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10 results on '"de Rino, Francesca"'

1. BPSDiary study protocol: a multi-center randomized controlled trial to compare the efficacy of a BPSD diary vs. standard care in reducing caregiver's burden.

Author

Pozzi, Federico Emanuele, Calì, Luisa, D'Antonio, Fabrizia, Altomare, Arianna Ida, Monti, Micaela Sepe, Panigutti, Massimiliano, Di Crosta, Adolfo, Palumbo, Rocco, Bonanni, Laura, Carlucci, Valentina, Bussè, Cinzia, Cagning, Annachiara, Urso, Daniele, Vilella, Davide, Logroscino, Giancarlo, Alberoni, Margherita, Bellinvia, Angelo, Farina, Elisabetta, de Rino, Francesca, and Gavazzi, Armando

Published
2023
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2. BPSDiary study protocol: a multi-center randomized controlled trial to compare the efficacy of a BPSD diary vs. standard care in reducing caregiver's burden

Author

Pozzi, F, Calì, L, D'Antonio, F, Altomare, A, Sepe Monti, M, Panigutti, M, Di Crosta, A, Palumbo, R, Bonanni, L, Carlucci, V, Bussè, C, Cagning, A, Urso, D, Vilella, D, Logroscino, G, Alberoni, M, Bellinvia, A, Farina, E, de Rino, F, Gavazzi, A, Zuffi, M, Bruno, G, Bessi, V, Cotta Ramusino, M, Perini, G, Costa, A, Ferrarese, C, Appollonio, I, Tremolizzo, L, Pozzi, Federico Emanuele, Calì, Luisa, D'Antonio, Fabrizia, Altomare, Arianna Ida, Sepe Monti, Micaela, Panigutti, Massimiliano, Di Crosta, Adolfo, Palumbo, Rocco, Bonanni, Laura, Carlucci, Valentina, Bussè, Cinzia, Cagning, Annachiara, Urso, Daniele, Vilella, Davide, Logroscino, Giancarlo, Alberoni, Margherita, Bellinvia, Angelo, Farina, Elisabetta, de Rino, Francesca, Gavazzi, Armando, Zuffi, Marta, Bruno, Giuseppe, Bessi, Valentina, Cotta Ramusino, Matteo, Perini, Giulia, Costa, Alfredo, Ferrarese, Carlo, Appollonio, Ildebrando, Tremolizzo, Lucio, Pozzi, F, Calì, L, D'Antonio, F, Altomare, A, Sepe Monti, M, Panigutti, M, Di Crosta, A, Palumbo, R, Bonanni, L, Carlucci, V, Bussè, C, Cagning, A, Urso, D, Vilella, D, Logroscino, G, Alberoni, M, Bellinvia, A, Farina, E, de Rino, F, Gavazzi, A, Zuffi, M, Bruno, G, Bessi, V, Cotta Ramusino, M, Perini, G, Costa, A, Ferrarese, C, Appollonio, I, Tremolizzo, L, Pozzi, Federico Emanuele, Calì, Luisa, D'Antonio, Fabrizia, Altomare, Arianna Ida, Sepe Monti, Micaela, Panigutti, Massimiliano, Di Crosta, Adolfo, Palumbo, Rocco, Bonanni, Laura, Carlucci, Valentina, Bussè, Cinzia, Cagning, Annachiara, Urso, Daniele, Vilella, Davide, Logroscino, Giancarlo, Alberoni, Margherita, Bellinvia, Angelo, Farina, Elisabetta, de Rino, Francesca, Gavazzi, Armando, Zuffi, Marta, Bruno, Giuseppe, Bessi, Valentina, Cotta Ramusino, Matteo, Perini, Giulia, Costa, Alfredo, Ferrarese, Carlo, Appollonio, Ildebrando, and Tremolizzo, Lucio

Abstract

Behavioral and Psychological Symptoms of Dementia (BPSD) are a heterogeneous set of psychological and behavioral abnormalities seen in persons with dementia (PwD), significantly impacting their quality of life and that of their caregivers. Current assessment tools, such as the Neuropsychiatric Inventory (NPI), are limited by recall bias and lack of direct observation. This study aims to overcome this limitation by making caregiver reports more objective through the use of a novel instrument, referred to as the BPSDiary. This randomized controlled trial will involve 300 caregiver-PwD dyads. The objective is to evaluate whether the use of the BPSDiary could significantly reduce caregiver burden, assessed using the Zarit Burden Interview (ZBI), compared to usual care. The study will include adult PwD, caregivers living with or close to the patient, and BPSD related to the HIDA (hyperactivity, impulsivity, irritability, disinhibition, aggression, agitation) domain. Caregivers randomized to the intervention arm will use the BPSDiary to record specific BPSD, including insomnia, agitation/anxiety, aggression, purposeless motor behavior, and delusions/hallucinations, registering time of onset, severity, and potential triggers. The primary outcome will be the change in ZBI scores at 3 months, with secondary outcomes including changes in NPI scores, olanzapine equivalents, NPI-distress scores related to specific BPSD domains, and caregiver and physician satisfaction. The study will be conducted in 9 Italian centers, representing diverse geographic and sociocultural contexts. While potential limitations include the relatively short observation period and the focus on specific BPSD disturbances, the BPSDiary could provide physicians with objective data to tailor appropriate non-pharmacological and pharmacological interventions. Additionally, it may empower caregivers by encouraging reflection on BPSD triggers, with the potential to improve the quality of life for both PwD and t

Published
2023

9. NEUROPROTECTIVE EFFECTS OF FELBAMATE ON GLOBAL ISCHAEMIA IN MONGOLIAN GERBILS

Author

BERTORELLI, ROSALIA, SMIRNE, SALVATORE, ADAMI, MARINA, DE RINO, FRANCESCA, and IANNACCONE, SANDRO

Abstract

Felbamate is an antiepileptic drug whose action appears to occur mainly through an interaction with neurotransmission mediated by excitatory amino acids. We assessed its effectiveness in a model of transient global ischaemia in Mongolian gerbils. Dizocilpine (MK 801) was used for comparison. Treatment was given 10min after transient forebrain ischaemia which was performed by occluding both common carotid arteries for 10min. Felbamate (300mg/kg i.p.) increased the number of surviving neurons in the CA1, CA2 and CA3 hippocampal cells. In particular, the CA1 area had a significantly higher number of surviving pyramidal neurons than that of vehicle-treated animals (67±11vs33±6 surviving neurons/mm;P<0.05). No significant difference in density of surviving neurons was observed between dizocilpine (3mg/kg i.p.) and vehicle (54±10vs33±6 surviving neurons/mm). The EEG results indicated that the effect of felbamate, used alone, is the same in the ischaemic-vehicle group as non-ischaemic group. Our results show that felbamate exerts neuroprotective effects in a model of severe cerebral ischaemia.

Published
1996
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10. Multiplex assessment of a panel of 16 serum molecules for the differential diagnosis of Alzheimer's disease.

Author

Biella G, Franceschi M, De Rino F, Davin A, Giacalone G, Brambilla P, Bountris P, Haritou M, Magnani G, Martinelli Boneschi F, Forloni G, and Albani D

Abstract

One of the current challenge in Alzheimer's disease (AD) is the identification of reliable biomarkers that might improve diagnostic accuracy, possibly correlating with the disease progression and patient's response to therapy. As the clinically validated AD biomarkers evaluate cerebrospinal fluid (CSF) parameters, the need for less invasive diagnostic markers is well evident. To this respect, blood circulating cytokines or growth factors have provided some encouraging results, even though no clinically validated to date. In 2007 Ray et al suggested a panel of 18 circulating molecules that might increase AD diagnostic accuracy. In an attempt of replicating their data, we designed a multiplex fluorimetric assay comprising 16 independent analytes and covering 15 out of the 18 described proteins. We collected serum samples from three diagnostic groups: probable AD (n=33), matched healthy controls (CNT, n=23) and non AD demented (NAD, n=14). After correction for age, we found an increased level of EGF-1 in AD in comparison to CNT and NAD, while an increase of TRAIL-R4 was found in NAD. However, evaluation of specificity/sensitivity by ROC curve analysis gave weak evidence of diagnostic accuracy (area under the curve = 0.63 and 0.66 for EGF and TRAIL-R4, respectively). Finally, we tried to find a diagnostic classifier by a multivariate algorithm. We found indication of diagnostic evidence for AD only, while NAD samples did not show a diagnostic pattern.

Published
2013

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