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1. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in multimodal therapy for patients with oligometastatic peritoneal gastric cancer: a randomized multicenter phase III trial PIPAC VEROne

Author

Casella Francesco, Bencivenga Maria, Rosati Riccardo, Fumagalli Uberto Romario, Marrelli Daniele, Pacelli Fabio, Macrì Antonio, Donini Annibale, Torroni Lorena, Pavarana Michele, and De Manzoni Giovanni

Subjects
gastric cancer, intraperitoneal chemotherapy, peritoneal metastases, pipac, systemic chemotherapy, Medicine, Specialties of internal medicine, RC581-951
Abstract

Peritoneal carcinomatosis is the most frequent site of metastases in patients with gastric cancer. Current standard treatment is palliative systemic chemotherapy with very poor prognosis. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) resulted in long-term benefits in selected patients. Among patients with peritoneal carcinomatosis, a distinctive subset is oligometastatic disease which is characterized by low metastatic burden. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a recent technique of intraperitoneal chemotherapy used in combination with systemic chemotherapy with promising results.

Published
2022
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5. International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape: Bertinoro Workshop, November 2022

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, and de Manzoni, Giovanni

Published
2024
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6. Correction: International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, and de Manzoni, Giovanni

Published
2024
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7. Clinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023

Author

Kitagawa, Yuko, Matsuda, Satoru, Gotoda, Takuji, Kato, Ken, Wijnhoven, Bas, Lordick, Florian, Bhandari, Pradeep, Kawakubo, Hirofumi, Kodera, Yasuhiro, Terashima, Masanori, Muro, Kei, Takeuchi, Hiroya, Mansfield, Paul F., Kurokawa, Yukinori, So, Jimmy, Mönig, Stefan Paul, Shitara, Kohei, Rha, Sun Young, Janjigian, Yelena, Takahari, Daisuke, Chau, Ian, Sharma, Prateek, Ji, Jiafu, de Manzoni, Giovanni, Nilsson, Magnus, Kassab, Paulo, Hofstetter, Wayne L., Smyth, Elizabeth Catherine, Lorenzen, Sylvie, Doki, Yuichiro, Law, Simon, Oh, Do-Youn, Ho, Khek Yu, Koike, Tomoyuki, Shen, Lin, van Hillegersberg, Richard, Kawakami, Hisato, Xu, Rui-Hua, Wainberg, Zev, Yahagi, Naohisa, Lee, Yeong Yeh, Singh, Rajvinder, Ryu, Min-Hee, Ishihara, Ryu, Xiao, Zili, Kusano, Chika, Grabsch, Heike Irmgard, Hara, Hiroki, Mukaisho, Ken-ichi, Makino, Tomoki, Kanda, Mitsuro, Booka, Eisuke, Suzuki, Sho, Hatta, Waku, Kato, Motohiko, Maekawa, Akira, Kawazoe, Akihito, Yamamoto, Shun, Nakayama, Izuma, Narita, Yukiya, Yang, Han-Kwang, Yoshida, Masahiro, and Sano, Takeshi

Published
2024
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9. European clinical practice guidelines for the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer (OMEC-4)

Author

Kroese, Tiuri E., Bronzwaer, Sebastiaan, van Rossum, Peter S.N., Schoppman, Sebastian F., Deseyne, Pieter R.A.J., van Cutsem, Eric, Haustermans, Karin, Nafteux, Philippe, Thomas, Melissa, Obermannova, Radka, Mortensen, Hanna R., Nordsmark, Marianne, Pfeiffer, Per, Elme, Anneli, Adenis, Antoine, Piessen, Guillaume, Bruns, Christiane J., Lordick, Florian, Gockel, Ines, Moehler, Markus, Gani, Cihan, Liakakos, Theodore, Reynolds, John V., Morganti, Alessio G., Rosati, Riccardo, Castoro, Carlo, Cellini, Francesco, D'Ugo, Domenico, Roviello, Franco, Bencivenga, Maria, de Manzoni, Giovanni, van Berge Henegouwen, Mark I., Hulshoff, Maarten C.C.M, van Dieren, Jolanda, Vollebergh, Marieke, van Sandick, Johanna W., Jeene, Paul, Muijs, Christel, Slingerland, Marije, Voncken, Francine E.M., Hartgrink, Henk, Creemers, Geert-Jan, van der Sangen, Maurice J.C., Nieuwenhuijzen, Grard A.P., Berbee, Maaike, Verheij, Marcel, Wijnhoven, Bas, Beerepoot, Laurens V., Mohammad, Nadia Haj, Mook, Stella, Ruurda, Jelle P., Kolodziejczyk, Piotr, Polkowski, Wojciech P., Wyrwicz, Lucjan, Alsina, Maria, Tabernero, Josep, Pera, Manuel, Kanonnikoff, Tania F., Cervantes, Andrés, Nilsson, Magnus, Monig, Stefan, Wagner, Anna D., Guckenberger, Matthias, Griffiths, Ewen A., Smyth, Elizabeth, Hanna, George B., Markar, Sheraz, Chaudry, M. Asif, Hawkins, Maria A., Cheong, Edward, van Laarhoven, Hanneke W.M., and van Hillegersberg, Richard

Published
2024
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11. A national survey on the current status of minimally invasive gastric practice on behalf of GIRCG

Author

Milone, Marco, D’Amore, Anna, Alfieri, Sergio, Ambrosio, Maria Raffaella, Andreuccetti, Jacopo, Ansaloni, Luca, Antonucci, Adelmo, Arganini, Marco, Baiocchi, Gianluca, Barone, Mirko, Bencini, Lapo, Bencivenga, Maria, Boccia, Luigi, Boni, Luigi, Braga, Marco, Cianchi, Fabio, Cipollari, Chiara, Contine, Alessandro, Cotsoglou, Christian, D’Imporzano, Simone, De Manzoni, Giovanni, De Pascale, Stefano, De Ruvo, Nicola, Degiuli, Maurizio, Donini, Annibale, Elmore, Ugo, Ercolani, Giorgio, Ferrari, Giovanni, Fumagalli, Romario Uberto, Garulli, Gianluca, Gelmini, Roberta, Graziosi, Luigina, Gualtierotti, Monica, Guglielmi, Alfredo, Inama, Marco, Maffeis, Federica, Maione, Francesco, Manigrasso, Michele, Marchesi, Federico, Marrelli, Daniele, Massobrio, Andrea, Moretto, Gianluigi, Moukachar, Aballah, Navarra, Giuseppe, Nigri, Giuseppe, Olmi, Stefano, Palaia, Raffaele, Papis, Davide, Parise, Paolo, Pedrazzani, Corrado, Petri, Roberto, Pignata, Giusto, Pisano, Michele, Rausei, Stefano, Reddavid, Rossella, Rocco, Giuseppe, Rosa, Fausto, Rosati, Riccardo, Rossit, Luca, Rottoli, Matteo, Roviello, Franco, Santi, Stefano, Scabini, Stefano, Scaringi, Stefano, Solaini, Leonardo, Staderini, Fabio, Taglietti, Lucio, Torre, Beatrice, Ubiali, Paolo, Uccelli, Matteo, Uggeri, Fabio, Vertaldi, Sara, Viganò, Jacopo, De Palma, Giovanni Domenico, and Giacopuzzi, Simone

Published
2023
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13. The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type

Author

Mattuzzi Silvia, Lamba Simona, Bersani Samantha, De Manzoni Giovanni, Cataldo Ivana, Barbi Stefano, Bardelli Alberto, and Scarpa Aldo

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background PIK3CA is one of the genes most frequently mutated in human cancers and it is a potential target for personalized therapy. The aim of this study was to assess the frequency and type of PIK3CA mutations in gastric carcinoma and compare them with their clinical pathological correlates. Methods We analysed 264 gastric cancers, including 39 with microsatellite instability (MSI), for mutations in the two PIK3CA hotspots in exons 9 and 20 by direct sequencing of DNA obtained from microdissected cancer cells. Results The cases harbouring mutations were 42 (16%). All were heterozygous missense single base substitutions; the most common was H1047R (26/42; 62%) in exon 20 and the second was Q546K (4/42; 9.5%) in exon 9. All the mutated MSI cases (8/39) carried the H1047R mutation. No other association between PI3KCA mutations and their clinical pathological covariates was found. A metanalysis of the mutations occurring in the same regions presented in 27 publications showed that ratio between exon 20 and exon 9 prevalences was 0.6 (95% CI: 0.5 -0.8) for colon, 1.6 (95% CI: 1.1 -2.3) for breast, 2.7 (95% CI: 1.6 -4.9) for gastric and 4.1 (95% CI: 1.9 -10.3) for endometrial cancer. Conclusions The overall prevalence of PIK3CA mutations implies an important role for PIK3CA in gastric cancer. The lack of association with any clinical-pathological condition suggests that mutations in PIK3CA occur early in the development of cancer. The metanalysis showed that exon-selectivity is an important signature of cancer type reflecting different contexts in which tumours arise.

Published
2010
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14. The CHOLEGAS study: multicentric randomized, blinded, controlled trial of gastrectomy plus prophylactic cholecystectomy versus gastrectomy only, in adults submitted to Gastric cancer surgery with curative intent

Author

Pedrazzani Corrado, Marrelli Daniele, Verlato Giuseppe, de Manzoni Giovanni, Manetti Roberto, Miranda Egidio, Bencini Lapo, Bernini Marco, Farsi Marco, Roviello Francesco, Marchet Alberto, Cristadoro Luigi, Gerard Leonardo, and Moretti Renato

Subjects
Medicine (General), R5-920
Abstract

Abstract Background The incidence of gallstones and gallbladder sludge is known to be higher in patients after gastrectomy than in general population. This higher incidence is probably related to surgical dissection of the vagus nerve branches and the anatomical gastrointestinal reconstruction. Therefore, some surgeons perform routine concomitant cholecystectomy during standard surgery for gastric malignancies. However, not all the patients who are diagnosed to have cholelithiasis after gastric cancer surgery will develop symptoms or require additional surgical treatments and a standard laparoscopic cholecystectomy is feasible even in those patients who underwent previous gastric surgery. At the present, no randomized study has been published and the decision of gallbladder management is left to each surgeon preference. Design The study is a randomized controlled investigation. The study will be performed in the General and Oncologic Surgery, Department of Oncology – Azienda Ospedaliero-Universitaria Careggi – Florence – Italy, a large teaching institution, with the participation of all surgeons who accept to be involved in, together with other Italian Surgical Centers, on behalf of the GIRCG (Italian Research Group for Gastric Cancer). The patients will be randomized into two groups: in the first group the patient will be submitted to prophylactic cholecystectomy during standard surgery for curable gastric cancer (subtotal or total gastrectomy), while in the second group he/she will be submitted to standard gastric surgery only. Trial Registration ClinicalTrials.gov ID. NCT00757640

Published
2009
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15. Major vessel resection for complete cytoreduction in primary advanced and recurrent ovarian malignancies: A case series and systematic review of the literature - pushing the boundaries in oncovascular surgery.

Author

Uccella, Stefano, Bosco, Mariachiara, Mezzetto, Luca, Garzon, Simone, Maggi, Veronica, Giacopuzzi, Simone, Antonelli, Alessandro, Pinali, Lucia, Zorzato, Pier Carlo, Festi, Anna, Polati, Enrico, Montemezzi, Stefania, De Manzoni, Giovanni, Franchi, Massimo P., and Veraldi, Gian Franco

Published
2023
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16. Perforated gastric carcinoma: a report of 10 cases and review of the literature

Author

Morgagni Paolo, Pedrazzani Corrado, De Manzoni Giovanni, Marrelli Daniele, Rossi Simone, Roviello Franco, Corso Giovanni, and Pinto Enrico

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Perforation is a rare complication of gastric carcinoma, accounting for less than 1% of all gastric cancer cases. The aim of the present study is to evaluate the prognostic value of perforation and to point out the surgical treatment options. Methods A total of 10 patients with perforated gastric carcinoma were retrospectively reviewed among 2564 consecutive cases of gastric cancer operated in three Centers belonging to the Italian Research Group for Gastric Cancer. The clinicopathological features including tumor stage and survival were analyzed and compared to literature data. Results Incidence rate was 0.39%. All patients underwent emergency surgery, being performed gastrectomy in 6 patients (mortality 17%) and repair surgery in 4 patients (mortality 75%). The survival of patients was related to the stage of the disease, with 2 long-survival cases. Conclusion Perforation usually occurs in advanced stages of gastric cancer; nevertheless surgeons should not be always discouraged from a radical treatment of perforated gastric cancer, since perforation even occurs in early stages and seems not to be a negative prognostic factor itself. When possible, emergency gastrectomy should be performed, leaving repair surgery for unresectable tumors. A two-stage treatment is a good treatment option for frail patients with resectable tumors.

Published
2006
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18. Clinical outcomes of patients with complicated post-operative course after gastrectomy for cancer: a GIRCG study using the GASTRODATA registry

Author

Baiocchi, Gian Luca, Giacopuzzi, Simone, Vittimberga, Giovanni, De Pascale, Stefano, Pastorelli, Elisabetta, Gelmini, Roberta, Viganò, Jacopo, Graziosi, Luigina, Vagliasindi, Alessio, Rosa, Fausto, Steccanella, Francesca, Demartini, Paolo, Reddavid, Rossella, Berselli, Mattia, Elmore, Ugo, Romario, Uberto Fumagalli, Degiuli, Maurizio, Morgagni, Paolo, Marrelli, Daniele, D’Ugo, Domenico, Rosati, Riccardo, and De Manzoni, Giovanni

Published
2023
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20. Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe

Author

Rozema, Tom, Heisterkamp, Joos, Schaefer, Markus, Ozsahin, Esat-Mahmut, de Haan, Jacco, Willem van den Berg, Jan, Duprez, Frederic, Callebout, Eduard, van Daele, Elke, Hacker, Ulrich, Hoffmeister, Albrecht, Kuhnt, Thomas, Denecke, Timm, Kluge, Regine, Prager, Gerald, Ilhan-Mutlu, A., Cuicchi, Dajana, Ardizzoni, Andrea, Rosman, Camiel, Gootjes, Elske C., Rütten, Heidi, Puccetti, Francesco, Cascinu, Stefano, Slim, Najla, Barrios, Maria Eugenia, Fernandez, Maria Carmen, Martí-Oriol, Roberto, Alvaro, Marisol Huerta, Vera, Almudena, Jordá, Esther, Mozos, Fernando L., Reig, Anna, Visa, Laura, Ciseł, Bogumiła, Czechowska, Joanna, Kwietniewska, Magdalena, Pikuła, Agnieszka, Skórzewska, Magdalena, Kozłowska, Aleksandra, Rawicz-Pruszyński, Karol, Kroese, Tiuri E., van Laarhoven, Hanneke W.M., Schoppman, Sebastian F., Deseyne, Pieter R.A.J., van Cutsem, Eric, Haustermans, Karin, Nafteux, Philippe, Thomas, Melissa, Obermannova, Radka, Mortensen, Hanna R., Nordsmark, Marianne, Pfeiffer, Per, Elme, Anneli, Adenis, Antoine, Piessen, Guillaume, Bruns, Christiane J., Lordick, Florian, Gockel, Ines, Moehler, Markus, Gani, Cihan, Liakakos, Theodore, Reynolds, John, Morganti, Alessio G., Rosati, Riccardo, Castoro, Carlo, Cellini, Francesco, D'Ugo, Domenico, Roviello, Franco, Bencivenga, Maria, de Manzoni, Giovanni, van Berge Henegouwen, Mark I., Hulshof, Maarten C.C.M., van Dieren, Jolanda, Vollebergh, Marieke, van Sandick, Johanna W., Jeene, Paul, Muijs, Christel T., Slingerland, Marije, Voncken, Francine E.M., Hartgrink, Henk, Creemers, Geert-Jan, van der Sangen, Maurice J.C., Nieuwenhuijzen, Grard, Berbee, Maaike, Verheij, Marcel, Wijnhoven, Bas, Beerepoot, Laurens V., Mohammad, Nadia H., Mook, Stella, Ruurda, Jelle P., Kolodziejczyk, Piotr, Polkowski, Wojciech P., Wyrwicz, Lucjan, Alsina, Maria, Pera, Manuel, Kanonnikoff, Tania F., Cervantes, Andrés, Nilsson, Magnus, Monig, Stefan, Wagner, Anna D., Guckenberger, Matthias, Griffiths, Ewen A., Smyth, Elizabeth, Hanna, George B., Markar, Sheraz, Chaudry, M. Asif, Hawkins, Maria A., Cheong, Edward, van Hillegersberg, Richard, and van Rossum, Peter S.N.

Published
2023
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21. Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort

Author

Greijdanus, Nynke G., Wienholts, Kiedo, Ubels, Sander, Talboom, Kevin, Hannink, Gerjon, Wolthuis, Albert, de Lacy, Francisco B., Lefevre, Jérémie H., Solomon, Michael, Frasson, Matteo, Rotholtz, Nicolas, Denost, Quentin, Perez, Rodrigo O., Konishi, Tsuyoshi, Panis, Yves, Rutegård, Martin, Hompes, Roel, Rosman, Camiel, van Workum, Frans, Tanis, Pieter J., de Wilt, Johannes H.W., Bremers, Andreas J.A., Ferenschild, Floris T., de Vriendt, Stefanie, D’Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, Lacy, Antonio M., Atienza, Paula González, van Kessel, Charlotte S., Parc, Yann, Voron, Thibault, Collard, Maxime K., Muriel, Jorge Sancho, Cholewa, Hannia, Mattioni, Laura A., Frontali, Alice, Polle, Sebastiaan W., Polat, Fatih, Obihara, Ndidi J., Vailati, Bruna B., Kusters, Miranda, Tuynmann, Jurriaan B., Hazen, Sanne J.A., Grüter, Alexander A.J., Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicolas, Carrie, Augusto, Santillan, Mateo, Pantoja Pachajoa, Diana A., Parodi, Matias, Gielis, Manuel, Binder, Alf-Dorian, Gürtler, Thomas, Riedl, Peter, Badiani, Sarit, Berney, Christophe, Morgan, Matthew, Hollington, Paul, da Silva, Nigel, Nair, Gavin, Ho, Yiu M., Lamparelli, Michael, Kapadia, Raj, Kroon, Hidde M., Dudi-Venkata, Nagendra N., Liu, Jianliang, Sammour, Tarik, Flamey, Nicolas, Pattyn, Paul, Chaoui, Ahmed, Vansteenbrugge, Louis, van den Broek, Nathalie E.J., Vanclooster, Patrick, de Gheldere, Charles, Pletinckx, Pieter, Defoort, Barbara, Dewulf, Maxime, Slavchev, Mihail, Belev, Nikolay, Atanasov, Boyko, Krastev, Panche, Sokolov, Manol, Maslyankov, Svilen, Gribnev, Petar, Pavlov, Vasil, Ivanov, Tsvetomir, Karamanliev, Martin, Filipov, Emil, Tonchev, Pencho, Aigner, Felix, Mitteregger, Martin, Allmer, Caterina, Seitinger, Gerald, Colucci, Nicola, Buchs, Nicolas, Ris, Frédéric, Toso, Christian, Gialamas, Eleftherios, Vuagniaux, Aurélie, Chautems, Roland, Sauvain, Marc-Olivier, Daester, Silvio, von Flüe, Markus, Guenin, Marc-Olivier, Taha-Mehlitz, Stephanie, Hess, Gabriel F., Martínek, Lubomír, Skrovina, Matej, Machackova, Maria, Benčurik, Vladimir, Uluk, Deniz, Pratschke, Johann, Dittrich, Luca S., Guel-Klein, Safak, Perez, Daniel, Grass, Julia-Kristin, Melling, Nathaniel, Mueller, Simone, Iversen, Lene H., Eriksen, Jacob D., Baatrup, Gunnar, Al-Najami, Issam, Bjørsum-Meyer, Thomas, Teras, Jüri, Teras, Roland M., Monib, Fatma A., Abu Elnga Ahmed, Nagm Eldin, Alkady, Eithar, Ali, Ahmed K., Khedr, Gehan Abd Elatti, Abdelaal, Ahmed Samir, Bassyouni Ashoush, Fouad M., Ewedah, Moataz, Elshennawy, Eslam M., Hussein, Mohamed, Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, del Hoyo Aretxabala, Izaskun, Docampo, Iria Losada, Zabala, Jesús Gómez, Tejedor, Patricia, Morales Bernaldo de Quirós, Javier T., Quiroga, Ignacio Bodega, Navarro-Sánchez, Antonio, Darias, Iván Soto, Fernández, Cristina López, de La Cruz Cuadrado, Cristina, Sánchez-Guillén, Luis, López-Rodríguez-Arias, Francisco, Soler-Silva, Álvaro, Arroyo, Antonio, Bernal-Sprekelsen, Juan C., Gómez-Abril, Segundo Á., Gonzálvez, Paula, Torres, María T., Sánchez, Teresa Rubio, Antona, Francisco Blanco, Sánchez Lara, Juan E., Alcázar Montero, José A., Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, Colás-Ruiz, Enrique, Tasende-Presedo, Marta M., Fernández-Hurtado, Ignacio, Cifuentes-Ródenas, José A., Suárez, Marta Castro, Losada, Manuel, Hernández, Miguel, Alonso, Alfredo, Diéguez, Beatriz, Serralta, Daniel, Medina Quintana, Rita E., Gil Lopez, Jose M., Pinto, Francisca Lima, Nieto-Moreno, Elena, Bonito, Alba Correa, Santacruz, Carlos Cerdán, Marcos, Elena Bermejo, Septiem, Javier García, Calero-Lillo, Aránzazu, Alanez-Saavedra, Javier, Muñoz-Collado, Salvador, López-Lara, Manuel, Martínez, María Labalde, Herrero, Eduardo Ferrero, Borda, Francisco Javier García, Villar, Óscar García, Escartín, Jorge, Blas, Juan L., Ferrer, Rocío, Egea, Jorge García, Rodríguez-Infante, Antonio, Mínguez-Ruiz, Germán, Carreño-Villarreal, Guillermo, Pire-Abaitua, Gerardo, Dziakova, Jana, Rodríguez, Carlos Sáez-Cazallas, Pizarro Aranda, María J., Muguerza Huguet, José M., Borda-Arrizabalaga, Nerea, Enriquez-Navascués, José M., Echaniz, Garazi Elorza, Ansorena, Yolanda Saralegui, Estaire-Gómez, Mercedes, Martínez-Pinedo, Carlos, Barbero-Valenzuela, Alejandro, Ruíz-García, Pablo, Kraft, Miquel, Gómez-Jurado, María J., Pellino, Gianluca, Espín-Basany, Eloy, Cotte, Eddy, Panel, Nathalie, Goutard, Claire-Angéline, deÁngelis, Nicola, Lauka, Lelde, Shaikh, Shafaque, Osborne, Laura, Ramsay, George, Nichita, Vladimir-Ion, Bhandari, Santosh, Sarmah, Panchali, Bethune, Rob M., Pringle, Heather C.M., Massey, Lisa, Fowler, George E., Hamid, Hytham K.S., de Simone, Belinda D., Kynaston, James, Bradley, Nicholas, Stienstra, Roxane M., Gurjar, Shashank, Mukherjee, Tanmoy, Chandio, Ashfaq, Ahmed, Safia, Singh, Baljit, Runau, Francois, Chaudhri, Sanjay, Siaw, Oliver, Sarveswaran, Janahan, Miu, Victor, Ashmore, Daniel, Darwich, Haitham, Singh-Ranger, Deepak, Singh, Nirbhaibir, Shaban, Mohamed, Gareb, Fahed, Petropolou, Thalia, Polydorou, Adreas, Dattani, Mit, Afzal, Asma, Bavikatte, Akshay, Sebastian, Boby, Ward, Nicholas, Mishra, Amitabh, Manatakis, Dimitrios, Agalianos, Christos, Tasis, Nikolaos, Antonopoulou, Maria-Ioanna, Karavokyros, Ioannis, Charalabopoulos, Alexandros, Schizas, Dimitrios, Baili, Efstratia, Syllaios, Athanasios, Karydakis, Lysandros, Vailas, Michail, Balalis, Dimitrios, Korkolis, Dimitrios, Plastiras, Aris, Rompou, Aliki, Xenaki, Sofia, Xynos, Evangelos, Chrysos, Emmanuel, Venianaki, Maria, Christodoulidis, Grigorios, Perivoliotis, Konstantinos, Tzovaras, George, Baloyiannis, Ioannis, Ho, Man-Fung, Ng, Simon Siu-man, Mak, Tony Wing-chung, Futaba, Kaori, Šantak, Goran, Šimleša, Damir, osić, Jurica, Zukanović, Goran, Kelly, Michael E., Larkin, John O., McCormick, Paul H., Mehigan, Brian J., Connelly, Tara M., Neary, Peter, Ryan, Jessica, McCullough, Peter, Al-Juaifari, Maytham A., Hammoodi, Hayder, Abbood, Ali Hashim, Calabrò, Marcello, Muratore, Andrea, Terra, Antonio La, Farnesi, Francesca, Feo, Carlo V., Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Ripoli, Maria Cristina, Sambucci, Daniele, Porta, Andrea, Sinibaldi, Giovanni, Crescentini, Giacomo, larcinese, Antonella, Picone, Emanuele, Persiani, Roberto, Biondi, Alberto, Pezzuto, Roberto, Lorenzon, Laura, Rizzo, Gianluca, Coco, Claudio, D’Agostino, Luca, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Maroli, Annalisa, Palini, Gian M., Garulli, Gianluca, Zanini, Nicola, Delrio, Paolo, Rega, Daniela, Carbone, Fabio, Aversano, Alessia, Pirozzolo, Giovanni, Recordare, Alfonso, DʼAlimonte, Lucrezia, Vignotto, Chiara, Corbellini, Carlo, Sampietro, Gianluca M., Lorusso, Leonardo, Manzo, Carlo A., Ghignone, Federico, Ugolini, Giampaolo, Montroni, Isacco, Pasini, Franceso, Pasini, Francesco, Ballabio, Michele, Bisagni, Pietro, Armao, Francesca T., Longhi, Marco, Ghazouani, Omar, Galleano, Raffaele, Tamini, Nicolò, Oldani, Massimo, Nespoli, Luca, Picciariello, Arcangelo, Altomare, Donato F., Tomasicchio, Giovanni, Lantone, Giuliano, Catena, Fausto, Giuffrida, Mario, Annicchiarico, Alfredo, Perrone, Gennaro, Grossi, Ugo, Santoro, Giulio A., Zanus, Giacomo, Iacomino, Alessandro, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, deGiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, Mariani, Nicolò M., Ceretti, Andrea P., Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, Bottazzoli, Elisa I., Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, de Pasqual, Carlo A., de Manzoni, Giovanni, di Cosmo, Maria A., Alrayes, Bourhan M.H., Qandeel, Mahmoud W. M., Hani, Mohammad Bani, Rabadi, Alexander, el Muhtaseb, Mohammad S., Abdeen, Basel, Karmi, Fahed, Žilinskas, Justas, Latkauskas, Tadas, Tamelis, Algimantas, Pikūnienė, Ingrida, Šlenfuktas, Vygintas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Mikalauskas, Saulius, Jakubauskiene, Lina, Hassan, Soha Y., Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudus, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, Msherghi, Ahmed A., Tababa, Osama W.E., Majbar, Mohammed A., Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, Sainz-Hernández, Juan C., Alvarez-Bautista, Francisco E., Zakaria, Andee D., Zakaria, Zaidi, Wong, Michael P.K., Ismail, Razif, Ibrahim, Aini F., Abdullah, Nik A.N., Julaihi, Rokayah, Bhat, Sameer, OʼGrady, Greg, Bissett, Ian, Lamme, Bas, Musters, Gijsbert D., Dinaux, Anne M., Grotenhuis, Brechtje A., Steller Arend G.J. Aalbers, Ernst J., Leeuwenburgh, Marjolein M., Rutten, Harm J.T., Burger, Jacobus W.A., Bloemen, Johanne G., Ketelaers, Stijn H.J., Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Talsma, Aaldert K., Scheurink, Lieke, van Praagh, Jasper B., Segelman, Josefin, Nygren, Jonas, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, Beltrán de Heredia, Juan P., Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andreas, Niemer, Quirine, Doornebosch, Pascal G., Shapiro, Joël, Vermaas, Maarten, de Graaf, Eelco J.R., van Westreenen, Hendrik L., Zwakman, Marije, van Dalsen, Annette D., Vles, Wouter J., Nonner, Joost, Toorenvliet, Boudewijn R., Janssen, Paul T.J., Verdaasdonk, Emiel G.G., Amelung, Femke J., Peeters Renu R. Bahadoer, Koen C.M.J., Holman, Fabian A., Heemskerk, Jeroen, Vosbeek, Noortje, Leijtens, Jeroen W.A., Taverne, Sophie B.M., Heijnen, Bob H.M., El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, Consten, Esther C.J., Burghgraef, Thijs A., Geitenbeek, Ritch, Hulshof, Lorenzo G.W.L., Slooter, Gerrit D., Reudink, Muriël, Bouvy, Nicole D., Wildeboer, Aurelia C. L., Verstappen, Sonja, Pennings, Alexander J., van den Hengel, Berber, Wijma, Allard G., de Haan, Jael, de Nes, Lindsey C.F., Heesink, Vera, Karsten, Tom, Heidsma, Charlotte M., Koemans, Willem J., Dekker, Jan-Willem T., van der Zijden, Charlène J., Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, Oosterling, Steven J., Hoogteijling, Tijs J., Wiering, Bastiaan, Smeeing, Diederik P.J., Havenga, Klaas, Lutfi, Hamid, Consten, Esther C.J., Tsimogiannis, Konstantinos, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, van Schaik, Ted G., van Gerven, Pieter, Sietses, Colin, Hol, Jeroen C., Boerma, Evert-Jan G., Creemers, Davy M.J., Schultz, Johannes K., Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, Sjo, Ole H., Gaard, Maria, Krohn, Nina, Ersryd, Amanda L., Leung, Edmund, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Sultan, Hytham, Hajjaj, Baraa Nabil, Alhisi, Ahmed Jehad, Khader, Ahmed A.E., Mendes, Ana Filipa Dias, Semião, Miguel, Faria, Luis Queiroz, Azevedo, Constança, da Costa Devesa, Helena M., Martins, Sónia Fortuna, Rodrigues Jarimba, Aldo M., Ribeiro Marques, Sónia M., Ferreira, Rita Marques, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, Surlin, Valeriu M., Graure, Giorgiana M., Ramboiu, Stefan Patrascu Sandu D., Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, Stoica, Bogdan, Ciubotaru, Cezar, Negoita, Valentina M., Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mu[Latin Small Letter s with comma below]ină, Ana-Maria, Garmanova, Tatiana, Agapov, Mikhail N., Markaryan, Daniil G., Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, Rodimov, Sergey V., Filimonov, Victor B., Melnikov, Andrey A., Suchkov, Igor A., Drozdov, EvgeniyS., Kostromitskiy, Dmitriy N., Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Jadid, Kaveh Dehlaghi, Staffan, Maria, Park, Jennifer M., Rydbeck, Daniel, Lydrup, Marie-Louise, Buchwald, Pamela, Jutesten, Henrik, Darlin, Lotten, Lindqvist, Ebba, Nilsson, Karl, Larsson, Per-Anders, Jangmalm, Staffan, Košir, Jurij A., Tomažič, Aleš, Grosek, Jan, Božič, Tajda Košir, Zazo, Aya, Zazo, Rama, Fares, Hala, Ayoub, Kusay, Niazi, Ammar, Mansour, Ali, Abbas, Ayman, Tantoura, Mohammad, Hamdan, Alaa, Hassan, Naya, Hasan, Bassam, Saad, Ahmad, Sebai, Amine, Haddad, Anis, Maghrebi, Houcine, Kacem, Montasser, Yalkın, Ömer, Samsa, Mehmet Veysi, Atak, İbrahim, Balci, Bengi, Haberal, Elifcan, Dogan, Lütfi, Gecim, Ibrahim E., Akyol, Cihangir, Koc, Mehmet A., Sivrikoz, Emre, Piyadeoğlu, Deniz, Larkin, John O., avanagh, Dara O., Sökmen, Selman, Bişgin, Tayfun, Günenç, Erşan, Güzel, Melek, Leventoğlu, Sezai, Yüksel, Osman, Kozan, Ramazan, Göbüt, Hüseyin, Cengiz, Fevzi, Erdinc, Kemal, Acar, Nihan Coşgun, Kamer, Erdinc, Özgür, İlker, Aydın, Oguzhan, Keskin, Metin, Bulut, Mehmet Türker, Kulle, Cemil B., Kara, Yasin, Sıbıç, Osman, Özata, İbrahim H., Buğra, Dursun, Balık, Emre, Kulle, Cemil B., Çakır, Murat, Alhardan, Anas, Colak, Elif, CiftciEngin Aybar, Ahmet B., Sari, Ahmet Can, Atici, Semra Demirli, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Özkan, Ömer Faruk, Ülgür, Hanife Şeyda, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, and Lambrechts, Anton

Published
2023
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27. Textbook Oncological Outcome in European GASTRODATA

Author

Sędłak, Katarzyna, Rawicz-Pruszyński, Karol, Mlak, Radosław, Van Sandick, Johanna, Gisbertz, Suzanne, Pera, Manuel, Dal Cero, Mariagiulia, Baiocchi, Gian Luca, Celotti, Andrea, Morgagni, Paolo, Vittimberga, Giovani, Hoelscher, Arnulf, Moenig, Stefan, Kołodziejczyk, Piotr, Richter, Piotr, Gockel, Ines, Piessen, Guillaume, Da Costa, Paulo Matos, Davies, Andrew, Baker, Cara, Allum, William, Romario, Uberto Fumagalli, De Pascale, Stefano, Rosati, Ricccardo, Reim, Daniel, Santos, Lucio Lara, D’ugo, Domenico, Wijnhoven, Bas, Degiuli, Maurizio, De Manzoni, Giovanni, Kielan, Wojciech, Frejlich, Ewelina, Schneider, Paul, and Polkowski, Wojciech P.

Published
2023
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28. Pre-Surgical Endoscopic Biopsies Are Representative of Esophageal and Esophago-Gastric Junction Adenocarcinoma Histologic Classes and Survival Risk.

Author

Gambella, Alessandro, Fiocca, Roberto, Lugaresi, Marialuisa, D'Errico, Antonietta, Malvi, Deborah, Spaggiari, Paola, Tomezzoli, Anna, Albarello, Luca, Ristimäki, Ari, Bottiglieri, Luca, Bonora, Elena, Krishnadath, Kausilia K., Raulli, Gian Domenico, Rosati, Riccardo, Romario, Uberto Fumagalli, De Manzoni, Giovanni, Räsänen, Jari, Mattioli, Sandro, Grillo, Federica, and Mastracci, Luca

Subjects
PREOPERATIVE period, BIOPSY, ADENOCARCINOMA, PREDICTIVE tests, RISK assessment, STOMACH tumors, RESEARCH funding, DATA analysis, ESOPHAGEAL tumors, RETROSPECTIVE studies, DESCRIPTIVE statistics, LONGITUDINAL method, ENDOSCOPIC gastrointestinal surgery, MEDICAL records, ACQUISITION of data, RESEARCH, HISTOLOGICAL techniques, STATISTICS, SURVIVAL analysis (Biometry), COLLECTION & preservation of biological specimens, TUMOR classification, SENSITIVITY & specificity (Statistics)
Abstract

Simple Summary: The surgical specimen histology of esophageal and esophago-gastric junction adenocarcinomas (EA-EGJAs) classified according to the Esophageal Adenocarcinoma Study Group Europe (EACSGE) proposal, eventually combined with the pTNM stage, is an efficient indicator of prognosis, molecular events, and response to treatment. To explore if this histologic classification may be applied to endoscopic biopsies collected at the initial diagnostic workup, we compared the histology of endoscopic and matched surgical specimen tissues collected from 106 cases of EA-EGJA with no neoadjuvant therapy. Histologic classes of endoscopic biopsies and surgical specimen were coincident. Further studies will indicate if EA-EGJA biopsy provides detailed morphological/biological information "per se" for planning therapy, if biopsy histomorphology/clinical TNM crossing is as efficient as the surgical specimen histomorphology/pTNM one, to predict prognosis and to tailor therapy. Background and Objectives: The Esophageal Adenocarcinoma Study Group Europe (EACSGE) recently proposed a granular histologic classification of esophageal–esophago-gastric junctional adenocarcinomas (EA-EGJAs) based on the study of naïve surgically resected specimens that, when combined with the pTNM stage, is an efficient indicator of prognosis, molecular events, and response to treatment. In this study, we compared histologic classes of endoscopic biopsies taken before surgical resection with those of the surgical specimen, to evaluate the potential of the EACSGE classification at the initial diagnostic workup. Methods: A total of 106 EA-EGJA cases with available endoscopic biopsies and matched surgical resection specimens were retrieved from five Italian institutions. Histologic classification was performed on all specimens to identify well-differentiated glandular adenocarcinoma (WD-GAC), poorly differentiated glandular adenocarcinoma (PD-GAC), mucinous muconodular carcinoma (MMC), infiltrative mucinous carcinoma (IMC), diffuse desmoplastic carcinoma, diffuse anaplastic carcinoma (DAC), and mixed subtypes. Related risk subgroups (low-risk versus high-risk) were also assessed. The correlations of histologic classes and risk subgroups between diagnostic biopsies and surgical resection specimens were explored with Spearman's correlation test. Sensitivity, specificity, accuracy, positive predictive value, negative predictive value, true positives, true negatives, false positives, and false negatives were also calculated. Results: A strong positive correlation between biopsies and surgical specimens occurred for both histologic classes (coefficient: 0.75, p < 0.001) and risk subgroups (coefficient: 0.65, p < 0.001). The highest sensitivities and specificities were observed for MMC, IMC, and DAC (100% and 99% for all), followed by WD-GAC (sensitivity 91%, specificity 79%) and PD-GAC (sensitivity 722%, specificity 86%). The low-risk and high-risk groups presented a sensitivity and specificity of 89% and 76% (low-risk) and 76% and 89% (high-risk). Conclusions: The EACSGE histologic classification of EA-EGJAs and associated prognostic subgroups can be reliably assessed on pre-operative diagnostic biopsies. Further studies on larger and more representative cohorts of EA-EGJAs will allow us to validate our findings and confirm if the EA-EGJA biopsy histomorphology and clinical TNM staging will be as efficient as the surgical specimen histomorphology and pTNM in predicting patient prognoses and tailoring personalized therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Structured and shared CT radiological report of gastric cancer: a consensus proposal by the Italian Research Group for Gastric Cancer (GIRCG) and the Italian Society of Medical and Interventional Radiology (SIRM)

Author

Mazzei, Maria Antonietta, Bagnacci, Giulio, Gentili, Francesco, Capitoni, Iacopo, Mura, Gianni, Marrelli, Daniele, Petrioli, Roberto, Brunese, Luca, Cappabianca, Salvatore, Catarci, Marco, Degiuli, Maurizio, De Manzoni, Giovanni, De Prizio, Marco, Donini, Annibale, Romario, Uberto Fumagalli, Funicelli, Luigi, Laghi, Andrea, Minetti, Giuseppe, Morgagni, Paolo, Petrella, Enrico, Pittiani, Frida, Rausei, Stefano, Romanini, Laura, Rosati, Riccardo, Ianora, Amato Antonio Stabile, Tiberio, Guido A. M., Volterrani, Luca, Roviello, Franco, and Grassi, Roberto

Published
2022
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31. Genomic characterization of hepatoid tumors: context matters

Author

Lawlor, Rita T., Mafficini, Andrea, Sciammarella, Concetta, Cantù, Cinzia, Rusev, Borislav C., Piredda, Maria L., Antonello, Davide, Grimaldi, Sonia, Bonizzato, Giada, Sperandio, Nicola, Marchegiani, Giovanni, Malleo, Giuseppe, Pea, Antonio, Salvia, Roberto, Mombello, Aldo, Mazzoleni, Guido, Nottegar, Alessia, Hanspeter, Esther, Riva, Giulio, Tomezzoli, Anna, Bencivenga, Maria, de Manzoni, Giovanni, Pedron, Serena, Paolino, Gaetano, Mattiolo, Paola, Brosens, Lodewijk A., Silvestris, Nicola, Fassan, Matteo, Cooke, Susanna L., Beer, Philip A., Milella, Michele, Adsay, Volkan N., Cheng, Liang, Scarpa, Aldo, and Luchini, Claudio

Published
2021
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38. Current trends in the management of Gastro-oEsophageal cancers: Updates to the ESSO core curriculum (ESSO-ETC-UGI-WG initiative)

Author

Herrera Kok, Johnn Henry, primary, Marano, Luigi, additional, van den Berg, Jan Willem, additional, Shetty, Preethi, additional, Vashist, Yogesh, additional, Lorenzon, Laura, additional, Rau, Beate, additional, van Hillegersberg, Richard, additional, de Manzoni, Giovanni, additional, Spallanzani, Andrea, additional, Seo, Won Jun, additional, Nagata, Hiromi, additional, Eveno, Clarisse, additional, Mönig, Stefan, additional, van der Sluis, Karen, additional, Solaini, Leonardo, additional, Wijnhoven, Bas PL., additional, Puccetti, Francesco, additional, Chevallay, Mickael, additional, Lee, Eunju, additional, and D´Ugo, Domenico, additional

Published
2024
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39. Textbook Neoadjuvant Outcome—Novel Composite Measure of Oncological Outcomes among Gastric Cancer Patients Undergoing Multimodal Treatment

Author

Pelc, Zuzanna, primary, Sędłak, Katarzyna, additional, Leśniewska, Magdalena, additional, Mielniczek, Katarzyna, additional, Chawrylak, Katarzyna, additional, Skórzewska, Magdalena, additional, Ciszewski, Tomasz, additional, Czechowska, Joanna, additional, Kiszczyńska, Agata, additional, Wijnhoven, Bas P. L., additional, Van Sandick, Johanna W., additional, Gockel, Ines, additional, Gisbertz, Suzanne S., additional, Piessen, Guillaume, additional, Eveno, Clarisse, additional, Bencivenga, Maria, additional, De Manzoni, Giovanni, additional, Baiocchi, Gian Luca, additional, Morgagni, Paolo, additional, Rosati, Riccardo, additional, Fumagalli Romario, Uberto, additional, Davies, Andrew, additional, Endo, Yutaka, additional, Pawlik, Timothy M., additional, Roviello, Franco, additional, Bruns, Christiane, additional, Polkowski, Wojciech P., additional, and Rawicz-Pruszyński, Karol, additional

Published
2024
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47. International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape

Author

Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ine, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Marku, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Ba, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, de Manzoni, Giovanni, Allum, William, Bagnacci, Giulio, Baiocchi, Gian Luca, Berlth, Felix, Borgno, Laura, Yan, Jimmy So Bok, Caccialanza, Riccardo, Casella, Francesco, Castelli, Claudia, Chevallay, Mikael, Corso, Simona, Da Costa, Paulo Mato, Dal Cero, Mariagiulia, De Giuli, Maurizio, De Pascale, Stefano, Donini, Annibale, D'Ugo, Domenico, Ercolani, Giorgio, Filippini, Federica, Framarini, Massimo, Frejlich, Ewelina, Romario, Uberto Fumagalli, Giacopuzzi, Simone, Giordano, Silvia, Graziosi, Luigina, Hartgrink, Henk, Hölscher, Arnulf H., Kim, Jeesun, Kroese, Tiuri, Gomes, Lourenco Laercio, Santos, Lucio Lara, Liu, Drolaiz, Lordick, Florian, Marano, Luigi, Marino, Elisabetta, Martinelli, Giovanni, Meyer, Hans-Joachim, Ministrini, Silvia, Mansfield, Paul F., Molinari, Chiara, Monti, Manlio, Moulla, Yusef, Nilsson, Magnu, Patuzzo, Sara, Pera, Manuel, Castro, Osvaldo Antonio Prado, Quinzii, Alberto, Rapposelli, Ilario Giovanni, Rausei, Stefano, Reddavid, Rossella, Rosa, Fausto, Rosati, Riccardo, Rossi, Romina, Roviello, Giandomenico, Rudno-Rudzinska, Julia, Sacco, Michele, Salati, Massimiliano, Schneider, Paul M., Solaini, Leonardo, Terashima, Masanori, Tomezzoli, Anna, Valgiusti, Martina, Weston, Antonio Carlo, Wojciech, Kielan, Thortsen, Goetze, Null, Null, D'Ugo, Domenico (ORCID:0000-0001-6657-6318), Rosa, Fausto (ORCID:0000-0002-7280-8354), Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ine, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Marku, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Ba, Tiberio, Guido Alberto Massimo, Yang, Han-Kwang, Roviello, Franco, de Manzoni, Giovanni, Allum, William, Bagnacci, Giulio, Baiocchi, Gian Luca, Berlth, Felix, Borgno, Laura, Yan, Jimmy So Bok, Caccialanza, Riccardo, Casella, Francesco, Castelli, Claudia, Chevallay, Mikael, Corso, Simona, Da Costa, Paulo Mato, Dal Cero, Mariagiulia, De Giuli, Maurizio, De Pascale, Stefano, Donini, Annibale, D'Ugo, Domenico, Ercolani, Giorgio, Filippini, Federica, Framarini, Massimo, Frejlich, Ewelina, Romario, Uberto Fumagalli, Giacopuzzi, Simone, Giordano, Silvia, Graziosi, Luigina, Hartgrink, Henk, Hölscher, Arnulf H., Kim, Jeesun, Kroese, Tiuri, Gomes, Lourenco Laercio, Santos, Lucio Lara, Liu, Drolaiz, Lordick, Florian, Marano, Luigi, Marino, Elisabetta, Martinelli, Giovanni, Meyer, Hans-Joachim, Ministrini, Silvia, Mansfield, Paul F., Molinari, Chiara, Monti, Manlio, Moulla, Yusef, Nilsson, Magnu, Patuzzo, Sara, Pera, Manuel, Castro, Osvaldo Antonio Prado, Quinzii, Alberto, Rapposelli, Ilario Giovanni, Rausei, Stefano, Reddavid, Rossella, Rosa, Fausto, Rosati, Riccardo, Rossi, Romina, Roviello, Giandomenico, Rudno-Rudzinska, Julia, Sacco, Michele, Salati, Massimiliano, Schneider, Paul M., Solaini, Leonardo, Terashima, Masanori, Tomezzoli, Anna, Valgiusti, Martina, Weston, Antonio Carlo, Wojciech, Kielan, Thortsen, Goetze, Null, Null, D'Ugo, Domenico (ORCID:0000-0001-6657-6318), and Rosa, Fausto (ORCID:0000-0002-7280-8354)

Abstract

Background: Many gastric cancer patients in Western countries are diagnosed as metastatic with a median overall survival of less than twelve months using standard chemotherapy. Innovative treatments, like targeted therapy or immunotherapy, have recently proved to ameliorate prognosis, but a general agreement on managing oligometastatic disease has yet to be achieved. An international multi-disciplinary workshop was held in Bertinoro, Italy, in November 2022 to verify whether achieving a consensus on at least some topics was possible. Methods: A two-round Delphi process was carried out, where participants were asked to answer 32 multiple-choice questions about CT, laparoscopic staging and biomarkers, systemic treatment for different localization, role and indication of palliative care. Consensus was established with at least a 67% agreement. Results: The assembly agreed to define oligometastases as a "dynamic" disease which either regresses or remains stable in response to systemic treatment. In addition, the definition of oligometastases was restricted to the following sites: para-aortic nodal stations, liver, lung, and peritoneum, excluding bones. In detail, the following conditions should be considered as oligometastases: involvement of para-aortic stations, in particular 16a2 or 16b1; up to three technically resectable liver metastases; three unilateral or two bilateral lung metastases; peritoneal carcinomatosis with PCI ≤ 6. No consensus was achieved on how to classify positive cytology, which was considered as oligometastatic by 55% of participants only if converted to negative after chemotherapy. Conclusion: As assessed at the time of diagnosis, surgical treatment of oligometastases should aim at R0 curativity on the entire disease volume, including both the primary tumor and its metastases. Conversion surgery was defined as surgery on the residual volume of disease, which was initially not resectable for technical and/or oncological reasons but nevertheless r

Published
2024

48. Reconstruction Techniques and Associated Morbidity in Minimally Invasive Gastrectomy for Cancer Insights From the GastroBenchmark and GASTRODATA databases

Author

Schneider, Marcel Andre, Kim, Jeesun, Berlth, Felix, Sugita, Yutaka, Grimminger, Peter P., Wijnhoven, Bas P. L., Overtoom, Hidde, Gockel, Ines, Thieme, Rene, Griffiths, Ewen A., Butterworth, William, Nienhuser, Henrik, Mueller, Beat, Crnovrsanin, Nerma, Gero, Daniel, Nickel, Felix, Gisbertz, Suzanne, van Berge Henegouwen, Mark I., Pucher, Philip H., Khan, Kashuf, Chaudry, Asif, Patel, Pranav H., Pera, Manuel, Dal Cero, Mariagiulia, Garcia, Carlos, Martinez Salinas, Guillermo, Kassab, Paulo, Prado Castro, Osvaldo Antonio, Norero, Enrique, Wisniowski, Paul, Putnam, Luke Randall, Lombardi, Pietro Maria, Ferrari, Giovanni, Gudaityte, Rita, Maleckas, Almantas, Prodehl, Leanne, Castaldi, Antonio, Prudhomme, Michel, Lee, Hyuk-Joon, Sano, Takeshi, Baiocchi, Gian Luca, De Manzoni, Giovanni, Giacopuzzi, Simone, Bencivenga, Maria, Rosati, Riccardo, Puccetti, Francesco, D'Ugo, Domenico, Nunobe, Souya, Yang, Han-Kwang, Gutschow, Christian Alexander, Schneider, Marcel Andre, Kim, Jeesun, Berlth, Felix, Sugita, Yutaka, Grimminger, Peter P., Wijnhoven, Bas P. L., Overtoom, Hidde, Gockel, Ines, Thieme, Rene, Griffiths, Ewen A., Butterworth, William, Nienhuser, Henrik, Mueller, Beat, Crnovrsanin, Nerma, Gero, Daniel, Nickel, Felix, Gisbertz, Suzanne, van Berge Henegouwen, Mark I., Pucher, Philip H., Khan, Kashuf, Chaudry, Asif, Patel, Pranav H., Pera, Manuel, Dal Cero, Mariagiulia, Garcia, Carlos, Martinez Salinas, Guillermo, Kassab, Paulo, Prado Castro, Osvaldo Antonio, Norero, Enrique, Wisniowski, Paul, Putnam, Luke Randall, Lombardi, Pietro Maria, Ferrari, Giovanni, Gudaityte, Rita, Maleckas, Almantas, Prodehl, Leanne, Castaldi, Antonio, Prudhomme, Michel, Lee, Hyuk-Joon, Sano, Takeshi, Baiocchi, Gian Luca, De Manzoni, Giovanni, Giacopuzzi, Simone, Bencivenga, Maria, Rosati, Riccardo, Puccetti, Francesco, D'Ugo, Domenico, Nunobe, Souya, Yang, Han-Kwang, and Gutschow, Christian Alexander

Abstract

Objective/Background: Various anastomotic and reconstruction techniques are used for minimally invasive total (miTG) and distal gastrectomy (miDG). Their effects on postoperative morbidity have not been extensively studied. Methods: MiTG and miDG patients were selected from 9356 oncological gastrectomies performed in 2017-2021 in 43 centers. Endpoints included anastomotic leakage (AL) rate and postoperative morbidity tested by multivariable analysis. Results: Three major anastomotic techniques [circular stapled (CS); linear stapled (LS); and hand sewn (HS)], and 3 major bowel reconstruction types [Roux (RX); Billroth I (BI); Billroth II (BII)] were identified in miTG (n=878) and miDG (n=3334). Postoperative complications, including AL (5.2% vs 1.1%), overall (28.7% vs 16.3%), and major morbidity (15.7% vs 8.2%), as well as 90-day mortality (1.6% vs 0.5%) were higher after miTG compared with miDG. After miTG, the AL rate was higher after CS (4.3%) and HS (7.9%) compared with LS (3.4%). Similarly, major complications (LS: 9.7%, CS: 16.2%, and HS: 12.7%) were lowest after LS. Multivariate analysis confirmed anastomotic technique as a predictive factor for AL, overall, and major complications. In miDG, AL rate (BI: 1.4%, BII 0.8%, and RX 1.2%), overall (BI: 14.5%, BII: 15.0%, and RX: 18.7%), and major morbidity (BI: 7.9%, BII: 9.1%, and RX: 7.2%), and mortality (BI: 0%, BII: 0.1%, and RY: 1.1%%) were not affected by bowel reconstruction. Conclusions: In oncologically suitable situations, miDG should be preferred to miTG, as postoperative morbidity is significantly lower. LS should be a preferred anastomotic technique for miTG in Western Centers. Conversely, bowel reconstruction in DG may be chosen according to the surgeon's preference.

Published
2024

49. Correction: International consensus on the management of metastatic gastric cancer: step by step in the foggy landscape (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2024) 27 4 DOI: 10.1007/s10120-024-01479-5)

Author

MS CGO, Cancer, Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han Kwang, Roviello, Franco, de Manzoni, Giovanni, Bertinoro Workshop Working Group, MS CGO, Cancer, Morgagni, Paolo, Bencivenga, Maria, Carneiro, Fatima, Cascinu, Stefano, Derks, Sarah, Di Bartolomeo, Maria, Donohoe, Claire, Eveno, Clarisse, Gisbertz, Suzanne, Grimminger, Peter, Gockel, Ines, Grabsch, Heike, Kassab, Paulo, Langer, Rupert, Lonardi, Sara, Maltoni, Marco, Markar, Sheraz, Moehler, Markus, Marrelli, Daniele, Mazzei, Maria Antonietta, Melisi, Davide, Milandri, Carlo, Moenig, Paul Stefan, Mostert, Bianca, Mura, Gianni, Polkowski, Wojciech, Reynolds, John, Saragoni, Luca, Van Berge Henegouwen, Mark I., Van Hillegersberg, Richard, Vieth, Michael, Verlato, Giuseppe, Torroni, Lorena, Wijnhoven, Bas, Tiberio, Guido Alberto Massimo, Yang, Han Kwang, Roviello, Franco, de Manzoni, Giovanni, and Bertinoro Workshop Working Group

Published
2024

50. Clinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023

Author

MS CGO, Cancer, Kitagawa, Yuko, Matsuda, Satoru, Gotoda, Takuji, Kato, Ken, Wijnhoven, Bas, Lordick, Florian, Bhandari, Pradeep, Kawakubo, Hirofumi, Kodera, Yasuhiro, Terashima, Masanori, Muro, Kei, Takeuchi, Hiroya, Mansfield, Paul F., Kurokawa, Yukinori, So, Jimmy, Mönig, Stefan Paul, Shitara, Kohei, Rha, Sun Young, Janjigian, Yelena, Takahari, Daisuke, Chau, Ian, Sharma, Prateek, Ji, Jiafu, de Manzoni, Giovanni, Nilsson, Magnus, Kassab, Paulo, Hofstetter, Wayne L., Smyth, Elizabeth Catherine, Lorenzen, Sylvie, Doki, Yuichiro, Law, Simon, Oh, Do Youn, Ho, Khek Yu, Koike, Tomoyuki, Shen, Lin, van Hillegersberg, Richard, Kawakami, Hisato, Xu, Rui Hua, Wainberg, Zev, Yahagi, Naohisa, Lee, Yeong Yeh, Singh, Rajvinder, Ryu, Min Hee, Ishihara, Ryu, Xiao, Zili, Kusano, Chika, Grabsch, Heike Irmgard, Hara, Hiroki, Mukaisho, Ken Ichi, Makino, Tomoki, Kanda, Mitsuro, Booka, Eisuke, Suzuki, Sho, Hatta, Waku, Kato, Motohiko, Maekawa, Akira, Kawazoe, Akihito, Yamamoto, Shun, Nakayama, Izuma, Narita, Yukiya, Yang, Han Kwang, Yoshida, Masahiro, Sano, Takeshi, MS CGO, Cancer, Kitagawa, Yuko, Matsuda, Satoru, Gotoda, Takuji, Kato, Ken, Wijnhoven, Bas, Lordick, Florian, Bhandari, Pradeep, Kawakubo, Hirofumi, Kodera, Yasuhiro, Terashima, Masanori, Muro, Kei, Takeuchi, Hiroya, Mansfield, Paul F., Kurokawa, Yukinori, So, Jimmy, Mönig, Stefan Paul, Shitara, Kohei, Rha, Sun Young, Janjigian, Yelena, Takahari, Daisuke, Chau, Ian, Sharma, Prateek, Ji, Jiafu, de Manzoni, Giovanni, Nilsson, Magnus, Kassab, Paulo, Hofstetter, Wayne L., Smyth, Elizabeth Catherine, Lorenzen, Sylvie, Doki, Yuichiro, Law, Simon, Oh, Do Youn, Ho, Khek Yu, Koike, Tomoyuki, Shen, Lin, van Hillegersberg, Richard, Kawakami, Hisato, Xu, Rui Hua, Wainberg, Zev, Yahagi, Naohisa, Lee, Yeong Yeh, Singh, Rajvinder, Ryu, Min Hee, Ishihara, Ryu, Xiao, Zili, Kusano, Chika, Grabsch, Heike Irmgard, Hara, Hiroki, Mukaisho, Ken Ichi, Makino, Tomoki, Kanda, Mitsuro, Booka, Eisuke, Suzuki, Sho, Hatta, Waku, Kato, Motohiko, Maekawa, Akira, Kawazoe, Akihito, Yamamoto, Shun, Nakayama, Izuma, Narita, Yukiya, Yang, Han Kwang, Yoshida, Masahiro, and Sano, Takeshi

Published
2024

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