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1. Technical Design Report EuroGammaS proposal for the ELI-NP Gamma beam System

Author

Adriani, O., Albergo, S., Alesini, D., Anania, M., Angal-Kalinin, D., Antici, P., Bacci, A., Bedogni, R., Bellaveglia, M., Biscari, C., Bliss, N., Boni, R., Boscolo, M., Broggi, F., Cardarelli, P., Cassou, K., Castellano, M., Catani, L., Chaikovska, I., Chiadroni, E., Chiche, R., Cianchi, A., Clarke, J., Clozza, A., Coppola, M., Courjaud, A., Curatolo, C., Dadoun, O., Delerue, N., De Martinis, C., Di Domenico, G., Di Pasquale, E., Di Pirro, G., Drago, A., Druon, F., Dupraz, K., Egal, F., Esposito, A., Falcoz, F., Fell, B., Ferrario, M., Ficcadenti, L., Fichot, P., Gallo, A., Gambaccini, M., Gatti, G., Georges, P., Ghigo, A., Goulden, A., Graziani, G., Guibout, D., Guilbaud, O., Hanna, M., Herbert, J., Hovsepian, T., Iarocci, E., Iorio, P., Jamison, S., Kazamias, S., Labaye, F., Lancia, L., Marcellini, F., Martens, A., Maroli, C., Martlew, B., Marziani, M., Mazzitelli, G., McIntosh, P., Migliorati, M., Mostacci, A., Mueller, A., Nardone, V., Pace, E., Palmer, D. T., Palumbo, L., Pelorosso, A., Perin, F. X., Passaleva, G., Pellegrino, L., Petrillo, V., Pittman, M., Riboulet, G., Ricci, R., Ronsivalle, C., Ros, D., Rossi, A., Serafini, L., Serio, M., Sgamma, F., Smith, R., Smith, S., Soskov, V., Spataro, B., Statera, M., Stecchi, A., Stella, A., Stocchi, A., Tocci, S., Tomassini, P., Tomassini, S., Tricomi, A., Vaccarezza, C., Variola, A., Veltri, M., Vescovi, S., Villa, F., Wang, F., Yildiz, E., and Zomer, F.

Subjects
Physics - Accelerator Physics
Abstract

The machine described in this document is an advanced Source of up to 20 MeV Gamma Rays based on Compton back-scattering, i.e. collision of an intense high power laser beam and a high brightness electron beam with maximum kinetic energy of about 720 MeV. Fully equipped with collimation and characterization systems, in order to generate, form and fully measure the physical characteristics of the produced Gamma Ray beam. The quality, i.e. phase space density, of the two colliding beams will be such that the emitted Gamma ray beam is characterized by energy tunability, spectral density, bandwidth, polarization, divergence and brilliance compatible with the requested performances of the ELI-NP user facility, to be built in Romania as the Nuclear Physics oriented Pillar of the European Extreme Light Infrastructure. This document illustrates the Technical Design finally produced by the EuroGammaS Collaboration, after a thorough investigation of the machine expected performances within the constraints imposed by the ELI-NP tender for the Gamma Beam System (ELI-NP-GBS), in terms of available budget, deadlines for machine completion and performance achievement, compatibility with lay-out and characteristics of the planned civil engineering.

Published
2014

3. The LILIA (laser induced light ions acceleration) experiment at LNF

Author

Agosteo, S., Anania, M.P., Caresana, M., Cirrone, G.A.P., De Martinis, C., Delle Side, D., Fazzi, A., Gatti, G., Giove, D., Giulietti, D., Gizzi, L.A., Labate, L., Londrillo, P., Maggiore, M., Nassisi, V., Sinigardi, S., Tramontana, A., Schillaci, F., Scuderi, V., Turchetti, G., Varoli, V., and Velardi, L.

Published
2014
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5. SPARC_LAB present and future

Author

Ferrario, M., Alesini, D., Anania, M., Bacci, A., Bellaveglia, M., Bogdanov, O., Boni, R., Castellano, M., Chiadroni, E., Cianchi, A., Dabagov, S.B., De Martinis, C., Di Giovenale, D., Di Pirro, G., Dosselli, U., Drago, A., Esposito, A., Faccini, R., Gallo, A., Gambaccini, M., Gatti, C., Gatti, G., Ghigo, A., Giulietti, D., Ligidov, A., Londrillo, P., Lupi, S., Mostacci, A., Pace, E., Palumbo, L., Petrillo, V., Pompili, R., Rossi, A.R., Serafini, L., Spataro, B., Tomassini, P., Turchetti, G., Vaccarezza, C., Villa, F., Dattoli, G., Di Palma, E., Giannessi, L., Petralia, A., Ronsivalle, C., Spassovsky, I., Surrenti, V., Gizzi, L., Labate, L., Levato, T., and Rau, J.V.

Published
2013
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6. A fast monitoring system for radiotherapeutic proton beams based on scintillating screens and a CCD camera

Author

Cirrone, G.A.P., Coco, S., Cuttone, G., De Martinis, C., Giove, D., Lojacono, P.A., Mauri, M., and Messina, R.

Subjects
Proton beams -- Technology application, Eye, Instruments and apparatus for -- Service enhancement, Eye diseases -- Care and treatment, Charge coupled devices -- Usage, Technology application, Business, Electronics, Electronics and electrical industries
Abstract

A facility in which a 62 MeV proton beam is employed in the radiotherapeutic treatment of several ocular disease has been active since March 2002 at Laboratori Nazionali del Sud. A fast and accurate quality control system of such beam has been designed and tested. The system consists of a scintillating screen mounted perpendicularly to the beam axis at a fixed distance and observed by a highly sensitive charge-coupled device camera. The basic idea is the possibility to obtain real time information about the relative spatial dose distribution delivered to tissue through the measurement of the light emission in the scintillating screen. A comparison with the presently used dosimetric system (a motorized silicon diode) that, in the future, will be replaced by the device introduced in this paper (if its experimental performance will be successful) has been carried out. The good capabilities of the system make it worthy of further investigations into its applicability in proton beams monitoring for radiotherapeutic treatments (i.e., reconstruction of depth dose distribution and beam monitoring during patient irradiation). Index Terms--Charge-coupled device (CCD), monitoring, proton, scintillator, therapy.

Published
2004

9. A new Thomson Spectrometer for high energy laser-driven beams diagnostic

Author

Cirrone, G, Tramontan, A, Candiano, G, Carpinelli, M, Cavallaro, S, Cutroneo, M, Cuttone, G, De Martinis, C, Giove, D, Krasa, J, Korn, G, Maggiore, M, Margarone, D, Pisciotta, P, Prokupek, J, Romano, F, Schillaci, F, Scuderi, V, Torrisi, L, Velyhan, A, Cirrone G. A. P., Tramontan A., Candiano G., CARPINELLI, Massimo, Cavallaro S., Cutroneo M., Cuttone G., De Martinis C., Giove D., Krasa J., Korn G., Maggiore M., Margarone D., Pisciotta P., Prokupek J., Romano F., Schillaci F., Scuderi V., Torrisi L., Velyhan A., Cirrone, G, Tramontan, A, Candiano, G, Carpinelli, M, Cavallaro, S, Cutroneo, M, Cuttone, G, De Martinis, C, Giove, D, Krasa, J, Korn, G, Maggiore, M, Margarone, D, Pisciotta, P, Prokupek, J, Romano, F, Schillaci, F, Scuderi, V, Torrisi, L, Velyhan, A, Cirrone G. A. P., Tramontan A., Candiano G., CARPINELLI, Massimo, Cavallaro S., Cutroneo M., Cuttone G., De Martinis C., Giove D., Krasa J., Korn G., Maggiore M., Margarone D., Pisciotta P., Prokupek J., Romano F., Schillaci F., Scuderi V., Torrisi L., and Velyhan A.

Abstract

Thomson Spectrometers (TPs) are widely used for beam diagnostic as they provide simultaneous information on charge over mass ratio, energy and momentum of detected ions. A new TP design has been realized at INFN-LNS within the LILIA (Laser Induced Light Ion Acceleration) and ELIMED (MEDical application at ELI-Beamlines) projects. This paper reports on the construction details of the TP and on its experimental tests performed at PALS laboratory in Prague, with the ASTERIX IV laser system. Reported data are obtained with polyethylene and polyvinyl alcohol solid targets, they have been compared with data obtained from other detectors. Consistency among results confirms the correct functioning of the new TP. The main features, characterizing the design, are a wide acceptance of the deflection sector and a tunability of the, partially overlapping, magnetic and electric fields that allow to resolve ions with energy up to about 40 MeV for protons.

Published
2014

10. ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines

Author

Schillaci, F, Anzalone, A, Cirrone, G, Carpinelli, M, Cuttone, G, Cutroneo, M, De Martinis, C, Giove, D, Korn, G, Maggiore, M, Manti, L, Margarone, D, Musumarra, A, Perozziello, F, Petrovic, I, Pisciotta, P, Renis, M, Ristic Fira, A, Romano, F, Schettino, G, Scuderi, V, Torrisi, L, Tramontana, A, Tudisco, S, Schillaci F., Anzalone A., Cirrone G. A. P., CARPINELLI, Massimo, Cuttone G., Cutroneo M., De Martinis C., Giove D., Korn G., Maggiore M., Manti L., Margarone D., Musumarra A., Perozziello F. M., Petrovic I., Pisciotta P., Renis M., Ristic Fira A., Romano F., Romano F. P., Schettino G., Scuderi V., Torrisi L., Tramontana A., Tudisco S., Schillaci, F, Anzalone, A, Cirrone, G, Carpinelli, M, Cuttone, G, Cutroneo, M, De Martinis, C, Giove, D, Korn, G, Maggiore, M, Manti, L, Margarone, D, Musumarra, A, Perozziello, F, Petrovic, I, Pisciotta, P, Renis, M, Ristic Fira, A, Romano, F, Schettino, G, Scuderi, V, Torrisi, L, Tramontana, A, Tudisco, S, Schillaci F., Anzalone A., Cirrone G. A. P., CARPINELLI, Massimo, Cuttone G., Cutroneo M., De Martinis C., Giove D., Korn G., Maggiore M., Manti L., Margarone D., Musumarra A., Perozziello F. M., Petrovic I., Pisciotta P., Renis M., Ristic Fira A., Romano F., Romano F. P., Schettino G., Scuderi V., Torrisi L., Tramontana A., and Tudisco S.

Abstract

ELI-Beamlines is one of the pillars of the pan-European project ELI (Extreme Light Infrastructure). It will be an ultra high-intensity, high repetition-rate, femtosecond laser facility whose main goal is generation and applications of high-brightness X-ray sources and accelerated charged particles in different fields. Particular care will be devoted to the potential applicability of laser-driven ion beams for medical treatments of tumors. Indeed, such kind of beams show very interesting peculiarities and, moreover, laser-driven based accelerators can really represent a competitive alternative to conventional machines since they are expected to be more compact in size and less expensive. The ELIMED project was launched thanks to a collaboration established between FZU-ASCR (ELI-Beamlines) and INFN-LNS researchers. Several European institutes have already shown a great interest in the project aiming to explore the possibility to use laser-driven ion (mostly proton) beams for several applications with a particular regard for medical ones. To reach the project goal several tasks need to be fulfilled, starting from the optimization of laser-target interaction to dosimetric studies at the irradiation point at the end of a proper designed transport beam-line. Researchers from LNS have already developed and successfully tested a high-dispersive power Thomson Parabola Spectrometer, which is the first prototype of a more performing device to be used within the ELIMED project. Also a Magnetic Selection System able to produce a small pencil beam out of a wide energy distribution of ions produced in laser-target interaction has been realized and some preliminary work for its testing and characterization is in progress. In this contribution the status of the project will be reported together with a short description of the of the features of device recently developed.

Published
2014

13. High density electron beam for gamma-ray compton sources (orale)

Author

Vaccarezza, C., Adriani, O., Albergo, S., Alesini, D., Anania, M., Bacci, A., Bedogni, R., Bellaveglia, M., Biscari, C., Boni, R., Boscolo, I., Boscolo, M., Broggi, F., Cardarelli, P., Castellano, M., Catani, L., Chiadroni, E., Cianchi, A., Curatolo, C., De Martinis, C., Di Domenico, G., Dipasquale, E., Dipirro, G., Drago, A., Esposito, A., Gallo, A., Gambaccini, M., Gatti, G., Ghigo, A., Graziani, G., Marcellini, F., Maroli, C., Marziani, M., Pace, E., Passaleva, G., Pellegrino, L., Petrillo, V., Pompili, R., Ricci, R., R. Rossi, ., Serio, M., Serafini, L., Sgamma, F., Spataro, B., Stecchi, A., Stella, A., Tomassini, Pascale, Tricomi, A., Veltri, M., Vescovi, S., Villa, F., Antici, P., Coppola, M., Iarocci, E., Lancia, L., Mostacci, A., Migliorati, M., Nardone, V., Palumbo, L., Chaickovska, I., Dadoun, O., Druon, Frédéric, Fichot, P., Georges, Patrick, Mueller, A., Stocchi, A., Variola, A., Zomer, F., Angal-Kalinin, D., Bliss, N., Clarke, J., Fell, B., Goulden, A., Herbert, J., Jamison, S., Martlew, B., Mcintosh, P., Smith, R., Smith, S., Laboratori Nazionali di Frascati (LNF), Istituto Nazionale di Fisica Nucleare (INFN), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), Dept. Accelerateurs, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
[PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph]
Abstract

SCK-CEN (2014) - ISBN: 978-1-62993-828-8; International audience

Published
2013

15. SPARC_LAB RECENT RESULTS

Author

Ferrario, M., Alesini, D., Anania, M., Bacci, A., Bellaveglia, M., Castellano, M., Chiadroni, E., Cianchi, A., De Martinis, C., Di Giovenale, D., Di Pirro, G., Drago, A., Esposito, A., Faccini, Riccardo, Gallo, A., Gambaccini, M., Gatti, G., Ghigo, A., Giulietti, D., Lupi, Stefano, Mostacci, Andrea, Palumbo, Luigi, Petrillo, V., Rossi, A. R., Serafini, L., Spataro, B., Turchetti, G., Vaccarezza, C., Villa, F., Dattoli, G., Di Palma, E., Giannessi, L., Petralia, A., Ronsivalle, C., and Surrenti, V.

Published
2013

16. Modulation of apoptosis by caprine herpesvirus 1 infection in a neuronal cell line

Author

Montagnaro, S., Ciarcia, R., De Martinis, C., Pacilio, C., Sasso, S., Puzio, M. V., De Angelis, M., Pagnini, U., Boffo, S., Kenez, I., Iovane, G., Giordano, A., Montagnaro, Serena, Ciarcia, Roberto, Claudio De, Martini, Carmen, Pacilio, Sasso, Simona, Maria Valeria, Puzio, Morena De, Angeli, Pagnini, Ugo, Silvia, Boffo, Ivanna, Kenez, Iovane, Giuseppe, and Antonio, Giordano

Subjects
APOPTOSIS, CAPRINE HERPESVIRUS TYPE 1, GENE EXPRESSION, NEURONS, Gene expression, apoptosi, neuron
Abstract

Caprine herpesvirus type 1 (CpHV-1), like other members of the alpha subfamily of herpesviruses, establishes latent infections in trigeminal ganglion neurons. Our groups previously demonstrated that CpHV-1 induces apoptosis in goat peripheral blood mononuclear cells and in an epithelial bovine cell line, but the ability of CpHV-1 to induce apoptosis in neuronal cells remains unexplored. In this report, the susceptibility of Neuro 2A cells to infection by CpHV-1 was examined. Following infection of cultured cells with CpHV-1, expression of cell death genes was evaluated using real-time PCR and Western blot assays. Analysis of virus-infected cells revealed activation of caspase-8, a marker for the extrinsic pathway of apoptosis, and caspase-9, a marker for the intrinsic pathway of apoptosis at 12 and 24 h post-infection. Significant increase in the levels of cleaved caspase-3 was also observed at the acme of cytopathic effect at 24 h post-infection. In particular, at 3 and 6 h post-infection, several proapototic genes were under-expressed. At 12 h post-infection several proapototic genes such as caspases, TNF, Cd70, and Traf1 were over expressed while Bcl2a1a, Fadd, and TNF genes were underexpressed. In conclusion, the simultaneous activation of caspase-8 and caspase-9 suggests that CpHV-1 can trigger the death-receptor pathway and the mitochondrial pathway separately and in parallel. Our findings are significant because this is the first published study showing the effect of CpHV-1 infection in neuronal cells in terms of gene expression and apoptosis modulation.

Published
2013

17. High density electron beam for gamma-ray Compton sources

Author

Vaccarezza, Cristina, Adriani, O., Albergo, S., Alesini, David, Anania, M., Bacci, A., Bedogni, R., Bellaveglia, M., Biscari, C., Boni, R., Boscolo, I., Boscolo, M., Broggi, F., Cardarelli, P., Castellano, M., Catani, L., Chiadroni, E., Cianchi, A., Curatolo, C., De Martinis, C., Di Domenico, G., Dipasquale, E., Dipirro, G., Drago, A., Esposito, A., Gallo, A., Gambaccini, M., Gatti, G., Ghigo, A., Graziani, G., Marcellini, F., Maroli, C., Marziani, M., Pace, E., Passaleva, G., Pellegrino, L., Petrillo, V., Pompili, R., Ricci, R., Rossi, . R., Serio, M., Serafini, L., Sgamma, F., Spataro, B., Stecchi, A., Stella, A., Tomassini, P., Tricomi, A., Veltri, M., Vescovi, S., Villa, F., Antici, Patrizio, Coppola, M., Iarocci, Enzo, Lancia, Livia, Mostacci, Andrea, Migliorati, Mauro, Nardone, V., Palumbo, Luigi, Chaickovska, I., Dadoun, O., Druon, F., Ficho, P., Georges, P., Mueller, A., Stocchi, A., Variola, A., Zomer, F., Angal Kalinin, D., Bliss, N., Clarke, J., Fell, B., Goulden, A., Herbert, J., Jamison, S., Martlew, B., Mcintosh, P., Smith, R., and Smith, S.

Published
2013

18. A European Proposal for the Compton Gamma-ray Source of ELI-NP

Author

Vaccarezza, C., Adriani, O., Albergo, S., Alesini, D., Anania, M., Bacci, A., Bedogni, R., Bellaveglia, M., Biscari, C., Boni, R., Boscolo, I., Boscolo, M., Broggi, F., Cardarelli, Paolo, Castellano, M., Catani, L., Chiadroni, E., Cianchi, A., Clozza, A., Curatolo, C., De Martinis, C., DI DOMENICO, Giovanni, Di Pasquale, E., Dipirro, G., Drago, A., Esposito, A., Ferrario, M., Gallo, A., Gambaccini, Mauro, Gatti, G., Ghigo, A., Graziani, G., Marcellini, F., Maroli, C., Marziani, Michele, Mazzitelli, G., Pace, E., Passaleva, G., Pellegrino, L., Petrillo, V., Pompili, R., Ricci, R., Rossi, R., Serio, M., Serafini, L., Sgamma, F., Spataro, B., Stecchi, A., Stella, A., Tomassini, P., Tricomi, A., Veltri, M., Vescovi, S., Villa, F., Ronsivalle, Italy C., Antici, Italy P., Coppola, M. E., Iarocci, L., Lancia, A., Mostacci, M., Migliorati, V., Nardone, L., Palumbo, Chaickovska, I., Dadoun, O., Druon, F., Fichot, P., Georges, P., Mueller, A., Stocchi, A., Variola, A., Zomer, F., Angal Kalinin, D., Bliss, N., Clarke, J., Fell, B., Goulden, A., Herbert, J., Jamison, S., Martlew, B., Mcintosh, P., Smith, R., Smith, S., Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Charles Fabry / Lasers, Laboratoire Charles Fabry (LCF), and Université Paris-Sud - Paris 11 (UP11)-Institut d'Optique Graduate School (IOGS)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut d'Optique Graduate School (IOGS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Astrophysics::High Energy Astrophysical Phenomena, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Physics::Accelerator Physics
Abstract

ISBN978-3-95450-115-1 - http://accelconf.web.cern.ch/AccelConf/IPAC2012/papers/tuobb01.pdf; International audience; A European proposal is under preparation for the Compton gamma-ray Source of ELI-NP. In the Romanian pillar of ELI (the European Extreme Light Infrastructure) an advanced gamma-ray beam is foreseen, coupled to two 10 PW laser systems. The photons will be generated by Compton back- scattering in the collision between a high quality electron beam and a high power laser. A European collaboration formed by INFN, Univ. of Roma La Sapienza, Orsay-LAL of IN2P3, Univ. de Paris Sud XI and ASTeC at Daresbury, is preparing a TDR exploring the feasibility of a machine expected to achieve the Gamma-ray beam specifications: energy tunable between 1 and 20 MeV, narrow bandwidth (0.3%) and high spectral density, 104 photons/sec/eV. We will describe the layout of the 720 MeV RF Linac and the collision laser with the associated optical cavity, as well as the optimized beam dynamics to achieve maximum phase space density at the collision, taking into account beam loading and beam break-up due to the acceleration of long bunch trains. The predicted gamma-ray spectra will be evaluated as the gamma photons collimators background. An option for electron bunches recirculation will also be illustrated.

Published
2012

19. Corrigendum to “Instrumentation for diagnostics and control of laser-accelerated proton (ion) beams” [Phys Med 30 (2014) 255–270]

Author

Bolton, P.R., primary, Borghesi, M., additional, Brenner, C., additional, Carroll, D.C., additional, De Martinis, C., additional, Fiorini, F., additional, Flacco, A., additional, Floquet, V., additional, Fuchs, J., additional, Gallegos, P., additional, Giove, D., additional, Green, J.S., additional, Green, S., additional, Jones, B., additional, Kirby, D., additional, McKenna, P., additional, Neely, D., additional, Nuesslin, F., additional, Prasad, R., additional, Reinhardt, S., additional, Roth, M., additional, Schramm, U., additional, Scott, G.G., additional, Ter-Avetisyan, S., additional, Tolley, M., additional, Turchetti, G., additional, and Wilkens, J.J., additional

Published
2015
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20. ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines

Author

Schillaci, F., Anzalone, A., Cirrone, Giuseppe Antonio Pablo, Carpinelli, M., Cuttone, Giacomo, Cutroneo, M., De Martinis, C., Giove, D., Korn, G., Maggiore, M., Manti, L., Margarone, D., Musumarra, A., Perozziello, F. M., Petrović, Ivan M., Pisciotta, P., Renis, M., Ristić-Fira, Aleksandra, Romano, Francesco, Schettino, G., Scuderi, V., Torrisi, L., Tramontana, A., Tudisco, S., Schillaci, F., Anzalone, A., Cirrone, Giuseppe Antonio Pablo, Carpinelli, M., Cuttone, Giacomo, Cutroneo, M., De Martinis, C., Giove, D., Korn, G., Maggiore, M., Manti, L., Margarone, D., Musumarra, A., Perozziello, F. M., Petrović, Ivan M., Pisciotta, P., Renis, M., Ristić-Fira, Aleksandra, Romano, Francesco, Schettino, G., Scuderi, V., Torrisi, L., Tramontana, A., and Tudisco, S.

Abstract

ELI-Beamlines is one of the pillars of the pan-European project ELI (Extreme Light Infrastructure). It will be an ultra high-intensity, high repetition-rate, femtosecond laser facility whose main goal is generation and applications of high-brightness X-ray sources and accelerated charged particles in different fields. Particular care will be devoted to the potential applicability of laser-driven ion beams for medical treatments of tumors. Indeed, such kind of beams show very interesting peculiarities and, moreover, laser-driven based accelerators can really represent a competitive alternative to conventional machines since they are expected to be more compact in size and less expensive. The ELIMED project was launched thanks to a collaboration established between FZU-ASCR (ELI-Beamlines) and INFN-LNS researchers. Several European institutes have already shown a great interest in the project aiming to explore the possibility to use laser-driven ion (mostly proton) beams for several applications with a particular regard for medical ones. To reach the project goal several tasks need to be fulfilled, starting from the optimization of laser-target interaction to dosimetric studies at the irradiation point at the end of a proper designed transport beam-line. Researchers from LNS have already developed and successfully tested a high-dispersive power Thomson Parabola Spectrometer, which is the first prototype of a more performing device to be used within the ELIMED project. Also a Magnetic Selection System able to produce a small pencil beam out of a wide energy distribution of ions produced in laser-target interaction has been realized and some preliminary work for its testing and characterization is in progress. In this contribution the status of the project will be reported together with a short description of the of the features of device recently developed.

Published
2014

21. Recent results of the SPARC FEL experiments

Author

Ferrario, M., Alesini, D., Bellaveglia, M., Benfatto, M., Boni, R., Boscolo, M., Castellano, M., Chiadroni, E., Clozza, A., Cultrera, L., Di Pirro, G., Drago, A., Esposito, A., Ficcadenti, L., Filippetto, D., Fusco, V., Gallo, A., Gatti, G., Ghigo, A., Marinelli, A., Marcelli, A., Marrelli, C., Migliorati, Mauro, Mostacci, Andrea, Pace, E., Palumbo, Luigi, Pellegrino, L., Ricci, R., Rotundo, U., Sanelli, C., Sgamma, F., Spataro, B., Tomassini, S., Vaccarezza, C., Vescovi, M., Vicario, C., Ciocci, F., Dattoli, G., Del Franco, M., Dipace, A., Doria, A., Gallerano, G. P., Giannessi, L., Giovenale, E., Orlandi, G. L., Pagnutti, S., Petralia, A., Quattromini, M., Ronsivalle, C., Sabia, E., Spassovsky, I., Surrenti, V., Bacci, A., Boscolo, I., Broggi, F., Castelli, F., Cialdi, S., De Martinis, C., Giove, D., Maroli, C., Petrillo, V., Rossi, A. R., Serafini, L., Mattioli, M., Petrarca, Massimo, Serluca, M., Catani, L., Cianchi, A., Marchetti, B., Rosenzweig, J., Couprie, M. E., Bougeard, M., Carré, B., Garzella, D., Labat, M., Lambert, G., Merdji, H., Salières, P., Tchebakoff, O., Saclay, Cea, and Rezvani Jalal, M.

Published
2009

22. CERN PSB beam tests of CNAO Synchrotron's digital LLRF

Author

E. Angoletta, M., Findlay, A., Bourrion, O., Foglio, R., Tourres, D., Vescovi, C., Falbo, L., Hunt, S., De Martinis, C., European Organization for Nuclear Research (CERN), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), and Vernay, Emmanuelle

Subjects
[PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Accelerators and Storage Rings
Abstract

International audience; The Italian National Centre for Oncological hAdrontherapy (CNAO), in its final construction phase, uses proton and carbon ion beams to treat patients affected by solid tumours. At the heart of CNAO is a 78- meter circumference synchrotron that accelerates particles to up to 400 MeV/u. The synchrotron relies on a digital LLRF system based upon Digital Signal Processors (DSPs) and Field Programmable Gate Array (FPGA). This system implements cavity servoing and beam control capabilities, such as phase and radial loops. Beam tests of the CNAO synchrotron LLRF system were carried out at CERN's Proton Synchrotron Booster (PSB) in autumn 2007, to verify the combined DSP/FPGA architecture and the beam control capabilities. For this, a prototype version of CNAO's LLRF system was adapted to the PSB requirements. This paper outlines the prototype system layout and describes the tests carried out and their results. In particular, system architecture and beam control capabilities were successfully proven by comparison with the PSB operational beam control system and with the help of several existing beam diagnostic systems.

Published
2008

23. The SPARX project: R&D activity towards X-rays FEL sources

Author

Alesini, D., Bertolucci, S., Bellaveglia, M., Biagini, M. E., Boni, R., Boscolo, M., Castellano, M., Clozza, A., Di Pirro, G., Drago, A., Esposito, A., Ferrario, M., Filippetto, D., Fusco, V., Gallo, A., Ghigo, A., Guiducci, S., Incurvati, M., Ligi, C., Marcellini, F., Migliorati, Mauro, Mostacci, Andrea, Palumbo, Luigi, Pellegrino, L., Preger, M., Raimondi, P., Ricci, R., Sanelli, C., Serio, M., Sgamma, F., Spataro, B., Stecchi, A., Stella, A., Tazzioli, F., Vaccarezza, C., Vescovi, M., Vicario, C., Alessandria, F., Bacci, A., Boscolo, I., Broggi, F., Cialdi, S., De Martinis, C., Giove, D., Maroli, C., Mauri, M., Petrillo, V., Romè, M., Serafini, L., Mattioli, M., Musumeci, P., Catani, L., Chiadroni, E., Cianchi, A., Schaerf, C., Ciocci, F., Dattoli, G., Di Pace, A., Doria, A., Flora, F., Gallerano, G. P., Giannessi, L., Giovenale, E., Messina, G., Mezi, L., Ottaviani, P. L., Pagnutti, S., Parisi, G., Picardi, L., Quattromini, M., Renieri, A., Ronsivalle, C., Torre, A., Zucchini, A., De Silvestri, S., Nisoli, M., Stagira, S., Rosenzweig, J. B., and Reiche, S.

Published
2004

25. SPARC/X projects

Author

Alesini, D., Bertolucci, S., Biagini, M. E., Boni, R., Boscolo, M., Castellano, M., Clozza, A., Di Pirro, G., Drago, A., Esposito, A., Ferrario, M., Fusco, V., Gallo, A., Ghigo, A., Guiducci, S., Incurvati, M., Ligi, C., Marcellini, F., Migliorati, Mauro, Mostacci, Andrea, Palumbo, Luigi, Pellegrino, L., Preger, M., Ricci, R., Sanelli, C., Serio, M., Sgamma, F., Spataro, B., Stecchi, A., Stella, A., Tazzioli, F., Vaccarezza, C., Vescovi, M., Vicario, C., Alessandria, F., Bacci, A., Boscolo, I., Broggi, F., Cialdi, S., De Martinis, C., Giove, D., Maroli, C., Petrillo, V., Romè, M., Serafini, L., Levi, D., Medici, G., Mattioli, Mario Claudio, Musumeci, P., Catani, L., Chiadroni, E., Moricciani, D., Ciocci, F., Dattoli, G., Doria, A., Flora, F., Gallerano, G. P., Giannessi, L., Giovenale, E., Messina, G., Mezi, L., Ottaviani, P. L., Picardi, L., Quattromini, M., Renieri, A., Ronsivalle, C., Cianchi, A., Schaerf, C., and Rosenzweig, J. B.

Published
2004

26. ELIMED, MEDical and multidisciplinary applications at ELI-Beamlines

Author

Schillaci, F, primary, Anzalone, A, additional, Cirrone, G A P, additional, Carpinelli, M, additional, Cuttone, G, additional, Cutroneo, M, additional, De Martinis, C, additional, Giove, D, additional, Korn, G, additional, Maggiore, M, additional, Manti, L, additional, Margarone, D, additional, Musumarra, A, additional, Perozziello, F M, additional, Petrovic, I, additional, Pisciotta, P, additional, Renis, M, additional, Ristic-Fira, A, additional, Romano, F, additional, Romano, F P, additional, Schettino, G, additional, Scuderi, V, additional, Torrisi, L, additional, Tramontana, A, additional, and Tudisco, S, additional

Published
2014
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29. The LILIA (Light ions laser induced acceleration) experiment at LNF

Author

Agosteo, S., primary, Anania, M. P., additional, Buccolieri, G., additional, Caresana, M., additional, De Martinis, C., additional, Delle Side, D., additional, Fazzi, A., additional, Galli, G., additional, Giove, D., additional, Giulielli, D., additional, Gizzi, L., additional, Labale, L., additional, Londrillo, P., additional, Nassisi, V., additional, Pola, A., additional, Sinigardi, S., additional, Turchetti, G., additional, Varoli, V., additional, and Velardi, L., additional

Published
2013
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31. Acceleration tests of a 3GHz proton linear accelerator (LIBO) for hadrontherapy

Author

De Martinis, C., primary, Giove, D., additional, Amaldi, U., additional, Berra, P., additional, Crandall, K., additional, Mauri, M., additional, Weiss, M., additional, Zennaro, R., additional, Rosso, E., additional, Szeless, B., additional, Vretenar, M., additional, Masullo, M.R., additional, Vaccaro, V., additional, Calabretta, L., additional, and Rovelli, A., additional

Published
2012
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35. Status of the SPARX FEL project

Author

Vaccarezza, C., primary, Alesini, D., additional, Bellaveglia, M., additional, Bertolucci, S., additional, Biagini, M. E., additional, Boni, R., additional, Boscolo, M., additional, Castellano, M., additional, Clozza, A., additional, Cultrera, L., additional, Di Pirro, G., additional, Drago, A., additional, Esposito, A., additional, Ferrario, M., additional, Filippetto, D., additional, Fusco, V., additional, Gallo, A., additional, Ghigo, A., additional, Guiducci, S., additional, Migliorati, M., additional, Palumbo, L., additional, Pellegrino, L., additional, Preger, M., additional, Sanelli, C., additional, Serio, M., additional, Sgamma, F., additional, Spataro, B., additional, Stella, A., additional, Tazzioli, F., additional, Vescovi, M., additional, Vicario, C., additional, Ciocci, F., additional, Dattoli, G., additional, Doria, A., additional, Flora, F., additional, Gallerano, G., additional, Giannessi, L., additional, Giovenale, E., additional, Messina, G., additional, Ottaviani, P. L., additional, Parisi, G., additional, Picardi, L., additional, Quattromini, M., additional, Renieri, A., additional, Ronsivalle, C., additional, Cialdi, S., additional, Maroli, C., additional, Petrillo, V., additional, Romè, M., additional, Serafini, L., additional, Catani, L., additional, Chiadroni, E., additional, Cianchi, A., additional, Schaerf, C., additional, Musumeci, P., additional, Alessandria, F., additional, Bacci, A., additional, Broggi, F., additional, De Martinis, C., additional, Giove, D., additional, Mauri, M., additional, Ficcadenti, L., additional, Mattioli, M., additional, Mostacci, A., additional, Emma, P., additional, Reiche, S., additional, and Rosenzweig, J., additional

Published
2007
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37. Status of the sparc-x project

Author

Vaccarezza, C., primary, Alesini, D., additional, Bellaveglia, M., additional, Bertolucci, S., additional, Boni, R., additional, Boscolo, M., additional, Castellano, M., additional, Clozza, A., additional, Cultrera, L., additional, Di Pirro, G., additional, Drago, A., additional, Esposito, A., additional, Ferrario, M., additional, Ficcadenti, L., additional, Filippetto, D., additional, Fusco, V., additional, Gallo, A., additional, Gatti, G., additional, Ghigo, A., additional, Ligi, C., additional, Marinelli, A., additional, Migliorati, M., additional, Mostacci, A., additional, Pace, E., additional, Palumbo, L., additional, Pellegrino, L., additional, Preger, M., additional, Ricci, R., additional, Sanelli, C., additional, Serio, M., additional, Sgamma, F., additional, Spataro, B., additional, Stella, A., additional, Tazzioli, F., additional, Vescovi, M., additional, Vicario, C., additional, Ciocci, F., additional, Dattoli, G., additional, Dipace, A., additional, Doria, A., additional, Flora, F., additional, Gallerano, G.P., additional, Giannessi, L., additional, Giovenale, E., additional, Messina, G., additional, Ottaviani, P.L., additional, Pagnutti, S., additional, Parisi, G., additional, Picardi, L., additional, Quattromini, M., additional, Renieri, A., additional, Ronci, G., additional, Ronsivalle, C., additional, Rosetti, M., additional, Sabia, E., additional, Sassi, M., additional, Torre, A., additional, Zucchini, A., additional, Mattioli, M., additional, Pelliccia, D., additional, Catani, L., additional, Chiadroni, E., additional, Cianchi, A., additional, Gabrielli, E., additional, Schaerf, C., additional, Musumeci, P., additional, Petrarca, M., additional, Alessandria, F., additional, Bacci, A., additional, Bonifacio, R., additional, Boscolo, I., additional, Broggi, F., additional, De Martinis, C., additional, Castelli, F., additional, Cialdi, S., additional, Giove, D., additional, Flacco, A., additional, Maroli, C., additional, Petrillo, V., additional, Rossi, A.R., additional, Serafini, L., additional, Perrone, A., additional, Labat, M., additional, Tcherbakoff, O., additional, Lambert, G., additional, Garzella, D., additional, Bougeard, M., additional, Breger, P., additional, Monchicourt, P., additional, Merdji, H., additional, Salieres, P., additional, Carre, B., additional, Couprie, M. E., additional, Emma, P., additional, Pellegrini, C., additional, Reiche, S., additional, and Rosenzweig, J., additional

Published
2007
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38. SPARC/X Projects

Author

Alesini, D., primary, Bertolucci, S., additional, Biagini, M. E., additional, Boni, R., additional, Boscolo, M., additional, Castellano, M., additional, Clozza, A., additional, Di Pirro, G., additional, Drago, A., additional, Esposito, A., additional, Ferrario, M., additional, Fusco, V., additional, Gallo, A., additional, Ghigo, A., additional, Guiducci, S., additional, Incurvati, M., additional, Ligi, C., additional, Marcellini, F., additional, Migliorati, M., additional, Mostacci, A., additional, Palumbo, L., additional, Pellegrino, L., additional, Preger, M., additional, Ricci, R., additional, Sanelli, C., additional, Serio, M., additional, Sgamma, F., additional, Spataro, B., additional, Stecchi, A., additional, Stella, A., additional, Tazzioli, F., additional, Vaccarezza, C., additional, Vescovi, M., additional, Vicario, C., additional, Alessandria, F., additional, Bacci, A., additional, Boscolo, I., additional, Broggi, F., additional, Cialdi, S., additional, De Martinis, C., additional, Giove, D., additional, Maroli, C., additional, Petrillo, V., additional, Romè, M., additional, Serafini, L., additional, Levi, D., additional, Medici, G., additional, Mattioli, M., additional, Musumeci, P., additional, Catani, L., additional, Chiadroni, E., additional, Moricciani, D., additional, Ciocci, F., additional, Dattoli, G., additional, Doria, A., additional, Flora, F., additional, Gallerano, G. P., additional, Giannessi, L., additional, Giovenale, E., additional, Messina, G., additional, Mezi, L., additional, Ottaviani, P. L., additional, Picardi, L., additional, Quattromini, M., additional, Renieri, A., additional, Ronsivalle, C., additional, Cianchi, A., additional, Schaerf, C., additional, and Rosenzweig, J. B., additional

Published
2005
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39. The SPARC/X SASE-FEL Projects

Author

ALESINI, D., primary, BERTOLUCCI, S., additional, BIAGINI, M.E., additional, BONI, R., additional, BOSCOLO, M., additional, CASTELLANO, M., additional, CLOZZA, A., additional, DI PIRRO, G.., additional, DRAGO, A., additional, ESPOSITO, A., additional, FERRARIO, M., additional, FUSCO, V., additional, GALLO, A., additional, GHIGO, A., additional, GUIDUCCI, S., additional, INCURVATI, M., additional, LIGI, C., additional, MARCELLINI, F., additional, MIGLIORATI, M., additional, MILARDI, C., additional, MOSTACCI, A., additional, PALUMBO, L., additional, PELLEGRINO, L., additional, PREGER, M., additional, RAIMONDI, P., additional, RICCI, R., additional, SANELLI, C., additional, SERIO, M., additional, SGAMMA, F., additional, SPATARO, B., additional, STECCHI, A., additional, STELLA, A., additional, TAZZIOLI, F., additional, VACCAREZZA, C., additional, VESCOVI, M., additional, VICARIO, C., additional, ZOBOV, M., additional, ALESSANDRIA, F., additional, BACCI, A., additional, BOSCOLO, I., additional, BROGGI, F., additional, CIALDI, S., additional, DE MARTINIS, C., additional, GIOVE, D., additional, MAROLI, C., additional, PETRILLO, V., additional, ROMÈ, M., additional, SERAFINI, L., additional, MUSUMECI, P., additional, MATTIOLI, M., additional, CATANI, L., additional, CHIADRONI, E., additional, TAZZARI, S., additional, CIOCCI, F., additional, DATTOLI, G., additional, DORIA, A., additional, FLORA, F., additional, GALLERANO, G.P., additional, GIANNESSI, L., additional, GIOVENALE, E., additional, MESSINA, G., additional, MEZI, L., additional, OTTAVIANI, P.L., additional, PICARDI, L., additional, QUATTROMINI, M., additional, RENIERI, A., additional, RONSIVALLE, C., additional, CIANCHI, A., additional, SCHAERF, C., additional, and ROSENZWEIG, J.B., additional

Published
2004
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41. The synergistic effect of simultaneous addition of retinoic acid and vitamin D3 on the in-vitro differentiation of human promyelocytic leukemia cell lines could be efficiently transposed in vivo

Author

Camagna, A., primary, Testa, U., additional, Masciulli, R., additional, Barberi, T., additional, Samoggia, P., additional, Tritarelli, E., additional, Pustorino, E., additional, Cipollone, L., additional, Ciancio, L., additional, del Duca, P., additional, Dionisi, S., additional, del Vecchio, L.R., additional, Misasi, G., additional, de Martinis, C., additional, and Peschle, C., additional

Published
1998
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44. First operations of the LNS heavy ions facility

Author

Calabretta, L, primary, Ciavola, G, additional, Cuttone, G, additional, Gammino, S, additional, Gmaj, P, additional, Migneco, E, additional, Raia, G, additional, Rifuggiato, D, additional, Rovelli, A, additional, Sura, J, additional, Scuderi, V, additional, Acerbi, E, additional, Alessandria, F, additional, Bellomo, G, additional, Bosotti, A, additional, De Martinis, C, additional, Giove, D, additional, Michelato, P, additional, Pagani, C, additional, and Rossi, L, additional

Published
1996
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46. PROGRESS REPORT ON THE MILAN SUPERCONDUCTING CYCLOTRON.

Author

Acerbi, E., Alessandria, F., Baccaglioni, G., Bellomo, G., Birattari, C., Bosotti, A., Broggi, F., Cuttone, G., De Martinis, C., Di Giacomo, M., Fabrici, E., Ferrari, A., Giove, D., Giussani, A., Giussani, V., Gmaj, P., Hichelato, P., Pagani, C., Rivoltella, G. C., and Rossi, L.

Subjects
CYCLOTRONS, SUPERCONDUCTING coils, MAGNETIC fields, NUCLEAR energy, NUCLEAR physics experiments
Published
1991

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