therapeutic purposes, and recent studies have pointed out that it produces a vasodilation effect after it is locally injected, which helps amplify the reconstructive potentiality of an expanded-muscle flap. MATERIALS AND METHODS: Thirty male Wistar rats, weighting between 350 and 400 g, were randomly divided into three groups of 10. In the first group, single intra-operative rapid expansion was carried out under the right latissimus dorsi muscle. In the second group, for five days prior to surgery, a pre-treatment with intramuscular injections of CO2 was performed. The third group served as controls. For each group, the latissimus dorsi muscle was fixed as soon possible after mice died, and ultrathin sections of it examined with transmission electron microscope. RESULTS: In the treated group, the majority of expanded muscles showed a normal striation pattern, whereas a few fibers showed mild disorganization of the myo-filaments in the sarcomeres, which appeared overstretched (average 2.37 µm). CONCLUSIONS: This evidence could demonstrate a greater capacity of muscle recovery after treatment by CO2 expansion. [ABSTRACT FROM AUTHOR]

Published
2014

38. Intimal-type primary sarcoma of the aorta. Report of a case with evidence of rhabdomyosarcomatous differentiation.

Author

Miracco, C, Laurini, L, Santopietro, R, De Santi, M M, Sassi, C, Neri, E, Pepi, F, and Luzi, P

Abstract

We report an intimal sarcoma presenting as an aortic aneurysm. A 68-year-old man suffered from chest pain and speech disturbance. Computed tomography showed a sacciform aneurysm of the aorta, which was resected, revealing a polypoid tumour measuring 1.5x2x2.5 cm projecting into the lumen. This proved to be a poorly differentiated high-grade sarcoma having morphological, immunophenotypic and ultrastructural features consistent with rhabdomyosarcomatous differentiation. Primary sarcomas of the aorta are extremely rare. Many cases have been diagnosed as "intimal" on the basis of their site of origin, and they are not easy to classify from their histological pattern. Electron microscopy and the use of a more comprehensive panel of immunohistochemical markers should be applied in the histological classification of"intimal" sarcoma. [ABSTRACT FROM AUTHOR]

Published
1999

50. Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases

Author

Leonardo Del Porro, Reiner Siebert, Lucia Mundo, Joshua Nyagol, Stefano Lazzi, Noel Onyango, Isaac Ndede, Mohsen Navari, Robert B. Russell, Nicholas Othieno Abinya, Roshanak Bob, Cristina López, Virginia Mancini, Harald Stein, Bruno Jim Rocca, Kirkita Patel, Massimo Granai, Maria Margherita De Santi, Maria Raffaella Ambrosio, Susanne Bens, Francesco Raimondi, Lorenzo Leoncini, Raffaella Guazzo, Pier Paolo Piccaluga, Mundo, L., Ambrosio, M. R., Raimondi, F., Del Porro, L., Guazzo, R., Mancini, V., Granai, M., Jim Rocca, B., Lopez, C., Bens, S., Onyango, N., Nyagol, J., Abinya, N., Navari, M., Ndede, I., Patel, K., Paolo Piccaluga, P., Bob, R., de Santi, M. M., Russell, R. B., Lazzi, S., Siebert, R., Stein, H., and Leoncini, L.

Subjects
Adult, Male, Models, Molecular, Adolescent, Lymphoma, Protein Conformation, Genes, myc, Biology, medicine.disease_cause, lcsh:RC254-282, Translocation, Genetic, Article, Immunophenotyping, Proto-Oncogene Proteins c-myc, Structure-Activity Relationship, Young Adult, Neoplasms, Neuroblastoma, medicine, Humans, Gene family, RNA, Messenger, Child, neoplasms, Gene, MYC Gene Rearrangement, Aged, Neoplasms, Proto-Oncogene Proteins c-myc, Human cancers, Regulation of gene expression, Haematological cancer, Mutation, Human cancers, Oncogene, High-Throughput Nucleotide Sequencing, Genomics, Hematology, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Burkitt Lymphoma, Immunohistochemistry, Gene Expression Regulation, Neoplastic, Oncology, Cancer research, Female, N-Myc, Genes, Switch
Abstract

MYC is the most altered oncogene in human cancer, and belongs to a large family of genes, including MYCN and MYCL. Recently, while assessing the degree of correlation between MYC gene rearrangement and MYC protein expression in aggressive B-cell lymphomas, we observed few Burkitt lymphoma (BL) cases lacking MYC protein expression despite the translocation involving the MYC gene. Therefore, in the present study we aimed to better characterize such cases. Our results identified two sub-groups of MYC protein negative BL: one lacking detectable MYC protein expression but presenting MYCN mRNA and protein expression; the second characterized by the lack of both MYC and MYCN proteins but showing MYC mRNA. Interestingly, the two sub-groups presented a different pattern of SNVs affecting MYC gene family members that may induce the switch from MYC to MYCN. Particulary, MYCN-expressing cases show MYCN SNVs at interaction interface that stabilize the protein associated with loss-of-function of MYC. This finding highlights MYCN as a reliable diagnostic marker in such cases. Nevertheless, due to the overlapping clinic, morphology and immunohistochemistry (apart for MYC versus MYCN protein expression) of both sub-groups, the described cases represent bona fide BL according to the current criteria of the World Health Organization.

Published
2019

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