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24 results on '"de Oliveira, Grasieli"'

2. Metalloproteomic approach of mercury-binding proteins in liver and kidney tissues of Plagioscion squamosissimus (corvina) and Colossoma macropomum (tambaqui) from Amazon region: Possible identification of mercury contamination biomarkers

Author

Bittarello, Alis Correia, Vieira, José Cavalcante Souza, Braga, Camila Pereira, da Cunha Bataglioli, Izabela, de Oliveira, Grasieli, Rocha, Leone Campos, Zara, Luiz Fabrício, Buzalaf, Marília Afonso Rabelo, de Oliveira, Lincoln Carlos Silva, Adamec, Jiri, and de Magalhães Padilha, Pedro

Published
2020
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3. The Impact of miR-155-5p on Myotube Differentiation: Elucidating Molecular Targets in Skeletal Muscle Disorders

Author

Lopes, Letícia Oliveira, primary, Cury, Sarah Santiloni, additional, de Moraes, Diogo, additional, Oliveira, Jakeline Santos, additional, de Oliveira, Grasieli, additional, Cabral-Marques, Otavio, additional, Fernandez, Geysson Javier, additional, Hirata, Mario Hiroyuki, additional, Wang, Da-Zhi, additional, Dal-Pai-Silva, Maeli, additional, Carvalho, Robson Francisco, additional, and Freire, Paula Paccielli, additional

Published
2024
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6. Muscle cell atrophy induced by miR-155-5p reveals molecular targets in skeletal muscle disorders

Author

Lopes, Leticia Oliveira, primary, Cury, Sarah Santiloni, additional, de Moraes, Diogo, additional, Oliveira, Jakeline Santos, additional, de Oliveira, Grasieli, additional, Cabral-Marques, Otavio, additional, Fernandez, Geysson Javier, additional, Hirata, Mario Hiroyuki, additional, WANG, Da-Zhi, additional, Dal-Pai-Silva, Maeli, additional, Carvalho, Robson, additional, and Freire, Paula P, additional

Published
2023
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10. Decreased miR-497-5p Suppresses IL-6 Induced Atrophy in Muscle Cells

Author

Freire, Paula P., primary, Cury, Sarah S., additional, Lopes, Letícia O., additional, Fernandez, Geysson J., additional, Liu, Jianming, additional, de Moraes, Leonardo Nazario, additional, de Oliveira, Grasieli, additional, Oliveira, Jakeline S., additional, de Moraes, Diogo, additional, Cabral-Marques, Otavio, additional, Dal-Pai-Silva, Maeli, additional, Hu, Xiaoyun, additional, Wang, Da-Zhi, additional, and Carvalho, Robson F., additional

Published
2021
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12. Investigation of Protein Biomarkers and Oxidative Stress in Pinirampus pirinampu Exposed to Mercury Species from the Madeira River, Amazon-Brazil

Author

Vieira, José Cavalcante Souza, primary, de Oliveira, Grasieli, additional, Cavallini, Nubya Gonçalves, additional, Braga, Camila Pereira, additional, Adamec, Jiri, additional, Zara, Luiz Fabrício, additional, Buzalaf, Marília Afonso Rabelo, additional, and de Magalhães Padilha, Pedro, additional

Published
2021
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15. Tumor Transcriptome Reveals High Expression of IL-8 in Non-Small Cell Lung Cancer Patients with Low Pectoralis Muscle Area and Reduced Survival

Author

Santiloni Cury, Sarah, primary, de Moraes, Diogo, additional, Paccielli Freire, Paula, additional, de Oliveira, Grasieli, additional, Venâncio Pereira Marques, Douglas, additional, Javier Fernandez, Geysson, additional, Dal-Pai-Silva, Maeli, additional, Nishida Hasimoto, Érica, additional, Pintor dos Reis, Patricia, additional, Regina Rogatto, Silvia, additional, and Francisco Carvalho, Robson, additional

Published
2019
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16. Tumor Transcriptome in Patients with Lower Pectoralis Muscle Area Reveals IL-8 as a Prognostic Biomarker in Non-Small Cell Lung Cancer

Author

Santiloni Cury, Sarah, primary, de Moraes, Diogo, additional, Paccielli Freire, Paula, additional, de Oliveira, Grasieli, additional, Venâncio Pereira Marques, Douglas, additional, Javier Fernandez, Geysson, additional, Dal-Pai-Silva, Maeli, additional, Nishida Hasimoto, Érica, additional, Pintor dos Reis, Patricia, additional, Regina Rogatto, Silvia, additional, and Francisco Carvalho, Robson, additional

Published
2019
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19. Identification of Biomarkers of Mercury Contamination in Brachyplatystoma filamentosum of the Madeira River, Brazil, Using Metalloproteomic Strategies

Author

de Queiroz, João Vitor, primary, Vieira, José Cavalcante Souza, additional, de Oliveira, Grasieli, additional, Braga, Camila Pereira, additional, da Cunha Bataglioli, Izabela, additional, da Silva, Janaína Macedo, additional, de Paula Araújo, Wellington Luiz, additional, and de Magalhães Padilha, Pedro, additional

Published
2018
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21. Osteoglycin inhibition by microRNA miR-155 impairs myogenesis

Author

Freire, Paula Paccielli, primary, Cury, Sarah Santiloni, additional, de Oliveira, Grasieli, additional, Fernandez, Geysson Javier, additional, Moraes, Leonardo Nazario, additional, da Silva Duran, Bruno Oliveira, additional, Ferreira, Juarez Henrique, additional, Fuziwara, César Seigi, additional, Kimura, Edna Teruko, additional, Dal-Pai-Silva, Maeli, additional, and Carvalho, Robson Francisco, additional

Published
2017
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22. Correction to: Mercury Exposure: Protein Biomarkers of Mercury Exposure in Jaraqui Fish from the Amazon Region

Author

Vieira, José Cavalcante Souza, primary, Braga, Camila Pereira, additional, de Oliveira, Grasieli, additional, do Carmo Federici Padilha, Cilene, additional, de Moraes, Paula Martin, additional, Zara, Luiz Fabricio, additional, de Lima Leite, Aline, additional, Buzalaf, Marília Afonso Rabelo, additional, and de Magalhães Padilha, Pedro, additional

Published
2017
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23. Mercury Exposure: Protein Biomarkers of Mercury Exposure in Jaraqui Fish from the Amazon Region

Author

Vieira, José Cavalcante Souza, primary, Braga, Camila Pereira, additional, de Oliveira, Grasieli, additional, Padilha, Cilene do Carmo Federici, additional, de Moraes, Paula Martin, additional, Zara, Luiz Fabricio, additional, Leite, Aline de Lima, additional, Buzalaf, Marília Afonso Rabelo, additional, and Padilha, Pedro de Magalhães, additional

Published
2017
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24. Tumor Transcriptome Reveals High Expression of IL-8 in Non-Small Cell Lung Cancer Patients with Low Pectoralis Muscle Area and Reduced Survival.

Author

Cury SS, de Moraes D, Freire PP, de Oliveira G, Marques DVP, Fernandez GJ, Dal-Pai-Silva M, Hasimoto ÉN, Dos Reis PP, Rogatto SR, and Carvalho RF

Abstract

Cachexia is a syndrome characterized by an ongoing loss of skeletal muscle mass associated with poor patient prognosis in non-small cell lung cancer (NSCLC). However, prognostic cachexia biomarkers in NSCLC are unknown. Here, we analyzed computed tomography (CT) images and tumor transcriptome data to identify potentially secreted cachexia biomarkers (PSCB) in NSCLC patients with low-muscularity. We integrated radiomics features (pectoralis muscle, sternum, and tenth thoracic (T10) vertebra) from CT of 89 NSCLC patients, which allowed us to identify an index for screening muscularity. Next, a tumor transcriptomic-based secretome analysis from these patients (discovery set) was evaluated to identify potential cachexia biomarkers in patients with low-muscularity. The prognostic value of these biomarkers for predicting recurrence and survival outcome was confirmed using expression data from eight lung cancer datasets (validation set). Finally, C2C12 myoblasts differentiated into myotubes were used to evaluate the ability of the selected biomarker, interleukin (IL)-8, in inducing muscle cell atrophy. We identified 75 over-expressed transcripts in patients with low-muscularity, which included IL-6, CSF3, and IL-8 . Also, we identified NCAM1 , CNTN1 , SCG2 , CADM1 , IL-8 , NPTX1 , and APOD as PSCB in the tumor secretome. These PSCB were capable of distinguishing worse and better prognosis (recurrence and survival) in NSCLC patients. IL-8 was confirmed as a predictor of worse prognosis in all validation sets. In vitro assays revealed that IL-8 promoted C2C12 myotube atrophy. Tumors from low-muscularity patients presented a set of upregulated genes encoding for secreted proteins, including pro-inflammatory cytokines that predict worse overall survival in NSCLC. Among these upregulated genes, IL-8 expression in NSCLC tissues was associated with worse prognosis, and the recombinant IL-8 was capable of triggering atrophy in C2C12 myotubes.

Published
2019
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