281 results on '"de Krijger R"'
Search Results
2. P04.02 Imaging mass cytometry reveals the spatial network of immune cells in neuroblastoma
- Author
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Bergsma, FJ, primary, Krijgsman, D, additional, van den Ham, F, additional, Amini, M, additional, Verdonschot, M, additional, van Dam, S, additional, de Krijger, R, additional, Molenaar, J, additional, Vercoulen, Y, additional, and Wienke, J, additional
- Published
- 2024
- Full Text
- View/download PDF
3. Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
- Author
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Fassnacht, M., Assie, G., Baudin, E., Eisenhofer, G., de la Fouchardiere, C., Haak, H.R., de Krijger, R., Porpiglia, F., Terzolo, M., and Berruti, A.
- Published
- 2020
- Full Text
- View/download PDF
4. Renal cell carcinoma in young FH mutation carriers: case series and review of the literature
- Author
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Hol, J. A., Jongmans, M. C. J., Littooij, A. S., de Krijger, R. R., Kuiper, R. P., van Harssel, J. J. T., Mensenkamp, A., Simons, M., Tytgat, G. A. M., van den Heuvel-Eibrink, M. M., and van Grotel, M.
- Published
- 2020
- Full Text
- View/download PDF
5. Handelen bij overlijden
- Author
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van Zeben-van der Aa, D. M. C. B., de Krijger, R. R., Semmekrot, B. A., Derksen-Lubsen, G., editor, Moll, H.A., editor, Oudesluys-Murphy, A.M., editor, Sprij, A.J., editor, Bolt-Wieringa, J.W., editor, van den Elzen, A.P.M., editor, Leeuwenburgh-Pronk, W.G., editor, Ropers, F.G., editor, and Verhoeven, J.J., editor
- Published
- 2018
- Full Text
- View/download PDF
6. Verrichtingen
- Author
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de Laat, P. C. J., Derksen-Lubsen, G., de Krijger, R. R., Derksen-Lubsen, G., editor, Moll, H.A., editor, Oudesluys-Murphy, A.M., editor, Sprij, A.J., editor, Bolt-Wieringa, J.W., editor, van den Elzen, A.P.M., editor, Leeuwenburgh-Pronk, W.G., editor, Ropers, F.G., editor, and Verhoeven, J.J., editor
- Published
- 2018
- Full Text
- View/download PDF
7. Deep Learning Approaches Applied to Image Classification of Renal Tumors: A Systematic Review
- Author
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Amador, Sandra, primary, Beuschlein, Felix, additional, Chauhan, Vedant, additional, Favier, Judith, additional, Gil, David, additional, Greenwood, Phillip, additional, de Krijger, R. R., additional, Kroiss, Matthias, additional, Ortuño-Miquel, Samanta, additional, Patocs, Attila, additional, Stell, Anthony, additional, and Walch, Axel, additional
- Published
- 2023
- Full Text
- View/download PDF
8. Corrigendum to “Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up”
- Author
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Fassnacht, M., primary, Assie, G., additional, Baudin, E., additional, Eisenhofer, G., additional, Fouchardiere, C. de la, additional, Haak, H.R., additional, de Krijger, R., additional, Porpiglia, F., additional, Terzolo, M., additional, and Berruti, A., additional
- Published
- 2023
- Full Text
- View/download PDF
9. Primary extrarenal rhabdoid tumour of the liver: a case report and literature review.
- Author
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Meyers, M., Demetter, P., De Roo, A. K., Pezzullo, M., Jungels, C., Brichard, B., De Magnee, C., De Krijger, R. R., and Verset, G.
- Published
- 2023
- Full Text
- View/download PDF
10. Quand les tumeurs pédiatriques et adultes se rejoignent. Pré-test
- Author
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de Krijger, R., Mussini, Charlotte, Picard, Cécile, Dijoud, Frédérique, Le Loarer, François, Bruneau, Julie, and Guettier, Catherine
- Published
- 2023
- Full Text
- View/download PDF
11. Reactivity of Germ Cell Maturation Stage-specific Markers in Classical and Spermatocytic Seminoma
- Author
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Looijenga, L. H. J., Stoop, H., van Gurp, R. J. H. L. M., de Krijger, R., Oosterhuis, J. W., Harnden, Patricia, editor, Joffe, Johnathan K., editor, and Jones, William G., editor
- Published
- 2002
- Full Text
- View/download PDF
12. Treatment-related neuroendocrine prostatic carcinoma
- Author
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Rubin, M A, de Krijger, R R, Meon, S, Moch, Holger, University of Zurich, and WHO Classification of Tumours Editorial Board
- Subjects
10049 Institute of Pathology and Molecular Pathology ,610 Medicine & health - Published
- 2022
13. Corrigendum to 'Adrenocortical carcinomas and malignant phaeochromocytomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up': [Annals of Oncology volume 31 (2020) 1476–1490, (S0923753420421076), (10.1016/j.annonc.2020.08.2099)]
- Author
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Fassnacht, M., Assie, G., Baudin, E., Eisenhofer, G., Fouchardiere, C. D. L., Haak, H. R., de Krijger, R., Porpiglia, F., Terzolo, M., and Berruti, A.
- Published
- 2022
14. ENSAT registry-based randomized clinical trials for adrenocortical carcinoma
- Author
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Crona, J. Baudin, E. Terzolo, M. Chrisoulidou, A. Angelousi, A. Ronchi, C.L. Oliveira, C.L. Nieveen van Dijkum, E.J.M. Ceccato, F. Borson-Chazot, F. Reimondo, G. Tiberi, G.A.M. Ettaieb, H. Kiriakopoulos, A. Letizia, C. Kastelan, D. Osher, E. Yiannakopoulou, E. Arnaldi, G. Assié, G. Paiva, I. Bourdeau, I. Newell-Price, J. Nowak, K.M. Tous Romero, M. de Martino, M.C. Bugalho, M.J. Sherlock, M. Vantyghem, M.-C. Dennedy, M.C. Loli, P. Rodien, P. Feelders, R. de Krijger, R. van Slycke, S. Aylwin, S. Morelli, V. Vroonen, L. Shafigullina, Z. Bancos, I. Trofimiuk-Müldner, M. Quinkler, M. Luconi, M. Kroiss, M. Naruse, M. Igaz, P. Mihai, R. della Casa, S. Berruti, A. Fassnacht, M. Beuschlein, F.
- Abstract
Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease. © 2021 BioScientifica Ltd.. All rights reserved.
- Published
- 2021
15. Immunohistochemical localization and quantitative expression of somatostatin receptors in normal human spleen and thymus: Implications for the in vivo visualization during somatostatin receptor scintigraphy
- Author
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Ferone, D., Pivonello, R., Kwekkeboom, D. J., Gatto, F., Ameri, P., Colao, A., de Krijger, R. R., Minuto, F., Lamberts, S. W. J., van Hagen, P. M., and Hofland, L. J.
- Published
- 2012
- Full Text
- View/download PDF
16. Placental Vascularization in Early Onset Small for Gestational Age and Preeclampsia
- Author
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van Oppenraaij, R. H. F., Bergen, N. E., Duvekot, J. J., de Krijger, R. R., Ir, W. C. J. Hop, Steegers, E. A. P., and Exalto, N.
- Published
- 2011
- Full Text
- View/download PDF
17. Oncogenic signaling pathways in the Cancer Genome Atlas
- Author
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Sanchez-Vega, F., Mina, M., Armenia, J., Chatila, W. K., Luna, A., La, K. C., Dimitriadoy, S., Liu, D. L., Kantheti, H. S., Saghafinia, S., Chakravarty, D., Daian, F., Gao, Q., Bailey, M. H., Liang, W. -W., Foltz, S. M., Shmulevich, I., Ding, L., Heins, Z., Ochoa, A., Gross, B., Gao, J., Zhang, H., Kundra, R., Kandoth, C., Bahceci, I., Dervishi, L., Doğrusöz, Uğur, Zhou, W., Shen, H., Laird, P. W., Way, G. P., Greene, C. S., Liang, H., Xiao, Y., Wang, C., Iavarone, A., Berger, A. H., Bivona, T. G., Lazar, A. J., Hammer, G. D., Giordano, T., Kwong, L. N., McArthur, G., Huang, C., Tward, A. D., Frederick, M. J., McCormick, F., Meyerson, M., Caesar-Johnson, S. J., Demchok, J. A., Felau, I., Kasapi, M., Ferguson, M. L., Hutter, C. M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J. J., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Cho, J., DeFreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Meier, S., Noble, M. S., Saksena, G., Voet, D., Bernard, B., Chambwe, N., Dhankani, V., Knijnenburg, T., Kramer, R., Leinonen, K., Liu, Y., Miller, M., Reynolds, S., Thorsson, V., Zhang, W., Akbani, R., Broom, B. M., Hegde, A. M., Ju, Z., Kanchi, R. S., Korkut, A., Li, J., Ling, S., Liu W., Lu, Y., Mills, G. B., Ng, K. -S., Rao, A., Ryan, M., Wang, J., Weinstein, J. N., Zhang, J., Abeshouse, A., de, Bruijn, I., Gross, B. E., Heins, Z. J., La, K., Ladanyi, M., Nissan, M. G., Phillips, S. M., Reznik, E., Sander, C., Schultz, N., Sheridan, R., Sumer, S. O., Sun, Y., Taylor, B. S., Anur, P., Peto, M., Spellman, P., Benz, C., Stuart, J. M., Wong, C. K., Yau, C., Hayes, D. N., Parker, J. S., Wilkerson, M. D., Ally, A., Balasundaram, M., Bowlby, R., Brooks, D., Carlsen, R., Chuah, E., Dhalla, N., Holt, R., Jones, S. J. M., Kasaian, K., Lee, D., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Mungall, K., Robertson, A. G., Sadeghi, S., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Berger, A. C., Beroukhim, R., Cherniack, A. D., Cibulskis, C., Gabriel, S. B., Gao, G. F., Ha, G., Schumacher, S. E., Shih, J., Kucherlapati, M. H., Kucherlapati, R. S., Baylin, S., Cope, L., Danilova, L., Bootwalla, M. S., Lai, P. H., Maglinte, D. T., Van, Den, Berg, D. J., Weisenberger, D. J., Auman, J. T., Balu, S., Bodenheimer, T., Fan, C., Hoadley, K. A., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Mose, L. E., Perou, A. H., Perou, C. M., Roach, J., Shi, Y., Simons, J. V., Skelly, T., Soloway, M. G., Tan, D., Veluvolu, U., Fan, H., Hinoue, T., Bellair, M., Chang, K., Covington, K., Creighton, C. J., Dinh, H., Doddapaneni, H., Donehower, L. A., Drummond, J., Gibbs, R. A., Glenn, R., Hale, W., Han, Y., Hu, J., Korchina, V., Lee, S., Lewis, L., Li, W., Liu, X., Morgan, M., Morton, D., Muzny, D., Santibanez, J., Sheth, M., Shinbrot, E., Wang, L., Wang, M., Wheeler, D. A., Xi, L., Zhao, F., Hess, J., Appelbaum, E. L., Bailey, M., Cordes, M. G., Fronick, C. C., Fulton, L. A., Fulton, R. S., Mardis, E. R., McLellan, M. D., Miller, C. A., Schmidt, H. K., Wilson, R. K., Crain, D., Curley, E., Gardner, J., Lau, K., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, C., Shelton, T., Sherman, M., Thompson, E., Yena, P., Bowen, J., Gastier-Foster, J. M., Gerken, M., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Wise, L., Zmuda, E., Corcoran, N., Costello, T., Hovens, C., Carvalho, A. L., de, Carvalho, A. C., Fregnani, J. H., Longatto-Filho, A., Reis, R. M., Scapulatempo-Neto, C., Silveira, H. C. S., Vidal, D. O., Burnette, A., Eschbacher, J., Hermes, B., Noss, A., Singh, R., Anderson, M. L., Castro, P. D., Ittmann, M., Huntsman, D., Kohl, B., Le, X., Thorp, R., Andry, C., Duffy, E. R., Lyadov, V., Paklina, O., Setdikova, G., Shabunin, A., Tavobilov, M., McPherson, C., Warnick, R., Berkowitz, R., Cramer, D., Feltmate, C., Horowitz, N., Kibel, A., Muto, M., Raut, C. P., Malykh, A., Barnholtz-Sloan, J. S., Barrett, W., Devine, K., Fulop, J., Ostrom, Q. T., Shimmel, K., Wolinsky, Y., Sloan, A. E., De, Rose, A., Giuliante, F., Goodman, M., Karlan, B. Y., Hagedorn, C. H., Eckman, J., Harr, J., Myers, J., Tucker, K., Zach, L. A., Deyarmin, B., Hu, H., Kvecher, L., Larson, C., Mural, R. J., Somiari, S., Vicha, A., Zelinka, T., Bennett, J., Iacocca, M., Rabeno, B., Swanson, P., Latour, M., Lacombe, L., Têtu, B., Bergeron, A., McGraw, M., Staugaitis, S. M., Chabot, J., Hibshoosh, H., Sepulveda, A., Su, T., Wang, T., Potapova, O., Voronina, O., Desjardins, L., Mariani, O., Roman-Roman, S., Sastre, X., Stern, M. -H., Cheng, F., Signoretti, S., Berchuck, A., Bigner, D., Lipp, E., Marks, J., McCall, S., McLendon, R., Secord, A., Sharp, A., Behera, M., Brat, D. J., Chen, A., Delman, K., Force, S., Khuri, F., Magliocca, K., Maithel, S., Olson, J. J., Owonikoko, T., Pickens, A., Ramalingam, S., Shin, D. M., Sica, G., Van, Meir, E. G., Eijckenboom, W., Gillis, A., Korpershoek, E., Looijenga, L., Oosterhuis, W., Stoop, H., van, Kessel, K. E., Zwarthoff, E. C., Calatozzolo, C., Cuppini, L., Cuzzubbo, S., DiMeco, F., Finocchiaro, G., Mattei, L., Perin, A., Pollo, B., Chen, C., Houck, J., Lohavanichbutr, P., Hartmann, A., Stoehr, C., Stoehr, R., Taubert, H., Wach, S., Wullich, B., Kycler, W., Murawa, D., Wiznerowicz, M., Chung, K., Edenfield, W. J., Martin, J., Baudin, E., Bubley, G., Bueno, R., De, Rienzo, A., Richards, W. 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A., Behrens, C., Bondaruk, J., Broaddus, R., Czerniak, B., Esmaeli, B., Fujimoto, J., Gershenwald, J., Guo, C., Logothetis, C., Meric-Bernstam, F., Moran, C., Ramondetta, L., Rice, D., Sood, A., Tamboli, P., Thompson, T., Troncoso, P., Tsao, A., Wistuba, I., Carter, C., Haydu, L., Hersey, P., Jakrot, V., Kakavand, H., Kefford, R., Lee, K., Long, G., Mann, G., Quinn, M., Saw, R., Scolyer, R., Shannon, K., Spillane, A., Stretch, J., Synott, M., Thompson, J., Wilmott, J., Al-Ahmadie, H., Chan, T. A., Ghossein, R., Gopalan, A., Levine, D. A., Reuter, V., Singer, S., Singh, B., Tien, N. V., Broudy, T., Mirsaidi, C., Nair, P., Drwiega, P., Miller, J., Smith, J., Zaren, H., Park, J. -W., Hung, N. P., Kebebew, E., Linehan, W. M., Metwalli, A. R., Pacak, K., Pinto, P. A., Schiffman, M., Schmidt, L. S., Vocke, C. D., Wentzensen, N., Worrell, R., Yang, H., Moncrieff, M., Goparaju, C., Melamed, J., Pass, H., Botnariuc, N., Caraman, I., Cernat, M., Chemencedji, I., Clipca, A., Doruc, S., Gorincioi, G., Mura, S., Pirtac, M., Stancul, I., Tcaciuc, D., Albert, M., Alexopoulou, I., Arnaout, A., Bartlett, J., Engel, J., Gilbert, S., Parfitt, J., Sekhon, H., Thomas, G., Rassl, D. M., Rintoul, R. C., Bifulco, C., Tamakawa, R., Urba, W., Hayward, N., Timmers, H., Antenucci, A., Facciolo, F., Grazi, G., Marino, M., Merola, R., de, Krijger, R., Gimenez-Roqueplo, A. -P., Piché, A., Chevalier, S., McKercher, G., Birsoy, K., Barnett, G., Brewer, C., Farver, C., Naska, T., Pennell, N. A., Raymond, D., Schilero, C., Smolenski, K., Williams, F., Morrison, C., Borgia, J. A., Liptay, M. J., Pool, M., Seder, C. W., Junker, K., Omberg, L., Dinkin, M., Manikhas, G., Alvaro, D., Bragazzi, M. 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Walker J., Zuna R., Feldman M., Valdivieso F., Dhir R., Luketich J., Pinero E.M.M., Quintero-Aguilo M., Carlotti C.G., Dos Santos J.S., Kemp R., Sankarankuty A., Tirapelli D., Catto J., Agnew K., Swisher E., Creaney J., Robinson B., Shelley C.S., Godwin E.M., Kendall S., Shipman C., Bradford C., Carey T., Haddad A., Moyer J., Peterson L., Prince M., Rozek L., Wolf G., Bowman R., Fong K.M., Yang I., Korst R., Rathmell W.K., Fantacone-Campbell J.L., Hooke J.A., Kovatich A.J., Shriver C.D., DiPersio J., Drake B., Govindan R., Heath S., Ley T., Van Tine B., Westervelt P., Rubin M.A., Lee J.I., Aredes N.D., Mariamidze A., Van Allen E.M., and Ciriello G.
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0301 basic medicine ,cancer genome atlas ,cancer genomics ,combination therapy ,pan-cancer ,PanCanAtlas ,precision oncology ,signaling pathways ,TCGA ,therapeutics ,whole exome sequencing ,Signaling pathways ,Somatic cell ,Wnt Protein ,Cancer Genome Atlas Research Network ,Biochemistry ,Medical and Health Sciences ,Phosphatidylinositol 3-Kinases ,Transforming Growth Factor beta ,Neoplasms ,Databases, Genetic ,LS2_1 ,Cancer genomics ,LS4_6 ,610 Medicine & health ,11 Medical and Health Sciences ,Cancer ,biology ,Wnt signaling pathway ,cancer genomic ,Precision oncology ,Biological Sciences ,Cell cycle ,DNA methylation ,Signal transduction ,CICLO CELULAR ,Life Sciences & Biomedicine ,Genes, Neoplasm ,Humans ,Neoplasms/genetics ,Neoplasms/pathology ,Phosphatidylinositol 3-Kinases/genetics ,Phosphatidylinositol 3-Kinases/metabolism ,Signal Transduction/genetics ,Transforming Growth Factor beta/genetics ,Transforming Growth Factor beta/metabolism ,Tumor Suppressor Protein p53/genetics ,Tumor Suppressor Protein p53/metabolism ,Wnt Proteins/genetics ,Wnt Proteins/metabolism ,Biotechnology ,Human ,Signal Transduction ,signaling pathway ,EXPRESSION ,Biochemistry & Molecular Biology ,GENES ,Pan-cancer ,Therapeutics ,General Biochemistry, Genetics and Molecular Biology ,NO ,Databases ,03 medical and health sciences ,Genetic ,Genetics ,Combination therapy ,Protein kinase B ,Gene ,SIGNATURES ,Cancer genome atlas ,Science & Technology ,LANDSCAPE ,MUTATIONS ,Biochemistry, Genetics and Molecular Biology(all) ,Human Genome ,Whole exome sequencing ,Cell Biology ,Transforming growth factor beta ,cancer genome atla ,06 Biological Sciences ,COMPREHENSIVE MOLECULAR CHARACTERIZATION ,Wnt Proteins ,therapeutic ,Good Health and Well Being ,030104 developmental biology ,Genes ,PanCanAtla ,biology.protein ,Cancer research ,Neoplasm ,Phosphatidylinositol 3-Kinase ,Tumor Suppressor Protein p53 ,Digestive Diseases ,Genetics and Molecular Biology(all) ,Developmental Biology - Abstract
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity. Eighty-nine percent of tumors had at least one driver alteration in these pathways, and 57% percent of tumors had at least one alteration potentially targetable by currently available drugs. Thirty percent of tumors had multiple targetable alterations, indicating opportunities for combination therapy. An integrated analysis of genetic alterations in 10 signaling pathways in >9,000 tumors profiled by TCGA highlights significant representation of individual and co-occurring actionable alterations in these pathways, suggesting opportunities for targeted and combination therapies. Michael Seiler, Peter G. Smith, Ping Zhu, Silvia Buonamici, and Lihua Yu are employees of H3 Biomedicine, Inc. Parts of this work are the subject of a patent application: WO2017040526 titled “Splice variants associated with neomorphic sf3b1 mutants.” Shouyoung Peng, Anant A. Agrawal, James Palacino, and Teng Teng are employees of H3 Biomedicine, Inc. Andrew D. Cherniack, Ashton C. Berger, and Galen F. Gao receive research support from Bayer Pharmaceuticals. Gordon B. Mills serves on the External Scientific Review Board of Astrazeneca. Anil Sood is on the Scientific Advisory Board for Kiyatec and is a shareholder in BioPath. Jonathan S. Serody receives funding from Merck, Inc. Kyle R. Covington is an employee of Castle Biosciences, Inc. Preethi H. Gunaratne is founder, CSO, and shareholder of NextmiRNA Therapeutics. Christina Yau is a part-time employee/consultant at NantOmics. Franz X. Schaub is an employee and shareholder of SEngine Precision Medicine, Inc. Carla Grandori is an employee, founder, and shareholder of SEngine Precision Medicine, Inc. Robert N. Eisenman is a member of the Scientific Advisory Boards and shareholder of Shenogen Pharma and Kronos Bio. Daniel J. Weisenberger is a consultant for Zymo Research Corporation. Joshua M. Stuart is the founder of Five3 Genomics and shareholder of NantOmics. Marc T. Goodman receives research support from Merck, Inc. Andrew J. Gentles is a consultant for Cibermed. Charles M. Perou is an equity stock holder, consultant, and Board of Directors member of BioClassifier and GeneCentric Diagnostics and is also listed as an inventor on patent applications on the Breast PAM50 and Lung Cancer Subtyping assays. Matthew Meyerson receives research support from Bayer Pharmaceuticals; is an equity holder in, consultant for, and Scientific Advisory Board chair for OrigiMed; and is an inventor of a patent for EGFR mutation diagnosis in lung cancer, licensed to LabCorp. Eduard Porta-Pardo is an inventor of a patent for domainXplorer. Han Liang is a shareholder and scientific advisor of Precision Scientific and Eagle Nebula. Da Yang is an inventor on a pending patent application describing the use of antisense oligonucleotides against specific lncRNA sequence as diagnostic and therapeutic tools. Yonghong Xiao was an employee and shareholder of TESARO, Inc. Bin Feng is an employee and shareholder of TESARO, Inc. Carter Van Waes received research funding for the study of IAP inhibitor ASTX660 through a Cooperative Agreement between NIDCD, NIH, and Astex Pharmaceuticals. Raunaq Malhotra is an employee and shareholder of Seven Bridges, Inc. Peter W. Laird serves on the Scientific Advisory Board for AnchorDx. Joel Tepper is a consultant at EMD Serono. Kenneth Wang serves on the Advisory Board for Boston Scientific, Microtech, and Olympus. Andrea Califano is a founder, shareholder, and advisory board member of DarwinHealth, Inc. and a shareholder and advisory board member of Tempus, Inc. Toni K. Choueiri serves as needed on advisory boards for Bristol-Myers Squibb, Merck, and Roche. Lawrence Kwong receives research support from Array BioPharma. Sharon E. Plon is a member of the Scientific Advisory Board for Baylor Genetics Laboratory. Beth Y. Karlan serves on the Advisory Board of Invitae.
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- 2018
18. Mutational Analyses of EGFR and Downstream Pathways in Adrenocortical Carcinoma: Correlation with Mitotane Response and Survival
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Hermsen, IGC, primary, Haak, HR, additional, de Krijger, R, additional, Kerkhofs, TMA, additional, Feelders, RA, additional, de Herder, W, additional, Wilmink, JW, additional, Smit, JWA, additional, Gelderblom, AJ, additional, Miranda, NFCC, additional, v Eijck, R, additional, Wezel, T, additional, and Morreau, H, additional
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- 2011
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19. Thyroid Hormone Signalling Is Suppressed in Progeroid and Normal Aging.
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Visser, W.E., primary, Garinis, G.A., additional, Bombardieri, C., additional, van der Pluijm, I., additional, Kaptein, E., additional, Brandt, R., additional, van Toor, H., additional, de Waard, M.C., additional, de Krijger, R., additional, Kopchick, J.J., additional, List, E.O., additional, Darras, V.M., additional, Dolle, M.E., additional, van der Horst, G.T.J., additional, Hoeijmakers, J.H.J., additional, and Visser, T.J., additional
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- 2010
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20. Adult hyperinsulinemic hypoglycemia not caused by an insulinoma: a report of two cases
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van der Wal, B. C. H., de Krijger, R. R., de Herder, W. W., Kwekkeboom, D. J., van der Ham, F., Bonjer, H. J., and van Eijck, C. H. J.
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- 2000
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21. TNM Staging of Neoplasms of the Endocrine Pancreas: Results From a Large International Cohort Study
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Rindi, G., Falconi, M., Klersy, C., Albarello, L., Boninsegna, L., Buchler, M. W., Capella, C., Caplin, M., Couvelard, A., Doglioni, C., Delle Fave, G., Fischer, L., Fusai, G., de Herder, W. W., Jann, H., Komminoth, P., de Krijger, R. R., La Rosa, S., Luong, T. V., Pape, U., Perren, A., Ruszniewski, P., Scarpa, A., Schmitt, A., Solcia, E., and Wiedenmann, B.
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- 2012
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22. Outcome of pregnancies complicated by oligohydramnios or anhydramnios of renal origin
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Grijseels, E. W. M., van-Hornstra, Echteld PTM, Govaerts, L. C. P., Cohen-Overbeek, T. E., de Krijger, R. R., Smit, B. J., and Cransberg, K.
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- 2011
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23. 41P Identifying novel target therapies for paediatric kidney cancer patients using patient-derived tumour organoids
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Calandrini, C., primary, Derakhshan, S., additional, Dolman, E.M., additional, De Krijger, R., additional, Tytgat, L., additional, Molenaar, J., additional, Van den Heuvel-Eibrink, M., additional, and Drost, J., additional
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- 2020
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24. Renal cell carcinoma in young FH mutation carriers: case series and review of the literature
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Hol, J. A., primary, Jongmans, M. C. J., additional, Littooij, A. S., additional, de Krijger, R. R., additional, Kuiper, R. P., additional, van Harssel, J. J. T., additional, Mensenkamp, A., additional, Simons, M., additional, Tytgat, G. A. M., additional, van den Heuvel-Eibrink, M. M., additional, and van Grotel, M., additional
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- 2019
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25. Self-limiting sternal tumors of childhood (SELSTOC)
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te Winkel, M. L., Lequin, M. H., de Bruyn, J. R., van de Ven, C. P., de Krijger, R. R., Pieters, R., and van den Heuvel-Eibrink, M. M.
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- 2010
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26. Phaeochromocytomas and sympathetic paragangliomas
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Petri, B.-J., van Eijck, C. H. J., de Herder, W. W., Wagner, A., and de Krijger, R. R.
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27. Cushing syndrome as a presenting symptom of renal tumors in children
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Segers, H., van der Heyden, J. C., van den Akker, E. L.T., de Krijger, R. R., Zwaan, C. M., and van den Heuvel-Eibrink, M. M.
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- 2009
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28. Effects of Somatostatin Analogs on a Growth Hormone-Releasing Hormone Secreting Bronchial Carcinoid, in Vivo and in Vitro Studies
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van Hoek, M, Hofland, L J., de Rijke, Y B., van Nederveen, F H., de Krijger, R R., van Koetsveld, P M., Lamberts, S W. J., van der Lely, A J., de Herder, W W., and Feelders, R A.
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- 2009
29. European Society for Pathology Symposium, September 2007: Controversial issues in thyroid pathology: what have we learned?
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de Krijger, R. R.
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- 2008
30. Stem cell factor as a novel diagnostic marker for early malignant germ cells#π
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Stoop, H, Honecker, F, van de Geijn, G JM, Gillis, A JM, Cools, M C, de Boer, M, Bokemeyer, C, Wolffenbuttel, K P, Drop, S LS, de Krijger, R R, Dennis, N, Summersgill, B, McIntyre, A, Shipley, J, Oosterhuis, J W, and Looijenga, L HJ
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- 2008
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31. FOXL2 and SOX9 as parameters of female and male gonadal differentiation in patients with various forms of disorders of sex development (DSD)#
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Hersmus, R, Kalfa, N, de Leeuw, B, Stoop, H, Oosterhuis, J W, de Krijger, R, Wolffenbuttel, K P, Drop, S LS, Veitia, R A, Fellous, M, Jaubert, F, and Looijenga, L HJ
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- 2008
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32. Erratum: The Immune Landscape of Cancer (Immunity (2018) 48(4) (812–830.e14), (S1074761318301213), (10.1016/j.immuni.2018.03.023))
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Thorsson, V., Gibbs, D. L., Brown, S. D., Wolf, D., Bortone, D. S., Ou Yang, T. -H., Porta-Pardo, E., Gao, G. F., Plaisier, C. L., Eddy, J. A., Ziv, E., Culhane, A. C., Paull, E. O., Sivakumar, I. K. A., Gentles, A. J., Malhotra, R., Farshidfar, F., Colaprico, A., Parker, J. S., Mose, L. E., N. S., Vo, Liu, J., Liu, Y., Rader, J., Dhankani, V., Reynolds, S. M., Bowlby, R., Califano, A., Cherniack, A. D., Anastassiou, D., Bedognetti, D., Mokrab, Y., Newman, A. M., Rao, A., Chen, K., Krasnitz, A., Hu, H., Malta, T. M., Noushmehr, H., Pedamallu, C. S., Bullman, S., Ojesina, A. I., Lamb, A., Zhou, W., Shen, H., Choueiri, T. K., Weinstein, J. N., Guinney, J., Saltz, J., Holt, R. A., Rabkin, C. S., Caesar-Johnson, S. J., Demchok, J. A., Felau, I., Kasapi, M., Ferguson, M. L., Hutter, C. M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J. J., Chudamani, S., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Cho, J., Defreitas, T., Frazer, S., Gehlenborg, N., Getz, G., Heiman, D. I., Kim, J., Lawrence, M. S., Lin, P., Meier, S., Noble, M. S., Saksena, G., Voet, D., Zhang, H., Bernard, B., Chambwe, N., Knijnenburg, T., Kramer, R., Leinonen, K., Miller, M., Reynolds, S., Shmulevich, I., Zhang, W., Akbani, R., Broom, B. M., Hegde, A. M., Ju, Z., Kanchi, R. S., Korkut, A., Li, J., Liang, H., Ling, S., Liu, W., Lu, Y., Mills, G. B., K. -S., Ng, Ryan, M., Wang, J., Zhang, J., Abeshouse, A., Armenia, J., Chakravarty, D., Chatila, W. K., de Bruijn, I., Gao, J., Gross, B. E., Heins, Z. J., Kundra, R., La, K., Ladanyi, M., Luna, A., Nissan, M. G., Ochoa, A., Phillips, S. M., Reznik, E., Sanchez-Vega, F., Sander, C., Schultz, N., Sheridan, R., Sumer, S. O., Sun, Y., Taylor, B. S., Anur, P., Peto, M., Spellman, P., Benz, C., Stuart, J. M., Wong, C. K., Yau, C., Hayes, D. N., Wilkerson, M. D., Ally, A., Balasundaram, M., Brooks, D., Carlsen, R., Chuah, E., Dhalla, N., Holt, R., Jones, S. J. M., Kasaian, K., Lee, D., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Mungall, K., Robertson, A. G., Sadeghi, S., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Berger, A. C., Beroukhim, R., Cibulskis, C., Gabriel, S. B., Ha, G., Meyerson, M., Schumacher, S. E., Shih, J., Kucherlapati, M. H., Kucherlapati, R. S., Baylin, S., Cope, L., Danilova, L., Bootwalla, M. S., Lai, P. H., Maglinte, D. T., Van Den Berg, D. J., Weisenberger, D. J., Auman, J. T., Balu, S., Bodenheimer, T., Fan, C., Hoadley, K. A., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Perou, A. H., Perou, C. M., Roach, J., Shi, Y., Simons, J. V., Skelly, T., Soloway, M. G., Tan, D., Veluvolu, U., Fan, H., Hinoue, T., Laird, P. W., Bellair, M., Chang, K., Covington, K., Creighton, C. J., Dinh, H., Doddapaneni, H., Donehower, L. A., Drummond, J., Gibbs, R. A., Glenn, R., Hale, W., Han, Y., Hu, J., Korchina, V., Lee, S., Lewis, L., Li, W., Liu, X., Morgan, M., Morton, D., Muzny, D., Santibanez, J., Sheth, M., Shinbrot, E., Wang, L., Wang, M., Wheeler, D. A., Xi, L., Zhao, F., Hess, J., Appelbaum, E. L., Bailey, M., Cordes, M. G., Ding, L., Fronick, C. C., Fulton, L. A., Fulton, R. S., Kandoth, C., Mardis, E. R., Mclellan, M. D., Miller, C. A., Schmidt, H. K., Wilson, R. K., Crain, D., Curley, E., Gardner, J., Lau, K., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, C., Shelton, T., Sherman, M., Thompson, E., Yena, P., Bowen, J., Gastier-Foster, J. M., Gerken, M., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Wise, L., Zmuda, E., Corcoran, N., Costello, T., Hovens, C., Carvalho, A. L., de Carvalho, A. C., Fregnani, J. H., Longatto-Filho, A., Reis, R. M., Scapulatempo-Neto, C., Silveira, H. C. S., Vidal, D. O., Burnette, A., Eschbacher, J., Hermes, B., Noss, A., Singh, R., Anderson, M. L., Castro, P. D., Ittmann, M., Huntsman, D., Kohl, B., Le, X., Thorp, R., Andry, C., Duffy, E. R., Lyadov, V., Paklina, O., Setdikova, G., Shabunin, A., Tavobilov, M., Mcpherson, C., Warnick, R., Berkowitz, R., Cramer, D., Feltmate, C., Horowitz, N., Kibel, A., Muto, M., Raut, C. P., Malykh, A., Barnholtz-Sloan, J. S., Barrett, W., Devine, K., Fulop, J., Ostrom, Q. T., Shimmel, K., Wolinsky, Y., Sloan, A. E., De Rose, A., Giuliante, F., Goodman, M., Karlan, B. Y., Hagedorn, C. H., Eckman, J., Harr, J., Myers, J., Tucker, K., Zach, L. A., Deyarmin, B., Kvecher, L., Larson, C., Mural, R. J., Somiari, S., Vicha, A., Zelinka, T., Bennett, J., Iacocca, M., Rabeno, B., Swanson, P., Latour, M., Lacombe, L., Tetu, B., Bergeron, A., Mcgraw, M., Staugaitis, S. M., Chabot, J., Hibshoosh, H., Sepulveda, A., Su, T., Wang, T., Potapova, O., Voronina, O., Desjardins, L., Mariani, O., Roman-Roman, S., Sastre, X., Stern, M. -H., Cheng, F., Signoretti, S., Berchuck, A., Bigner, D., Lipp, E., Marks, J., Mccall, S., Mclendon, R., Secord, A., Sharp, A., Behera, M., Brat, D. J., Chen, A., Delman, K., Force, S., Khuri, F., Magliocca, K., Maithel, S., Olson, J. J., Owonikoko, T., Pickens, A., Ramalingam, S., Shin, D. M., Sica, G., Van Meir, E. G., Eijckenboom, W., Gillis, A., Korpershoek, E., Looijenga, L., Oosterhuis, W., Stoop, H., van Kessel, K. E., Zwarthoff, E. C., Calatozzolo, C., Cuppini, L., Cuzzubbo, S., Dimeco, F., Finocchiaro, G., Mattei, L., Perin, A., Pollo, B., Chen, C., Houck, J., Lohavanichbutr, P., Hartmann, A., Stoehr, C., Stoehr, R., Taubert, H., Wach, S., Wullich, B., Kycler, W., Murawa, D., Wiznerowicz, M., Chung, K., Edenfield, W. J., Martin, J., Baudin, E., Bubley, G., Bueno, R., De Rienzo, A., Richards, W. G., Kalkanis, S., Mikkelsen, T., Scarpace, L., Girard, N., Aymerich, M., Campo, E., Gine, E., Guillermo, A. L., Van Bang, N., Hanh, P. T., Phu, B. D., Tang, Y., Colman, H., Evason, K., Dottino, P. R., Martignetti, J. A., Gabra, H., Juhl, H., Akeredolu, T., Stepa, S., Hoon, D., Ahn, K., Kang, K. J., Beuschlein, F., Breggia, A., Birrer, M., Bell, D., Borad, M., Bryce, A. H., Castle, E., Chandan, V., Cheville, J., Copland, J. A., Farnell, M., Flotte, T., Giama, N., Ho, T., Kendrick, M., Kocher, J. -P., Kopp, K., Moser, C., Nagorney, D., O'Brien, D., O'Neill, B. P., Patel, T., Petersen, G., Que, F., Rivera, M., Roberts, L., Smallridge, R., Smyrk, T., Stanton, M., Thompson, R. H., Torbenson, M., Yang, J. D., Zhang, L., Brimo, F., Ajani, J. A., Gonzalez, A. M. A., Behrens, C., Bondaruk, J., Broaddus, R., Czerniak, B., Esmaeli, B., Fujimoto, J., Gershenwald, J., Guo, C., Lazar, A. J., Logothetis, C., Meric-Bernstam, F., Moran, C., Ramondetta, L., Rice, D., Sood, A., Tamboli, P., Thompson, T., Troncoso, P., Tsao, A., Wistuba, I., Carter, C., Haydu, L., Hersey, P., Jakrot, V., Kakavand, H., Kefford, R., Lee, K., Long, G., Mann, G., Quinn, M., Saw, R., Scolyer, R., Shannon, K., Spillane, A., Stretch, O., Synott, M., Thompson, J., Wilmott, J., Al-Ahmadie, H., Chan, T. A., Ghossein, R., Gopalan, A., Levine, D. A., Reuter, V., Singer, S., Singh, B., Tien, N. V., Broudy, T., Mirsaidi, C., Nair, P., Drwiega, P., Miller, J., Smith, J., Zaren, H., Park, J. -W., Hung, N. P., Kebebew, E., Linehan, W. M., Metwalli, A. R., Pacak, K., Pinto, P. A., Schiffman, M., Schmidt, L. S., Vocke, C. D., Wentzensen, N., Worrell, R., Yang, H., Moncrieff, M., Goparaju, C., Melamed, J., Pass, H., Botnariuc, N., Caraman, I., Cernat, M., Chemencedji, I., Clipca, A., Doruc, S., Gorincioi, G., Mura, S., Pirtac, M., Stancul, I., Tcaciuc, D., Albert, M., Alexopoulou, I., Arnaout, A., Bartlett, J., Engel, J., Gilbert, S., Parfitt, J., Sekhon, H., Thomas, G., Rassl, D. M., Rintoul, R. C., Bifulco, C., Tamakawa, R., Urba, W., Hayward, N., Timmers, H., Antenucci, A., Facciolo, F., Grazi, G., Marino, M., Merola, R., de Krijger, R., Gimenez-Roqueplo, A. -P., Piche, A., Chevalier, S., Mckercher, G., Birsoy, K., Barnett, G., Brewer, C., Farver, C., Naska, T., Pennell, N. A., Raymond, D., Schilero, C., Smolenski, K., Williams, F., Morrison, C., Borgia, J. A., Liptay, M. J., Pool, M., Seder, C. W., Junker, K., Omberg, L., Dinkin, M., Manikhas, G., Alvaro, D., Bragazzi, M. C., Cardinale, V., Carpino, G., Gaudio, E., Chesla, D., Cottingham, S., Dubina, M., Moiseenko, F., Dhanasekaran, R., Becker, K. -F., Janssen, K. -P., Slotta-Huspenina, J., Abdel-Rahman, M. H., Aziz, D., Bell, S., Cebulla, C. M., Davis, A., Duell, R., Elder, J. B., Hilty, J., Kumar, B., Lang, J., Lehman, N. L., Mandt, R., Nguyen, P., Pilarski, R., Rai, K., Schoenfield, L., Senecal, K., Wakely, P., Hansen, P., Lechan, R., Powers, J., Tischler, A., Grizzle, W. E., Sexton, K. C., Kastl, A., Henderson, J., Porten, S., Waldmann, J., Fassnacht, M., Asa, S. L., Schadendorf, D., Couce, M., Graefen, M., Huland, H., Sauter, G., Schlomm, T., Simon, R., Tennstedt, P., Olabode, O., Nelson, M., Bathe, O., Carroll, P. R., Chan, J. M., Disaia, P., Glenn, P., Kelley, R. K., Landen, C. N., Phillips, J., Prados, M., Simko, J., Smith-McCune, K., Vandenberg, S., Roggin, K., Fehrenbach, A., Kendler, A., Sifri, S., Steele, R., Jimeno, A., Carey, F., Forgie, I., Mannelli, M., Carney, M., Hernandez, B., Campos, B., Herold-Mende, C., Jungk, C., Unterberg, A., von Deimling, A., Bossler, A., Galbraith, J., Jacobus, L., Knudson, M., Knutson, T., Ma, D., Milhem, M., Sigmund, R., Godwin, A. K., Madan, R., Rosenthal, H. G., Adebamowo, C., Adebamowo, S. N., Boussioutas, A., Beer, D., Giordano, T., Mes-Masson, A. -M., Saad, F., Bocklage, T., Landrum, L., Mannel, R., Moore, K., Moxley, K., Postier, R., Walker, J., Zuna, R., Feldman, M., Valdivieso, F., Dhir, R., Luketich, J., Pinero, E. M. M., Quintero-Aguilo, M., Carlotti, C. G., Dos Santos, J. S., Kemp, R., Sankarankuty, A., Tirapelli, D., Catto, J., Agnew, K., Swisher, E., Creaney, J., Robinson, B., Shelley, C. S., Godwin, E. M., Kendall, S., Shipman, C., Bradford, C., Carey, T., Haddad, A., Moyer, J., Peterson, L., Prince, M., Rozek, L., Wolf, G., Bowman, R., Fong, K. M., Yang, I., Korst, R., Rathmell, W. K., Fantacone-Campbell, J. L., Hooke, J. A., Kovatich, A. J., Shriver, C. D., Dipersio, J., Drake, B., Govindan, R., Heath, S., Ley, T., Van Tine, B., Westervelt, P., Rubin, M. A., Lee, J. I., Aredes, N. D., Mariamidze, A., Serody, J. S., Demicco, E. G., Disis, M. L., and Vincent, B. G.
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immune ,cancer ,methods - Published
- 2019
33. The prognostic value of two different histopathological scoring systems for adrenocortical carcinomas
- Author
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vanʼt Sant, H P, Bouvy, N D, Kazemier, G, Bonjer, H J, Hop, W C J, Feelders, R A, de Herder, W W, and de Krijger, R R
- Published
- 2007
34. Differences in telomerase expression by the CD1a+ cells in Langerhans cell histiocytosis reflect the diverse clinical presentation of the disease
- Author
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da Costa, C ET, Egeler, R M, Hoogeboom, M, Szuhai, K, Forsyth, R G, Niesters, M, de Krijger, R R, Tazi, A, Hogendoorn, P CW, and Annels, N E
- Published
- 2007
- Full Text
- View/download PDF
35. Expression of activin and inhibin subunits, receptors and binding proteins in human pheochromocytomas: a study based on mRNA analysis and immunohistochemistry
- Author
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Hofland, J., van Nederveen, F. H., Timmerman, M. A., Korpershoek, E., de Herder, W. W., Lenders, J. W., Verhofstad, A. A., de Krijger, R. R., and de Jong, F. H.
- Published
- 2007
36. Expression of activin and inhibin subunits, receptors and binding proteins in Human adrenocortical neoplasms
- Author
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Hofland, J., Timmerman, M. A., de Herder, W. W., van Schaik, R. H. N., de Krijger, R. R., and de Jong, F. H.
- Published
- 2006
37. Genetic Analyses of Apparently Sporadic Pheochromocytomas: The Rotterdam Experience
- Author
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KORPERSHOEK, E, VAN NEDERVEEN, F. H, DANNENBERG, H, PETRI, B. J, KOMMINOTH, P, PERREN, A, LENDERS, J. W, VERHOFSTAD, A. A, DE HERDER, W. W, DE KRIJGER, R. R, and DINJENS, W. N. M
- Published
- 2006
38. PTEN gene loss, but not mutation, in benign and malignant phaeochromocytomas
- Author
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van Nederveen, F H, Perren, A, Dannenberg, H, Petri, B-J, Dinjens, W NM, Komminoth, P, and de Krijger, R R
- Published
- 2006
- Full Text
- View/download PDF
39. The distribution of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the lungs of congenital diaphragmatic hernia patients and age-matched controls
- Author
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Masumoto, K, de Rooij, J D, Suita, S, Rottier, R, Tibboel, D, and de Krijger, R R
- Published
- 2006
40. Islet cell cytoplasmic antibody reactivity in midgestational human fetal pancreas
- Author
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de Krijger, R. R., van Krugten, M. V., Kranenburg, G., Aanstoot, H. J., Molenaar, J. L., and Bruining, G. J.
- Published
- 1994
- Full Text
- View/download PDF
41. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases during normal human pulmonary development
- Author
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Masumoto, K, de Rooij, J D, Suita, S, Rottier, R, Tibboel, D, and de Krijger, R R
- Published
- 2005
42. Differentiation and development of human female germ cells during prenatal gonadogenesis: an immunohistochemical study
- Author
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Stoop, H., Honecker, F., Cools, M., de Krijger, R., Bokemeyer, C., and Looijenga, L.H.J.
- Published
- 2005
43. Arterial infarction caused by carotid artery dissection in the neonate
- Author
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Lequin, M.H, Peeters, E.A.J, Holscher, H.C, de Krijger, R, and Govaert, P
- Published
- 2004
- Full Text
- View/download PDF
44. Enrichment of Beta cells from the human fetal pancreas by fluorescence activated cell sorting with a new monoclonal antibody
- Author
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de Krijger, R. R., Aanstoot, H. J., Kranenburg, G., Verkerk, A., Jongkind, J. F., van Strik, R., Lafferty, K. J., and Bruining, G. J.
- Published
- 1992
- Full Text
- View/download PDF
45. Cellular composition of pancreas-associated lymphoid tissue during human fetal pancreatic development
- Author
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Korpershoek, E, Leenen, P J M, Drexhage, H A, and de Krijger, R R
- Published
- 2004
46. Genotype-phenotype correlations in phaeochromocytoma
- Author
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de Krijger, R. R.
- Published
- 2004
47. Marqueurs moléculaires ciblés dérivés de la génomique pour le pronostic des corticosurrénalomes
- Author
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Jouinot, A., primary, Assié, G., additional, Fassnacht, M., additional, Libé, R., additional, Dousset, B., additional, Sbierae, S., additional, Ronchi, C., additional, Kroiss, M., additional, Korpershoek, E., additional, De Krijger, R., additional, Waldmann, J., additional, Quinkler, M., additional, Tabarin, A., additional, Chabre, O., additional, Luconi, M., additional, Mannelli, M., additional, Groussin, L., additional, Baudin, E., additional, Amar, L., additional, Beuschlein, F., additional, and Bertherat, J., additional
- Published
- 2017
- Full Text
- View/download PDF
48. 9B.09: IDENTIFICATION OF MARKERS PREDICTIVE FOR MALIGNANT BEHAVIOR OF PHEOCHROMOCYTOMAS AND PARAGANGLIOMAS
- Author
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Evenepoel, Lucie, Van Nederveen, F H, Oudijk, L, Papathomas, T G, Restuccia, D F, Belt, E J T, Franssen, G J H, Feelders, R A, Van Eeden, S, Timmers, H, De Herder, W W, Aydin, Selda, Vikkula, Miikka, De Krijger, R R, Dinjens, W N M, Persu, Alexandre, Korpershoek, E, 25th European Meeting on Hypertension and Cardiovascular Protection, UCL - (SLuc) Service d'anatomie pathologique, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Centre de génétique médicale UCL, and UCL - (SLuc) Service de pathologie cardiovasculaire
- Subjects
Pathology ,medicine.medical_specialty ,Mutation ,Tissue microarray ,Physiology ,business.industry ,SDHB ,IL13RA2 ,Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16] ,Interleukin-13 receptor ,medicine.disease_cause ,Genetic marker ,Internal Medicine ,Medicine ,Immunohistochemistry ,Cardiology and Cardiovascular Medicine ,business ,Gene - Abstract
Item does not contain fulltext OBJECTIVE: Pheochromocytomas and paragangliomas (PPGL) are relatively rare and mostly benign tumours. Approximately 10% of PPGL are malignant, as defined by the presence of metastases, i.e chromaffin tissue at a location that usually does not contain chromaffin cells. However, up to 35% of tumours in patients carrying an SDHB mutation appears to be malignant. Nowadays, no reliable marker allows to predict whether a PPGL is, or will become malignant. In addition, there are no curative treatments if metastases occur. The aim of the present study was to dentify genetic markers allowing to distinguish benign from malignant tumours. DESIGN AND METHOD: An mRNA expression array was performed on benign and malignant PPGL. The genes showing a different expression between the benign and malignant tumours were selected to be confirmed and validated by qRT-PCR. Finally, the remaining genes were stained by immunohistochemistry on Tissue MicroArray including a large series of PPGL. RESULTS: Forty benign and 12 malignant PPGL were investigated for differences in mRNA expression with Affymetrix arrays. Expression data were normalized according to Affymetrix recommendations. Then, using Pomelo II (http://pomelo2.bioinfo.cnio.es/), a Limma t-test was performed, to assess which genes were differentially expressed between benign and malignant PPGL. First, a non-clustered analysis was performed and 10 genes with a False Discovery Rate (FDR) below 0.05 and a relative overexpression ratio of at least 4 were found, including Interleukin 13 Receptor alpha 2 (IL13RA2) and Monooxygenase DBH-like 1 (MOXD1). Secondly, a supervised cluster analysis was performed (based on HIF target genes), resulting in 2 groups, which were both investigated for differences in mRNA expression between benign and malignant tumours. Five genes showed an FDR below 0.01 and were overexpressed in malignant tumours with a ratio higher than 4, including Contactin 4 (CNTN4), Iroquois Homeobox 3 (IRX3), and Sulfatase 2 (SULF2). These genes were further investigated using qRT-PCR, and immunohistochemistry on Tissue Micro Array including 91 benign and 12 malignant PPGL. CONCLUSIONS: Significant overexpression of Contactin 4 was shown in malignant compared to benign tumours, and may therefore contribute to distinguish malignant from benign PPGL.
- Published
- 2015
49. A new autosomal dominant syndrome with hypertrophic cardiomyopathy, heterotaxy, conduction abnormalities, atrial septal defect and pulmonary stenosis
- Author
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Wessels, M., Spitaels, S., De Krijger, R., Cohen-Overbeek, T., Niermeijer, M., Heutink, P., and Willems, P.
- Subjects
Human genetics -- Research ,Cardiomyopathy, Hypertrophic -- Genetic aspects ,Genetic disorders -- Research ,Biological sciences - Published
- 2001
50. Marqueurs moléculaires ciblés pour le pronostic des corticosurrénalomes
- Author
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Jouinot, A., primary, Assié, G., additional, Garinet, S., additional, Neou, M., additional, Faillot, S., additional, Libé, R., additional, Sibony, M., additional, Groussin, L., additional, Dousset, B., additional, Fassnacht, M., additional, Beuschlein, F., additional, De Krijger, R., additional, Baudin, E., additional, Touraine, P., additional, Sanson, M.L. Raffin, additional, Kerlan, V., additional, Barrande, G., additional, Amar, L., additional, Chazot, F. Borson, additional, Cohen, R., additional, Clauser, E., additional, Tabarin, A., additional, Chabre, O., additional, and Bertherat, J., additional
- Published
- 2016
- Full Text
- View/download PDF
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