1. CCR2 and CCR5 genes polymorphisms in women with cervical lesions from Pernambuco, Northeast Region of Brazil: a case-control study
- Author
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Erinaldo Ubirajara Damasceno dos Santos, Gessica Dayane Cordeiro de Lima, Sergio Crovella, Paulo Roberto Eleutério de Souza, Micheline de Lucena Oliveira, Maria de Mascena Diniz Maia, Hildson Dornelas Angelo da Silva, Sandra de Andrade Heráclio, dos Santos, Erinaldo Ubirajara Damasceno, de Lima, Géssica Dayane Cordeiro, Oliveira, Micheline De Lucena, Heráclio, Sandra De Andrade, da Silva, Hildson Dornelas Angelo, Crovella, Sergio, Maia, Maria de Mascena Diniz, and de Souza, Paulo Roberto Eleutério
- Subjects
0301 basic medicine ,Cervical cancer ,Cervical intraepithelial neoplasia ,Chemokine receptors ,Single nucleotide polymorphism ,Microbiology (medical) ,cervical cancer ,lcsh:QR1-502 ,chemokine receptors ,Gastroenterology ,lcsh:Microbiology ,Uterine Cervical Diseases ,0302 clinical medicine ,single nucleotide polymorphism ,Genotype ,Prevalence ,Medicine ,Papillomaviridae ,biology ,virus diseases ,Articles ,Middle Aged ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,Squamous Intraepithelial Lesions of the Cervix ,Brazil ,Adult ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,Adolescent ,Receptors, CCR5 ,lcsh:RC955-962 ,Chemokine receptor ,Receptors, CCR2 ,Single-nucleotide polymorphism ,cervical intraepithelial neoplasia ,03 medical and health sciences ,Young Adult ,Internal medicine ,Humans ,Genetic Predisposition to Disease ,Genotyping ,Cervix ,Aged ,Polymorphism, Genetic ,business.industry ,Papillomavirus Infections ,medicine.disease ,biology.organism_classification ,Uterine Cervical Dysplasia ,030104 developmental biology ,Case-Control Studies ,Immunology ,business - Abstract
Polymorphisms in chemokine receptors play an important role in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer (CC). Our study examined the association of CCR2-64I (rs1799864) andCCR5-Δ32 (rs333) polymorphisms with susceptibility to develop cervical lesion (CIN and CC) in a Brazilian population. The genotyping of 139 women with cervical lesions and 151 women without cervical lesions for the CCR2-64I and CCR5-Δ32 polymorphisms were performed using polymerase chain reaction-restriction fragment length polymorphism. The individuals carrying heterozygous or homozygous genotypes (GA+AA) for CCR2-64I polymorphisms seem to be at lower risk for cervical lesion [odds ratio (OR) = 0.37, p = 0.0008)]. The same was observed for the A allele (OR = 0.39, p = 0.0002), while no association was detected (p > 0.05) with CCR5-Δ32 polymorphism. Regarding the human papillomavirus (HPV) type, patients carrying the CCR2-64Ipolymorphism were protected against infection by HPV type 16 (OR = 0.35, p = 0.0184). In summary, our study showed a protective effect ofCCR2-64I rs1799864 polymorphism against the development of cervical lesions (CIN and CC) and in the susceptibility of HPV 16 infection.
- Published
- 2016