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Feline infectious peritonitis (FIP) is one of the most important infectious diseases and a significant cause of death in cats. While the pathology of FIP has been well documented, there is little information on the hepatic lesions. The aim of this study was to characterize the macroscopic, microscopic and immunohistochemical patterns of the liver lesions in cats with FIP. A retrospective study was conducted on 131 cats with FIP, of which 59 had histological inflammatory lesions in the liver and were immunopositive for feline coronavirus. Four major gross patterns were defined: perihepatitis (21/59); nodular with perihepatitis (18/59); nodular multifocal (13/59); and diffuse (7/59). Four histological patterns were observed: (1) random pyogranulomas; (2) random multifocal to coalescent caseous necrosis surrounded by pyogranulomatous inflammatory infiltrate, fibrin and cellular debris; (3) perihepatitis; and (4) random multifocal to coalescent caseous necrosis surrounded by neutrophils, macrophages, lymphocytes and plasma cells. Most cats had more than one histological pattern. FIP virus antigen was detected in macrophages in the pyogranulomas and around the necrotic areas. The diagnosis of FIP remains challenging, especially in cats without effusion. The liver can be considered a suitable site for biopsy when feasible., Competing Interests: Declaration of competing interests The authors declared no conflicts of interest in relation to the research, authorship or publication of this article., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Two 1-day-old full-term female calves from different farms located in the Brazilian state of Rio Grande do Sul were unable to stand due to paresis of the pelvic limbs. Both calves had spina bifida on the spinal lumbar segment and were submitted to euthanasia due to poor prognosis. Postmortem examination revealed cerebellar herniation, caudal displacement of the brainstem, rostral deviation of the cranial nerves, caudal extension of occipital lobes, absence of dorsal lamina of lumbar vertebrae with exposed spinal cord, myelodysplasia, kyphosis, segmental spinal agenesis, renal fusion, muscular atrophy, and arthrogryposis. Histology highlighted myelodysplasia (syringomyelia and diplomyelia) and muscular atrophy. The reverse transcription-polymerase chain reactions for ruminant pestivirus were negative. Based on these lesions, the diagnosis of complex neural tube and skeletal malformations was made. A review of previous publications on calves diagnosed with these malformations, originally called Chiari or Arnold-Chiari malformations, revealed a wide range of nervous system and skeletal lesions. These variations amplified the uncertainty regarding whether all cases represent the same disorder and reinforced the importance of reconfiguring the terminology., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)